1. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis.
- Author
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Dorr MB, Nelson AL, Mayer PR, Ranganath RP, Norris PM, Helzner EC, and Preston RA
- Subjects
- Administration, Intravaginal, Administration, Oral, Aged, Atrophy blood, Atrophy drug therapy, Atrophy metabolism, Cross-Over Studies, Drug Administration Schedule, Estrogens, Conjugated (USP) blood, Estrogens, Conjugated (USP) pharmacokinetics, Estrone blood, Female, Humans, Middle Aged, Osmolar Concentration, Vagina drug effects, Vaginal Creams, Foams, and Jellies, Vaginitis blood, Vaginitis metabolism, Estradiol blood, Estrogens, Conjugated (USP) administration & dosage, Vagina pathology, Vaginitis drug therapy
- Abstract
In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E2 and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens., (Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2010
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