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Allergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the allergens available, and the concentration and vehicle advised for those that still remain unavailable., (Copyright © 2024 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Competing Interests: Conflicts of interest None declared.

Objectives: The objective of this study was to assess the diagnostic performance of combined computerised tomography (CT) and positron emission tomography (PET) in mediastinal staging of surgical lung cancer based on data obtained from the prospective cohort of the Spanish Group for Video-Assisted Thoracic Surgery (GEVATS)., Methods: A total of 2782 patients underwent surgery for primary lung carcinoma. We analysed diagnostic success in mediastinal lymph node staging (cN2) using CT and PET. Bivariate and multivariate analyses were performed of the factors involved in this success. The risk of unexpected pN2 disease was analysed for cases in which an invasive testing is recommended: cN1, the tumour centrally located or the tumour diameter >3 cm., Results: The overall success of CT together with PET was 82.9% with a positive predictive value of 0.21 and negative predictive value of 0.93. If the tumour was larger than 3 cm and for each unit increase in mediastinal SUVmax, the probability of success was lower with OR 0.59 (0.44-0.79) and 0.71 (0.66-0.75), respectively. In the video-assisted thoracic surgery (VATS) approach, the probability of success was higher with OR 2.04 (1.52-2.73). The risk of unexpected pN2 increased with the risk factors cN1, the tumour centrally located or the tumour diameter >3 cm: from 4.5% (0 factors) to 18.8% (3 factors) but did not differ significantly as a function of whether invasive testing was performed., Conclusions: CT and PET together have a high negative predictive value. The overall success of the staging is lower in the case of tumours >3 cm and high mediastinal SUVmax, and it is higher when VATS is performed. The risk of unexpected pN2 is higher if the disease is cN1, the tumour centrally located or the tumour diameter >3 cm but does not vary significantly as a function of whether patients have undergone invasive testing., (Copyright © 2022 AEC. Published by Elsevier España, S.L.U. All rights reserved.)

Objectives: Main objective: To compare the effectiveness for checking surgical margins between SPECT-portable and mammography of the piece (RxM)., Secondary Objective: To standardize a pre-operative protocol using SPECT-portable and to evaluate the time required in the use of this technique., Material and Methods: Prospective longitudinal study with 36 patients (39 lesions) diagnosed with breast cancer (CM) with criteria for SNOLL/ROLL. A pre-surgical study of the tumor lesion was performed, after the eco-guided administration of 99m Tc-nanocolloids of albumin/ 99m Tc-macroaggregates of albumin, in the tumor lesion. Hybrid images (optical + SPECT) and 3D navigation images with gamma probe are obtained using freehandSPECT. In the operating room, 4-5 images are obtained with freehandSPECT, (I) on skin for tumor location, (II) after exposure of surgical bed for resection guide, (III) of the surgical bed after exeresis, (IV and V) the anterior-posterior and lateral surface of the surgical specimen. The three criteria to decide to extend the margins are: (a) residual activity (cps) at the edges of the surgical bed resection; (b) visual analysis of the uptake in the specimen; (c) a minimum distance of 10 mm from the edges of the specimen to the center of greatest uptake, plus the radius of the lesion. We study the concordance of: the depth measurement between ultrasound and freehandSPECT; the surgical margins between freehandSPECT vs. mammography of the specimen (RxM), considering anatomical pathology (AP) as the gold standard technique as reference; surgical time used with freehandSPECT and RxM., Results: Intraoperative localization was performed in all cases. False negative (FN: no detection margin affected) with freehandSPECT: 9 margins; with RxM: 8. True positive (TP: detection margin affected) with freehandSPECT: 5 margins, with RxM: 6. True negative (TN: consider free margin when healthy) with freehandSPECT: 213 margins; with RxM: 196. Negative predictive value (NPV: probability of negative margin on unaffected part) with freehandSPECT: 95.9%, with RxM: 96.07%. Specificity with freehandSPECT: 96.8%, with RxM: 97%. The concordance of surgical bed margins between freehandSPECT and RxM: 94.5%. Between freehandSPECT and AP: 93.1%. Between RxM and PA: 93.5%, being all statistically significant (p-value <0.000), so we can affirm that both techniques are related or dependent on the reference technique, the PA. Degree of correlation between SPECT-portable and low PA (Kappa index: 0.34, 95% CI [0.22-0.47], and between RxM and moderate PA (Kappa index: 0.42, 95% CI [0.29-0.56], p-value <0.001. Comparison of the successes and failures of both techniques (SPECT-portable and RxM) and PA: Distribution χ2: 0.023 with degree of freedom 1, with value <0.05, so we can affirm that both techniques are similar, since there are no significant statistical differences. Median total OR time: 60.25 min (30-145). Mean freehandSPECT OR time: 5 scans = 10 min., Conclusions: There are no statistically significant differences in the probability to rule out affective margins that require a second surgery between both techniques (SPECT-portable and RxM) so, the technique performed with SPECT-Portable is a useful and effective procedure, which requires specific training with an optimized and multidisciplinary protocol. The time spent with SPECT-portable is feasible for daily practice., (Copyright © 2022 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.)

Objectives: To validate Trauma and Injury Severity Score (TRISS) methodology as an auditing tool in the Spanish ICU Trauma Registry (RETRAUCI)., Design: A prospective, multicenter registry evaluation was carried out., Setting: Thirteen Spanish Intensive Care Units (ICUs)., Patients: Individuals with traumatic disease and available data admitted to the participating ICUs., Interventions: Predicted mortality using TRISS methodology was compared with that observed in the pilot phase of the RETRAUCI from November 2012 to January 2015. Discrimination was evaluated using receiver operating characteristic (ROC) curves and the corresponding areas under the curves (AUCs) (95% CI), with calibration using the Hosmer-Lemeshow (HL) goodness-of-fit test. A value of p<0.05 was considered significant., Main Variables of Interest: Predicted and observed mortality., Results: A total of 1405 patients were analyzed. The observed mortality rate was 18% (253 patients), while the predicted mortality rate was 16.9%. The area under the ROC curve was 0.889 (95% CI: 0.867-0.911). Patients with blunt trauma (n=1305) had an area under the ROC curve of 0.887 (95% CI: 0.864-0.910), and those with penetrating trauma (n=100) presented an area under the curve of 0.919 (95% CI: 0.859-0.979). In the global sample, the HL test yielded a value of 25.38 (p=0.001): 27.35 (p<0.0001) in blunt trauma and 5.91 (p=0.658) in penetrating trauma. TRISS methodology underestimated mortality in patients with low predicted mortality and overestimated mortality in patients with high predicted mortality., Conclusions: TRISS methodology in the evaluation of severe trauma in Spanish ICUs showed good discrimination, with inadequate calibration - particularly in blunt trauma., (Copyright © 2015 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)

Objective: To describe the characteristics and management of severe trauma disease in Spanish Intensive Care Units (ICUs). Registry of trauma in the ICU (RETRAUCI). Pilot phase., Design: A prospective, multicenter registry., Setting: Thirteen Spanish ICUs., Patients: Patients with trauma disease admitted to the ICU., Interventions: None., Main Variables of Interest: Epidemiology, out-of-hospital attention, registry of injuries, resources utilization, complications and outcome were evaluated., Results: Patients, n=2242. Mean age 47.1±19.02 years. Males 79%. Blunt trauma 93.9%. Injury Severity Score 22.2±12.1, Revised Trauma Score 6.7±1.6. Non-intentional in 84.4% of the cases. The most common causes of trauma were traffic accidents followed by pedestrian and high-energy falls. Up to 12.4% were taking antiplatelet medication or anticoagulants. Almost 28% had a suspected or confirmed toxic influence in trauma. Up to 31.5% required an out-of-hospital artificial airway. The time from trauma to ICU admission was 4.7±5.3hours. At ICU admission, 68.5% were hemodynamically stable. Brain and chest injuries predominated. A large number of complications were documented. Mechanical ventilation was used in 69.5% of the patients (mean 8.2±9.9 days), of which 24.9% finally required a tracheostomy. The median duration of stay in the ICU and in hospital was 5 (range 3-13) and 9 (5-19) days, respectively. The ICU mortality rate was 12.3%, while the in-hospital mortality rate was 16.0%., Conclusions: The pilot phase of the RETRAUCI offers a first impression of the epidemiology and management of trauma disease in Spanish ICUs., (Copyright © 2015 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)

Ablation of pulmonary veins for treatment of atrial fibrillation involves applying radiofrequency energy wave by a catheter that causes a circumferential lesion to achieve electrical isolation and voltage drop in the interior. It is mainly applied when there is resistance to treatment and recurrence of symptoms affecting the quality of life of patients. The nurse is an important part of the multidisciplinary team who care for patients who undergo this procedure. The provision of comprehensive nursing care should include nursing procedures prior to, during, and after treatment to ensure the careful and systematic quality required. The aims of this article are: to provide specialised knowledge on the procedure of atrial fibrillation ablation, to describe the preparation of the electrophysiology laboratory, analyse nursing care and develop a standardized care plan for patients on whom this procedure is performed using the NANDA (North American Nursing Association) taxonomy and NIC (Nursing Intervention Classification)., (Copyright © 2010 Elsevier España, S.L. All rights reserved.)

Introduction: Attention deficit disorder and hyperactivity (ADDH), is a condition that affects the normal development of children. The symptoms include difficulty of controlling physical activity, inattention and learning disorders. The ADDH must be diagnosed in accordance with the clinical findings defined in the DSM IV., Objective: To describe the epidemiology and clinical characteristics of children diagnosed with ADDH in our hospital., Material and Methods: Biannual observational study. Variables evaluated were: age, sex, personal and family medical history, symptoms, therapy and treatment response., Results: There 83 participants (87 % Male and 13 % Female), of which 32.5 % were diagnosed during the study. Ages ranged from 3-8 years (84 %). There was a family history related to ADDH in 38 % of patients, and personal history of prematurity, acute foetal distress, small for gestational age, convulsions were reported. Association of hyperactivity and attention deficit was found in 65 % of participants. Other related symptoms were cognitive disorder (62 %), language disabilities (41 %) and motor disorders (35 %). Treatment was on-going in 65 % of the patients, 27.7 % of them having adverse effect. Evolution with therapy was favourable in 61 %., Conclusions: These findings suggest that ADDH is one of the most common childhood psychiatric disorders, mainly affecting boys. There is usually a family history. Failure in school was one of the principal conditions. Association between attention deficit and hyperactivity, mainly hyperactivity, is the most common presentation. Other disorders such as motor and language disabilities are also common in these patients. Methylphenidate showed favourable outcomes in 61 % of the patients studied.

Introduction: research into memory in geriatrics and gerontology has become increasingly important in recent years. However, various studies have shown that not all aspects or types of memory are affected in the same way or with the same severity by old age., Objectives: the present study aimed to establish differential profiles in objective and subjective memory associated with old age with a view to establishing criteria that could be used to distinguish between age-associated memory loss and pathological memory loss, thus aiding diagnosis of cognitive impairment., Material and Methods: a total of 143 participants between 60 and 98 years of age were evaluated using a battery of tests comprising the validated Spanish version of the Mini-Mental State Examination [Lobo's Mini-Examen Cognoscitivo (MEC)], diverse tests for objective memory [the auditory verbal learning test of learning potential (AVLT-LP) and a working memory test], and the subjective memory questionnaire., Results and Conclusions: significant differences were found between distinct age groups in different measures of subjective and objective memory. In general terms, persons who complained most about memory problems were not those with poorer performance on objective memory tests. The results show that measures of subjective and objective memory assess different aspects of memory.

Introduction: A basic indicator for assessing a program aimed at improving hand hygiene (HH) is the degree of compliance with the recommendations established for this purpose. The aim of this study is to investigate this indicator and related determinant factors in a general hospital., Methods: We performed 166 observation periods of one hour's duration, distributed over three work shifts and covering all the hospitalization units; 3957 HH opportunities were recorded. Variables associated with the observation period, the professionals involved and the medical activity taking place were also recorded. The Chi-square test, and calculation of the raw OR and the adjusted OR with a logistic regression model were used to study associations between the variables studied and failure to perform HH., Results: The overall frequency of HH activity was 30%, ranging from 8.9% to 60.5% depending on the professional tasks involved. The most important independent risk factors for failure to perform HH were the following: no availability of alcohol in a pocket size bottle (OR: 2.3 [1.7-3.3]); medical activities carried out in the surgical unit (OR: 2.6 [2.0-3.3]); activities taking place before entering into contact with patients (OR: 3.2 [2.4-4.2]); and use of gloves during the activity (OR: 2.2 [1.6-3.2])., Conclusion: The frequency of HH is low, but there are several potentially modifiable factors involved, which could improve with interventions. One example might be better education of hospital personnel on the importance of HH.

Background and Objective: Influenza vaccination is indicated in health professionals. Nevertheless, vaccination coverage in healthcare workers tends to be low. This paper determines the reasons why some workers are vaccinated whereas others are not and investigates what type of intervention can modify the latter attitude., Method: This was a cross-sectional descriptive study using a questionnaire survey., Setting: workers at Hospital General Universitario de Alicante (Alicante, Spain). Absolute frequencies and relative frequencies expressed in percentages were calculated for each of the variables studied. Results were analyzed considering the professional categories of the persons involved and the departments where they worked., Results: The reasons for influenza vaccination stated by hospital workers were to protect their health (65.6%), the belief that vaccination is beneficial (45.7%), and to avoid transmitting influenza to their patients (42.5%), and to their own families (39.8%). The main reasons for not undergoing vaccination were to avoid medication (17.9%), confidence in their own defenses (17%), or fear of the secondary effects of the vaccine (16.8%)., Conclusion: The main reason given by hospital personnel for undergoing vaccination was to protect their own health and that of their family and patients. The reasons most frequently given for not undergoing vaccination were based on possible side effects of the vaccine, the conviction of not being part of a high-risk group, and doubts about the effectiveness of the vaccine as a protective agent. Many of the reasons given for not undergoing vaccination were based on erroneous beliefs and should be taken into account when designing strategies to increase influenza vaccination coverage among health personnel.

Introduction: Diagnosis of Gilbert's disease often involves unnecessary testing and patient anxiety. Rifampin test can support the diagnosis; it has been described in short series and lacks standardization in dose, collection times, result presentation and interpretation. Our objective was to compare the response to oral rifampin in a series of patients with Gilbert's disease, 2 and 4 h after drug administration., Patients and Methods: Eighty-nine patients with Gilbert's disease (elevated total bilirubin with no hepatopathy or hemolysis) were recruited. After a basal blood collection, 900 mg rifampin were administered per os and new samples were drawn 2 and 4 h later. Total and esterified bilirubin were measured in every sample. Haptoglobin concentration was also analyzed., Results: When expressed as relative increase with respect to basal values, variations observed 2 h after rifampin intake were all above 15%. A significant correlation (r = 0.902; p = 0.000) was found between relative increases 2 and 4 h after drug administration. No significant variations were found in haptoglobin concentrations., Conclusion: Rifampin test is useful in diagnosing Gilbert's disease, but variations in total bilirubin concentrations (basal and post-rifampin) make that no absolute cut-off value can be used. Correlation between 2- and 4-h relative increases suggests that a shortened version could simplify the test.

Introduction and Objectives: The aim of this study was to analyze the influence of modifiable cardiovascular risk factors on the circadian rhythm of acute myocardial infarction., Patients and Method: We analyzed a retrospective cohort of 54,249 patients from a multicenter study of acute myocardial infarction (the Spanish ARIAM study). The variables were time of onset of symptoms, age, sex, previous ischemic heart disease, coronary unit discharge status, previous stroke, familial antecedents of ischemic heart disease, hypertension, diabetes, dyslipidemia, smoking, and reinfarction. To verify the presence of circadian rhythm, we developed a simple test of equality of time series based on cosinor analysis of multiple sinusoid curves. Three sinusoids (24, 12 and 8 hour periods) were used., Results: The time of onset of pain showed a circadian rhythm (P< .01), with a peak at 10:07 am and a trough at 4:46 am. All subgroups categorized according to the presence of the variables analyzed here showed a circadian rhythm, with a sinusoid curve after adjustment. In patients with diabetes or reinfarction or who were smokers, the sinusoid curve was bimodal., Conclusions: Time of onset of symptoms in patients with acute myocardial infarction follows a circadian rhythm. Diabetes, smoking and reinfarction can modify the standard circadian rhythm of onset of myocardial infarction.

Objective: To assess the burden (incidence, treatment and complications) of acute otitis media (AOM) and otitis media with effusion (OME) in children younger than 5 years of age from Valencia, Spain., Subject and Methods: We performed a retrospective cohort study of 1,399 children followed-up for the first 5 years of life. Seventeen pediatricians reviewed the medical records of their patients born in 1995 and 1996 and followed-up from birth until the age of 5 years. For each child, the number of otitis episodes, treatment, complications, and surgical interventions was obtained., Results: There were 2,961 episodes of AOM in the first 5 years of life (2.23 cases/child). Four hundred seventy-six cases (16.1 %) occurred before 1 year of age and 1,346 between the first and second year of life (45.5 %). By the third year of life, 59.8 % had had at least one episode. In most children (80.9 %), diagnosis was made in primary care and required a median of 1.81 visits/episode for follow-up. A total of 94.5 % were treated with antibiotics (amoxicillin-clavulanate 38.8 %, cefuroxime 14.3 %, clarithromycin 8.2 % and amoxicillin 5.9 %) and 8.5 % required a change of antibiotic therapy. Two hundred seventeen children (15.2 %) had at least one episode of OME. Twenty-six patients (1.8 %, 95 % CI: 1.2-2.7 %) required insertion of ventilation tubes. Twenty-four patients (1.7 %) had secondary hypoacusis. There was one case of meningitis and two cases of chronic otorrhea. No cases of mastoiditis were recorded., Conclusions: The incidence of AOM in Valencia is 40,014 episodes/100,000 children younger than 5 years/year (95 % CI: 39,700-40,300). It represents a significant burden due to the large number of visits, antibiotic use, associated surgical procedures and need for auditory rehabilitation.

Fournier's gangrene is a skin infectious-necrotising process in the peri-neogenital area affecting males, usually in their sixties or seventies. Isolated flora from cultures of the necrotic lesion is commonly multi-microbial. In a majority of cases both aerobic and anaerobic micro-organisms are found in the cultures, Escherichia coli being the most commonly identified germ. Although considered in the past an idiopathic condition, in most patients today a genitourinary, anorectal or dermal triggering factor can be identified. There are a series of systemic host debilitating disorders such as diabetes mellitus, chronic alcohol abuse, and malignant neoplasia that are associated to this condition and may be considered risk factor to suffer this disease. Fournier's gangrene in children show specific bacteriological, pathogenic, clinical, therapeutic and prognostic features that distinguish it from that in adults. The most extensively accepted management for this condition includes therapy with broad-spectrum parenteral antibiotics and early and aggressive surgical debridement of the necrotic areas. Mortality continues to be high, ranging between 10-80% in the various series. Finally, a group of 7 patients with Fournier's gangrene is analyzed (1991-1998) aiming to establish a comparison between our results and those seen in recent series.

Abdomino-pelvic actinomycosis is a condition caused by Actinomyces israelii, a Gram-positive opportunistic bacteria that triggers and develops the infection only in previously injured tissues, and then slowly progresses and spreads until it extrinsically affects the urinary tract. Use of an intrauterine device is a known risk factor to suffer from this disease. Relative risk in IUD users is two- to four-fold higher compared to IUD non-users. Risk increased with prolonged IUD use. Treatment is by removal of the causative agent, surgical resection of necrotic tissues and administration of intravenous Penicillin G, 4 million units every 4 hours for 30 days, followed by Amoxicillin 500 mg every 8 hours for 12 months. This paper contributes two cases of abdomino-pelvic actinomycosis with urinary tract involvement in IUD users. Standard treatment was employed with good evolution.

Introduction and Objectives: Recent studies have demonstrated that adenosine is an endogenous modulator of the cardiac excitatory afferent nerves, and could provoke a vasovagal response during head-up tilt test. Isoproterenol has been the drug of choice to increase the sensitivity of this testing. The aim of the present study was to analyze the role of adenosine in head-up tilt-induced syncope in susceptible patients, and to compare the relative sensitivities of adenosine and isoproterenol., Methods: Thirty patients with unexplained syncope (16 female and 14 male, mean age 37.1 +/- 18 years), no heart disease and negative baseline head-up tilt test were studied. After the baseline test, patients were randomized to receive adenosine triphosphate (bolus injections of 3, 6 and 9 mg/ 5 min) or isoproterenol (bolus injections of 2, 4 and 6 micrograms/5 min) and underwent a second tilt test. After 15 min at rest, patients received the alternative drug and a third test was performed. Eleven normal control subjects were tested with adenosine in the upright position to determine its effects., Results: A vasovagal response was induced in 7 patients (23.3%) after ATP administration. Nine patients (30%) showed a positive response with isoproterenol. Only 2 patients (6.6%) showed a positive response with both drugs. Of the control subjects, one (9%) had a vasovagal response after ATP administration., Conclusions: We conclude that adenosine triphosphate seems to be a useful tool to provoke vasovagal reaction in susceptible patients during head-up tilt test.

We report a fetus of 35 weeks gestation in which a continuous flow was detected in the lower portion of the right atrium with a peak velocity of 0.8 m/s. After delivery the echo-doppler study showed a dilated coronary sinus in the long axis parasternal view, and a bilateral superior vena cava in the short axis suprasternal notch view. Comments about the cause of this anomalous continuous flow are discussed.

Introduction and Objectives: Prognosis and therapeutic assessment of patients with syncope and prolonged asystole during head-up tilt test remain unclear. The aim of the present study was to analyze the clinical evolution of patients with syncope of unknown origin, no heart disease and severe cardioinhibitory response induced by head-up tilt., Methods: A prospective follow-up study was performed in 12 patients (6 male and 6 female, mean age 31 +/- 20 years) with recurrent syncope, no heart disease and affected by severe cardioinhibitory syncope induced by head-up tilt test. This was defined as syncope or near-syncope induced by baseline or isoproterenol tilt with asystole of > or = 3 seconds. All patients were re-tilted twice: with salt and fluid and with metoprolol (25 mg/b.i.d). According to the results of these tests, 5 patients were discharged with dietetic measures (salt & fluid) and 5 with metoprolol. In 2 patients who showed recurrent prolonged asystole a DDD pacemaker was implanted., Results: After follow-up of 34 +/- 20 months all patients ae alive. The number of recurrences was small (2 syncopes and 2 near-syncopes). No relationship was observed between the number of syncopal recurrences and the applied treatment., Conclusions: We conclude that prolonged asystole induced by head-up tilt test does not confer an adverse prognosis in patients with syncope of unknown origin and no heart disease, thus, the clinical evolution of these patients is benign.

Objective: To describe nutritional habits in a Health District by defining the patterns of food consumption., Design: A descriptive, crossover study., Setting: Health District of Molina de Segura, Murcia., Method: A community survey by interview of 1,071 people (95% confidence; accuracy to 3%), selected from the Municipal Roll by simple randomised sampling, was performed. The statistical methods were: Chi-squared and Student's tests, ANOVA, Pearson's linear correlation, factorial and discriminatory analysis., Measurements and Main Results: 17.3%, especially men, never took milk products (p < 0.0005). 12.5%, mainly young people, consumed more than 3 eggs a week (p < 0.02). 85% ate fruit daily; 70%, green and root vegetables; and 78%, olive oil. 12.6% had pulses more than 3 days a week. Only 6.5% had potatoes or pasta daily. Among men and young people there was a "bar culture", along with a "fast food" pattern., Conclusions: The abandoned Mediterranean diet must be promoted. Measures should be taken to moderate young people's and men's alcohol consumption. "Fast food" and "bar culture" patterns are the most deeply rooted. The nutritional education of the chronically ill should also be emphasised.

Objective: To find the prevalence of tobacco dependency in our community and to identify tobacco consumption in our chronic patients., Design: A crossover study. A descriptive analysis of the data., Setting: A Health District. Mixed population, both urban and rural., Participants: A Health Survey which included 1,071 individuals (95% Confidence and 3% precision), selected by means of simple random sampling from the Municipal Census., Measurements and Main Results: A 32.3% prevalence of tobacco dependency, greater among men (50.7%) than women (15.7%). Among the young, there is a marked tendency for the number of smokers to level out between the sexes. 15.6% of smokers consume more than 24 cigarettes per day. Between 15 and 20% of patients suffering hypertension, diabetes, hypercholesterolaemia and the effects of ischaemic cardiopathy, along with 25% of those who had suffered a CVA and almost 40% of chronic bronchitics, continue to smoke., Conclusions: Advice against smoking must be directed towards younger and younger age groups, including both men and women. The high prevalence of people still smoking among the chronically ill should cause us to reflect on our advice against tobacco to such patients.

Objective: Identification of the social profile of our anxious patients, and analysis of the usefulness of Bell's questionnaire for our area of work., Design: A retrospective observation study of a crossover type., Setting: Primary Care., Participants: 55 patients who consulted their Family Doctor and were diagnosed as suffering from Anxiety., Measurements and Main Results: We confirmed the diagnosis with the DSM-III-R and then analysed the level of Anxiety with the Hamilton Scale. The social evaluation was done by means of Bell's profile. As test statistics we used the lineal correlation Coefficient, the Student's t and Xi2 tests and Variance Analysis. 65% of diagnoses were Generalised Anxiety. The Hamilton mean was 20.9 points (S = 9.2). Overall social adaptation was unsatisfactory, with the worst results being for the emotional aspects. We observed a higher level of Anxiety as age increased (p = 0.021), related to a worse adaptation to Health (p = 0.014). Dissatisfaction with work and the working environment took the form of professional adaptation being poorer as their work situation deteriorated (p = 0.006). Anxiety levels were higher among the unemployed. Social adaptation was less among people with higher Anxiety levels (p = 0.04), above all as a consequence of worse adaptation to Health (p = 0.002) and worse emotional (p = 0.00001) adaptation., Conclusions: 1) We must introduce social aspects into analysis of patients with Anxiety. 2) Bell's profile enables us to identify those social aspects which can be tackled when caring for our patients. Its fundamental use is in individual application.

The intrahospital transport of a critically ill child is always a risky procedure. While it is being done, some complications which can worsen their initial situation may appear, so the benefits that this transport can provide must outweigh the possible risks. Preparing the patient and succeeding in performing a safe transport need the use of the proper equipment and human resources. Its degree of complexity and preparation must be proportional to the situation of instability of the patient and to the probability of increasing such instability, which implies performing a careful evaluation of the child and its real and potential needs previously. We also state some general ideas about the way of preparing and performing this kind of intrahospital transport in its different stages.

Objective: To revise clinical histological, therapeutic and evolutive specifications of Bowen's disease. To emphasise the importance of an early diagnosis and to promote treatment with topical 5-fluorouracil by the family doctor., Design: Descriptive and transversal study., Setting: Outpatient and dermatology departments in a hospital in the metropolitan area of Madrid., Patients and Other Participants: Nine patients (5 male and 4 female), aged over 50, with slightly pigmented skin and diagnosed to have Bowen's disease., Treatment: In five patients. Topical 5-fluorouracil (Efudix) was applied once a day for 20-30 days. Surgery was performed on three patients and one underwent radiotherapy., Measurements and Main Results: The clinical histories of the patients were used. In each case a histological study of the papule that had confirmed diagnosis was carried out. Treatment was effective in all patients and no recidivation was observed during the one year follow up., Conclusions: An early diagnosis and treatment of Bowen's disease is important for preventing its progression to invasive epidermoid carcinoma and later dissemination. The use of topical 5-fluorouracil is an efficient measure that can be prescribed by the family doctor.

Three cases are presented of patent uncomplicated ductus arteriosus in children, with short systolic murmur, in which the noninvasive diagnosis could not be possible without the echo-Doppler help. Although are cases with small shunts and hemodynamically well tolerated, its diagnosis and surgical treatment are essential in order to prevent the risk of bacterial endocarditis of those patients.