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Competing Interests: Funding Support and Author Disclosures Dr Parikh has received research support from Bayer, Infraredx, and Abbott Vascular; and consulting fees from Abbott Vascular and Infraredx. Dr Seto has received honoraria from Janssen, Terumo, Getinge, and GE Healthcare; and is a consultant to Frond Medical and Summacor. Dr Tehrani has reported that he has no relationships relevant to the contents of this paper to disclose.

Axillary artery access has become increasingly widespread as an alternative to the femoral route for large-bore transcatheter aortic valve replacement (TAVR), endovascular aortic repair (EVAR), and mechanical circulatory support (MCS) procedures. Advantages of percutaneous access include avoidance of a surgical incision, general anesthesia, and conduit graft infection. This statement aims to review the anatomic considerations and risks for percutaneous axillary artery access, suggest best practices for access techniques, hemostasis/closure strategies, and complication management, and recommend options for training and privileging., (© 2022 The Author(s).)