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Background: Ketapang District, located in West Kalimantan, is a region where rabies is endemic. The first human death from rabies was reported in 2014 and the problem persists to this day. In response, the government has implemented the one health approach to control rabies since 2017. This study aimed to assess the disease burden of rabies control using zDALY metrics., Methods: The zoonotic burden for human and animal was measured by developing Zoonotic Disability-Adjusted Life Years (zDALY), which combines DALY and local values of animals and their products, considering animal morbidity and mortality due to the disease (Animal Loss Equivalent/ALE). Data were gathered through interviews with victims or their families, dog owners, and secondary data from the Animal Husbandry Service, and the District Health Office., Results: Before implementing the one health approach, the zDALY value was 1,561.22 person-years (the zDALY rate: 109.53 years/100,000 people). After the intervention, the zDALY value was 1,808.86 person-years (the zDALY rate: 86.62 years/100,000 people)., Conclusions: This reduction in the zDaly rate indicates that rabies control through the one health approach in Ketapang District was effective in alleviating the disease burden caused by rabies., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)