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Strategies to sustainably transform road transformation often focus on electrification and environmental benefits. However, transportation is also intricately linked to socio-economic aspects of sustainable development and electrification poses its own challenges.

Background: No adequately powered studies exist to compare major clinical outcomes after endovascular therapy (EVT) with stent implantation vs bypass surgery (BSx) for symptomatic femoropopliteal peripheral artery disease. Objectives: This study sought to perform a pooled analysis of individual patient data from all randomized controlled trials comparing EVT vs BSx. Methods: Principal investigators of 5 of 6 available randomized controlled trials agreed to pool individual patient data. The primary endpoint was major adverse limb events, a composite of all-cause death, major amputation, or target limb reintervention. Secondary endpoints included amputation-free survival, individual major adverse limb event components, and primary patency. Early complications were bleeding, infection, or all-cause death within 30 days. Results: A total of 639 patients were analyzed with a mean age of 68.1 ± 9.1 years and 29.0% women. Baseline characteristics were comparable between groups. At 2 years, there were no significant differences between patients who received EVT and those who received BSx regarding major adverse limb events (40.1% vs 36.4%; log-rank P = 0.447; adjusted HR [aHR]: 1.04; 95% CI: 0.80-1.36), amputation-free survival (88.1% vs 90.0%; log-rank P = 0.455; aHR for death or amputation: 1.04; 95% CI: 0.63-1.71) and the other secondary endpoints except for primary patency, which was lower in patients who received EVT vs those who received BSx (51.2% vs 61.3%; log-rank P = 0.024; aHR for loss of primary patency: 1.31; 95% CI: 1.02-1.69). EVT was associated with significantly lower rates of early complications (6.8% vs 22.6%; P < 0.001) and shorter hospital stay (3.1 ± 4.2 days vs 7.4 ± 4.9 days; P < 0.001). Conclusions: These findings further support the efficacy and safety of EVT as an alternative to BSx in patients with symptomatic femoropopliteal peripheral artery disease.

Most transport equity and transport-related social exclusion (TRSE) studies assume that increasing accessibility levels lead to increased activity participation and, therefore, a reduction in social exclusion. Although this assumption makes sense from a theoretical point of view, this causal relationship has not yet been validated in practice. Previous studies investigating the accessibility-participation relationship were inconclusive, indicating that increasing accessibility has a limited impact on activity participation levels, if any. Moreover, the existing empirical evidence in the literature in the Global South context is scarce, is merely correlational and fails to infer causality between both variables. The contributions of the paper are threefold. First, (a) to provide a conceptual model of the causal relationship between accessibility, activity participation and risk of transport-related social exclusion (TRSE); second, (b) to summarise the available empirical evidence about the accessibility-activity participation relationship through a systematic literature review; and third, (c) to provide evidence of the causal relationship between accessibility and activity participation levels in a Global South context. Three Poisson regression models associated with an instrumental variable identification strategy were used to assess the causal effect between accessibility and participation in total, mandatory and discretionary activities in the city of São Paulo, Brazil. The three models showed a highly significant, strong correlation between an individual's accessibility level and their actual participation in total, mandatory and discretionary activities. Models that ignore the possible endogeneity present in the relationship between accessibility and activity participation may underestimate the effect of accessibility. Based on our results, we argue that low accessibility levels may severely restrict individuals’ life chances and add evidence that accessibility has to be an important instrument to support transport policies' decision-making.

BaCe0.65Zr0.2Y0.15O3-δ – Ce0.85Gd0.15O2-δ (BCZ20Y15-GDC15) dual-phase material revealed potential for H2 production technologies due to its exceptional H2 permeation and chemical resistance. In this article, mechanical properties of BCZ20Y15-GDC15 dual-phase material were investigated to evaluate the mechanical behavior and develop strategies to warrant structural stability. Elastic modulus, hardness and fracture toughness values were studied using different indentation-based methods. The fracture experiments at different length-scales both revealed that the introduction of GDC15 makes the material tougher, facilitating the further design of robust and reliable components.

Executives in family firms are often confronted with emotionally loaded issues, in part due to the need to include the interests of the owning family. Given this context, we hypothesize how high family-firm performance is affected by the emotional intelligence (EI) of a family-based CEO and top-management team (TMT), in addition to the CEO's transformational leadership (TFL) and TMT's behavioral integration. Survey measures were taken from a random sample of 72 CEOs of German family firms and 245 members of their TMTs. We found that TMT behavioral integration mediates between CEO TFL and objective firm performance while CEO EI is significantly related to both CEO TFL and TMT EI. Implications are discussed for future research thereby suggesting an extension to upper-echelon theory.

Aims To analyse the disease-free survival and overall survival in older adults with breast cancer after breast-conserving therapy, focusing on the relevance of non-breast malignancy (NBM) with respect to survival rates. Materials and methods Analyses were based on 1205 women aged 65 years and older with breast cancer treated with breast-conserving therapy between 1999 and 2015. Patients were divided into three age categories: 65–70, 71–75 and >75 years. Multivariate survival analysis was carried out using Cox regression analysis. Results The two youngest age categories showed excellent results, with a 12-year disease-free survival of 84.6 and 86.3%, respectively. We noted a 17.2% incidence of NBM, particularly for colon cancer and lung cancer. Most (72.9%) occurred after a diagnosis of breast cancer. Of those 72.9%, about 50% died as a result of NBM within 2 years of the diagnosis of NBM. The overall 12-year NBM-specific survival was 92.0%. The 12-year overall survival was 60.0% for all and for the three abovementioned age categories was 73.3, 54.4 and 28.4%, respectively. The cause of death for all was predominantly non-malignancy-related morbidity. Conclusion The impact of breast cancer on life expectancy was limited, in particularly for women aged 65–75 years. The relevance of NBM on survival was limited.

Mass-scale red blood cell genotyping of donors and transfusion recipients increases the availability of extended antigen matched red blood cell units. Therefore, a new mathematical framework is developed that can be applied for general blood groups (i.e., beyond the ABO, RhD blood groups). It determines which red blood cell units should be issued from inventory, such that requests from hospitals can be satisfied with antigen compatible red blood cell units, shortages for future requests are avoided, and outdating is prevented. The optimization model consists of two steps: a binary vector representation for general blood groups and the formulation of the inventory allocation problem as a minimum cost flow problem. The potential practical performance of the optimization model is evaluated by iterative simulations, based on historical data on supply and demand of red blood cell units in the Netherlands. When including the fourteen clinically most relevant antigens, more than 90% of all requests can be satisfied with antigen identical red blood cell units. Shortages and outdating can be kept restricted and could even be reduced to virtually zero, when only the ABO, RhD blood groups are considered.

Endorheic freshwater lakes can be vital water resources for sustaining large populations. However, their land-locked nature can lead to overexploitation and long-term sediment accumulation, reducing water storage and quality. Lake Naivasha supports a rapidly expanding population and agricultural industry. Therefore, maintaining good water storage and quality within this endorheic lake is crucial for the Kenyan economy and population. The lake has a long history of level fluctuations and the region is considered to be suffering from a chronic imbalance between water supply and demand. This study quantifies the sediment deposition rate and its impact on Lake Naivasha's water levels and volume, using inexpensive remote sensing techniques that could be easily replicated for future monitoring. Evidence of sedimentation in the northern area averaging 23 mm yr−1 was identified, which is likely annually displacing between 40.2 – 576 × 103 m³ of water. The volume displaced each year is equivalent to the water required to sustain between 40 – 1152 people. These results imply that current abstraction management, based purely upon lake level readings that govern a ‘traffic lights’ system, are detrimental to the long-term survival of the lake. The results also imply that lake health is decreasing. We recommend that future monitoring of this water resource and all endorheic lakes consider measurements of available water volume in combination with lake level data using the remote sensing methods we describe.

“Mesenteric arterial thrombosis? Here we call it cemetery thrombosis” (trombosis cementerico in Spanish), said the moderator at a meeting discussing this topic in Cartagena, Colombia. That metaphor, unfortunately, is still justified worldwide.

Purpose Studies of the relation of fibromyalgia (FM) and widespread pain (WSP) to mortality have differed as to the presence or absence of an association and the extent of cause-specific mortality. However, no studies have investigated which definitions of FM and WSP associate with mortality, nor of FM mortality in other diseases. We investigated these issues and the meaning of mortality in patients with FM. Methods We used Cox regression to study 35,248 rheumatic disease patients with up to 16 years of mortality follow-up in all patients and separately in those with diagnoses of rheumatoid arthritis (RA) (N = 26,458), non-inflammatory rheumatic disorders (NIRMD) (N = 5,167) and clinically diagnosed FM (N = 3,659). We applied 2016 FM criteria and other FM and WSP criteria to models adjusted for age and sex as well as to models that included a full range of covariates, including comorbid disease and functional status. We estimated the degree of explained of variance (R2) as a measure of predictive ability. Results We found positive associations between al`l definitions of FM and WSP and all-cause mortality, with relative risks (RR)s ranging from 1.19 (95%CI 1.15–1.24) for American College of Rheumatology (ACR) 1990 WSP to 1.38 (1.31–1.46) in age and sex adjusted revised 2016 criteria (FM 2016). However, in full covariate models the FM 2016 RR reduced further to 1.15 (1.09–1.22). The association with mortality was noted with RA (1.52 (1.43–1.61)), NIRMD (1.43 (1.24–1.66)) and clinical FM (1.41 (1.14–1.75) - where 37% of FM diagnosed patients did not satisfy FM 2016 criteria. In the all-patient analyses, the age and sex explained variation (R2) was 0.255, increasing to 0.264 (4.4%) when FM 2016 criteria were added, and to 0.378 in a full covariate model. Death causes related to FM 2016 status included accidents, 1.45 (1.11–1.91); diabetes 1.78 (1.16–2,71); suicide, 3.01 (1.55–5.84) and hypertensive related disorders, 3.01 (1.55–5.84). Cancer deaths were less common 0.77 (0.68–0.88). Conclusions FM is weakly associated with mortality within all criteria definitions of FM and WSP examined (3.4% of explained variance), and across all diseases (RA, NIRMD, clinical FM) equally. Clinical and criteria-defined FM had different mortality outcomes. We found no evidence for a positive association of cancer and FM or WSP.

Purpose: To determine the burden of non-epilepsy drugs on people with epilepsy, using administrative health care data. Methods: The Achmea Health Insurance Database (AHID) contains health claims data from 25 % of the Dutch population. From the AHID, we selected all policyholders with coverage for at least one full calendar year between 2006−2009. We included adults with diagnostic codes for epilepsy and randomly selected two frequency-matched controls per case. We labeled drugs dispensed at least twice per calendar year as chronic and excluded antiseizure medications. We estimated and compared the prevalence of chronic medication use, number of chronic medications used, number of prescriptions dispensed, Rx Risk comorbidity index, and drug burden index (DBI) between people with epilepsy and controls. Results: Non-epilepsy chronic medication use was more frequent in people with epilepsy than controls (67 % versus 59 %, p < 0.001). People with epilepsy had an increased DBI (average 0.19 versus 0.10, p < 0.001), used more chronic medications (median 2 versus 1, p < 0.001) and had more prescriptions dispensed (median 7 versus 3, p < 0.001). The DBI and number of unique chronic medications were higher among older (>60 years) than younger (

Antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides include granulomatosis with polyangiitis (GPA, previously called Wegener's), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss). In this report we used mycophenolate mofetil (MMF) and steroids to induce and maintain remission in two newly diagnosed cases with c-ANCA associated GPA. The two patients' maintained remission with no disease relapses during one year follow-up.Copyright © 2018 Sociedad Espanola de Reumatologia y Colegio Mexicano de Reumatologia. Publicado por Elsevier Espana, S.L.U. All rights reserved.

Background Studies examining sex-related outcomes following percutaneous coronary intervention (PCI) have reported conflicting results. Objectives The purpose of this study was to examine the sex-related risk of 5-year cardiovascular outcomes after PCI. Methods The authors pooled patient-level data from 21 randomized PCI trials and assessed the association between sex and major adverse cardiac events (MACE) (cardiac death, myocardial infarction [MI], or ischemia-driven target lesion revascularization [ID-TLR]) as well as its individual components at 5 years. Results Among 32,877 patients, 9,141 (27.8%) were women. Women were older and had higher body mass index, more frequent hypertension and diabetes, and less frequent history of surgical or percutaneous revascularization compared with men. By angiographic core laboratory analysis, lesions in women had smaller reference vessel diameter and shorter lesion length. At 5 years, women had a higher unadjusted rate of MACE (18.9% vs. 17.7%; p = 0.003), all-cause death (10.4% vs. 8.7%; p = 0.0008), cardiac death (4.9% vs. 4.0%; p = 0.003) and ID-TLR (10.9% vs. 10.2%; p = 0.02) compared with men. By multivariable analysis, female sex was an independent predictor of MACE (hazard ratio [HR:]: 1.14; 95% confidence interval [CI:]: 1.01 to 1.30; p = 0.04) and ID-TLR (HR: 1.23; 95% CI: 1.05 to 1.44; p = 0.009) but not all-cause death (HR: 0.91; 95% CI: 0.75 to 1.09; p = 0.30) or cardiac death (HR: 0.97; 95% CI: 0.73 to 1.29; p = 0.85). Conclusions In the present large-scale, individual patient data pooled analysis of contemporary PCI trials, women had a higher risk of MACE and ID-TLR compared with men at 5 years following PCI.

Preserving articular cartilage extends the life span and functional capabilities of a joint, and prevents early joint arthroplasty. Mesenchymal signaling cells (MSCs) induce chondrocytes and stimulate the innate capacity to regenerate and restore damaged cartilage. Preserving the pericellular matrix of chondrocytes boosts the ability of MSC to stimulate chondrocytes. The ability to augment joint homeostasis and induce cartilage regeneration with the use of allogenic MSCs unlocks the possibility of a single stage cell based surgical therapy for medium to large cartilage defects. The results of cell therapy with recycled autologous chondrons mixed with allogeneic (bone-marrow or adipose derived) mesenchymal signaling cells (IMPACT/RECLAIM) after 7 years have supported the safety and clinical efficacy of this treatment. Patients have shown clinically relevant and statistically significant improvement in multiple validated patient reported outcome measures for knee pain and quality of life. Once fully industrialized the single stage approach, compared to conventional 2 stage procedures, should also provide a more economical and logistically friendly treatment option. Low failure rates and similar results compared to the current golden standard reinforce the longevity of this proof of concept. The phase III randomized controlled trial comparing results of the treatment after a non-surgical approach will conclude in 2024. As for now, research supports this unique first in man one stage cartilage repair to be safe, feasible, and have good clinical outcomes when combining recycled cartilage with allogeneic MSCs.

Here we study the kinetics of liquefaction and solidification of thin bismuth films grown on the insulating substrate by the pulsed laser deposited (PLD) and molecular beam epitaxy (MBE) and investigated by in situ electron and X-ray diffraction. By PLD, we can grow films similar to those obtained using MBE, studied by ex-situ AFM, KPFM, XRR, and XRD. The liquefaction-solidification transition is monitored in real-time by RHEED and synchrotron XRD, resulting in a dewetting phenomenon and the formation of spherical droplets which size depends on the initial film thickness. Studying this phase transition in more detail, we find instantaneous liquefaction and solidification, resulting in formation of the nanodots oriented with a (110) crystallographic plane parallel to the substrate. Furthermore, we propose a two-step growth mechanism by analyzing the recorded specular diffraction rods. Overall, we show that the PLD and MBE can be used as a method for the highly controlled growth of Bi nanostructures, including their crystallographic orientation on the substrate., Comment: 39 pages, 20 figures

We calibrate the lateral mode AFM (LFM) by determining the position-sensitive photodetector (PSPD) signal dependency on the lateral tip displacement, which is analogous to the constant-compliance region in normal-force calibration. By stick-slip on stiff, amorphous surfaces (silica or glass), the lateral tip displacement is determined accurately using the feedback loop control of AFM system. The sufficiently high contact stiffness between the Si AFM tip and stiff, amorphous surfaces substantially reduces the error of PSPD signal dependency on the lateral tip displacement. No damage or modification of the AFM probe is involved and only a clean silicon or glass wafer is needed.

This paper uses an actor-oriented political ecology approach, and procedural and distributional lenses to explore whether large-scale land acquisitions (LSLAs) exhibit the characteristics of land grabs. We apply these perspectives in two LSLAs in Ghana (oil palm, jatropha) that reflect different drivers/processes of land acquisition, crops and modes of production. For the procedural analysis, we track how LSLAs unfolded on the ground using (a) legal perspectives, (b) narratives of the local communities and other key players (e.g. chiefs, investor, government institutions), and (c) formal documentary evidence. For the distributional analysis, we examine some of the key socioeconomic and environmental impacts of these LSLAs through household surveys in the affected communities affected. Through the triangulation of this information, we conclude that even though these LSLAs have some characteristics of land grabs, it is problematic to concretely label them as such. This is because they followed the appropriate legal provisions, even though some of the consultation and compensation processes were questionable. These processes were largely mediated through the unconstructive involvement of chiefs (and their manipulation of customary procedures), rather than unethical practices from the side of investors. These questionable processes have affected transparency and accountability, and have had negative distributional outcomes. This indicates ‘benefit grabbing' by traditional authorities at the expense of local communities, rather than actual land grabbing by investors. It is therefore imperative to consider chiefs’ involvement in LSLAs and further formalise LSLA processes (especially in terms of consultations and compensation) to avoid instances of land and/or benefit grabbing in Ghana, and elsewhere in Africa.

Agriculture is a key sector and a major consumer of water resources; therefore, a clear understanding of the agricultural water demand for crop production and consumption is imperative for addressing water scarcity problems, particularly in water export regions. This study provides new insights into the influential factors driving the changes in the agricultural production water footprint (WFprod) and consumption water footprint (WFcon) in the net water import and net water export regions. The WFprod and WFcon of wheat are evaluated in Beijing city (the net water import region) and Heilongjiang province (the net water export region) over the period 1996–2015. The statistical significances of the influential factors, i.e., climate change, gross domestic product, population, dietary demand and technology update are determined using a multivariate linear regression model (LRM) and nonlinear regression model (NLRM). The results indicate that the gross domestic product and population were the dominant positive influential factors, whereas technology update and dietary demand were the dominant negative influential factors affecting the changes in the WFprod and WFcon in the net water import region. In the net water export region, technology update was the dominant negative influential factor affecting the changes in the WFprod and WFcon. Climate change did not contribute significantly to the changes in the WFprod and WFcon of wheat; however, it was an important factor (especially precipitation for the green WF with an average relative importance of more than 22% and the blue WF with an average relative importance of more than 15%) affecting the changes in the WFprod and WFcon of the crop. An in-depth analysis of the influential factors that contribute to the changes in the WFs is fundamentally important for decision-makers to develop countermeasures and strategic planning implementations to mitigate water resource pressure in China.

Asymmetric forces exerted on the horse's back during riding are assumed to have a negative effect on rider–horse interaction, athletic performance, and health of the horse. Visualized on a saddle pressure mat, they are initially blamed on a nonfitting saddle. The contribution of horse and rider to an asymmetric loading pattern, however, is not well understood. The aim of this study was to investigate the effects of horse and rider asymmetries during stance and in sitting trot on the force distribution on the horse's back using a saddle pressure mat and motion capture analysis simultaneously. Data of 80 horse-rider pairs (HRP) were collected and analyzed using linear (mixed) models to determine the influence of rider and horse variables on asymmetric force distribution. Results showed high variation between HRP. Both rider and horse variables revealed significant relationships to asymmetric saddle force distribution (P < .001). During sitting trot, the collapse of the rider in one hip increased the force on the contralateral side, and the tilt of the rider's upper body to one side led to more force on the same side of the pressure mat. Analyzing different subsets of data revealed that rider posture as well as horse movements and conformation can cause an asymmetric force distribution. Because neither horse nor rider movement can be assessed independently during riding, the interpretation of an asymmetric force distribution on the saddle pressure mat remains challenging, and all contributing factors (horse, rider, saddle) need to be considered.

Item does not contain fulltext Children with dyslexia are often provided with audio-support to compensate for their reading problems, but this may intervene with their learning. The aim of the study was to examine modality and redundancy effects in 21 children with dyslexia, compared to 21 typically developing peers (5th grade), on study outcome (retention and transfer knowledge) and study time in user-paced learning environments and the role of their executive functions (verbal and visual working memory, inhibition, and cognitive flexibility) on these effects. Results showed no effects on retention knowledge. Regarding transfer knowledge, a modality effect in children with dyslexia was found, and a reversed redundancy effect in typically developing children. For transfer knowledge, written text with pictures supported knowledge gain in typically developing children, but not in children with dyslexia who benefited more from auditory-presented information with pictures. Study time showed modality and reversed redundancy effects in both groups. In all children, studying in a written text with pictures condition took longer than with audio replacing the text or being added to it. Results also showed that executive functions were related to learning, but they did not differ between the groups, nor did they impact the found modality and redundancy effects. The present research thus shows that, irrespectively of children’s executive functions, adding audio-support for all children, can potentially lead to more efficient learning. 10 p.

In this micromechanical study of the behaviour of granular materials, relationships are investigated between deformation at the continuum macro-scale and at the micro-scale of interparticle contacts. Special attention is paid to the role of the microstructure, or fabric, as it is well known to have a strong influence on the behaviour of granular materials. Two-dimensional Discrete Element Method simulations of isobaric tests have been used to formulate truncated Fourier series representations for suitably-averaged relative displacement increment vectors at interparticle contacts and of parameters that describe the fabric. Based on a micromechanical expression for the average strain tensor that is valid in the two-dimensional case considered here and on these Fourier series representations, a Strain–Displacement–Fabric relationship has been derived that links the macro-scale dilatancy rate to the micro-scale relative displacements and fabric. Results of the Discrete Element Method simulations, using samples with different densities, have been employed to verify the accuracy of the proposed relationship for the dilatancy rate.

Background The public transport access, an important dimension of neighborhood built environments and usually defined as the access to public transport stops/stations (PTS), has been revealed to be associated with more participation in physical activity (PA) in western countries. The perceptions of such features could have additional benefits to healthy behaviors. However, such research is lacking in developing countries. This study aimed to explore the association between perceived PTS access and PA participation among urban adults in China. Methods A population-based cross-sectional survey conducted in Nanjing in 2017 was used, where 1,568 participants aged 35–74 were recruited from eight randomly selected urban neighborhoods under a multi-stage sampling strategy. The individual's PTS access and PA participation were self-reported using the Physical Activity Neighborhood Environment Scale and the International Physical Activity Questionnaire, respectively. Mixed-effect logistic regression models were used to estimate the association between perceived PTS access and PA participation. Results Among 1,551 participants who completed the survey, 84.7% of participants achieved the World Health Organization (WHO) recommended PA level. After adjusting for potential individual- and neighborhood-level confounders, participants who perceived a PTS within 10–15 min’ walking distance from their residence were 3.18 (95%CI = [1.74, 5.80]) times more likely to meet WHO recommended PA guidelines than their counterparts who did not perceive any PTS in their neighborhoods. This association also held true in either men (OR = 2.71, 95%CI = [1.07, 6.86]) or women (OR = 3.50, 95%CI = [1.59, 7.70]), separately. Conclusions Such findings will provide health practitioners and urban planners evidence-based insights on potential health effects of expanding and improving public transport systems, and on how to incorporate these effects into strategies of PA promotion and chronic disease prevention.

We consider the integrated planning of spare parts and service engineers that are needed for serving a group of systems. These systems are subject to different failure types, and for each failure, a service engineer with the necessary spare part has to be assigned to repair the system. The service provider follows a backlogging policy with part reservations. That is, a repair request is backlogged if one of the required resources is not immediately available upon demand. Moreover, a spare part is reserved if the requested spare part is in stock but no service engineer is immediately available. The spare parts are typically slow-movers and are managed according to a base-stock policy. The objective is to jointly determine the stock levels and the number of service engineers to minimize the total service costs subject to a constraint on the expected total waiting times of the repair calls. For the evaluation of a given setting, we present an exact method (computationally feasible for small problems) and an accurate approximation. For the joint optimization, we present a greedy heuristic that efficiently produces close-to-optimal results. We test how the heuristic performs compared to the optimal solution and the separate optimization of spare parts and service engineers in an extensive numerical study. In a case study with 93 types of spare parts, we show that the solution of the greedy algorithm is always within 2% of the optimal solution and is up to 20% better than a separated optimization approach encountered in practice.

In recent decades, wild cherry has been one of the species most widely used for reforestation in Europe. Studies aiming to select and improve trees to give them the best growth rates and wood properties have increased in response to growers’ demands. However, information relating to key physiological processes such as transpiration or stomatal conductance and to the effect of the common practice of pruning on plant–water relations is scarce. The main objective of this study was to assess the effects of environmental conditions on canopy conductance dynamics. Its secondary objective was to examine the short- and medium-term effects of branch pruning on tree transpiration, growth and derived water productivity. To this end, we measured sap flow in an experimental plantation where trees were subjected to drip irrigation and rain-fed conditions and where variables characterizing climate, soil and tree growth were also monitored. The results demonstrated that the Jarvis–Stewart approach was appropriate for studying the responses of canopy conductance to environmental factors. As well as the role of vapour pressure deficit and net radiation in controlling the daily variations of canopy conductance, the single effects of decreasing soil water content (optimum relative extractable water, REW, higher than 0.4) and increasing air temperature (optimum of 21 °C), as summer conditions approached, were correctly incorporated into the modelling exercise. Soil water content exerted the greatest control on canopy conductance for trees growing under rain-fed conditions, while air temperature did for irrigated trees. Pruning significantly reduced transpiration to about 35% when pre- and post-sub-periods were compared, but also affected annual water productivity regardless of the irrigation treatment. To assess the long-term effects of pruning on water productivity, measurements in both pruned and unpruned trees would be desirable. © 2019 Elsevier B.V., This research was financially supported by the GRIFO (AGL2010-21012) and CONSOLIDER-MONTES (CSD 2008-00040) projects. A.J. Molina is beneficiary of a Juan de la Cierva post-doctoral fellowship. A. Galindo is beneficiary of a Ramón Areces foundation post-doctoral fellowship. The field work of Eulalia Serra, Beatriz Grau, Marc Ferrer and Cristian Morales is greatly appreciated. We also want to thank the work of two anonymous reviewers in improving the quality of the manuscript.

The film thickness for grease lubricated bearings is normally calculated using the base oil viscosity, where it is assumed that the bearing is running under fully flooded conditions. It is well known that this is not accurate since grease lubricated bearings are usually running under starved lubrication conditions leading to thinner films. Single contact measurements have shown that, in the case of starvation, the film thickness decreases with increasing speed. It is shown in this paper that this effect seems to be very small though. The film thickness measurements, for three types of thickener material and base oil, show that the film thickness is almost independent of speed. To quantify this starvation effect, the film thickness can be expressed as the ratio between real film thickness and calculated film thickness using the base oil viscosity, hg/hff. The measurements in this paper show that hg/hff > 1 for very low speeds but decreases with speed asymptomatically reaching a constant value. It is shown here that hg/hff depends on speed, load and temperature and on the grease properties. It is not only the base oil viscosity that determines the film thickness. It is also governed by other grease properties that are today not known.

Study Objective To prospectively evaluate the mesh exposure rate after robot-assisted laparoscopic pelvic floor surgery for the treatment of female pelvic organ prolapse (POP) in a large cohort. Design Prospective observational cohort study (Canadian Task Force classification II-2). Setting Two large teaching hospitals with a tertiary referral function for pelvic floor disorders. Patients Patients with symptomatic POP and simplified POP quantification (S-POP) stage ≥2. Patients with a history of mesh repair or concomitant insertion of a tension-free vaginal tape were excluded. Interventions Robot-assisted laparoscopic sacrocolpopexy or robot-assisted laparoscopic supracervical hysterectomy with a sacrocervicopexy. Measurements and Main Results A blinded vaginal examination with the aid of a transparent speculum was performed to look for mesh-related complications. Mesh exposures were described following the International Urogynecological Association/International Continence Society classification system. One hundred and ninety-two patients were included, of whom 166 (86.5%) were seen for follow-up examination. The median duration of follow-up was 15.7 months (range, 8.2–44.4 months). Two vaginal mesh exposures (1.2%) were detected, both of which were treated in the outpatient clinic. One patient without any complaints had a suture exposure, which was removed in the outpatient clinic. Conclusion The safety of the use of mesh in pelvic floor surgery is a matter of debate owing to the occurrence of mesh-related complications. Based on the current literature, mesh-related complications seem to be lower in transabdominal mesh surgery than in transvaginal mesh surgery. In this study, a low mesh exposure rate was observed in robot-assisted abdominal pelvic floor surgery for POP.

10 páginas.--6 figuras.-- 3 tablas.-- 49 referencias, Around the world, the tomato is considered the most important vegetable because of the extent of the cultivated area. In addition, it requires vast amounts of irrigation but little is known about the management of deficit irrigation. This study aims to evaluate the effect of regulated deficit irrigation (RDI) on development of crop and fruit quality for cherry tomatoes (ʽLazarinoʼ and ʽSummerbrixʼ). Two different cherry cultivars were used during two crop cycles (autumn and spring). RDI was scheduled with an initial period of no water stress and with a period of deficit from the beginning of the flowering, with a threshold of midday leaf water potential of around −1 MPa. It was found that the response to the irrigation treatment was affected by the season and even by the cluster considered. During the autumn cycle, there were no clear differences in yield despite water stress being mild but still significant. In the spring cycle, yield reduction peaked with different responses between cultivars. Water stress reduced fruit weight and fruit number per cluster in cv Summerbrix, producing a continuous decrease throughout the harvest period. In cv Lazarino, a yield reduction was detected only at the end of the harvest period and was related to the decrease in fruit weight and the number of inflorescence. The application of RDI reduced water by 85% and increased the content of soluble sugar, carotenoids and total phenols in both cultivars and cycles, the funding received from the Spanish Ministerio de Ciencia, Innovación y Universidades (Before Ministerio de Economía y Competitivida) , project ref. AGL2012-37610 , co-funded by FEDER). ECC, DH, AMBG, CMS and AJMM thank the Ibero-American Programme for Science, Technology and Development (CYTED, http://www.cyted.org ) for the funding of the IBERCAROT network. AJMM acknowledges the funding received from the Carotenoid Network: from microbial and plants to food and health (CaRed), funded by the Spanish Ministerio de Ciencia, Innovación y Universidades (Before Ministerio de Economía y Competitivida) (BIO2015-71703-REDT). The authors wish to thank the Fitó Company for the seeds provided.

This study examines the press coverage of initiatives taken by three companies, in three different countries, to propose chip implants to their employees (‘insideable’ technology). The study sought to identify prevalent topics, the motivations and measures taken by the companies, the drivers and barriers of employees towards the chips, and the issues raised by experts in the newspaper articles. Content analysis was performed, with each Case being analysed separately. Then, overarching themes and differences are observed. The ethical considerations driving perception of technology have to do with privacy, the proportionality principle, harm and safety. People accepting the technology do not mention such constructs, they focus on the possibility of being pioneers and the convenience offered by the technology. Societal acceptance, through the gaze of others and the infrastructure developed in the different countries to use microchips, also plays a role to drive personal and work-related acceptance of insideables. A modelling to investigate the acceptance of insideables taking into account different dimensions of acceptability is proposed.

The plasma membrane of cells has a complex architecture based on the bidimensional liquid-crystalline bilayer arrangement of phospho- and sphingolipids, which in turn embeds several proteins and is connected to the cytoskeleton. Several studies highlight the spatial membrane organization into more ordered (L o or lipid raft) and more disordered (L d ) domains. We here report on a fluorescent analog of the green fluorescent protein chromophore that, when conjugated to a phospholipid, enables the quantification of the L o and L d domains in living cells on account of its large fluorescence lifetime variation in the two phases. The domain composition is straightforwardly obtained by the phasor approach to confocal fluorescence lifetime imaging, a graphical method that does not require global fitting of the fluorescence decay in every spatial position of the sample. Our imaging strategy was applied to recover the domain composition in human oligodendrocytes at rest and under treatment with galactosylsphingosine (psychosine). Exogenous psychosine administration recapitulates many of the molecular fingerprints of a severe neurological disease, globoid cell leukodystrophy, better known as Krabbe disease. We found out that psychosine progressively destabilizes plasma membrane, as witnessed by a shrinking of the L o fraction. The unchanged levels of galactosyl ceramidase, i.e., the enzyme lacking in Krabbe disease, upon psychosine treatment suggest that psychosine alters the plasma membrane structure by direct physical effect, as also recently demonstrated in model membranes.

Visible and near-infrared spectroscopy (VNIRS, 350–2500 nm) is a promising alternative to rapidly investigate soil contamination by heavy metals. To explore the possibility of predicting heavy metal concentration in soils using laboratory and field reflectance spectroscopy and examine transferability of the prediction method, 46 soil samples from a mining area, 42 soil samples from an agricultural land, and the corresponding two sets of field soil spectra were collected. Cadmium (Cd) was taken as an example in this study. The collected soil samples were air-dried, ground, sieved, and then used for laboratory spectral measurement and chemical analysis. Soil reflectance spectroscopy associated with organic matter was extracted from the VNIRS and used to predict Cd concentration based on strong sorption and retention of Cd on soil organic matter. Genetic algorithm (GA) was adopted for band selection, and the selected bands were used to calibrate the prediction model with partial least squares regression (PLSR). Compared with the prediction using entire VNIR region, the ratio of prediction to deviation (RPD) and the coefficient of determination (R2) were improved from 1.473 and 0.508 to 2.997 and 0.881 for laboratory spectra and 1.437 and 0.484 to 1.992 and 0.731 for field spectra by using spectral bands associated with organic matter in the mining area. The RPD and R2 values were improved from 1.919 and 0.707 to 3.727 and 0.923 for laboratory spectra and 1.057 and 0.036 to 1.747 and 0.646 for field spectra by the prediction method in the agricultural land. The improvement was further revealed by prediction of Cd concentration with a selected subset of soil samples from the mining area. The results suggest that predicting Cd concentration in soils with GA-PLSR using reflectance spectroscopy associated with organic matter is feasible and the prediction method could have the potential to be applied to field conditions.

Glucocorticoids are the cornerstone in the clinic for treatment of hematological malignancies, including multiple myeloma. Nevertheless, poor pharmacokinetic properties of glucocorticoids require high and frequent dosing with the off-target adverse effects defining the maximum dose. Recently, nanomedicine formulations of glucocorticoids have been developed that improve the pharmacokinetic profile, limit adverse effects and improve solid tumor accumulation. Multiple myeloma is a hematological malignancy characterized by uncontrolled growth of plasma cells. These tumors initiate increased angiogenesis and microvessel density in the bone marrow, which might be exploited using nanomedicines, such as liposomes. Nano-sized particles can accumulate as a result of the increased vascular leakiness at the bone marrow tumor lesions. Pre-clinical screening of novel anti-myeloma therapeutics in vivo requires a suitable animal model that represents key features of the disease. In this study, we show that fluorescently labeled long circulating liposomes were found in plasma up to 24 h after injection in an advanced human-mouse hybrid model of multiple myeloma. Besides the organs involved in clearance, liposomes were also found to accumulate in tumor bearing human-bone scaffolds. The therapeutic efficacy of liposomal dexamethasone phosphate was evaluated in this model showing strong tumor growth inhibition while free drug being ineffective at an equivalent dose (4 mg/kg) regimen. The liposomal formulation slightly reduced total body weight of myeloma-bearing mice during the course of treatment, which appeared reversible when treatment was stopped. Liposomal dexamethasone could be further developed as monotherapy or could fit in with existing therapy regimens to improve therapeutic outcomes for multiple myeloma.

Percutaneous needle procedures are among the most frequently performed minimally invasive surgical procedure. For tracking the needle tip in the tissue, 2D ultrasound (US) imaging is commonly used; however, the low resolution of the images creates a challenge for tracking. This paper describes a robotic system that can perform US image guided biopsies by tracking the needle and the target simultaneously. It uses a template-based visual tracking method for small and deformable targets. During the experiments, a needle was inserted into realistic phantoms using a 5-DOF robot. The 2D US probe was held by a robotic arm that was servoed along the needle path. The 3D shape of the needle was estimated using the 2D transverse US images, which was used to align the needle axis with the 2D imaging plane. The accuracy of the visual needle tip tracking was evaluated using an optical tracking system, and a computed tomography scanner was used to determine the accuracy of the 3D needle shape estimation method. Target reaching accuracies were measured using an electromagnetic tracking system. The results of the experiments showed that the proposed system can track the needle tip in 2D US guided needle procedures in real-time with a sub-millimeter positional error.

International audience; The Bight of Benin in the Gulf of Guinea, West Africa, forms an embayment between the Volta River delta in the west (Ghana) and the Niger River delta (Nigeria) in the east. The bight coast comprises sandy beaches backed by Holocene beach-ridge barriers. Incident swell waves, beachface gradient and the unidirectional longshore sand transport from west to east are intimately linked, generating a classic example of a strongly wave-dominated drift-aligned coast. The stability of this coast, which hosts several major cities in addition to three large international deepwater ports, has been strongly affected by human activities. We analyzed shoreline mobility and coastal area change over the period 1990-2015. Our results show how the stability of this coast has been strongly affected by the three ports therein, and by natural and human-altered shoreline dynamics related to the Volta River delta and to distributaries at the northwestern flank of the Niger delta. The combination of these factors has impacted alongshore sediment redistribution by segmenting the previously unrestrained longshore transport of sand that prevailed along this open coast. The result is a mixture of natural and artificial sediment cells increasingly dominated by shoreline stretches subject to erosion, endangering parts of the rapidly expanding port cities of Lomé (Togo), Cotonou (Benin) and Lagos (Nigeria), coastal roads and infrastructure, and numerous villages. Post-2000, the entire bight shoreline has undergone a significant decrease in accretion, which is here attributed to an overall diminution of sand supply via the longshore transport system. We attribute this diminution to the progressive depletion of sand-sized bedload supplied to the coast through the main Volta river channel downstream of the Akosombo dam, built between 1961 and 1965. Sand mining to cater for urban construction in Lomé, Cotonou and Lagos has also contributed locally to beach sediment budget depletion. Although alongshore sediment supply from the Volta River has been the dominant source of sand for the stability or progradation of the Bight of Benin coast, potential sand supply from the shoreface, and the future impacts of sea-level rise on this increasingly vulnerable coast are also important. The continued operation of the three ports and of existing river dams, and sea-level rise, will lead to sustained shoreline erosion along the Bight of Benin in the coming decades.

Buying services in a triad constellation is associated with challenges related to quality control, performance monitoring, and a deteriorating information position for the buyer. There is growing attention for service triads in Supply Chain Management (SCM) literature. However, these studies are mainly theoretical. The studies suggest to manage the identified challenges by monitoring supplier performance, maintaining a strong position in the service triad, developing collaborative trusting relationships, using outcome-based contracts, and aligning incentives between buyer and suppliers. Empirical studies on service triads and management mechanisms are rare, especially in a public procurement context. We study the application of management mechanisms in a public procurement context where 393 Dutch municipalities each had to contract social care service providers at the same time. This context allows us to study which of the management mechanisms proposed in literature are actually employed in a public procurement context, and whether other mechanisms are applied that are not addressed in the literature. We find municipalities deviate from traditional bureaucratic procurement procedures and apply a relational approach to the procurement procedure, including establishing social contracts, to cope with buyer challenges in service triads. Furthermore we identify municipalities apply ex post competition to drive up service quality through tendering framework agreements and allowing clients to choose their care provider of choice. This mechanism of ex post competition through the use of framework agreements has not been suggested in service triad literature before, and may be an effective mechanism in other service triads to address service quality and customer needs fulfilment issues.

Recent advances in instruments and retrieval methods enable measurements of solar-induced chlorophyll fluorescence (SIF) across a wide range of scales. Radiative transfer (RT) models for simulating scattering and (re-)absorption of SIF provide a powerful tool to study the upscaling of SIF signal from leaf level to terrestrial ecosystems. Based on the Monte Carlo ray-tracing (MCRT) model, WPS (Weighted Photon Spread), we made major extensions with new functionalities and systematic evaluation of the new modules. By modeling the radiative coupling between atmosphere and land surface with the same MCRT method, the non-fluorescent and SIF radiance received by sensors can be simulated at levels from top-of canopy to top-of-atmosphere (TOA) in a coherent manner. New extension to represent the three-dimensional (3-D) canopies with geometrical primitives composed of turbid medium makes the hyperspectral simulation (especially SIF) for a sensor with medium spatial resolution at kilometer-scale feasible and practical. Evaluations through ROMC (Radiation transfer model intercomparison Online Model Checker) show that the accuracy of the new module of 3-D structure representation in WPS is within 1% of the reference solution. The spectra of TOA radiance and SIF and their components simulated at nadir by WPS agree closely with those simulated by the coupled SCOPE and MODTRAN models with the coefficient of determination (R2) higher than 0.99 and the average absolute relative error (AARE) lower than 6.39%; for angular distributions of TOA radiance and SIF at 685 nm and 740 nm, R2 is higher than 0.81 and AARE is lower than 6.94%. Comparisons of the spectra of TOA radiance and SIF and their components simulated at nadir by WPS and the DART model give R2 higher than 0.99 and AARE lower than 3.5%; R2 is higher than 0.92 and AARE is lower than 5.92% for the TOA angular simulations. The WPS model was also evaluated by hyperspectral measurements through unmanned aerial vehicle at different altitudes, which shows that WPS can reproduce the spectral features of a rapeseed crop. WPS can be used as a versatile tool to assess the impacts of various factors on the SIF signal and to evaluate the SIF retrieval methods under different conditions.

The in situ generated emerging phase inside the dual-phase oxygen transport membranes (DP-OTMs) plays a crucial role in boosting the overall performance of DP-OTMs. However, its detailed structure and properties are still not fully understood. Utilizing advanced transmission electron microscopy (TEM) techniques, the emerging phase GdxCe1-xFeyCo1-yO3-δ (GCFCO) inside the CexGd1-xO2-δ-FeCo2O4 (CGO-FC2O) OTMs was successfully characterized at the atomic scale. The newly formed GCFCO is primarily surrounded by the CGO, and contributes to a significant reduction of non-solute segregation at the CGO grain boundaries. Electronic characteristics of the GCFCO shows a sensitive dependence on its chemical composition, including the valence state of Ce and Fe as well as the oxygen vacancies. Additional CGO-GCFCO interfaces were introduced, where almost intact crystal structures were observed with slight Gd and Co segregation ∼1 nm at the edges. Approaching the interface, on the CGO side, only a minimum drop of the Ce valence was determined. On the GCFCO side, mixed Ce3+ and Ce4+ are partially occupying the Gd sites, while Fe and Co valence stay constant until the edge. Our study provides novel insight into the phase information within CGO-FC2O composites, which paves the path towards superior performance of various DP-OTMs.

The cable-in-conduit conductor (CICC) technology has been widely used in large scale superconducting magnet. The Short-Twist-Pitch (STP) design was aimed to avoid the conductor degradation during electromagnetic and thermal cycling. But manufacture of STP CICC deforms the cabled strands significantly. Indentations appear on superconducting strands after cabling and compaction. The conductor used for China Fusion Engineering Test Reactor (CFETR) magnet will be subjected to much higher Lorentz force than ITER. The STP CICC will be the first choice for the conductor design, since it showed no observed current sharing temperature Tcs degradation after electromagnetic cycling. In order to estimate the effects of indentation on the superconducting and mechanical properties of Nb3Sn strands, series measurements have been done on an internal-tin (IT) Nb3Sn strand, fabricated by Western Superconducting Technologies Co., Ltd (WST). The strand was artificially indented and cut to several sections for different kinds of measurements, which mainly included the critical current Ic versus axial strain measurements with Pacman device and stress-strain tests. The results show that the indentation has less impact on Ic, but more impact on mechanical performance. The sample preparation, test results and analysis have been described in details.

Objective The aim of this study was to analyse the efficacy of breast-conserving therapy (BCT) for women with primary DCIS in a population-based setting. Methods Data were used from five Radiotherapy centres in The Netherlands from 2000 to 2010, all treated with BCT. Of all the cases, 59.2% received a boost of radiotherapy after their whole breast irradiation (WBI), irrespective of margin status. Results A total of 1248 cases with primary DCIS were analysed. The 10-years LRFS was 92.9%. Age ≤50 years and a positive margin were significantly related to local relapse free survival (LRFS). Having a boost had no impact on LRFS, showing a nearly equal recurrence pattern in patients with and without a boost. Separate analyses were done on patients who had received and not received a boost of radiotherapy after WBI. We noted 9.1% contra-lateral breast tumours. The 10-years disease specific survival (DSS) rate was 99.0%. Conclusions DCIS of the breast and treated with BCT results in excellent LRFS and DSS. Primary surgical lumpectomy with negative margins followed by WBI seems to be the treatment of choice in DCIS treated with BCS with respect to IBTR.

Polyelectrolyte composite hollow fiber membranes show a high potential to become applied in industrial nanofiltration applications such as water purification or downstream processing in several industries. This material platform allows multiple routes to achieve tailored selectivities and high permeances. Hollow fiber membranes promise a higher process efficiency due to higher packing densities and their backwash stability. However, the fabrication of composite polyelectrolyte hollow fiber nanofiltration membranes is more challenging compared to state of the art spiral wound modules. While the Layer-by-Layer deposition has proven versatile opportunities and is recently entering the commercial market, the multi-step post-treatment is elaborate. In this work, we streamline the fabrication of polyelectrolyte composite hollow fiber membranes. We extend our recently presented ”chemistry-in-a-spinneret” approach with a membrane modification in a subsequent coating bath. The additional modification can be incorporated in the composite hollow fiber membrane manufacturing process without additional process steps. Sulfonated polyethersulfone as a polyanionic additive is used in the polymer solution which complexates with the polycations polyethylenimine (PEI) or poly(diallyldimethylammonium chloride (PDADMAC) in the bore fluid during fiber spinning. The extruded fibers have a positively charged lumen surface which allows a subsequent modification with the polyanion poly(sodium 4-styrenesulfonate) (PSS) in the coating bath. The spun fibers reveal with 16-4 LMH/bar pure water permeance (PWP) and 2000-1100 Dalton (Da) molecular weight cut-off (MWCO) open nanofiltration characteristics, while the PEI+PSS modified fibers show dense nanofiltration characteristics (0.6 LMH/bar PWP and 360 Da MWCO). The fibers are backwash stable and the PDADMAC and PDADMAC+PSS fibers show a significantly higher sodium hypochlorite (NaOCl) stability compared to the PEI and PEI+PSS fibers. This new technique creates composite hollow fiber nanofiltration membranes with a polyelectrolyte bilayer without multi-step post-treatment. Therefore, it provides a promising alternative to the Layer-by-Layer post-modification, where two coating steps and one water washing post-treatment step are required to create a polyelectrolyte bilayer on a porous hollow fiber membrane support.

Objective A crucial step in designing fenestrated stent grafts for treatment of complex aortic abdominal aneurysms is the accurate positioning of the fenestrations. The deployment of a fenestrated stent graft prototype in a patient-specific rigid aortic model can be used for design verification in vitro, but is time and human resources consuming. Numerical simulation (NS) of fenestrated stent graft deployment using the finite element analysis has recently been developed; the aim of this study was to compare the accuracy of fenestration positioning by NS and in vitro. Methods All consecutive cases of complex aortic abdominal aneurysm treated with the Fenestrated Anaconda (Terumo Aortic) in six European centers were included in a prospective, observational study. To compare fenestration positioning, the distance from the center of the fenestration to the proximal end of the stent graft (L) and the angular distance from the 0° position (C) were measured and compared between in vitro testing (L1, C1) and NS (L2, C2). The primary hypothesis was that ΔL (|L2 – L1|) and ΔC (|C2 – C1|) would be 2.5 or less mm in more than 80% of the cases. The duration of both processes was also compared. Results Between May 2018 and January 2019, 50 patients with complex aortic abdominal aneurysms received a fenestrated stent graft with a total of 176 fenestrations. The ΔL and ΔC was 2.5 mm or less for 173 (98%) and 174 (99%) fenestrations, respectively. The NS process duration was significantly shorter than the in vitro (2.1 days [range, 1.0-5.2 days] vs 20.6 days [range, 9-82 days]; P Conclusions Positioning of fenestrations using NS is as accurate as in vitro and could significantly decrease delivery time of fenestrated stent grafts.

Crop models are widely used to evaluate the response of crop growth to drought. However, over large geographic regions, the most advanced models are often restricted by available computing resource. This limits capacity to undertake uncertainty analysis and prohibits the use of models in real-time ensemble forecasting systems. This study addresses these concerns by presenting an integrated system for the dynamic prediction and assessment of agricultural yield using the top-ranked Sunway TaihuLight supercomputer platform. This system enables parallelization and acceleration for the existing AquaCrop, DNDC (DeNitrification and DeComposition) and SWAP (Soil Water Atmosphere Plant) models, thus facilitating multi-model ensemble and parameter optimization and subsequent drought risk analysis in multiple regions and at multiple scales. The high computing capability also opens up the possibility of real-time simulation during droughts, providing the basis for more effective drought management. Initial testing with varying core group numbers shows that computation time can be reduced by between 2.6 and 3.6 times. Based on the powerful computing capacity, a county-level model parameter optimization (2043 counties for 1996–2007) by Bayesian inference and multi-model ensemble using BMA (Bayesian Model Average) method were performed, demonstrating the enhancements in predictive accuracy that can be achieved. An application of this system is presented predicting the impacts of the drought of May–July 2017 on maize yield in North and Northeast China. The spatial variability in yield losses is presented demonstrating new capability to provide high resolution information with associated uncertainty estimates.

We analyze the joint optimization of spare parts inventories and workforce allocation in a single-site maintenance system. In this system, for each failure, a service engineer with a necessary replacement part has to be allocated. If one of the required resources is not available, the incoming failure request is routed to an external provider, such as a centralized repair facility or a sub-contractor. We study multiple failure types (related to failing components) with exponentially distributed inter-failure times. The system repair times and the replenishment times of the spare parts inventory are also exponentially distributed. The inventory replenishment is done according to a Base-Stock policy. The objective is to minimize the total system cost consisting of annual holding costs of the spare parts and the service engineers, and incidental outsourcing costs. For the joint optimization of the resources, we propose a Mixed-Integer Programming (MIP) formulation using the balance equations of the Markov Chain representation of the system. Furthermore, we provide a simple and efficient heuristic that produces close-to-optimal (< 0.3% difference) results, for solving larger instances. Using the proposed optimization methods and real-life data, we analyze the optimal balance between the costs of the resources and the outsourcing costs and show how the outsourcing rates and the total costs behave for different system parameters.

We discuss methods of multiscale forcing to enhance the mixing efficiency of an incompressible flow. To introduce a variety of length- and time-scales into a flow, we focus on two methods. First, we concentrate on effects due to guiding a fluid over a complex-shaped object placed in the flow domain. Specifically, we apply direct numerical simulation to predict flow through a cylindrical pipe in which a periodic array of orifice plates with a fractal perimeter is mounted. To represent the complex orifice, a volume penalisation immersed boundary method is used. Adding a periodic array of fractal orifice plates, derived from the Koch snowflake, to a cylindrical pipe is shown to increase the average laminar stretching rate by a factor of up to five, compared to pipe flow without orifice plates. Second, we consider the inclusion of multiple length- and time scales at inflow boundaries to enhance mixing efficiency for combustion in Bunsen-type flames. By using a combination of large- and small-scale flow perturbations at an inflow, a two-fold increase of flame wrinkling and flame intensity could be realised. The scale-dependency of the intensification of the combustion is investigated, showing a narrow range of length-scales with strongest response, reminiscent of ‘resonant turbulence’ conditions.

In this study we describe a novel and simple method to couple covalently poly (maleic anhydride-alt-1-alkenes) to γ-alumina nanofiltration membranes for the first time. The 1-alkenes varied from 1-hexene, 1-decene, 1-hexadecane to 1-octadecene. The grafting reaction was between the reactive anhydride moieties of the polymer and surface hydroxyl groups, resulting in highly stable bonds. The modified membranes were investigated for their permeation and rejection performance of Sudan Black (SB, Mw 457 Da) in either toluene or ethyl acetate (EA) solution, and very high rejections (> 90%) and high permeation flux were observed compared to unmodified membranes. Initially, the SB in toluene solution was found to bind strongly to the surface hydroxyl groups of the unmodified membranes, an effect not observed in EA solution.

Background Physically active cancer survivors have a reduced risk of cancer recurrence and mortality. Given the health advantages of active lifestyles in cancer survivorship, as well as the barriers preventing physical activity (e.g., geography, time) there is a need to develop and evaluate effective physical activity interventions that employ distance-based (i.e., non face-to-face) approaches. The primary objective of this study was to provide a systematic review and meta-analysis of present-day (2013–2018) distance-based physical activity behaviour change interventions for cancer survivors. Methods PubMed and Embase databases were searched from November 2012 up to June 2018. Studies were included that met the following criteria: (1) written in English, (2) included adult cancer survivors (either undergoing or completed treatment), (3) was a controlled intervention study, and (4) the intervention was distance-based (delivered via distance) with no more than one face-to-face contact. Review Manager 5 (RevMan 5) software was used to perform a meta-analysis on all randomized controlled trials (RCTs) that presented self-reported or objectively measured physical activity post-intervention means and standard deviations. Risk of bias for each study was assessed using The Cochrane Risk of Bias Tool. Results We included 29 RCTs. Across the 29 studies, the total number of participants in these studies was 5218. Median sample size was 95 and ranged from 19 to 463. Thirteen (45%) studies focused on breast cancer survivors and median months since diagnosis was 24 (range 6–79). Moderate-to-vigorous intensity physical activity data from 24 RCTs were included in the meta-analysis and indicated an overall small effect (standardized mean difference) of 0.21 (95% CI 0.11–0.32) favoring the interventions. Conclusions Intervention effects on physical activity were small. Drawing conclusions from these trials remains challenging given major limitations of these trials included poor methodological design, small sample sizes, lack of statistical power, homogeneous samples (e.g., caucasian, young, well-educated), and poor measures of physical activity (e.g., self-report). Relying on the present landscape of distance-based programs aiming to facilitate physical activity among cancer survivors may not be prudent.

The integration of adsorbents with ultrafiltration (UF) membranes is a promising method for alleviating membrane fouling and reducing land use. However, adsorbents typically are only injected into the membrane tank once, resulting in a single dynamic protection layer and low removal efficiency over long-term operation. In addition, the granular adsorbents used can cause membrane surface damage. To overcome these disadvantages, we injected inexpensive and loose aluminum (Al)-based flocs directly into a membrane tank with bottom aeration in the presence of humic acid (HA) or raw water taken from the Miyun Reservoir (Beijing, China). Results showed that the flocs were well suspended in the membrane tank, and multiple dynamic floc protection layers were formed (sandwich-like) on the membrane surface with multiple batch injections. Higher frequency floc injections resulted in better floc utilization efficiency and less severe membrane fouling. With continuous injection, acid solutions demonstrated better performance in removing HA molecules, especially those with small molecular weight, and in alleviating membrane fouling compared with the use of high aeration rate or polyacrylamide injection. This was attributed to the small particle size, large specific surface area, and high zeta potential of the flocs. Additionally, excellent UF membrane performance was exhibited by reservoir water with continuous injection and acid solution. Based on the outstanding UF membrane performance, this innovative integrated filtration with loose Al-based flocs has great application potential for water treatment.

Item does not contain fulltext In 2015 and 2016 the Central Unit of the Dutch National Police created and submitted 21 cartridge case comparison tests as real cases to the Netherlands Forensic Institute (NFI), under supervision of the University of Twente (UT). A total of 53 conclusions were drawn in these 21 tests. For 31 conclusions the underlying ground truth was "positive", in the sense that it addressed a cluster of cartridge cases that was fired from the same firearm. For 22 conclusions the ground truth was "negative", in the sense that the cartridge cases were fired from different firearms. In none of the conclusions, resulting from examinations under casework conditions, misleading evidence was reported. All conclusions supported the hypothesis reflecting the ground truth. This article discusses the design and results of the tests in more detail. 6 p.

Five types of sediment samplers designed to measure aeolian sand transport were tested during a wind erosion event on the Sand Motor, an area on the west coast of the Netherlands prone to severe wind erosion. Each of the samplers operates on a different principle. The MWAC (Modified Wilson And Cooke) is a passive segmented trap. The modified Leatherman sampler is a passive vertically integrating trap. The Saltiphone is an acoustic sampler that registers grain impacts on a microphone. The Wenglor sampler is an optical sensor that detects particles as they pass through a laser beam. The SANTRI (Standalone AeoliaN Transport Real-time Instrument) detects particles travelling through an infrared beam, but in different channels each associated with a particular grain size spectrum. A procedure is presented to transform the data output, which is different for each sampler, to a common standard so that the samplers can be objectively compared and their relative efficiency calculated. Results show that the efficiency of the samplers is comparable despite the differences in operating principle and the instrumental and environmental uncertainties associated to working with particle samplers in field conditions. The ability of the samplers to register the temporal evolution of a wind erosion event is investigated. The strengths and weaknesses of the samplers are discussed. Some problems inherent to optical sensors are looked at in more detail. Finally, suggestions are made for further improvement of the samplers.