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Objective: As a maritime country, Indonesia has diverse biodiversity. Recently in coastal area, the industry that manages marine products has been grown rapidly and one of them is the seaweed industry. Takalar Regency has become one of center of seaweed industry development in Indonesia especially in South Sulawesi. However, there is lack of concern about health and safety problems particularly ergonomics and musculoskeletal disorders (MSDs) among seaweed farmers. Method: The study uses a mixed method design combining quantitative and qualitative approach. The sample were taken from four districts; Mangarabombang, Mappakasunggu, Sanrobone and North Galesong. Results: More than 50% of the workers mentioned that they often work in bending position and almost 45% of the workers mentioned that they often work sitting sideways or twisting. self-reporting symptoms of MSDs include pain/sore particularly in lower back area 66.5%, fever 5.6%, sprain 8.7%, numb 3.1% and strain more than 60%. Conclusion: This research found that large number of employees performed their job in nonergonomics positions that might be associated with MSDs. The research revealed as well the number of farmers who suffer from MSDs symptoms. It is suggested to apply ergonomic rules and principles by redesign tools and the work process.