1. Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib.
- Author
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Contreras-Díaz M, Medina-Tapia A, Martínez-Bernal G, Rueda-Rueda T, López-Herrero F, Molina-Socola FE, and Sánchez-Vicente JL
- Subjects
- Adenocarcinoma diagnosis, Adenocarcinoma drug therapy, Adenocarcinoma enzymology, Adenocarcinoma of Lung, Afatinib, Antineoplastic Agents pharmacology, Carcinoma, Non-Small-Cell Lung diagnosis, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung enzymology, Choroid Neoplasms diagnosis, Choroid Neoplasms drug therapy, Choroid Neoplasms enzymology, ErbB Receptors antagonists & inhibitors, Humans, Lung Neoplasms drug therapy, Lung Neoplasms enzymology, Male, Middle Aged, Neoplasm Proteins antagonists & inhibitors, Protein Kinase Inhibitors pharmacology, Quinazolines pharmacology, Remission Induction, Signal Transduction drug effects, Adenocarcinoma secondary, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung secondary, Choroid Neoplasms secondary, Lung Neoplasms diagnosis, Protein Kinase Inhibitors therapeutic use, Quinazolines therapeutic use
- Abstract
Case Report: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up., Discussion: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation., (Copyright © 2016 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
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