98 results on '"F. Pons"'
Search Results
2. Radiology's and nuclear medicine's paths converge.
- Author
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Pons F
- Subjects
- Nuclear Medicine
- Published
- 2020
- Full Text
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3. Clinical characteristics of hepatocellular carcinoma in Spain. Comparison with the 2008-2009 period and analysis of the causes of diagnosis out of screening programs. Analysis of 686 cases in 73 centers.
- Author
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Rodríguez de Lope C, Reig M, Matilla A, Ferrer MT, Dueñas E, Mínguez B, F Castroagudín J, Ortiz I, Pascual S, Lledó JL, Gallego A, Arenas JI, Aracil C, Forne M, Muñoz C, Pons F, Sala M, Iñarrairaegui M, Martin-Llahi M, Andreu V, Garre C, Rendón P, Fuentes J, Crespo J, Rodríguez M, Bruix J, and Varela M
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular etiology, Carcinoma, Hepatocellular therapy, Female, Guideline Adherence statistics & numerical data, Humans, Liver Neoplasms etiology, Liver Neoplasms therapy, Male, Middle Aged, Practice Guidelines as Topic, Practice Patterns, Physicians' statistics & numerical data, Prospective Studies, Spain, Carcinoma, Hepatocellular diagnosis, Early Detection of Cancer, Liver Neoplasms diagnosis
- Abstract
Background and Objective: In 2010 we published that 53% of cases of hepatocellular carcinoma (HCC) detected in Spain were diagnosed outside the context of standard screening programs, which consequently leads to lower survival rates. The aim of this study was to analyze the current situation and the causes of diagnosis out of screening programs., Material and Methods: Prospective registry of 73 second- and third-level Spanish healthcare centers carried out between October 1, 2014 and January 31, 2015. The baseline characteristics of the disease and the first treatment administered for the incidental primary liver tumors during such period were recorded., Results: A total of 720 patients were included in the study: HCC (n=686), intrahepatic cholangiocarcinoma (n=29), hepatic cholangiocarcinoma (n=2), other (n=3). HCC characteristics: male 82%; mean age 67 years; cirrhosis 87%; main etiologies: alcohol 35%, HCV 30%, alcohol and HCV 15%, non-alcoholic fatty liver disease 6%; tumor stage: BCLC-0 11%, A 43%, B 19%, C 16% and D 11%; first treatment: transarterial chemoembolization (23%), percutaneous ablation (22%), symptomatic treatment (20%), resection (11%), sorafenib (11%). Three hundred and fifty-six patients (53%) were diagnosed outside of screening programs, mainly owing to the fact that they suffered from an undiagnosed liver disease (76%) and to the poor adherence to the screening program (18%). These patients were mainly male (P<.001), with an alcoholic etiology (P<.001) and active alcohol consumption (P<.001). Moreover, the disease was predominantly diagnosed at more advanced stages (P<.001) and was addressed with less radical treatments (P<.001)., Conclusions: In Spain, the main cause of diagnosis of a HCC outside the context of a screening program is the absence of a prior diagnosis of a liver disease, particularly in alcohol-consuming men. Detecting a liver disease in asymptomatic populations and improving adherence to screening programs are the main areas that must be subject to improvement in order to improve the early detection of HCC., (Copyright © 2017 Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
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4. 18 F-FDG PET/CT and sentinel lymph node biopsy in the staging of patients with cervical and endometrial cancer. Role of dual-time-point imaging.
- Author
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Mayoral M, Paredes P, Domènech B, Fusté P, Vidal-Sicart S, Tapias A, Torné A, Pahisa J, Ordi J, Pons F, and Lomeña F
- Subjects
- Adult, Carcinoma diagnostic imaging, Carcinoma pathology, Endometrial Neoplasms pathology, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lymph Node Excision, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Radiopharmaceuticals, Sensitivity and Specificity, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms pathology, Carcinoma secondary, Endometrial Neoplasms diagnostic imaging, Lymphatic Metastasis diagnostic imaging, Neoplasm Staging methods, Positron Emission Tomography Computed Tomography methods, Sentinel Lymph Node diagnostic imaging, Uterine Cervical Neoplasms diagnostic imaging
- Abstract
Objective: Definitive staging for cervical (CC) and endometrial cancer (EC) takes place once surgery is performed. The aim of this study was to evaluate the role of PET/CT in detecting lymphatic metastasis in patients with CC and EC using dual-time-point imaging (DPI), taking the histopathological results of sentinel lymph node (SLN) and lymphadenectomy as the reference., Material and Methods: A prospective study was conducted on 17 patients with early CC, and 13 patients with high-risk EC. The patients had a pre-operative PET/CT, MRI, SLN detection, and lymphadenectomy, when indicated. PET/CT findings were compared with histopathological results., Results: In the pathology study, 4 patients with CC and 4 patients with EC had lymphatic metastasis. PET/CT showed hypermetabolic nodes in 1 patient with CC, and 5 with EC. Four of these had metastasis, one detected in the SLN biopsy. Four patients who had negative PET/CT had micrometastasis in the SLN biopsy, 1 patient with additional lymph nodes involvement. The overall patient-based sensitivity, specificity, positive and negative predictive values, and accuracy of PET/CT to detect lymphatic metastasis was 20.0%, 100.0%, 100.0%, 87.9%, and 88.2%, respectively, in CC, and 57.1%, 88.9%, 66.7%, 84.2% and 80.0%, respectively, in EC. DPI showed higher retention index in malignant than in inflammatory nodes, although no statistically significant differences were found., Conclusions: PET/CT has low sensitivity in lymph node staging of CC and EC, owing to the lack of detection of micrometastasis. Thus, PET/CT cannot replace SLN biopsy. Although no statistically significant differences were found, DPI may help to differentiate between inflammatory and malignant nodes., (Copyright © 2016 Elsevier España, S.L.U. y SEMNIM. All rights reserved.)
- Published
- 2017
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5. [Continuing to make progress].
- Author
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Pons F
- Subjects
- Diagnostic Imaging, Humans, Spain, Journal Impact Factor, Periodicals as Topic classification, Periodicals as Topic trends
- Published
- 2016
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6. Prognostic value of (18)F-FDG PET/CT volumetric parameters in recurrent epithelial ovarian cancer.
- Author
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Mayoral M, Fernandez-Martinez A, Vidal L, Fuster D, Aya F, Pavia J, Pons F, Lomeña F, and Paredes P
- Subjects
- Female, Humans, Multimodal Imaging, Neoplasm Recurrence, Local metabolism, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local pathology, Ovarian Neoplasms metabolism, Ovarian Neoplasms mortality, Ovarian Neoplasms pathology, Positron-Emission Tomography, Prognosis, Retrospective Studies, Tomography, X-Ray Computed, Tumor Burden, Neoplasm Recurrence, Local diagnostic imaging, Ovarian Neoplasms diagnostic imaging, Positron Emission Tomography Computed Tomography
- Abstract
Objective: Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are emerging prognostic biomarkers in various solid neoplasms. These volumetric parameters and the SUVmax have shown to be useful criteria for disease prognostication in preoperative and post-treatment epithelial ovarian cancer (EOC) patients. The purpose of this study was to evaluate the utility of (18)F-FDG PET/CT measurements to predict survival in patients with recurrent EOC., Material and Methods: Twenty-six patients with EOC who underwent a total of 31 (18)F-FDG PET/CT studies for suspected recurrence were retrospectively included. SUVmax and volumetric parameters whole-body MTV (wbMTV) and whole-body TLG (wbTLG) with a threshold of 40% and 50% of the SUVmax were obtained. Correlation between PET parameters and progression-free survival (PFS) and the survival analysis of prognostic factors were calculated., Results: Serous cancer was the most common histological subtype (76.9%). The median PFS was 12.5 months (range 10.7-20.6 months). Volumetric parameters showed moderate inverse correlation with PFS but there was no significant correlation in the case of SUVmax. The correlation was stronger for first recurrences. By Kaplan-Meier analysis and log-rank test, wbMTV 40%, wbMTV 50% and wbTLG 50% correlated with PFS. However, SUVmax and wbTLG 40% were not statistically significant predictors for PFS., Conclusion: Volumetric parameters wbMTV and wbTLG 50% measured by (18)F-FDG PET/CT appear to be useful prognostic predictors of outcome and may provide valuable information to individualize treatment strategies in patients with recurrent EOC., (Copyright © 2015 Elsevier España, S.L.U. and SEMNIM. All rights reserved.)
- Published
- 2016
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7. [Screening with angiographic images prior to (99m)Tc-HMPAO labelled leukocyte scintigraphy in the diagnosis of periprosthetic infection].
- Author
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Granados U, Fuster D, Soriano A, García S, Bori G, Martínez JC, Mayoral M, Perlaza P, Tomás X, and Pons F
- Subjects
- Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Prosthesis-Related Infections etiology, Sensitivity and Specificity, Staphylococcal Infections diagnostic imaging, Staphylococcal Infections etiology, Staphylococcus epidermidis, Angiography, Hip Prosthesis adverse effects, Knee Prosthesis adverse effects, Leukocytes, Prosthesis-Related Infections diagnostic imaging, Radionuclide Imaging, Radiopharmaceuticals, Technetium Tc 99m Exametazime
- Abstract
Aim: To evaluate the impact of the angioscintigrapy of the three phase bone scan as screening method to rule out infection of the hip and knee prosthesis prior to performing the (99m)Tc-HMPAO leukocyte scintigraphy., Material and Methods: A total of 120 (70 women, 50 men; mean age 71±11years) with clinical suspicion of hip (n=63) or knee (n=57) infection of the prosthesis and clinical suspicion of infection were evaluated prospectively. All patients underwent three-phase bone scan (angioscintigraphy, vascular and bone phase) and (99m)Tc-HMPAO-labelled white blood cell scintigraphy. Final diagnosis of infection was made by microbiological documentation or clinical follow-up for at least 12months., Results: Eighteen out of 120 patients were diagnosed of infection of hip prosthesis (n=10) or knee prosthesis (n=8). The angioscintigraphy was positive in 15/18 infected cases and in 21/102 of the non-infected cases with a sensitivity of 83%, specificity of 79% and negative predictive value of 97%. Sensitivity and specificity of (99m)Tc-HMPAO leukocyte scintigraphy were 72% and 95%, respectively. If the leukocyte labeled scintigraphies had been used exclusively for patients with positive angioscintigraphy, this would have saved up to 70% of the (99m)Tc-HMPAO leukocyte scintigraphies performed. There were no cases of infection with positive labeled leukocyte scintigraphy and negative angioscintigraphy., Conclusion: Angioscintigraphy (blood flow phase of bone scan) is a useful technique for screening for hip and knee joint prosthesis infection, significantly reducing the need for (99m)Tc-HMPAO leukocyte scintigraphy without affecting the sensitivity of the technique., (Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.)
- Published
- 2015
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8. The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report.
- Author
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Mayoral M, Paredes P, Sieira R, Vidal-Sicart S, Marti C, and Pons F
- Subjects
- Carcinoma, Squamous Cell surgery, Humans, Male, Middle Aged, Mouth Neoplasms surgery, Radionuclide Imaging, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell pathology, Gamma Cameras, Intraoperative Care instrumentation, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms pathology, Sentinel Lymph Node Biopsy instrumentation
- Abstract
The use of sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity is still subject to debate although some studies have reported its feasibility. The main reason for this debate is probably due to the high false-negative rate for floor-of-mouth tumors per se. We report the case of a 54-year-old man with a T1N0 floor-of-mouth squamous cell carcinoma who underwent the sentinel lymph node procedure. Lymphoscintigraphy and SPECT/CT imaging were performed for lymphatic mapping with a conventional gamma camera. Sentinel lymph nodes were identified at right Ib, left IIa and Ia levels. However, these sentinel lymph nodes were difficult to detect intraoperatively with a gamma probe owing to the activity originating from the injection site. The use of a portable gamma camera made it possible to localize and excise all the sentinel lymph nodes. This case demonstrates the usefulness of this tool to improve sentinel lymph node detecting in floor-of-mouth tumors, especially those close to the injection area., (Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.)
- Published
- 2014
- Full Text
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9. [Utility of positron emission tomography with 18F-FDG in a case of juvenile recurrent respiratory papillomatosis].
- Author
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Navales I, Paredes P, Cols M, Perissinotti A, Vancells M, and Pons F
- Subjects
- Adolescent, Female, Humans, Fluorodeoxyglucose F18, Papillomavirus Infections diagnostic imaging, Positron-Emission Tomography, Radiopharmaceuticals, Respiratory Tract Infections diagnostic imaging
- Abstract
Juvenile recurrent respiratory papillomatosis (JRRP) is an infectious disease caused by the growth of papillomas in the airway. Up to 4% of these cases degenerate into squamous cell carcinoma. We present the case of a 17-year-old female patient with JRRP in which the utility of (18)F-FDG-PET/CT in the characterization of suspicious papillomatous lesions of malignancy is evaluated. Morphometabolic techniques, CT scan and PET/CT scans were suggestive of malignancy. However, this was not confirmed in the histopathological analysis after its resection. The (18)F-FDG-PET/CT does not seem to be a useful tool for early detection of malignancy in JRRP. However, it does increase the diagnostic accuracy of the biopsy as it identifies the most active lesions and, therefore, those most likely to be malignant., (Copyright © 2012 Elsevier España, S.L. and SEMNIM. All rights reserved.)
- Published
- 2013
- Full Text
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10. Tumor thrombosis detected on PET/CT scanning in a patient with metastasic melanoma.
- Author
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Conejero A, Vidal-Sicart S, Navales I, and Pons F
- Subjects
- Aged, Female, Humans, Pulmonary Embolism etiology, Femoral Vein, Melanoma secondary, Multimodal Imaging, Neoplastic Cells, Circulating, Positron-Emission Tomography, Pulmonary Embolism diagnosis, Skin Neoplasms pathology, Tomography, X-Ray Computed
- Published
- 2013
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11. [Dual-time point images of the liver with (18)F-FDG PET/CT in suspected recurrence from colorectal cancer].
- Author
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Fuster D, Lafuente S, Setoain X, Navales I, Perissinotti A, Pavia J, Paredes P, Lomeña F, and Pons F
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma therapy, Aged, Bone Neoplasms diagnostic imaging, Bone Neoplasms secondary, Colorectal Neoplasms therapy, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Liver Neoplasms diagnostic imaging, Male, Middle Aged, Pelvic Neoplasms diagnostic imaging, Pelvic Neoplasms secondary, Prospective Studies, Radiopharmaceuticals, Sensitivity and Specificity, Time Factors, Adenocarcinoma secondary, Colorectal Neoplasms pathology, Liver diagnostic imaging, Liver Neoplasms secondary, Lymphatic Metastasis diagnostic imaging, Multimodal Imaging methods, Positron-Emission Tomography, Tomography, X-Ray Computed
- Abstract
Aim: To analyze the potential improvement of (18)F-fluorodeoxyglucose (FDG) PET/CT using additional delayed images of the liver in operated colorectal cancer., Material and Methods: The study prospectively included 71 patients (22 women, 49 men) with mean age of 65 ± 11 years with clinical, analytic or radiological suspicion of current disease. A whole body PET/CT scan was performed at 60 min. (standard images) and after 2 hr (delayed images) post-injection of 4.07 MBq/Kg of (18)F-FDG. Visual and quantitative SUV analysis of PET/CT findings was done. All findings were confirmed by histopathology and/or at least 6 months follow-up., Results: Thirty-seven out of 71 patients were diagnosed of liver metastases (79 metastases). In 38/71 cases there was extra-hepatic disease in the form of local recurrence (10), abdominopelvic (3) or mediastinal (3) lymph nodes, bone (1) or lung metastases (16) and carcinomatosis (10). Sensitivity and specificity in the diagnosis of liver metastases in a patient-by-patient basis in standard (81% and 91%) and in delayed images (95% y 97%) was calculated. The number of lesions detected in delayed images was significantly higher (66/79) than in standard images (57/79). Sensitivity and specificity for PET/CT in the diagnosis of extra-hepatic disease was 84% and 70%, contributing to the detection of synchronous tumors in 5 patients., Conclusions: PET/CT may be useful in the diagnosis of extra-hepatic disease in suspected recurrence of colorectal cancer. Delayed images on PET/CT may increase the sensitivity to identify liver metastases., (Copyright © 2011 Elsevier España, S.L. y SEMNIM. All rights reserved.)
- Published
- 2012
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12. [Advances in a two year adventure].
- Author
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Pons F
- Subjects
- Spain, Time Factors, Nuclear Medicine, Societies, Medical
- Published
- 2011
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13. [Casual finding of a pituitary adenoma in a PET-CT study].
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Solà-Gimferrer O, Rubí-Sureda S, Domenech-Brasero B, Navales-Mateu I, Lomeña-Caballero F, and Pons-Pons F
- Subjects
- Adenocarcinoma diagnostic imaging, Adenocarcinoma secondary, Aged, Cerebellar Neoplasms diagnostic imaging, Cerebellar Neoplasms secondary, Diagnosis, Differential, Humans, Lung Neoplasms, Male, Pituitary Neoplasms secondary, Incidental Findings, Neoplasms, Second Primary diagnostic imaging, Pituitary Neoplasms diagnostic imaging, Positron-Emission Tomography, Tomography, X-Ray Computed
- Published
- 2011
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14. [Rendu-Osler disease with hepatic involvement: first transplant in Spain].
- Author
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Núñez Viejo MA, Fernández Montes A, Hernández Hernández JL, Pons Romero F, Fábrega García E, and Zarrabeitia R
- Subjects
- Female, Hepatic Artery abnormalities, Hepatic Veins abnormalities, Humans, Middle Aged, Radiography, Abdominal, Spain, Telangiectasia, Hereditary Hemorrhagic diagnostic imaging, Tomography, X-Ray Computed, Arteriovenous Fistula etiology, Heart Failure etiology, Liver Transplantation, Telangiectasia, Hereditary Hemorrhagic complications, Telangiectasia, Hereditary Hemorrhagic surgery
- Abstract
Background and Objective: Rendu-Osler's disease (RO) is a rare systemic vascular disorder due to a fibrovascular dysplasia in the endothelium of vessels. Recurrent epistaxis is the main clinical manifestation, but arteriovenous malformations (AVMs) can involve many organs, including the liver. Hepatic involvement can develop refractory heart failure due to large shunts between the hepatic veins and the hepatic artery. Embolization and hepatic artery ligation have also demonstrated to reduce cardiac output in RO, but these therapeutic options have significant morbidity and complications such as necrosis or liver failure., Case Report: We report the case of a 48 years old woman diagnosed in 1987 with RO and significant hepatic involvement, with multiple fistulas between veins and hepatic artery. In the following years she developed progressive heart failure that limited her quality of life., Results: She was admitted on more times with heart failure and her dyspnea worsened progressively up to NYHA IV. At this time, an echocardiograph control showed an output cardiac about 10.6l/min. On December 2004, although the medical treatment, the worsening of the patient went on, so we finally decided to conduct a liver transplant that resolved the symptoms and the hyperdynamic circulation. Despite the fact that liver transplant has become without doubt into the best treatment for these patients in the last years., Conclusions: This is the first one done in Spain. There are different therapies available for these patients, but the indications for transplantation are greater each day, mainly due to the risks of the other options. Currently the stated guidelines are heart failure and portal hypertension refractory to medical treatment. So in these situations, liver transplantation should be proposed in the early stages of the disease and may be the only viable option., (Copyright © 2009 Elsevier España, S.L. All rights reserved.)
- Published
- 2010
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15. [Questions about the common core curriculum].
- Author
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Pons F
- Subjects
- Spain, Curriculum, Nuclear Medicine education
- Published
- 2010
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16. [Pruritus associated with cholestasis].
- Author
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Terán A, Fábrega E, and Pons-Romero F
- Subjects
- Animals, Anion Exchange Resins therapeutic use, Cholestasis physiopathology, Evidence-Based Medicine, Female, Gastrin-Releasing Peptide physiology, Haplorhini, Humans, Male, Models, Neurological, Narcotic Antagonists therapeutic use, Neural Pathways physiopathology, Opioid Peptides physiology, Posterior Horn Cells physiology, Pregnancy, Pregnancy Complications drug therapy, Pregnancy Complications etiology, Pregnancy Complications physiopathology, Pruritus drug therapy, Pruritus physiopathology, Randomized Controlled Trials as Topic, Rifampin therapeutic use, Ursodeoxycholic Acid pharmacology, Cholestasis complications, Pruritus etiology
- Abstract
Pruritus is commonly associated with cholestatic disorders and shows wide interindividual variability. The presence of skin lesions due to scratching and the application of a visual analogue scale are useful for clinical evaluation. Although the pathophysiology of this entity is not well understood, advances have recently been made in understanding of the pruritoceptive neural pathway, which shares certain similarities with the nociceptive pathway, although there are other distinguishing characteristics such as the action of a specific neurotransmitter, GPR, on the first synapsis at the posterior horn of the spinal cord. Amongst the modulator systems of the pruritoceptive pathway is the action of the endogenous opioids. An increase of these opioids in cholestatic situations is the most widely accepted hypothesis for pruritus in these patients. Some treatments have proven efficacy in randomized clinical trials in patients with cholestatic disorders, such as anion exchange resins, rifampicin, opioid antagonists and ursodeoxycholic acid; the latter is especially useful in intrahepatic cholestasis of pregnancy., (Copyright 2009 Elsevier España, S.L. All rights reserved.)
- Published
- 2010
- Full Text
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17. Mortality and cause of death in patients with heart failure: findings at a specialist multidisciplinary heart failure unit.
- Author
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Pons F, Lupón J, Urrutia A, González B, Crespo E, Díez C, Cano L, Cabanes R, Altimir S, Coll R, Pascual T, and Valle V
- Subjects
- Aged, Cause of Death, Female, Follow-Up Studies, Hospital Units, Humans, Male, Middle Aged, Heart Failure mortality
- Abstract
Introduction and Objectives: Heart failure mortality is similar to or even higher than that due to various cancers. It is usually associated with disease progression, though sudden death has also been reported as a frequent cause of mortality. The objectives of this study were to investigate mortality and its causes in outpatients with heart failure of different etiologies who were treated in a specialist multidisciplinary unit, and to identify associated factors., Methods: The follow-up cohort study (median duration 36 months) involved 960 patients (70.9% male; median age 69 years; ejection fraction 31%; and the majority had an ischemic etiology and were in functional class II or III)., Results: Overall, 351 deaths (36.5%) occurred: 230 due to cardiovascular causes (65.5%), mainly heart failure (33.2%) and sudden death (16%); 94 due to non-cardiovascular causes (26.8%), mainly malignancies (10.5%) and septic processes (6.8%); and 27 (7.7%) due to unknown causes. Mortality was independently associated with age, sex, functional class, ejection fraction, time since symptom onset, ischemic etiology, diabetes, creatinine clearance rate, peripheral vascular disease, fragility, and the absence of treatment with an angiotensin-converting enzyme inhibitor or angiotensin-II receptor blocker, beta-blockers, statins or antiplatelet agents. The principal factor associated with cardiovascular death was an ischemic etiology. No factor studied clearly predicted sudden death., Conclusions: Even though mortality in patients treated at a specialist heart failure unit was not low, a quarter died from non-cardiovascular causes. The principal factor associated with cardiovascular death was an ischemic etiology. Only 5.8% of the study population experienced sudden death.
- Published
- 2010
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18. [Arterial thrombosis of the renal graft diagnosed with (99m)Tc-MAG 3 renogram in a female patient with polycystosis].
- Author
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Domenech B, Fuster D, Haddad S, Setoain X, Lafuente S, and Pons F
- Subjects
- Arterial Occlusive Diseases surgery, Female, Hematoma diagnostic imaging, Humans, Ischemia etiology, Ischemia surgery, Kidney blood supply, Middle Aged, Postoperative Complications surgery, Radionuclide Imaging, Renal Artery surgery, Retroperitoneal Space, Thrombectomy, Thrombosis surgery, Arterial Occlusive Diseases diagnostic imaging, Ischemia diagnostic imaging, Kidney Transplantation, Postoperative Complications diagnostic imaging, Radiopharmaceuticals, Renal Artery diagnostic imaging, Technetium Tc 99m Mertiatide, Thrombosis diagnostic imaging
- Published
- 2010
- Full Text
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19. [Adult-onset Still's disease with liver failure requiring liver transplantation].
- Author
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Terán A, Casafont F, Fábrega E, Martínez-Taboada VM, Rodríguez-Valverde V, and Pons-Romero F
- Subjects
- Adrenal Cortex Hormones therapeutic use, Emergencies, Fever of Unknown Origin etiology, Humans, Interleukin 1 Receptor Antagonist Protein therapeutic use, Liver Failure surgery, Male, Still's Disease, Adult-Onset complications, Still's Disease, Adult-Onset drug therapy, Young Adult, Liver Failure etiology, Liver Transplantation, Still's Disease, Adult-Onset surgery
- Abstract
We present the case of a 23-year-old man with fever of unknown origin, who developed acute liver failure 2 months after symptom onset, requiring an urgent liver transplantation. The diagnosis of adult-onset Still's disease was established after the reappearance of symptoms after transplantation, and high doses of corticosteroids were used to control disease activity. Subsequently, given the impossibility of tapering the steroid dose, interleukin-1 receptor blocking treatment was started with satisfactory outcome. We also review the published literature.
- Published
- 2009
- Full Text
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20. [Comparison of skin complications between dermatome and U-graft technique in BAHA surgery].
- Author
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Tamarit Conejeros JM, Dalmau Galofre J, Murcia Puchades V, Pons Rocher F, Fernández Martínez S, and Estrems Navas P
- Subjects
- Adolescent, Adult, Aged, Child, Erythema etiology, Female, Foreign-Body Reaction pathology, Granulation Tissue pathology, Humans, Male, Middle Aged, Osseointegration, Otologic Surgical Procedures instrumentation, Otologic Surgical Procedures methods, Prosthesis Implantation instrumentation, Prosthesis Implantation methods, Retrospective Studies, Subcutaneous Tissue, Young Adult, Foreign-Body Reaction etiology, Hearing Aids, Otologic Surgical Procedures adverse effects, Postoperative Complications etiology, Prostheses and Implants, Prosthesis Implantation adverse effects, Surgical Flaps, Surgical Wound Infection etiology, Temporal Bone surgery
- Abstract
Introduction and Objective: The most common postoperative complications related to BAHA prosthetic surgery are skin complications. In this study we compare and evaluate these reactions with two different surgical techniques, the BAHA dermatome and the U-graft technique., Material and Method: Fifty-three patients who underwent implantation of a BAHA at our hospital between 2001 and 2008 were studied. The comparison of the skin reactions was carried out according to Holgers' classification. We also recorded the number of cures required until the skin was stabilized., Results: We used the dermatome in 27 patients and the U-graft in 26 patients. In the dermatome group we have reported a total of 74% of skin reactions (20 patients), in contrast with the 34% (9 patients) observed in the U-graft group. The average number of cures for patients in the dermatome group and those in the U-graft group was 4.1 and 2.7, respectively. The differences found were statistically significant and had a 95% confidence interval., Conclusions: In our experience, the use of the electric dermatome in BAHA surgery offers a higher incidence of skin complications in comparison with the U-graft technique. Since both techniques have a number of advantages and disadvantages, it may be that the selection of the technique to be employed according the individual characteristics of each patient may offer better results in the future.
- Published
- 2009
- Full Text
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21. [Sentinel node in gynaecological cancers. Our experience].
- Author
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Vidal-Sicart S, Doménech B, Luján B, Pahisa J, Torné A, Martínez-Román S, Antonio Lejárcegui J, Fusté P, Ordi J, Paredes P, and Pons F
- Subjects
- Adult, Aged, Aged, 80 and over, Endometrial Neoplasms pathology, Female, Humans, Lymphatic Metastasis diagnostic imaging, Middle Aged, Radionuclide Imaging, Uterine Cervical Neoplasms pathology, Vulvar Neoplasms pathology, Young Adult, Endometrial Neoplasms diagnostic imaging, Lymph Nodes diagnostic imaging, Uterine Cervical Neoplasms diagnostic imaging, Vulvar Neoplasms diagnostic imaging
- Abstract
Unlabelled: Although sentinel lymph node (SLN) identification is widespread used in melanoma and breast cancer some concerns exist in other malignancies, such gynaecologic cancers, and this staging method has not been adopted in many centers due to lack or large validation studies., Aim: To evaluate the applicability and results of SLN technique in gynaecological malignancies referred to our institution., Method: We studied 155 patients with different malignancies (70 vulvar, 50 cervical and 35 endometrial cancers). The day before surgery a lymphoscintigraphy was performed by injecting 111 MBq of (99m)Tc-nanocolloid in several ways depending on the type of cancer studied. Intraoperative detection of the SLN was always performed by using a hand-held gammaprobe and, in 100 cases with the aid of blue dye injection (70 vulvar and 30 in cervical cancer) few minutes before surgical intervention. Pathological study of SLN was performed in all cases. Lymphadenectomy was done in all cervix and endometrial cancer patients and in the first 35 vulvar cancer patients., Results: Pre-surgical lymphoscintigraphy demonstrated one, at least, SLN in 97% of vulvar cancer patients, 92% in the cervical malignancy and 64% in the endometrial cancer patients. During surgery, SLN was harvested in 97%, 90% and 62% of patients, respectively. The pathological study showed metastases in 24.2%, 8.8 and 4.5% of patients with vulvar, cervical and endometrial cancer, respectively. The false negative percentage was 5.5% in vulvar cancer patients, with 2 cases in the endometrial cancer and without any case in the cervical cancer patients., Conclusion: Lymphoscintigraphy is a relatively simple and useful technique to identify the SLN in this kind of tumours. However, in endometrial cancer more effort has to be made to reach a suitable result. Sentinel lymph node biopsy seems to be a reliable technique in vulvar and cervical malignancies.
- Published
- 2009
- Full Text
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22. [Baha: a new longitudinal incision with fixture out of the incision].
- Author
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Dalmau-Galofre J, Tamarit-Conejeros JM, Murcia-Puchades V, Pons-Rocher F, and Pastor-Canicio G
- Subjects
- Humans, Hearing Aids, Otorhinolaryngologic Surgical Procedures methods, Suture Anchors
- Abstract
Since the introduction of bone-anchored hearing aids (BAHA) a few decades ago, their effectiveness has made the use of these devices a well-established method. The most common complications associated with BAHA are dermatological, so a lot of changes were introduced in the surgical technique to reduce the frequency of skin reactions. We have analyzed our experience in the management of the skin and soft tissues over 8 years' experience with BAHA. We present a new longitudinal incision with the fixture out of the incision.
- Published
- 2009
- Full Text
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23. [Consolidate and open new pathways].
- Author
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Pons F
- Subjects
- Cooperative Behavior, Diagnostic Imaging trends, Europe, Interdisciplinary Communication, Neurology, Periodicals as Topic trends, Publishing trends, Radiology, Spain, Nuclear Medicine trends, Societies, Medical trends
- Published
- 2009
- Full Text
- View/download PDF
24. [Bilateral drainage in the internal mammary chain in the detection of the sentinel lymph node in a breast tumor].
- Author
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Ortín-Pérez J, Vidal-Sicart S, Duch J, Doménech B, and Pons F
- Subjects
- Axilla anatomy & histology, Breast anatomy & histology, Female, Genetic Variation, Humans, Lymph Nodes anatomy & histology, Lymphatic Vessels anatomy & histology, Lymphatic Vessels diagnostic imaging, Middle Aged, Radionuclide Imaging, Breast Neoplasms pathology, Lymph Nodes diagnostic imaging, Sentinel Lymph Node Biopsy
- Published
- 2009
- Full Text
- View/download PDF
25. [Peri-ictal SPECT in temporal lobe epilepsy: post-surgical evaluation].
- Author
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Setoain Perego X, Carreño Delgado M, Rumià Arboix J, Donaire Pedraza A, Bargalló Alabart N, Serés Roig E, Rubí Sureda S, Boget Llucia T, Pintor Pérez L, Fuster Pelfort D, Pavía Segura J, and Pons Pons F
- Subjects
- Adolescent, Adult, Brain diagnostic imaging, Brain pathology, Brain physiopathology, Electroencephalography, Epilepsy, Temporal Lobe pathology, Epilepsy, Temporal Lobe physiopathology, Epilepsy, Temporal Lobe surgery, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Postoperative Period, Retrospective Studies, Treatment Outcome, Video Recording, Young Adult, Epilepsy, Temporal Lobe diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Abstract
Introduction: our aim was to evaluate the usefulness of peri-ictal SPECT in localising the epileptogenic region (ER) in candidates for temporal lobectomy to treat medically refractory complex partial seizures (CPS). Interictal and ictal SPECT, MRI and video-EEG results were compared and the positive predictive value (PPV) was calculated in those patients with good surgical outcome., Materials and Methods: 37 patients who had a minimum of 3 years follow-up after surgery were studied retrospectively. Pre-surgical evaluation had included video-EEG monitoring, MRI and interictal and ictal SPECT. These results were compared to the surgically treated ER and successful outcome confirmed by post-surgical clinical follow-up. 29/37 patients remained seizure-free in the post-surgical follow-up. Interictal and peri-ictal SPECT were performed using 740 MBq of 99mTc-HMPAO. Peri-ictal SPECT was ictal in 25 patients and postictal in 12., Results: ER concordance with video-EEG and peri-ictal SPECT was 86% (32/37 patients). It was 84% (31/37) for MRI and 54% (20/37 patients) for interictal SPECT. Peri-ictal SPECT localised the ER in 8/11 patients with discordant MRI and video-EEG results. Ictal SPECT localised the ER in the correct temporal lobe in 23/25 patients (92% concordance). In the 29 patients with a good surgical outcome, the PPV of video-EEG was 95% (27/29) and it was 90% (26/29) for both MRI and peri-ictal SPECT., Conclusions: peri-ictal brain SPECT is well able to localize ER in patients with temporal lobe epilepsy. Periictal SPECT concordance with ER was as good as video-EEG and MRI and its PPV was as good as that of MRI. We strongly recommend its use in the pre-surgical evaluation of temporal lobe epilepsy, especially when MRI and EEG are discordant.
- Published
- 2009
26. [In-transit sentinel lymph nodes in malignant melanoma. What is their importance?].
- Author
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Ortín-Pérez J, Vidal-Sicart S, Doménech B, Rubí S, Lafuente S, and Pons F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Lymph Node Excision, Lymphatic Metastasis pathology, Male, Melanoma surgery, Middle Aged, Prospective Studies, Radionuclide Imaging, Radiopharmaceuticals, Skin Neoplasms surgery, Technetium Tc 99m Aggregated Albumin, Unnecessary Procedures, Young Adult, Lymphatic Metastasis diagnostic imaging, Melanoma diagnostic imaging, Melanoma secondary, Sentinel Lymph Node Biopsy, Skin Neoplasms pathology
- Abstract
Unlabelled: The sentinel lymph node (SLN) is the first node in a lymph node basin to receive direct drainage from the primary tumour. However, in some cases, lymphoscintigraphy images demonstrate the presence of lymph nodes located in the area between the primary tumour and the first regional lymph node basin. These nodes are called in-transit nodes and have to be considered SLNs as well., Aim: It was to determine the incidence and location of in-transit SLNs in patients with malignant melanoma and to evaluate whether it is necessary to harvest them. METHOD. Nine hundred patients with malignant melanoma were included. Lymphoscintigraphy was performed on the day before surgery following intradermal injection of 74-111 MBq of 99mTc-Nanocolloid in four doses around the primary lesion or the biopsy scar., Results: The presence of in-transit SLNs was revealed in 80 patients. During surgery, in-transit SLNs were identified and excised in all but 3 patients (96.2 %). Metastatic cell deposits were identified in these in-transit SLNs in 15 patients (19.4 %), with 4 patients with no tumour involvement of the regional lymph node basin., Conclusions: Lymphoscintigraphy is mandatory in the location of in-transit SLNs. Moreover, although the incidence of these nodes is relatively low in malignant melanoma, the presence of metastatic cells in these in-transit SLNs reaches a significant percentage. Therefore, excision of in-transit SLNs is necessary in all cases.
- Published
- 2008
27. [Potential use of bone marrow scintigraphy in suspected prosthetic hip infection evaluated with 99mTc-HMPAO-leukocytes].
- Author
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Fuster D, Duch J, Soriano A, García S, Setoain X, Bori G, Rubí S, Rodríguez D, Doménech B, Piera C, Mensa J, and Pons F
- Subjects
- Aged, Aged, 80 and over, Blood Sedimentation, C-Reactive Protein analysis, Female, Follow-Up Studies, Humans, Male, Middle Aged, Osteomyelitis etiology, Prosthesis Failure, Radionuclide Imaging, Sensitivity and Specificity, Staphylococcal Infections etiology, Bone Marrow diagnostic imaging, Femur diagnostic imaging, Hip Prosthesis adverse effects, Leukocytes, Osteomyelitis diagnostic imaging, Prosthesis-Related Infections diagnostic imaging, Radiopharmaceuticals, Staphylococcal Infections diagnostic imaging, Technetium Tc 99m Exametazime, Technetium Tc 99m Sulfur Colloid
- Abstract
Aim: To evaluate the usefulness of (99m)Tc-Sulphur colloid when combined with leukocyte scintigraphy in suspected prosthetic hip infection, comparing the results with information from (99m)Tc-HMPAO-leukocyte scintigraphy alone., Materials and Methods: Seventy patients (42 women, 28 men; mean age 68 +/- 13 years) with painful hip prostheses and suspicion of infection were evaluated prospectively. All patients had bone scintigraphy, (99m)Tc-HMPAO-labelled white blood cell scintigraphy and (99m)Tc-Sulphur colloid bone marrow scintigraphy. ESR and CRP levels were measured in all patients. The final diagnosis was made with microbiological findings or by clinical follow up of at least 12 months., Results: Infections were diagnosed in 12 of the 70 patients (3 coagulase-negative Staphylococcus, 2 Staphylococcus aureus, 2 Staphylococcus epidermidis, 2 enterococcus and 3 polymicrobial agents). ESR and CRP values were higher in patients with infection than in patients without infection (51.8 +/- 29.4 vs. 25.4 +/- 16.4 and 2.8 +/- 2.2 vs. 1.1 +/- 1.3, respectively; p < 0.05). Bone scintigraphy did not show a characteristic pattern to differentiate infection from aseptic loosening. The pool phase of the bone scintigraphy was positive in only 3/12 patients with infection (25 %). Sensitivity and specificity of the leukocyte scintigraphy was 83 % and 57 %, respectively. When the results of the bone marrow scintigraphy were added, these values increased to 92 % and 98 %, respectively., Conclusion: Performing bone marrow scintigraphy significantly improves results when compared with leukocyte scintigraphy alone in the diagnosis of infected hip prostheses. Bone scintigraphy did not help to differentiate aseptic loosening from infection in this series.
- Published
- 2008
28. [Application of the ROLL technique in a case of bilateral multifocal breast cancer].
- Author
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Paredes P, Vidal-Sicart S, Santamaría G, Zanón G, and Pons F
- Subjects
- Breast Neoplasms pathology, Breast Neoplasms surgery, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast surgery, Carcinoma, Lobular pathology, Carcinoma, Lobular surgery, Female, Humans, Lymphatic Metastasis, Lymphography methods, Mammography, Mastectomy, Segmental, Middle Aged, Neoplasms, Multiple Primary pathology, Neoplasms, Multiple Primary surgery, Particle Size, Radionuclide Imaging, Sentinel Lymph Node Biopsy, Ultrasonography, Interventional, Biopsy, Fine-Needle methods, Breast Neoplasms diagnostic imaging, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Lobular diagnostic imaging, Magnetic Resonance Imaging, Neoplasms, Multiple Primary diagnostic imaging, Radiopharmaceuticals, Technetium Tc 99m Aggregated Albumin
- Abstract
The increasing number of non-palpable breast lesions and the trend to perform less aggressive surgical procedures have prompted the development of radioguided surgery in breast lesions, alone (ROLL) or with sentinel node detection. We present a 55-year-old woman with four mammary lesions diagnosed by magnetic resonance. The ROLL technique allowed not only their characterisation but also the study of the lymphatic drainage of malignant lesions. Moreover, it was useful as a guide for surgical biopsy of the benign lesions. The combination of different colloid size allowed an accurate study of each lesion and avoided radical surgery. The applications of radioguided surgery are ever increasing. Individualisation of each indication will benefit a greater number of patients.
- Published
- 2008
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29. [The value of positron emission tomography/computed tomography (PET/CT) in the staging of diffuse large B-cell lymphoma].
- Author
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Fuertes S, Setoain X, López-Guillermo A, Montserrat E, Fuster D, Paredes P, Lomeña F, and Pons F
- Subjects
- Adult, Aged, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Radiopharmaceuticals, Lymphoma, B-Cell diagnostic imaging, Lymphoma, B-Cell pathology, Positron-Emission Tomography, Tomography, X-Ray Computed
- Abstract
Background and Objective: The aim of this study was to evaluate the role of positron emission tomography/computed tomography (PET/CT) in improving the staging and changing the management of aggressive lymphoma patients in comparison with the conventional imaging modalities (CT, and 67Ga scintigraphy)., Patients and Method: Forty consecutive patients with diffuse large B-cell non Hodgkin lymphoma, were prospectively evaluated. All 40 patients underwent a whole body FDG PET/CT and conventional staging techniques (chest and abdomen CT, 67Ga scintigraphy) were studied before therapy. Sixty minutes after the intravenous administration of 370 MBq FDG, a whole body PET/CT was acquired. We hypothesize that PET/CT improves the diagnostic staging of lymphoma and changes the clinical management of patients., Results: PET/CT and CT were concordant in 28 patients (65%). However, PET/CT detected more lesions than CT in 11 patients (27.5%). Only in one patient, CT revealed more extensive disease than PET/CT. Additional information of PET/CT had lead to a change in staging (upstaging) in 6 patients (15%), in turn leading to a change in treatment strategy in 1 patient. PET/CT and 67Ga scintigraphy were concordant in 23 patients (60.5%). PET/CT detected more lesions than 67Ga scintigraphy in 14 patients (42%). PET/CT results changed staging (upstaging) in 4 patients (15%), leading to a change of treatment strategy in one patient., Conclusions: The impression is that PET/CT detected more lesions than conventional examination, but this rarely translates into changes of staging and treatment strategy in aggressive lymphoma.
- Published
- 2007
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- View/download PDF
30. [Adefovir dipivoxil compassionate use program in Spain: efficacy and resistance analysis].
- Author
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Buti M, Rodríguez Frías F, Calleja JL, Jardí R, Pons F, Crespo J, Casanovas T, Enríquez J, Carnicer F, Romero M, García Bengoechea M, Prieto M, García Samaniego J, Miras M, Pérez Roldán F, Rueda M, and Esteban R
- Subjects
- Adenine therapeutic use, Adolescent, Adult, Aged, Drug Resistance, Viral, Female, Hepatitis B virus drug effects, Hepatitis B virus genetics, Humans, Lamivudine therapeutic use, Male, Middle Aged, Spain, Adenine analogs & derivatives, Antiviral Agents therapeutic use, Hepatitis B, Chronic drug therapy, Organophosphonates therapeutic use
- Abstract
Background and Objective: The extended treatment with lamivudine in patients with chronic hepatitis B is associated with the emergence of resistances. Patients with resistance to lamivudine show a loss of biochemical and virological responses and a higher progression of their liver disease. Adefovir dipivoxil, an analogue of the nucleotides, is effective for the treatment of patients with resistance to lamivudine. The aim of this study was to evaluate the efficacy, safety and resistance of adefovir dipivoxil in patients with chronic hepatitis B refractory to treatment with lamivudine., Patients and Method: One hundred and twenty hepatits B virus patients refractory to lamivudine were treated with adefovir dipivoxil. Seventy-four patients were followed up during two years. In all cases, the hepatitis B virus-DNA was determined by polymerase chain reaction, and in those cases without response to treatment, the presence of resistances to adefovir and lavimudine were studied., Results: At the second year of treatment, we observed a biological response of 54.1%, a biochemical response of 62.2%, while an elimination of hepatitis B e antigen was seen in 21% cases. 20% patients developed resistance to adefovir dipivoxil, and the most frequent detected mutations were: A181V, A181T and N236T. Drug safety was excellent; in fact, only one adverse effect related to the drug was detected., Conclusions: Treatment with adefovir dipivoxil for 2 years in mono-therapy in patient who are previously non-responders to lavimudine is associated with a high biochemical and virologycal response with an excellent safety. At the second year of treatment, the adefovir dipivoxil resistance rate is 20%.
- Published
- 2007
- Full Text
- View/download PDF
31. [Combined endoscopic therapy for the treatment of angiodysplasias of the colon].
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Gil-Simón P, Barrio Andrés J, Mata Román L, Pons Renedo F, Pérez-Miranda M, Saracibar Serrano E, Julián Gómez L, and Caro-Patón A
- Subjects
- Aged, 80 and over, Angiodysplasia complications, Angiodysplasia diagnosis, Angiodysplasia drug therapy, Argon, Blood Transfusion, Colonic Diseases complications, Colonic Diseases diagnosis, Colonic Diseases drug therapy, Combined Modality Therapy, Epinephrine administration & dosage, Epinephrine therapeutic use, Gastrointestinal Hemorrhage drug therapy, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage therapy, Hemostatic Techniques, Humans, Injections, Intralesional, Male, Angiodysplasia surgery, Colonic Diseases surgery, Colonoscopy, Electrocoagulation instrumentation, Electrocoagulation methods
- Published
- 2007
- Full Text
- View/download PDF
32. [Isoniazid-induced acute pancreatitis].
- Author
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Briongos-Figuero LS, Bachiller-Luque P, Pons-Renedo F, and Eiros-Bouza JM
- Subjects
- Acute Disease, Aged, 80 and over, Antitubercular Agents therapeutic use, Drug Therapy, Combination, Female, Femoral Neck Fractures drug therapy, Femoral Neck Fractures etiology, Fractures, Spontaneous drug therapy, Fractures, Spontaneous etiology, Humans, Isoniazid therapeutic use, Pyrazinamide therapeutic use, Rifampin therapeutic use, Tuberculosis, Osteoarticular drug therapy, Tuberculosis, Osteoarticular etiology, Antitubercular Agents adverse effects, Isoniazid adverse effects, Pancreatitis chemically induced
- Published
- 2007
- Full Text
- View/download PDF
33. [Revision stapedectomy].
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Pons Rocher F, Dalmau Galofre J, Murcia Puchades V, López Molla C, and Guallart Doménech F
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Reoperation methods, Stapes Surgery methods
- Abstract
Objective: The aim of the study was to determine the causes of failure in otosclerosis surgery., Material and Method: We performed 23 revisions of stapedectomy during the period between January 2000 and April 2005. The time between the primary surgery and the revision surgery ranged from 3 months to 25 years. The most frequent reasons for revision surgery were first of all patients with closed initial gap and progressive hearing loss in 56.52 % of cases and secondly patients without any initial hearing improvement in 39.12 % of cases., Results: The main surgical findings were: short prosthesis in correct position (13.04 %), displaced prosthesis (60.87 %), bridles over the oval window (65.22 %), necrosis of the long process of the incus (26.2 %), and obliterative footplate (26.09 %). As for the audiometric results, we got a complete closure of gap in 60.8 % of patients (n = 14), partial closure of gap in 13.2 % (n = 3), persistence of the initial gap in 21.7 % (n = 5), and cophosis in 4.3 % (n = 1)., Conclusions: The migration of the prosthesis is the main cause of failure after stapedectomy. Good closure of the gap was achieved in two thirds of the patients.
- Published
- 2007
34. [Rhabdomyolysis after treatment with atorvastatin detected by bone scintigraphy].
- Author
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Rubí S, Duch J, Ortín J, Setoain X, and Pons F
- Subjects
- Atorvastatin, Humans, Male, Middle Aged, Radionuclide Imaging, Heptanoic Acids adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Pyrroles adverse effects, Rhabdomyolysis chemically induced, Rhabdomyolysis diagnostic imaging
- Published
- 2006
- Full Text
- View/download PDF
35. [Usefulness of 111In-oxine labelled platelets in the management of febrile syndrome in dialysis patients with non-functional renal allografts].
- Author
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Ortín-Pérez J, Fuster D, Lomeña F, Torregrosa JV, Piera C, Rodríguez-Puig D, Duch J, Rubí S, Setoain X, Campistol JM, and Pons F
- Subjects
- Adrenal Cortex Hormones therapeutic use, Adult, Anti-Bacterial Agents therapeutic use, Bacterial Infections complications, Bacterial Infections diagnostic imaging, Bacterial Infections drug therapy, Diagnosis, Differential, Embolization, Therapeutic, Female, Fever drug therapy, Fever etiology, Fever immunology, Graft Rejection complications, Graft Rejection drug therapy, Graft Rejection surgery, Graft Rejection therapy, Humans, Kidney diagnostic imaging, Male, Middle Aged, Nephrectomy, Prospective Studies, Radionuclide Imaging, Sensitivity and Specificity, Transplantation, Homologous, Blood Platelets, Fever diagnostic imaging, Graft Rejection diagnostic imaging, Indium Radioisotopes, Kidney Transplantation, Organometallic Compounds, Oxyquinoline analogs & derivatives, Radiopharmaceuticals, Renal Dialysis
- Abstract
Aim: To evaluate the usefulness of 111In-oxine-labelled platelet scan in the therapeutic management of prolonged febrile syndrome in dialysis patients with a non-functional renal allograft., Material and Methods: One hundred and fifty-eight patients (94 men, 64 women; mean age 44 +/- 9 years) were studied. Duration of fever was 42 days (range 7-112). A total of 68 % of the patients (107/158) were on low doses of corticosteroids (<10 mg/day). Platelet scans were performed 48 hours after reinjection of 111In-ixone-labelled platelets. A platelet uptake index (PUI) was calculated by dividing the cpm/pixel in the allograft by the cpm/pixel in a mirror background. A PUI > or = 1.5 was considered as threshold for immunological fever. The final diagnosis of immunological fever was established when it disappeared after transplantectomy, embolization or high doses of corticosteroid therapy. Fever of non-immunological origin was established when it disappeared after antibiotic therapy., Results: In 102/158 patients the fever was considered of immunological origin. In 56/158 patients the fever was considered of non immunological origin. Sensitivity and the specificity of the platelet scan was 80 % and 100 %, respectively. All those patients considered as having fever of immunological origin who had PUI <1.5 had been using corticosteroids during platelet scan., Conclusion: 111In-labelled platelet scintigraphy is a useful technique in the therapeutic management of prolonged febrile syndrome in dialysis patients with non-functional renal allograft. The use of corticosteroids can reduce the sensitivity of 111In- labelled platelet scan.
- Published
- 2006
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36. [Proposal for the inclusion of Nuclear Medicine in the European Mastology Society (EUSOMA) criteria for breast unites and the convenience of their implementation in Spain].
- Author
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Intriago B, Vidal-Sicart S, Paredes P, Zanón G, and Pons F
- Subjects
- Cancer Care Facilities organization & administration, European Union, Female, Guideline Adherence, Humans, Patient Care Team standards, Radionuclide Imaging, Societies, Medical, Spain, Breast Neoplasms diagnostic imaging, Cancer Care Facilities standards, Guidelines as Topic, Nuclear Medicine standards
- Published
- 2006
- Full Text
- View/download PDF
37. [Radioimmunotherapy with 90Y-ibritumomab tiuxetan in lymphomas].
- Author
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Setoain X, López-Guillermo A, Ruiz A, and Pons F
- Subjects
- Adolescent, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal pharmacokinetics, Antibodies, Monoclonal, Murine-Derived, Antibody Specificity, Antigens, CD20 immunology, Antigens, Neoplasm immunology, Child, Child, Preschool, Contraindications, Female, Humans, Immunoconjugates administration & dosage, Immunoconjugates adverse effects, Immunoconjugates pharmacokinetics, Infant, Lymphoma, B-Cell immunology, Lymphoma, B-Cell radiotherapy, Lymphoma, Non-Hodgkin immunology, Male, Pregnancy, Pregnancy Complications, Neoplastic therapy, Radiation Protection, Randomized Controlled Trials as Topic, Rituximab, Tissue Distribution, Yttrium Radioisotopes administration & dosage, Yttrium Radioisotopes adverse effects, Yttrium Radioisotopes pharmacokinetics, Antibodies, Monoclonal therapeutic use, Immunoconjugates therapeutic use, Lymphoma, Non-Hodgkin radiotherapy, Radioimmunotherapy, Yttrium Radioisotopes therapeutic use
- Published
- 2006
- Full Text
- View/download PDF
38. [Ovarian and para-aortic recurrence from cervix cancer detected by PET/CT].
- Author
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Ubieto MA, Paredes P, Martínez S, Ortín J, Fuster D, Torné A, Setoain FJ, Pahisa J, Pons F, and Lomeña F
- Subjects
- Adult, Antineoplastic Agents, Alkylating therapeutic use, Brachytherapy, Carcinoma, Adenosquamous diagnostic imaging, Carcinoma, Adenosquamous therapy, Carcinoma, Squamous Cell diagnosis, Cisplatin therapeutic use, Combined Modality Therapy, Female, Humans, Hysterectomy, Lymphatic Metastasis diagnostic imaging, Ovarian Neoplasms diagnostic imaging, Ovarian Neoplasms pathology, Radiotherapy, Adjuvant, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms therapy, Carcinoma, Adenosquamous secondary, Lymphatic Metastasis diagnosis, Ovarian Neoplasms secondary, Positron-Emission Tomography, Tomography, X-Ray Computed
- Abstract
We present the case of a 34-year-old woman diagnosed of an adenosquamous carcinoma of the uterine cervix, stage IIB of the FIGO classification (International Federation of Gynecology and Obstetrics), treated with quimiotherapy, radiotheraphy and brachytheraphy with posterior hysterectomy. A recurrence of the disease was suspected due to the progressive rise of CEA levels. A PET/CT revealed abnormal foci in both ovaries, that had been transposed to avoid lesions due to radiation, and in a left para-aortic adenopathy. The diagnosis of recurrence in these sites was confirmed by biopsy. PET with FDG (F18-fluorodeoxyglucose) is useful in the staging of primary tumour and in the detection of recurrence in uterine cervical carcinoma, with better sensitivity and specificity than CT and MRI. PET/CT improves anatomic resolution and helps to resolve the origin of unclear foci like in the case presented in which ovaries were not in their normal situation due to transposition.
- Published
- 2006
- Full Text
- View/download PDF
39. [Different samarium-153 behavior in bone metastases and arthrosis in a case of breast cancer and painful bones].
- Author
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Paredes P, Fuster D, Vidal-Sicart S, Ortín J, Duch J, and Pons F
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Pain etiology, Radionuclide Imaging, Bone Neoplasms diagnostic imaging, Bone Neoplasms secondary, Breast Neoplasms secondary, Joint Diseases diagnostic imaging, Radioisotopes, Samarium
- Published
- 2005
- Full Text
- View/download PDF
40. [Usefulness of bone scintigraphy for staging in a case of histiocytosis of the temporal bone].
- Author
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Fuertes Cabero S, Fuster Pelfort D, Setoain Perego X, González Berenguer J, Mateos Fernández JJ, Paredes Barranco P, Ortín Pérez J, and Pons Pons F
- Subjects
- Adult, Humans, Male, Radionuclide Imaging, Bone Diseases diagnostic imaging, Histiocytosis, Langerhans-Cell diagnostic imaging, Temporal Bone diagnostic imaging
- Abstract
We present the case of a 43-year-old man diagnosed of insipid diabetes and hypogonadotropic hypogonadism in whom a right temporal bone lesion was observed in the control MRI, thus leading to his admission. A bone scintigraphy with 99mTc-HMDP showed increased uptake in the right temporal region with sphenoidal extension, coinciding with the MRI. In addition, increased uptake having less intensity and size was observed in the left temporal region. A biopsy on the newly appearing mouth ulcers in the jugal mucous was performed and showed Langerhan's cells, the diagnosis of histiocytosis X being confirmed. Six months later a new MRI indicated disease progression with bilateral temporal involvement. The bone scan findings in this case provided a more exact extension diagnosis of the disease than the MRI.
- Published
- 2005
- Full Text
- View/download PDF
41. [Usefulness of pilocarpine in the prevention of xerostomia in patients with head and neck cancer treated with radiotherapy. Assessment with gammagraphy and salivary flow].
- Author
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Fuertes Cabero S, Setoain Perego X, Rovirosa Casino A, Mateos Fernández JJ, Fuster Pelfort D, Ferre Jorge J, Navalpotro Yagüe V, Paredes Barranco P, Ortín Pérez J, Muxí Pradas A, and Pons Pons F
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Head and Neck Neoplasms radiotherapy, Humans, Male, Middle Aged, Prospective Studies, Radionuclide Imaging, Radiotherapy adverse effects, Xerostomia etiology, Xerostomia physiopathology, Pilocarpine therapeutic use, Salivary Glands diagnostic imaging, Salivary Glands physiopathology, Salivation, Xerostomia diagnostic imaging, Xerostomia prevention & control
- Abstract
Aim: To assess the utility of salivary gland scintigraphy and salivary flow to quantify salivary function and to evaluate the usefulness of pilocarpine in the treatment of radiation-induced xerestomia in head and neck cancer patients., Method: Thirty two patients with head and neck tumor treated with radiotherapy (RDT) were studied. Patients were classified into two groups: pilocarpine group (P), that received prophylactic pilocarpine before RDT and during the first year after treatment. No pilocarpine group (NP) that received RDT without pilocarpine. Salivary gland scintigraphy and salivary flow were performed before RDT and during one year after treatment. Parotid and submaxillary uptake and excretion were calculated. Salivary flow after stimulation during five minutes was also obtained., Results: Uptake and excretion in both salivary glands decreased after RDT. There were no statistical differences comparing P and NP groups (p < 0.001). However, in group P a trend to recovery was observed in parotid uptake values at 12 months after treatment, but it was not statistically significant. In both groups the salivary flow decreased after RDT and a good correlation (r = 0.8) between salivary flow and submaxillary excretion and parotid excretion was found., Conclusions: Salivary gland scintigraphy and salivary flow could be useful to evaluate salivary gland function in patients with head and neck irradiated tumors. Although better results on the salivary uptake at 12 months were noted, pilocarpine did not significantly improve salivary gland function.
- Published
- 2004
- Full Text
- View/download PDF
42. [Usefulness of the sentinel node in the treatment and staging of initial cervix cancer].
- Author
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Paredes P, Vidal-Sicart S, García S, Pahisa J, Torné A, Ordi J, Fuertes S, Ortega M, and Pons F
- Subjects
- Adult, Aged, Female, Humans, Intraoperative Period, Middle Aged, Neoplasm Staging, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms surgery
- Abstract
Objective: The aim of this study was to evaluate the usefulness of intraoperative sentinel node (SN) detection in patients with initial cervix cancer., Patients and Methods: Lymphoscintigraphy and intraoperative SN detection was performed in 17 patients with initial cervix cancer who we going to have a radical laparoscopic hysterectomy and pelvic lymphadenectomy. Conization was performed in 4/17. The day before surgery, an injection of 111 MBq 99mtechnetium nanocolloid around the primary tumour and a subsequent lymphoscintigraphy were carried out. Blue dye was injected at the same location intraoperatively. A laparoscopic gamma probe was used to identify SNs., Results: SNs were successfully localized using a combination of radiocolloid and blue dye in 16/17 patients (detection rate 94 %). The detection rate only using blue dye technique decreases to 71 % (12/17) and it reaches an 82 % (14/17) if we avoid the blue dye injection. In 3 cases, there was no migration in lymphoscintigraphy and in one of the three SN could not be detected. Thirty-three SNs were identified (1.9 nodes/patient). The most frequent location was left external iliac nodal group (13 nodes: 39 %). SNs were identified in regions that are not included in usual lymphadenectomy: right parametrium (2 sentinel nodes, one of them in the retrouterine region), and interiliac (2 SNs). In all four patients with previous conization SNs were identified (detection rate 100 %)., Conclusions: The rate of SN detection combining lymphoscintigraphy with gamma probe and blue dye is 82 %. The use of blue dye allows increasing this rate to 94 % in those cases which migration was not seen or when the SN is placed near the injection site. The SN technique offers the possibility to find SNs in regions not included in usual lymphadenectomy.
- Published
- 2004
- Full Text
- View/download PDF
43. [Psoas abscess as cause of lumbar spine pain detected by scintigraphy with gallium in a patient with suspicion of spondylodiscitis].
- Author
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Ortega M, Fuster D, Setoain X, Fuertes S, Paredes P, Ortín J, and Pons F
- Subjects
- Diagnosis, Differential, Discitis diagnosis, Humans, Male, Middle Aged, Radionuclide Imaging, Citrates, Gallium, Low Back Pain etiology, Psoas Abscess complications, Psoas Abscess diagnostic imaging, Radiopharmaceuticals
- Abstract
A 56 year old man with fever and lumbar pain who underwent an abdominal CT scan that showed lumbar arthrosic changes, although it was not possible to rule out infectious disease in L5/S1. Bone scintigraphy was requested. It showed heterogeneous hyperuptake that did not make it possible to exclude a spondylodiscitis in this site. Scintigraphy with 67Ga-citrate excluded infectious diseases in the lumbar spine column. However, a pathological uptake was observed in the left iliac fossa suggestive of psoas abscess, which was confirmed by ultrasonography, isolating streptococcus viridans.
- Published
- 2004
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44. [Comparative study of the different radiotracer administration route to locate the sentinel node in breast cancer].
- Author
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Ortega M, Vidal-Sicart S, Zanón G, Pahisa J, Santamaría G, Velasco M, Martín F, and Pons F
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Injections, Middle Aged, Prospective Studies, Radionuclide Imaging, Breast Neoplasms diagnostic imaging, Breast Neoplasms pathology, Radiopharmaceuticals administration & dosage, Sentinel Lymph Node Biopsy methods
- Abstract
Aim: To assess the results of Sentinel Lymph Node (SLN) detection in breast cancer patients depending on the radiotracer injection route, especially evaluating which route that makes it possible to identify the highest percentage of SLNs and its detection in the inner mammary chain., Methods: We prospectively studied 120 breast cancer patients. Three groups of 40 patients each were established depending on the radiotracer injection route. 1) Subdermal or subareolar route: 18 T1 and 22 T2, mean tumor diameter size of 1.76 cm. 2) Peritumoral route: 16 T1 and 24 T2, mean tumor diameter size of 1.86 cm. 3) Intratumoral route: 20 T1 and 20 T2, mean tumor diameter size of 1.61 cm. The day before surgery, a lymphoscintigraphic study was performed in all cases and intraoperative SLN resection was carried out with the aid of a hand-held gamma probe., Results: The SLN was identified in 38/40 cases (95%) of group 1, in 35/40 cases (88%) of group 2 and in 38/40 cases (95%) of group 3. No SLNs in the mammary chain were observed in patients who underwent subdermal/subareolar injection of the radiotracer. On the other hand, SLNs were visualized in this location in 4/35 patients with peritumoral injection (11%) and in 8/38 patients with intratumoral injection (21%)., Conclusion: The superficial (subdermal, subareolar) injection technique is more suitable when an unnecessary lymphadenectomy has to be prevented in cases without axillary metastases. The deeper injection technique (peritumoral, intratumoral) should be use when, moreover, we seek accurate staging or plan non-systematic mammary chain irradiation.
- Published
- 2004
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45. [Plasma leptin levels in patients with primary biliary cirrhosis and their relationship with degree of fibrosis].
- Author
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García-Suárez C, Crespo J, Fernández-Gil PL, Amado JA, García-Unzueta MT, and Pons Romero F
- Subjects
- Adult, Aged, Biopsy, Body Mass Index, Female, Humans, Liver Cirrhosis, Biliary pathology, Liver Function Tests, Male, Middle Aged, Radioimmunoassay, Severity of Illness Index, Leptin blood, Liver Cirrhosis, Biliary blood
- Abstract
Objectives: a) To analyze plasma leptin levels in patients with primary biliary cirrhosis (PBC) and b) to investigate the relationship between leptin levels and liver fibrosis stage in a cohort of patients with PBC., Patients and Methods: Serum leptin levels were evaluated through radioimmunoassay in 30 patients with PBC (mean age: 37.2 +/- 11.0 years; range:19-75) and in 29 controls matched for age and weight. Venous blood obtained after a 12-hour fast was centrifuged in EDTA tubes. Weight, height and body mass index (BMI) were measured using standard methods. Hepatitis C virus RNA was determined using qualitative and quantitative polymerase chain reaction. In all patients liver biopsies were performed and the degree of fibrosis and extent of inflammatory infiltrate were evaluated., Results: Plasma leptin levels in patients with PBC were lower than those obtained in control subjects (p<0.0001). No significant differences were found between the two groups in age, weight, height, BMI or body fat index. There was a clear increase in serum leptin levels according to histological stage of PBC (stage I: 2.1 ng/ml; stage II: 4.3 ng/ml; stage III: 5.3 ng/ml; stage IV: 12.1 ng/ml; p<0.01), Conclusions: The present study demonstrates the correlation between leptin and stage of liver fibrosis in a cohort of patients with PBC, providing further evidence of the involvement of leptin in the process of liver fibrosis.
- Published
- 2004
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46. [Pathogenesis of non-alcoholic fatty liver and potential therapeutic targets].
- Author
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Crespo J, Cayón A, and Pons-Romero F
- Subjects
- Antioxidants therapeutic use, Diabetes Complications, Diabetes Mellitus drug therapy, Disease Progression, Fatty Acids, Nonesterified metabolism, Fatty Liver therapy, Hepatocytes metabolism, Humans, Hypoglycemic Agents therapeutic use, Insulin Resistance, Lipid Peroxidation, Liver metabolism, Liver Cirrhosis etiology, Microsomes, Liver metabolism, Mitochondria, Liver metabolism, Models, Biological, Obesity complications, Obesity therapy, Oxidation-Reduction, Triglycerides metabolism, Fatty Liver etiology
- Published
- 2004
47. [Triple immunosuppressive therapy in the treatment of severe ulcerative colitis].
- Author
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Castro B, Crespo J, García-Suárez C, Fábrega E, Casafont F, and Pons-Romero F
- Subjects
- Adult, Colitis, Ulcerative immunology, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index, Colitis, Ulcerative drug therapy, Immunosuppressive Agents therapeutic use
- Abstract
Introduction: Severe episodes of steroid-refractory ulcerative colitis (UC) were considered an indication for surgery until the introduction of new immunosuppressive agents such as cyclosporine., Objectives: 1) To confirm the efficacy of intravenous cyclosporine in inducing remission in severe episodes of steroid-refractory UC; 2) To analyze the efficacy of triple immunosuppressive therapy with cyclosporine, azathioprine and prednisone in the maintenance of remission induced by intravenous cyclosporine., Patients and Method: Fourteen patients diagnosed with a severe episode of steroid-refractory UC were treated with intravenous cyclosporine at a dose of 4 mg/kg/day. In all patients, after response was induced, this regimen was substituted by oral cyclosporine plus azathioprine at a dose of 2-2.5 mg/kg/day and decreasing doses of corticoids. Neoral cyclosporine was progressively reduced until discontinuation within 3 months, coinciding with a simultaneous decrease of oral steroids., Results: All patients showed response to intravenous cyclosporine with a significant reduction in the Truelove index calculated before and after treatment. After remission was induced, all patients followed triple immunosuppressive therapy for 3 months. In the follow-up for a mean of 24 months (range: 14-34) only two patients required admission for a new episode of UC and colectomy was finally indicated in only one. None of the 14 patients treated with cyclosporine showed severe adverse effects attributable to the drug., Conclusions: Intravenous cyclosporine is a safe and effective alternative in the treatment of severe episodes of steroid-refractory UC. Early initiation of oral administration associated with azathioprine is useful in maintaining response, reducing subsequent relapses and the need for colectomy during the follow-up of these patients.
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- 2004
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48. [Palliative treatment of metastasic bone pain].
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Pons F, Fuster D, and Vidal-Sicart S
- Subjects
- Bone Neoplasms complications, Bone Neoplasms radiotherapy, Contraindications, Drug Costs, Forecasting, Humans, Pain etiology, Radioisotopes therapeutic use, Radiopharmaceuticals administration & dosage, Radiopharmaceuticals economics, Rhenium therapeutic use, Samarium therapeutic use, Strontium Radioisotopes therapeutic use, Tin Radioisotopes therapeutic use, Treatment Outcome, Analgesia methods, Bone Neoplasms secondary, Pain radiotherapy, Palliative Care, Radiopharmaceuticals therapeutic use
- Published
- 2003
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49. [Distribution of polyps in the inside region of Vizcaya (Spain): implications for diagnostic tests and colorectal cancer screening].
- Author
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Velayos Jiménez B, Durán Rigueira M, Arévalo Serna JA, Heras Martín I, Bernal Martínez A, Pons Renedo F, and Cabriada Nuño JL
- Subjects
- Colon pathology, Colon surgery, Colonic Polyps surgery, Colonoscopy, Female, Humans, Male, Mass Screening, Middle Aged, Prevalence, Spain epidemiology, Colonic Polyps diagnosis, Colonic Polyps epidemiology
- Abstract
Introduction: The importance of colonic polyp is increasing because colorectal cancer (CRC) screening is based on their identification. However, consensus is lacking on which technique should be used in CRC screening, whether colonoscopy or other methods such as sigmoidoscopy, which shows good sensitivity only in distal segments of the colon. We studied the characteristics and localization of polyps in our environment to verify their tendency to change localization and determine the implications of this in screening., Material and Methods: We reviewed the prevalence and characteristics of colonic polyps in 3604 patients who underwent colonoscopy for various causes in our service, as well as their distribution in 837 patients with a diagnosis of polyps who underwent complete colonoscopy. Localization proximal or distal to the splenic flexure and polyp size (less than or more than 1 cm) were analyzed., Results: Polyps were found in 28.3% of 3604 patients (11.7% showed polyps > or = 1 cm). Of the 837 patients who underwent complete colonoscopy, proximal polyps were found in 44.9% (14.6% showed polyps > or = 1 cm), while distal polyps were found in 79.9% (30.3% showed polyps > or = 1 cm). Both proximal and distal polyps were found in 24.8%. The probability of finding both proximal and distal lesions was 31%. Proximal lesions without distal lesions were found in 20% of the patients (5.6% presented polyps > or = 1 cm), and consequently sigmoidoscopy would miss 15.6% of polyps > or = 1 cm., Conclusions: A relatively high percentage of patients with proximal polyps > or = 1 cm would remain undiagnosed if complete colonoscopy were only performed in patients with distal polyps. Because of the well-known increase in the frequency of proximal polyps and because a considerable number of these present without distal sentinel lesions, there are increasing arguments for considering colonoscopy as the basic technique for CRC screening.
- Published
- 2003
- Full Text
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50. [Fast method of labelling leukocytes with 99mTc HM PAO].
- Author
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Piera C, Vázquez A, Hernández MA, Plancha MC, Ruiz A, Mateos JJ, Martín F, Ortega ML, Fuertes S, and Pons F
- Subjects
- Blood Cell Count, Centrifugation, Density Gradient, Chemical Precipitation, Diatrizoate, Erythrocytes, Ferric Compounds, Ficoll, Humans, Iron, Oxides, Radionuclide Imaging, Time Factors, Isotope Labeling methods, Leukocytes diagnostic imaging, Radiopharmaceuticals, Technetium Tc 99m Exametazime
- Abstract
Objective: To modify the method of labelling leukocytes with 99mTc HM-PAO by centrifuging 15 minutes at low gravity (g) instead of sedimentation at a variable time (30-90 minutes) to obtain leukocytic rich plasma (LRP)., Methods: The g number recovering the greatest number of leukocytes was determined. The cellular composition of LRP obtained by centrifugation and sedimentation was analyzed. Lastly, labelling results in two groups of patients (p) were compared: one group of 118 p using the traditional sedimentation method (SM) and another of 124 p using the proposed centrifugation alternative (CM)., Results: Centrifugation at 5xg produced the greatest recovery of leukocytes (93.1 5.1%). No significant difference was observed in leukocyte recovery in LRP obtained either by centrifugation or by sedimentation. However, red blood cell contamination was greater in centrifugation (12.8 4.9 x 108) than in sedimentation (7.7 3.5 x 108) (p < 0.0001). The comparison of the SM and the CM gave the following results:The number of leukocytes recovered in both methods was similar (73.9 15.1% vs 76.5 12.7%) with approximately the same platelet contamination (8.0 6.2 vs 8.4 6.5%). The number of red blood cell contaminants per leukocyte was 3.0 1.0 for the MS and 5.1 2.6 for the MC (p < 0.001). Labelling yield (LY) was somewhat higher for the CM (57.8 11.9%) than for the SM (50.8 12.6%) as a result of greater red blood cell contamination and superior radiochemical purity of the 99mTc HM-PAO used in the labelling by CM (90,9 5,9%) with regard to the SM (87.9 9.5%). No difference was observed in the scintigraphic images obtained with either of the methods, given the scarce uptake of the radiopharmaceutical by the red blood cells (3-7%) in comparison with the leukocyte uptake (70-90%)., Conclusion: The proposed MC considerably reduces the labelling time of leukocytes with 99mTc HM-PAO without affecting the quality of scintigraphic images and represents an important labelling alternative of great interest to the Radiopharmacy Units of Nuclear Medicine Services.
- Published
- 2002
- Full Text
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