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Angiodysplasias are one of the reasons of gastrointestinal bleeding, whose origin is usually due to vascular malformations. There are different types of therapies for angiodysplasia such as endoscopic, angiographic and pharmacological techniques. Among the last ones, there is little variety of effective drugs to treat the disease. We describe the therapeutic failure with thalidomide in a male with recurrent gastrointestinal bleeding due to angiodysplasias. A thorough diagnostic work-up, including gastroscopy, enteroscopy, angiography and capsule endoscopy were performed. Despite treatment with high-dose somatostatin analogues and oral iron, the patient continued bleeding. The patient was administered then thalidomide for three months with no clinical response. Thalidomide had to be withdrawn owing to adverse effects., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)

The cholesteatoma is characterized by Epidermic Keratinizated tissue in the middle ear and mastoid with capacity of migration and erosion of near-by structures. Commonly cholesteatoma is associated with chronic medium otitis, but in a few cases, tympanic membrana is integry and the diagnosis is made when appear complications. We report a case of giant cholesteatoma with intact tympanic membrana. The extension, silent period and evolution are evaluate.

We report a case of late-onset pneumoencephalus after fracture of the frontal sinus. Long-term follow-up sinus injuries is recommended.

A study was made of the variables that influence primary and secondary stapedectomy. We studied stapedectomies performed in the last 5 years at our hospital. The only variable that significantly influenced outcome was technique.

A case of lingual thyroid accompanied of primary thyroid insufficiency is reported, which reply property of the treatment with thyroides hormones.