1. Dermatofibrosarcoma Protuberans.
- Author
-
Allen A, Ahn C, and Sangüeza OP
- Subjects
- Dermatofibrosarcoma genetics, Dermatofibrosarcoma pathology, Dermatologic Surgical Procedures, Humans, Imatinib Mesylate therapeutic use, Margins of Excision, Oncogene Proteins, Fusion genetics, Oncogene Proteins, Fusion metabolism, Skin Neoplasms genetics, Skin Neoplasms pathology, Translocation, Genetic genetics, Antineoplastic Agents therapeutic use, Dermatofibrosarcoma therapy, Mohs Surgery, Skin Neoplasms therapy
- Abstract
Dermatofibrosarcoma protuberans (DFSP) is an uncommon dermal neoplasm that exhibits a high rate of local recurrence and infiltrative behavior, but has a low risk of metastasis. It arises as a slowly progressive, painless pink or violet plaque. Histologically, DFSP is characterized by a monomorphous spindle cell proliferation in a storiform pattern. The gold standard of treatment is surgical resection with negative margins. In cases where obtaining clear margins is not possible, radiation and systemic therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to be effective., (Published by Elsevier Inc.)
- Published
- 2019
- Full Text
- View/download PDF