1. The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment.
- Author
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Salehi-Rad R, Li R, Paul MK, Dubinett SM, and Liu B
- Subjects
- Humans, Immunotherapy methods, Lung Neoplasms diagnosis, Lung Neoplasms prevention & control, Lung Neoplasms therapy
- Abstract
Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients., Competing Interests: Disclosure S.M. Dubinett reports receiving a commercial research grant from Johnson & Johnson and is a consultant/advisory board member for LungLifeAI, Early Dx, Inc, the Johnson & Johnson Lung Cancer Initiative, and T-Cure Biosciences, Inc., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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