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7. Cardiovascular health, infection burden and their interactive association with brain volumetric and white matter integrity outcomes in the UK Biobank

Author

Beydoun, May A., primary, Beydoun, Hind A., additional, Gale, Shawn D., additional, Hedges, Dawson, additional, Weiss, Jordan, additional, Li, Zhiguang, additional, Erickson, Lance D., additional, Noren Hooten, Nicole, additional, Launer, Lenore J., additional, Evans, Michele K., additional, and Zonderman, Alan B., additional

Published
2023
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9. Biomarkers of glucose homeostasis as mediators of the relationship of body mass index and waist circumference with COVID-19 outcomes among postmenopausal women: The Women’s Health Initiative

Author

Beydoun, Hind A., primary, Ng, Ted K.S., additional, Beydoun, May A., additional, Shadyab, Aladdin H., additional, Jung, Su Yon, additional, Costanian, Christy, additional, Saquib, Nazmus, additional, Ikramuddin, Farha S., additional, Pan, Kathy, additional, Zonderman, Alan B., additional, and Manson, JoAnn E., additional

Published
2023
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10. Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults

Author

Beydoun, May A., primary, Noren Hooten, Nicole, additional, Beydoun, Hind A., additional, Weiss, Jordan, additional, Maldonado, Ana I., additional, Katzel, Leslie I., additional, Davatzikos, Christos, additional, Gullapalli, Rao P., additional, Seliger, Stephen L., additional, Erus, Guray, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, and Waldstein, Shari R., additional

Published
2023
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12. APOE gene region methylation is associated with cognitive performance in middle-aged urban adults

Author

Botong Shen, Dena G. Hernandez, Kumaraswamy Naidu Chitrala, Marie T. Fanelli-Kuczmarski, Nicole Noren Hooten, Natasha L. Pacheco, Nicolle A. Mode, Alan B. Zonderman, Ngozi Ezike, and Michele K. Evans

Subjects
Aging, Cognition, Genotype, Alzheimer Disease, General Neuroscience, Apolipoprotein E4, Humans, Neurology (clinical), Middle Aged, Neuropsychological Tests, Geriatrics and Gerontology, Methylation, Developmental Biology
Abstract

Apolipoprotein (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) and cognitive decline. Epigenetic modifications such as DNA methylation (DNAm) play a central role in cognition. This study sought to identify DNAm sites in the APOE genomic region associated with cognitive performance in a racially diverse middle-aged cohort (n = 411). Cognitive performance was measured by 11 standard neuropsychological tests. Two CpG sites were associated with the Card Rotation and Benton Visual Retention cognitive tests. The methylation level of the CpG site cg00397545 was associated with Card Rotation Test score (p = 0.000177) and a novel CpG site cg10178308 was associated with Benton Visual Retention Test score (p = 0.000084). Significant associations were observed among the dietary inflammatory index, which reflects the inflammatory potential of the diet, cognitive performance and the methylation level of several CpG sites. Our results indicate that DNAm in the APOE genomic area is correlated with cognitive performance and may presage cognitive decline.

Published
2022
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17. BMI and Allostatic Load Are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light among Urban Middle-Aged Adults

Author

Jordan Weiss, May A. Beydoun, Alan B. Zonderman, Hind A. Beydoun, Michele K. Evans, Ana I. Maldonado, and Nicole Noren Hooten

Subjects
Adult, Male, Mediation (statistics), medicine.medical_specialty, Neurofilament light, Intermediate Filaments, Medicine (miscellaneous), Disease, Body Mass Index, Internal medicine, Linear regression, medicine, Humans, Nutritional Epidemiology, Longitudinal Studies, Nutrition and Dietetics, business.industry, Confounding, Neurodegenerative Diseases, Middle Aged, Allostatic load, Endocrinology, Allostasis, Biomarker (medicine), Female, business, Body mass index, Biomarkers
Abstract

BACKGROUND: Plasma neurofilament light chain (NfL) is a novel biomarker for age-related neurodegenerative disease. We tested whether NfL may be linked to cardiometabolic risk factors, including BMI, the allostatic load (AL) total score (AL(total)), and related AL continuous components (AL(comp)). We also tested whether these relations may differ by sex or by race. METHODS: We used data from the HANDLS (Healthy Aging in Neighborhoods of Diversity across the Life Span) study [n = 608, age at visit 1 (v(1): 2004–2009): 30–66 y, 42% male, 58% African American] to investigate associations of initial cardiometabolic risk factors and time-dependent plasma NfL concentrations over 3 visits (2004–2017; mean ± SD follow-up time: 7.72 ± 1.28 y), with outcomes being NfL(v1) and annualized change in NfL (δNfL). We used mixed-effects linear regression and structural equations modeling (SM). RESULTS: BMI was associated with lower initial (γ(01) = −0.014 ± 0.002, P < 0.001) but faster increase in plasma NfL over time (γ(11) = +0.0012 ± 0.0003, P < 0.001), a pattern replicated for AL(total). High-sensitivity C-reactive protein (hsCRP), serum total cholesterol, and resting heart rate at v(1) were linked with faster plasma NfL increase over time, overall, while being uncorrelated with NfL(v1) (e.g., hsCRP × Time, full model: γ(11) = +0.004 ± 0.002, P = 0.015). In SM analyses, BMI's association with δNfL was significantly mediated through AL(total) among women [total effect (TE) = +0.0014 ± 0.00038, P < 0.001; indirect effect = +0.00042 ± 0.00019, P = 0.025; mediation proportion = 30%], with only a direct effect (DE) detected among African American adults (TE = +0.0011 ± 0.0004, P = 0.015; DE = +0.0010 ± 0.00048, P = 0.034). The positive associations between AL(total)/BMI and δNfL were mediated through increased glycated hemoglobin (HbA1c) concentrations, overall. CONCLUSIONS: Cardiometabolic risk factors, particularly elevated HbA1c, should be screened and targeted for neurodegenerative disease, pending comparable longitudinal studies. Other studies examining the clinical utility of plasma NfL as a neurodegeneration marker should account for confounding effects of BMI and AL.

Published
2022
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18. Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults

Author

Beydoun, May A., primary, Noren Hooten, Nicole, additional, Weiss, Jordan, additional, Maldonado, Ana I., additional, Beydoun, Hind A., additional, Katzel, Leslie I., additional, Davatzikos, Christos, additional, Gullapalli, Rao P., additional, Seliger, Stephen L., additional, Erus, Guray, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, and Waldstein, Shari R., additional

Published
2023
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20. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Author

Gorski, Mathias, primary, Rasheed, Humaira, additional, Teumer, Alexander, additional, Thomas, Laurent F., additional, Graham, Sarah E., additional, Sveinbjornsson, Gardar, additional, Winkler, Thomas W., additional, Günther, Felix, additional, Stark, Klaus J., additional, Chai, Jin-Fang, additional, Tayo, Bamidele O., additional, Wuttke, Matthias, additional, Li, Yong, additional, Tin, Adrienne, additional, Ahluwalia, Tarunveer S., additional, Ärnlöv, Johan, additional, Åsvold, Bjørn Olav, additional, Bakker, Stephan J.L., additional, Banas, Bernhard, additional, Bansal, Nisha, additional, Biggs, Mary L., additional, Biino, Ginevra, additional, Böhnke, Michael, additional, Boerwinkle, Eric, additional, Bottinger, Erwin P., additional, Brenner, Hermann, additional, Brumpton, Ben, additional, Carroll, Robert J., additional, Chaker, Layal, additional, Chalmers, John, additional, Chee, Miao-Li, additional, Chee, Miao-Ling, additional, Cheng, Ching-Yu, additional, Chu, Audrey Y., additional, Ciullo, Marina, additional, Cocca, Massimiliano, additional, Cook, James P., additional, Coresh, Josef, additional, Cusi, Daniele, additional, de Borst, Martin H., additional, Degenhardt, Frauke, additional, Eckardt, Kai-Uwe, additional, Endlich, Karlhans, additional, Evans, Michele K., additional, Feitosa, Mary F., additional, Franke, Andre, additional, Freitag-Wolf, Sandra, additional, Fuchsberger, Christian, additional, Gampawar, Piyush, additional, Gansevoort, Ron T., additional, Ghanbari, Mohsen, additional, Ghasemi, Sahar, additional, Giedraitis, Vilmantas, additional, Gieger, Christian, additional, Gudbjartsson, Daniel F., additional, Hallan, Stein, additional, Hamet, Pavel, additional, Hishida, Asahi, additional, Ho, Kevin, additional, Hofer, Edith, additional, Holleczek, Bernd, additional, Holm, Hilma, additional, Hoppmann, Anselm, additional, Horn, Katrin, additional, Hutri-Kähönen, Nina, additional, Hveem, Kristian, additional, Hwang, Shih-Jen, additional, Ikram, M. Arfan, additional, Josyula, Navya Shilpa, additional, Jung, Bettina, additional, Kähönen, Mika, additional, Karabegović, Irma, additional, Khor, Chiea-Chuen, additional, Koenig, Wolfgang, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kühnel, Brigitte, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Li, Man, additional, Lieb, Wolfgang, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Loos, Ruth J.F., additional, Lukas, Mary Ann, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Matias-Garcia, Pamela R., additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Melander, Olle, additional, Milaneschi, Yuri, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Morris, Andrew P., additional, Mychaleckyj, Josyf C., additional, Nadkarni, Girish N., additional, Naito, Mariko, additional, Nakatochi, Masahiro, additional, Nalls, Mike A., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ning, Boting, additional, Nolte, Ilja M., additional, Nutile, Teresa, additional, O’Donoghue, Michelle L., additional, O'Connell, Jeffrey, additional, Olafsson, Isleifur, additional, Orho-Melander, Marju, additional, Parsa, Afshin, additional, Pendergrass, Sarah A., additional, Penninx, Brenda W.J.H., additional, Pirastu, Mario, additional, Preuss, Michael H., additional, Psaty, Bruce M., additional, Raffield, Laura M., additional, Raitakari, Olli T., additional, Rheinberger, Myriam, additional, Rice, Kenneth M., additional, Rizzi, Federica, additional, Rosenkranz, Alexander R., additional, Rossing, Peter, additional, Rotter, Jerome I., additional, Ruggiero, Daniela, additional, Ryan, Kathleen A., additional, Sabanayagam, Charumathi, additional, Salvi, Erika, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Scholz, Markus, additional, Schöttker, Ben, additional, Schulz, Christina-Alexandra, additional, Sedaghat, Sanaz, additional, Shaffer, Christian M., additional, Sieber, Karsten B., additional, Sim, Xueling, additional, Sims, Mario, additional, Snieder, Harold, additional, Stanzick, Kira J., additional, Thorsteinsdottir, Unnur, additional, Stocker, Hannah, additional, Strauch, Konstantin, additional, Stringham, Heather M., additional, Sulem, Patrick, additional, Szymczak, Silke, additional, Taylor, Kent D., additional, Thio, Chris H.L., additional, Tremblay, Johanne, additional, Vaccargiu, Simona, additional, van der Harst, Pim, additional, van der Most, Peter J., additional, Verweij, Niek, additional, Völker, Uwe, additional, Wakai, Kenji, additional, Waldenberger, Melanie, additional, Wallentin, Lars, additional, Wallner, Stefan, additional, Wang, Judy, additional, Waterworth, Dawn M., additional, White, Harvey D., additional, Willer, Cristen J., additional, Wong, Tien-Yin, additional, Woodward, Mark, additional, Yang, Qiong, additional, Yerges-Armstrong, Laura M., additional, Zimmermann, Martina, additional, Zonderman, Alan B., additional, Bergler, Tobias, additional, Stefansson, Kari, additional, Böger, Carsten A., additional, Pattaro, Cristian, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, and Heid, Iris M., additional

Published
2022
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21. Insomnia as a predictor of diagnosed memory problems: 2006–2016 Health and Retirement Study

Author

Brook T Alemu, Sharmin Hossain, May A. Beydoun, Shuyan Huang, Jordan Weiss, Hind A. Beydoun, and Alan B. Zonderman

Subjects
Pediatrics, medicine.medical_specialty, Disease, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Memory, Sleep Initiation and Maintenance Disorders, mental disorders, Insomnia, medicine, Humans, Dementia, Memory impairment, Prospective Studies, Medical diagnosis, Prospective cohort study, Aged, Retirement, business.industry, Proportional hazards model, General Medicine, Health and Retirement Study, medicine.disease, 030228 respiratory system, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Objective To evaluate the longitudinal relationship in insomnia symptoms over time with incident memory problems and dementia diagnoses among U.S. adults aged 65 years and older. Methods Secondary analyses were performed on 9518 elderly participants (≥65 years) who completed the 2006 wave of the Health and Retirement Study (HRS) and were followed-up to determine if insomnia symptom scores (2006–2014) were associated with time-to-onset of [1] physician-diagnosed “memory-related disease”, “Alzheimer's disease” and/or “dementia, senility or any other serious memory impairment” and [2] diagnosis of dementia based on HRS-specific criteria. Cox proportional hazards models were constructed adjusting for socio-demographic, lifestyle, and health characteristics. Results In fully adjusted models, severe insomnia symptoms were associated with increased risk of physician-diagnosed memory problems. Individuals reporting any change (increase or decrease) in insomnia symptoms during the 2006–2010 period were more likely to be diagnosed with dementia based on HRS criteria. Finally, those who experienced an increase in the severity of insomnia symptoms over time exhibited 41–72% increased risks of physician-diagnosed memory problems and 45–58% increased risks of dementia diagnosis based on HRS criteria. Conclusions When severe insomnia symptoms increased over time, physician-diagnosed memory problems and dementia diagnoses also increased among U.S. elderly people over a 10-year follow-up period. More studies are required to confirm these findings using large prospective cohort designs and validated tools.

Published
2021
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23. Automated, High-Throughput Infrared Spectroscopy for Secondary Structure Analysis of Protein Biopharmaceuticals

Author

Libo Wang, Lucy L. Liu, Jason C. Rouse, Hai-Young Kim, and Jeffrey Zonderman

Subjects
Materials science, Spectrophotometry, Infrared, business.industry, Antibodies, Monoclonal, Pharmaceutical Science, Infrared spectroscopy, 02 engineering and technology, Repeatability, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, Protein Structure, Secondary, Characterization (materials science), 03 medical and health sciences, 0302 clinical medicine, Biopharmaceutical, Spectroscopy, Fourier Transform Infrared, New product development, Sensitivity (control systems), Fourier transform infrared spectroscopy, 0210 nano-technology, Biological system, business, Biosimilar Pharmaceuticals, Protein secondary structure
Abstract

Protein higher order structure (HOS) is an important product quality attribute that governs the structure-function characteristics, safety, and efficacy of therapeutic proteins. Infrared (IR) spectroscopy has long been recognized as a powerful biophysical tool in determining protein secondary structure and monitoring the dynamic structural changes. Such biophysics analyses help establish process and product knowledge, understand the impact of upstream (cell culture) and downstream (purification) process conditions, create stable formulations, monitor product stability, and assess product comparability when process improvements are implemented (or establish biosimilarity to originator products). This paper provides an overview of a novel automated mid-IR spectroscopic technique called microfluidic modulation spectroscopy (MMS) for the characterization of protein secondary structure. The study demonstrates that MMS secondary structure analysis of therapeutic monoclonal antibodies (mAb) is comparable with a conventional Fourier transform infrared (FTIR) method. More importantly the study shows MMS exhibits higher sensitivity and repeatability for low concentration samples over FTIR, as well as provides automated operation and superior robustness with simplified data analysis, increasing the utility of the instrument in determination of mAb secondary structure. Therefore, we propose that the MMS method can be widely applied in characterization and comparability/biosimilarity studies for biopharmaceutical process and product development.

Published
2020
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24. Longitudinal association of allostatic load with depressive symptoms among urban adults: Healthy Aging in Neighborhoods of Diversity across the Life Span study

Author

Hind A. Beydoun, May A. Beydoun, Edward Kwon, Sharmin Hossain, Marie T. Fanelli-Kuczmarski, Ana Maldonado, Michele K. Evans, and Alan B. Zonderman

Subjects
Psychiatry and Mental health, Endocrinology, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Biological Psychiatry
Published
2023
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27. Application of the Database of Flavonoid Values for USDA Food Codes 2007–2010 in assessing intake differences between the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study and What We Eat in America (WWEIA), NHANES

Author

Sebastian, Rhonda S., primary, Fanelli Kuczmarski, Marie, additional, Wilkinson Enns, Cecilia, additional, Goldman, Joseph D., additional, Murayi, Theophile, additional, Moshfegh, Alanna J., additional, Zonderman, Alan B., additional, and Evans, Michele K., additional

Published
2021
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28. Red Cell Distribution Width Is Directly Associated with Poor Cognitive Performance among Nonanemic, Middle-Aged, Urban Adults

Author

May A. Beydoun, Michele K. Evans, Sharmin Hossain, Danielle Shaked, Jordan Weiss, Alan B. Zonderman, and Hind A. Beydoun

Subjects
Erythrocyte Indices, Male, Elementary cognitive task, Erythrocytes, Urban Population, Anemia, Nutritional Status, Medicine (miscellaneous), Nutritional Epidemiology, Humans, Medicine, Cognitive Dysfunction, Effects of sleep deprivation on cognitive performance, Nutrition and Dietetics, California Verbal Learning Test, business.industry, Red blood cell distribution width, Cognition, Middle Aged, medicine.disease, Cross-Sectional Studies, Free recall, Female, Verbal memory, business, Demography
Abstract

BACKGROUND: Epidemiological evidence suggests that both anemia and elevated red cell distribution width (RDW) are associated with cognitive impairment. However, the interplay between these 2 predictors has been understudied. OBJECTIVES: We examined sex- and anemia-specific associations between RDW and cognitive performance among urban adults in the United States. METHODS: Data from the Healthy Aging in Neighborhoods of Diversity Across the Life Span Study (Baltimore, MD; participants aged 30–65 y at baseline, ∼59% African-American, 45% men) were used. Participants were selected based on the completion of 11 cognitive tasks at baseline (2004–2009) and follow-up (2009–2013) visits (mean time between visits: 4.64 ± 0.93 y) and availability of exposure and covariate data, yielding a sample of between 1526 and 1646 adults out of the initial 3720 adults recruited at baseline. Multiple linear mixed-effects regression models were conducted with RDW as the main exposure of interest and anemia/sex as the key effect modifiers. RESULTS: Overall, high RDWs were linked to poorer baseline performance on the California Verbal Learning Test (CVLT) List A (per 1 unit increase in RDW %, main effect: γ(01 )= −0.369 ± 0.114; P = 0.001) and to slower rates of decline on the CVLT Delayed Free Recall (per 1 unit increase in RDW %, RDW × time: γ(11 )= +0.036 ± 0.013; P = 0.007). Among nonanemic participants, RDWs were consistently associated with poorer baseline performance on the Trailmaking Test, Part A (γ(01 )= +3.11 ± 0.89; P

Published
2020
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29. Cytokines are associated with longitudinal changes in cognitive performance among urban adults

Author

May A. Beydoun, Hind A. Beydoun, Jordan Weiss, Alan B. Zonderman, Hailun Liang, Michele K. Evans, Hardeep K Obhi, and Gregory A. Dore

Subjects
Adult, Male, 0301 basic medicine, Mediation (statistics), Urban Population, Interleukin-1beta, Immunology, White People, Article, Executive Function, 03 medical and health sciences, Behavioral Neuroscience, Cognition, 0302 clinical medicine, Memory, Humans, Medicine, Cognitive Dysfunction, Longitudinal Studies, Effects of sleep deprivation on cognitive performance, Cognitive decline, Aged, Inflammation, Psychomotor learning, Interleukin-6, Endocrine and Autonomic Systems, business.industry, Confounding, Interleukin-18, Middle Aged, Black or African American, Cross-Sectional Studies, 030104 developmental biology, Cytokines, Female, Verbal memory, business, Psychosocial, 030217 neurology & neurosurgery, Demography
Abstract

Background Chronic systemic inflammation has been positively associated with structural and functional brain changes representing early markers of Alzheimer’s Disease (AD) and cognitive decline. The current study examined associations between systemic inflammation and cognitive performance among African-Americans and Whites urban adults. Methods Participants were selected from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (2004–2013, baseline age: 30–64 y, mean ± SD follow-up time of 4.64 ± 0.93 y, N = 189–222, k = 1.5–1.7 observations/participant). Cytokines known to be positively linked to AD incidence among others were tested against cross-sectional and longitudinal cognitive function, stratifying by age group (≤50 y vs. >50 y), sex and race. A series of mixed-effects regression models were conducted, adjusting for key confounders. Results Among key findings, IL1β was positively associated with a faster rate of decline on a test of executive functioning, among older adults (age >50 y, γ11 = +2.49 ± 0.89, p = 0.005), while in the total population, IL-6 was linked to a faster decline on a test of verbal memory (γ11 = −0.011 ± 0.004, p = 0.009). Among younger participants, IL-18 was linked to a poorer performance on a test of attention at baseline (age ≤50 y, γ01 = −0.007 ± 0.0025, p = 0.004) though a slower rate of decline with higher IL-18 was detected for a test of psychomotor speed in older adults (age >50 y, γ11 = +0.0010 ± 0.0004, p = 0.008). Finally, among Whites, unlike among African-Americans, IL-6 was associated with a better baseline performance on two tests of verbal and working memory. Conclusions Cytokines were shown to be associated with age-related cognitive decline among middle-aged and older urban adults in an age group and race-specific manner. Further longitudinal studies are needed to replicate our findings and mediation through relevant biological and psychosocial factors need to be studied as well.

Published
2019
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30. Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies

Author

May A. Beydoun, Richard J. Wood, Alan B. Zonderman, Sharmin Hossain, Xiaoli Chen, and Hind A. Beydoun

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Nutritional Status, Breast Neoplasms, 030209 endocrinology & metabolism, Context (language use), Article, vitamin D deficiency, law.invention, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Randomized controlled trial, law, Internal medicine, Odds Ratio, medicine, Vitamin D and neurology, Humans, Vitamin D, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Vitamins, Publication bias, Vitamin D Deficiency, medicine.disease, United States, Observational Studies as Topic, Meta-analysis, Relative risk, Dietary Supplements, Female, business
Abstract

CONTEXT: Breast cancer (BC) is the most common malignancy among women in the US. Vitamin D status and intakes are thought to be inversely associated with BC occurrence. OBJECTIVES: In our systematic review and meta-analysis, we evaluated evidence linking serum 25(OH)D (both in serum and diet) with breast cancer (BC) occurrence. DATA SOURCES AND EXTRACTION: Only observational studies from databases such as PubMed and Cochrane (January 1st 2000 through March 15th, 2018) were included using PRISMA guidelines. Publication bias and consistency upon replication were assessed, while harmonizing risk ratios (RR, 95% CI) of BC, per fixed increment of 5 exposures [10 ng/mL of 25(OH)D; 100 IU/d for total/dietary vitamin D intakes; vitamin D deficiency; supplement use). RRs were pooled using random effect models. DATA ANALYSIS: Pooled findings from 22 studies suggested a net direct association between 25(OH)D deficiency and BC, with RR(pooled) = 1.91, 95% CI: 1.51–2.41, P < 0.001). Total vitamin D intake (RR(pooled) = 0.99, 95% CI: 0.97–1.00, P = 0.022, per 100 IU/d) and supplemental vitamin D (RR(pooled) = 0.97, 95% CI:0.95–1.00, P = 0.026) were inversely associated with BC. No evidence of publication bias was found; all 5 exposures of interest were consistent upon replication. CONCLUSIONS: 25(OH)D deficiency was directly related to BC while total vitamin D and supplemental vitamin D intakes had an inverse relationship with this outcome. Randomized clinical trials are warranted pending further evidence from primary meta-analyses of observational studies.

Published
2019
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31. CKD Awareness in the General Population: Performance of CKD-Specific Questions

Author

Alexandra Velasquez, Delphine S. Tuot, Deidra C. Crews, Michele K. Evans, Alan B. Zonderman, Karen K. Wong, and Neil R. Powe

Subjects
Gerontology, knowledge, Population, Renal function, literacy, lcsh:RC870-923, urologic and male genital diseases, Logistic regression, HANDLS, Health care, CKD, Internal Medicine, medicine, Generalizability theory, education, Original Research, education.field_of_study, business.industry, Gold standard, CKD awareness, lcsh:Diseases of the genitourinary system. Urology, sensitivity, medicine.disease, female genital diseases and pregnancy complications, Nephrology, Albuminuria, medicine.symptom, business, Kidney disease
Abstract

Rationale & Objective Data from patients in one delivery system have suggested that the prevalence of chronic kidney disease (CKD) awareness differs by how the question is asked. We examined the sensitivity and specificity of different CKD awareness questions among diverse community-dwelling adults who were not necessarily engaged in primary care to determine the generalizability of prior results. Study Design Cross-sectional study. Setting & Participants Participants in the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Study. Predictor CKD awareness, ascertained using 5 different questions. Outcome Sensitivity and specificity of each awareness question, using laboratory results as the gold standard. Analytic Approach Logistic regression was used to compare sensitivities of different awareness questions. Results Among 2,046 participants, mean (SD) age was 56.5 (9.1) years, 41.5% were men, and 61.3% were African American. More than 40% were poor, 35% reported not having health insurance, and 16.9% had low health literacy. More than 20% (n = 424) had CKD. Sensitivities of single CKD awareness questions ranged from 2.2% for “kidney damage” to 5.2% for “kidney problem.” Sensitivity of the compound question asking about “weak kidneys, failing kidneys, or kidney disease” was 19.5%. Sensitivity of this compound CKD awareness question was higher among study participants with more advanced CKD and low health literacy, and those who lived below the poverty level. Limitations Single measures of estimated glomerular filtration rate and albuminuria; study participants may have been more engaged in their health care than the average US adult, potentially limiting the generalizability of results. Conclusions CKD awareness is low among community-dwelling adults with kidney disease, though data using a sensitive compound question ascertaining awareness suggest that we have met the Healthy People 2020 goal related to CKD awareness of 13.4%. Understanding the phrases about kidney disease that are most understandable to patients with and at risk for CKD is important to further increase CKD awareness., Graphical abstract

Published
2019
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34. Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults

Author

Beydoun, May A., primary, Shaked, Danielle, additional, Hossain, Sharmin, additional, Weiss, Jordan, additional, Beydoun, Hind A., additional, Maldonado, Ana I., additional, Katzel, Leslie I., additional, Davatzikos, Christos, additional, Gullapalli, Rao P., additional, Seliger, Stephen L., additional, Erus, Guray, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, and Waldstein, Shari R., additional

Published
2021
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38. The Polygenic and Monogenic Basis of Blood Traits and Diseases

Author

Vuckovic, Dragana, Bao, Erik L, Akbari, Parsa, Lareau, Caleb A, Mousas, Abdou, Jiang, Tao, Chen, Ming-Huei, Raffield, Laura M, Tardaguila, Manuel, Huffman, Jennifer E, Ritchie, Scott C, Megy, Karyn, Ponstingl, Hannes, Penkett, Christopher J, Albers, Patrick K, Wigdor, Emilie M, Sakaue, Saori, Moscati, Arden, Manansala, Regina, Lo, Ken Sin, Qian, Huijun, Akiyama, Masato, Bartz, Traci M, Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P, Brody, Jennifer A, Van Rooij, Frank JA, Chitrala, Kumaraswamy N, Wilson, Peter WF, Choquet, Hélène, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K, Felix, Stephan B, Floyd, James S, Broer, Linda, Grarup, Niels, Guo, Michael H, Guo, Qi, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna MM, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotios, Lange, Leslie A, Lehtimäki, Terho, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Matsuda, Koichi, Mohlke, Karen L, Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N, Nikus, Kjell, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Raitakari, Olli T, Rich, Stephen S, Rodriguez, Benjamin AT, Rosen, Jonathan D, Rotter, Jerome I, Schubert, Petra, Spracklen, Cassandra N, Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A, Weiss, Stefan, VA Million Veteran Program, Cai, Na, Kundu, Kousik, Watt, Stephen B, Walter, Klaudia, Zonderman, Alan B, Cho, Kelly, Li, Yun, Loos, Ruth JF, Knight, Julian C, Georges, Michel, Stegle, Oliver, Evangelou, Evangelos, Okada, Yukinori, Roberts, David J, Inouye, Michael, Johnson, Andrew D, Auer, Paul L, Astle, William J, Reiner, Alexander P, Butterworth, Adam S, Ouwehand, Willem H, Lettre, Guillaume, Sankaran, Vijay G, Soranzo, Nicole, Ritchie, Scott [0000-0002-8454-9548], Megy, Karyn [0000-0002-2826-3879], Danesh, John [0000-0003-1158-6791], Di Angelantonio, Emanuele [0000-0001-8776-6719], Kundu, Kousik [0000-0002-1019-8351], Inouye, Michael [0000-0001-9413-6520], Astle, William [0000-0001-8866-6672], Butterworth, Adam [0000-0002-6915-9015], Ouwehand, Willem [0000-0002-7744-1790], Soranzo, Nicole [0000-0003-1095-3852], and Apollo - University of Cambridge Repository

Subjects
Male, UK Biobank, Multifactorial Inheritance, polygenic risk, rare disease, Polymorphism, Single Nucleotide, hematopoiesis, splicing, Phenotype, fine-mapping, blood, chromatin, Humans, genetics, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, omnigenic, Genome-Wide Association Study
Abstract

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.

Published
2020
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39. Multiple forms of discrimination, social status, and telomere length: Interactions within race

Author

Danielle L. Beatty Moody, Michele K. Evans, Elizabeth J. Pantesco, Nan-ping Weng, Daniel K. Leibel, Shari R. Waldstein, Leslie I. Katzel, Jason J. Ashe, Alan B. Zonderman, and Hans B. Liu

Subjects
Adult, Male, Multiple forms, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Social Environment, Racism, Article, White People, 03 medical and health sciences, Race (biology), Discrimination, Psychological, 0302 clinical medicine, Endocrinology, Humans, Medicine, 030212 general & internal medicine, Socioeconomic status, Cellular Senescence, Biological Psychiatry, media_common, 030505 public health, Maryland, Endocrine and Autonomic Systems, business.industry, Racial Groups, Telomere Homeostasis, Health Status Disparities, Middle Aged, United States, Health equity, Telomere, Black or African American, Psychiatry and Mental health, Social Class, Cellular Aging, Female, 0305 other medical science, business, Demography, Social status
Abstract

Previous research has demonstrated inverse associations between experiences of interpersonal discrimination and telomere length, a marker of cellular aging. Here, we investigate within-race interactions between multiple indices of interpersonal discrimination and sociodemographic characteristics in relation to telomere length in African American and White adults. Participants were from the Healthy Aging in Neighborhoods of Diversity across the Life Span study (Baltimore, Maryland). Ages ranged from 30–64 years old and all self-identified as either African American (n = 176) or White (n = 165). Using linear regression, three patterns were observed within African Americans and one within Whites. Among African Americans, (1) women reporting greater lifetime burden (p = .02), racial (p = .03) and gender (p = .01) discrimination; (2) those with higher socioeconomic status reporting greater lifetime burden (p = .03) and racial discrimination (p = .02); and (3) younger adults reporting greater exposure to multiple sources of discrimination (p = .03) had shorter telomere length. Among Whites, younger and older men reporting greater racial discrimination had shorter and longer telomeres, respectively (p = .02). Findings demonstrate within-race patterns of interpersonal discrimination and cellular aging, which may contribute to racial health disparities.

Published
2018
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41. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Author

Graff, Mariaelisa, primary, Justice, Anne E., additional, Young, Kristin L., additional, Marouli, Eirini, additional, Zhang, Xinruo, additional, Fine, Rebecca S., additional, Lim, Elise, additional, Buchanan, Victoria, additional, Rand, Kristin, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Yanek, Lisa R., additional, Shao, Yaming, additional, Rohde, Rebecca, additional, Adeyemo, Adebowale A., additional, Aldrich, Melinda C., additional, Allison, Matthew A., additional, Ambrosone, Christine B., additional, Ambs, Stefan, additional, Amos, Christopher, additional, Arnett, Donna K., additional, Atwood, Larry, additional, Bandera, Elisa V., additional, Bartz, Traci, additional, Becker, Diane M., additional, Berndt, Sonja I., additional, Bernstein, Leslie, additional, Bielak, Lawrence F., additional, Blot, William J., additional, Bottinger, Erwin P., additional, Bowden, Donald W., additional, Bradfield, Jonathan P., additional, Brody, Jennifer A., additional, Broeckel, Ulrich, additional, Burke, Gregory, additional, Cade, Brian E., additional, Cai, Qiuyin, additional, Caporaso, Neil, additional, Carlson, Chris, additional, Carpten, John, additional, Casey, Graham, additional, Chanock, Stephen J., additional, Chen, Guanjie, additional, Chen, Minhui, additional, Chen, Yii-Der I., additional, Chen, Wei-Min, additional, Chesi, Alessandra, additional, Chiang, Charleston W.K., additional, Chu, Lisa, additional, Coetzee, Gerry A., additional, Conti, David V., additional, Cooper, Richard S., additional, Cushman, Mary, additional, Demerath, Ellen, additional, Deming, Sandra L., additional, Dimitrov, Latchezar, additional, Ding, Jingzhong, additional, Diver, W. Ryan, additional, Duan, Qing, additional, Evans, Michele K., additional, Falusi, Adeyinka G., additional, Faul, Jessica D., additional, Fornage, Myriam, additional, Fox, Caroline, additional, Freedman, Barry I., additional, Garcia, Melissa, additional, Gillanders, Elizabeth M., additional, Goodman, Phyllis, additional, Gottesman, Omri, additional, Grant, Struan F.A., additional, Guo, Xiuqing, additional, Hakonarson, Hakon, additional, Haritunians, Talin, additional, Harris, Tamara B., additional, Harris, Curtis C., additional, Henderson, Brian E., additional, Hennis, Anselm, additional, Hernandez, Dena G., additional, Hirschhorn, Joel N., additional, McNeill, Lorna Haughton, additional, Howard, Timothy D., additional, Howard, Barbara, additional, Hsing, Ann W., additional, Hsu, Yu-Han H., additional, Hu, Jennifer J., additional, Huff, Chad D., additional, Huo, Dezheng, additional, Ingles, Sue A., additional, Irvin, Marguerite R., additional, John, Esther M., additional, Johnson, Karen C., additional, Jordan, Joanne M., additional, Kabagambe, Edmond K., additional, Kang, Sun J., additional, Kardia, Sharon L., additional, Keating, Brendan J., additional, Kittles, Rick A., additional, Klein, Eric A., additional, Kolb, Suzanne, additional, Kolonel, Laurence N., additional, Kooperberg, Charles, additional, Kuller, Lewis, additional, Kutlar, Abdullah, additional, Lange, Leslie, additional, Langefeld, Carl D., additional, Le Marchand, Loic, additional, Leonard, Hampton, additional, Lettre, Guillaume, additional, Levin, Albert M., additional, Li, Yun, additional, Li, Jin, additional, Liu, Yongmei, additional, Liu, Youfang, additional, Liu, Simin, additional, Lohman, Kurt, additional, Lotay, Vaneet, additional, Lu, Yingchang, additional, Maixner, William, additional, Manson, JoAnn E., additional, McKnight, Barbara, additional, Meng, Yan, additional, Monda, Keri L., additional, Monroe, Kris, additional, Moore, Jason H., additional, Mosley, Thomas H., additional, Mudgal, Poorva, additional, Murphy, Adam B., additional, Nadukuru, Rajiv, additional, Nalls, Mike A., additional, Nathanson, Katherine L., additional, Nayak, Uma, additional, N’Diaye, Amidou, additional, Nemesure, Barbara, additional, Neslund-Dudas, Christine, additional, Neuhouser, Marian L., additional, Nyante, Sarah, additional, Ochs-Balcom, Heather, additional, Ogundiran, Temidayo O., additional, Ogunniyi, Adesola, additional, Ojengbede, Oladosu, additional, Okut, Hayrettin, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew, additional, Padhukasahasram, Badri, additional, Palmer, Julie, additional, Palmer, Cameron D., additional, Palmer, Nicholette D., additional, Papanicolaou, George, additional, Patel, Sanjay R., additional, Pettaway, Curtis A., additional, Peyser, Patricia A., additional, Press, Michael F., additional, Rao, D.C., additional, Rasmussen-Torvik, Laura J., additional, Redline, Susan, additional, Reiner, Alex P., additional, Rhie, Suhn K., additional, Rodriguez-Gil, Jorge L., additional, Rotimi, Charles N., additional, Rotter, Jerome I., additional, Ruiz-Narvaez, Edward A., additional, Rybicki, Benjamin A., additional, Salako, Babatunde, additional, Sale, Michele M., additional, Sanderson, Maureen, additional, Schadt, Eric, additional, Schreiner, Pamela J., additional, Schurmann, Claudia, additional, Schwartz, Ann G., additional, Shriner, Daniel A., additional, Signorello, Lisa B., additional, Singleton, Andrew B., additional, Siscovick, David S., additional, Smith, Jennifer A., additional, Smith, Shad, additional, Speliotes, Elizabeth, additional, Spitz, Margaret, additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stram, Alex, additional, Strom, Sara S., additional, Sucheston, Lara, additional, Sun, Yan V., additional, Tajuddin, Salman M., additional, Taylor, Herman, additional, Taylor, Kira, additional, Tayo, Bamidele O., additional, Thun, Michael J., additional, Tucker, Margaret A., additional, Vaidya, Dhananjay, additional, Van Den Berg, David J., additional, Vedantam, Sailaja, additional, Vitolins, Mara, additional, Wang, Zhaoming, additional, Ware, Erin B., additional, Wassertheil-Smoller, Sylvia, additional, Weir, David R., additional, Wiencke, John K., additional, Williams, Scott M., additional, Williams, L. Keoki, additional, Wilson, James G., additional, Witte, John S., additional, Wrensch, Margaret, additional, Wu, Xifeng, additional, Yao, Jie, additional, Zakai, Neil, additional, Zanetti, Krista, additional, Zemel, Babette S., additional, Zhao, Wei, additional, Zhao, Jing Hua, additional, Zheng, Wei, additional, Zhi, Degui, additional, Zhou, Jie, additional, Zhu, Xiaofeng, additional, Ziegler, Regina G., additional, Zmuda, Joe, additional, Zonderman, Alan B., additional, Psaty, Bruce M., additional, Borecki, Ingrid B., additional, Cupples, L. Adrienne, additional, Liu, Ching-Ti, additional, Haiman, Christopher A., additional, Loos, Ruth, additional, Ng, Maggie C.Y., additional, and North, Kari E., additional

Published
2021
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43. Application of the Database of Flavonoid Values for USDA Food Codes 2007–2010 in assessing intake differences between the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study and What We Eat in America (WWEIA), NHANES

Author

Cecilia Wilkinson Enns, Theophile Murayi, Joseph D. Goldman, Marie Fanelli Kuczmarski, Alan B. Zonderman, Alanna J. Moshfegh, Rhonda S Sebastian, and Michele K. Evans

Subjects
chemistry.chemical_classification, Database, Poverty, Life span, media_common.quotation_subject, fungi, Flavonoid, food and beverages, Biology, computer.software_genre, Poverty status, Article, Anthocyanidins, Human health, chemistry, heterocyclic compounds, Healthy aging, computer, Food Science, Diversity (politics), media_common
Abstract

Flavonoids are polyphenolic plant compounds whose biological activities may promote human health. It is worthwhile to examine whether flavonoid intake varies between populations with differing prevalence of diet-related diseases. This study compared flavonoid intakes in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with nationally representative estimates from What We Eat in America (WWEIA), NHANES stratified by sex, age (30–49, 50–64 years), and poverty status (income 125% of the 2004 HHS Poverty Guidelines). Flavonoid intakes from both surveys were estimated using the Database of Flavonoid Values for USDA Food Codes 2007–2010. Across all subpopulations analyzed, intake of anthocyanidins was lower in HANDLS (p

Published
2021
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44. Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Author

Sun, Daokun, primary, Richard, Melissa A., additional, Musani, Solomon K., additional, Sung, Yun Ju, additional, Winkler, Thomas W., additional, Schwander, Karen, additional, Chai, Jin Fang, additional, Guo, Xiuqing, additional, Kilpeläinen, Tuomas O., additional, Vojinovic, Dina, additional, Aschard, Hugues, additional, Bartz, Traci M., additional, Bielak, Lawrence F., additional, Brown, Michael R., additional, Chitrala, Kumaraswamy, additional, Hartwig, Fernando P., additional, Horimoto, Andrea R.V.R., additional, Liu, Yongmei, additional, Manning, Alisa K., additional, Noordam, Raymond, additional, Smith, Albert V., additional, Harris, Sarah E., additional, Kühnel, Brigitte, additional, Lyytikäinen, Leo-Pekka, additional, Nolte, Ilja M., additional, Rauramaa, Rainer, additional, van der Most, Peter J., additional, Wang, Rujia, additional, Ware, Erin B., additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R., additional, Arking, Dan E., additional, Arnett, Donna K., additional, Barac, Ana, additional, Boerwinkle, Eric, additional, Broeckel, Ulrich, additional, Chakravarti, Aravinda, additional, Chen, Yii-Der Ida, additional, Cupples, L. Adrienne, additional, Davigulus, Martha L., additional, de las Fuentes, Lisa, additional, de Mutsert, Renée, additional, de Vries, Paul S., additional, Delaney, Joseph A.C., additional, Diez Roux, Ana V., additional, Dörr, Marcus, additional, Faul, Jessica D., additional, Fretts, Amanda M., additional, Gallo, Linda C., additional, Grabe, Hans Jörgen, additional, Gu, C. Charles, additional, Harris, Tamara B., additional, Hartman, Catharina C.A., additional, Heikkinen, Sami, additional, Ikram, M. Arfan, additional, Isasi, Carmen, additional, Johnson, W. Craig, additional, Jonas, Jost Bruno, additional, Kaplan, Robert C., additional, Komulainen, Pirjo, additional, Krieger, Jose E., additional, Levy, Daniel, additional, Liu, Jianjun, additional, Lohman, Kurt, additional, Luik, Annemarie I., additional, Martin, Lisa W., additional, Meitinger, Thomas, additional, Milaneschi, Yuri, additional, O’Connell, Jeff R., additional, Palmas, Walter R., additional, Peters, Annette, additional, Peyser, Patricia A., additional, Pulkki-Råback, Laura, additional, Raffel, Leslie J., additional, Reiner, Alex P., additional, Rice, Kenneth, additional, Robinson, Jennifer G., additional, Rosendaal, Frits R., additional, Schmidt, Carsten Oliver, additional, Schreiner, Pamela J., additional, Schwettmann, Lars, additional, Shikany, James M., additional, Shu, Xiao-ou, additional, Sidney, Stephen, additional, Sims, Mario, additional, Smith, Jennifer A., additional, Sotoodehnia, Nona, additional, Strauch, Konstantin, additional, Tai, E. Shyong, additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van Duijn, Cornelia M., additional, Waldenberger, Melanie, additional, Wee, Hwee-Lin, additional, Wei, Wen-Bin, additional, Wilson, Gregory, additional, Xuan, Deng, additional, Yao, Jie, additional, Zeng, Donglin, additional, Zhao, Wei, additional, Zhu, Xiaofeng, additional, Zonderman, Alan B., additional, Becker, Diane M., additional, Deary, Ian J., additional, Gieger, Christian, additional, Lakka, Timo A., additional, Lehtimäki, Terho, additional, North, Kari E., additional, Oldehinkel, Albertine J., additional, Penninx, Brenda W.J.H., additional, Snieder, Harold, additional, Wang, Ya-Xing, additional, Weir, David R., additional, Zheng, Wei, additional, Evans, Michele K., additional, Gauderman, W. James, additional, Gudnason, Vilmundur, additional, Horta, Bernardo L., additional, Liu, Ching-Ti, additional, Mook-Kanamori, Dennis O., additional, Morrison, Alanna C., additional, Pereira, Alexandre C., additional, Psaty, Bruce M., additional, Amin, Najaf, additional, Fox, Ervin R., additional, Kooperberg, Charles, additional, Sim, Xueling, additional, Bierut, Laura, additional, Rotter, Jerome I., additional, Kardia, Sharon L.R., additional, Franceschini, Nora, additional, Rao, Dabeeru C., additional, and Fornage, Myriam, additional

Published
2021
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46. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Author

Chen, Ming-Huei, primary, Raffield, Laura M., additional, Mousas, Abdou, additional, Sakaue, Saori, additional, Huffman, Jennifer E., additional, Moscati, Arden, additional, Trivedi, Bhavi, additional, Jiang, Tao, additional, Akbari, Parsa, additional, Vuckovic, Dragana, additional, Bao, Erik L., additional, Zhong, Xue, additional, Manansala, Regina, additional, Laplante, Véronique, additional, Chen, Minhui, additional, Lo, Ken Sin, additional, Qian, Huijun, additional, Lareau, Caleb A., additional, Beaudoin, Mélissa, additional, Hunt, Karen A., additional, Akiyama, Masato, additional, Bartz, Traci M., additional, Ben-Shlomo, Yoav, additional, Beswick, Andrew, additional, Bork-Jensen, Jette, additional, Bottinger, Erwin P., additional, Brody, Jennifer A., additional, van Rooij, Frank J.A., additional, Chitrala, Kumaraswamynaidu, additional, Cho, Kelly, additional, Choquet, Hélène, additional, Correa, Adolfo, additional, Danesh, John, additional, Di Angelantonio, Emanuele, additional, Dimou, Niki, additional, Ding, Jingzhong, additional, Elliott, Paul, additional, Esko, Tõnu, additional, Evans, Michele K., additional, Floyd, James S., additional, Broer, Linda, additional, Grarup, Niels, additional, Guo, Michael H., additional, Greinacher, Andreas, additional, Haessler, Jeff, additional, Hansen, Torben, additional, Howson, Joanna M.M., additional, Huang, Qin Qin, additional, Huang, Wei, additional, Jorgenson, Eric, additional, Kacprowski, Tim, additional, Kähönen, Mika, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Karthikeyan, Savita, additional, Koskeridis, Fotis, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Lerch, Markus M., additional, Linneberg, Allan, additional, Liu, Yongmei, additional, Lyytikäinen, Leo-Pekka, additional, Manichaikul, Ani, additional, Martin, Hilary C., additional, Matsuda, Koichi, additional, Mohlke, Karen L., additional, Mononen, Nina, additional, Murakami, Yoshinori, additional, Nadkarni, Girish N., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ouwehand, Willem H., additional, Pankratz, Nathan, additional, Pedersen, Oluf, additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Roberts, David J., additional, Rich, Stephen S., additional, Rodriguez, Benjamin A.T., additional, Rosen, Jonathan D., additional, Rotter, Jerome I., additional, Schubert, Petra, additional, Spracklen, Cassandra N., additional, Surendran, Praveen, additional, Tang, Hua, additional, Tardif, Jean-Claude, additional, Trembath, Richard C., additional, Ghanbari, Mohsen, additional, Völker, Uwe, additional, Völzke, Henry, additional, Watkins, Nicholas A., additional, Zonderman, Alan B., additional, Wilson, Peter W.F., additional, Li, Yun, additional, Butterworth, Adam S., additional, Gauchat, Jean-François, additional, Chiang, Charleston W.K., additional, Li, Bingshan, additional, Loos, Ruth J.F., additional, Astle, William J., additional, Evangelou, Evangelos, additional, van Heel, David A., additional, Sankaran, Vijay G., additional, Okada, Yukinori, additional, Soranzo, Nicole, additional, Johnson, Andrew D., additional, Reiner, Alexander P., additional, Auer, Paul L., additional, and Lettre, Guillaume, additional

Published
2020
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47. The Polygenic and Monogenic Basis of Blood Traits and Diseases

Author

Vuckovic, Dragana, primary, Bao, Erik L., additional, Akbari, Parsa, additional, Lareau, Caleb A., additional, Mousas, Abdou, additional, Jiang, Tao, additional, Chen, Ming-Huei, additional, Raffield, Laura M., additional, Tardaguila, Manuel, additional, Huffman, Jennifer E., additional, Ritchie, Scott C., additional, Megy, Karyn, additional, Ponstingl, Hannes, additional, Penkett, Christopher J., additional, Albers, Patrick K., additional, Wigdor, Emilie M., additional, Sakaue, Saori, additional, Moscati, Arden, additional, Manansala, Regina, additional, Lo, Ken Sin, additional, Qian, Huijun, additional, Akiyama, Masato, additional, Bartz, Traci M., additional, Ben-Shlomo, Yoav, additional, Beswick, Andrew, additional, Bork-Jensen, Jette, additional, Bottinger, Erwin P., additional, Brody, Jennifer A., additional, van Rooij, Frank J.A., additional, Chitrala, Kumaraswamy N., additional, Wilson, Peter W.F., additional, Choquet, Hélène, additional, Danesh, John, additional, Di Angelantonio, Emanuele, additional, Dimou, Niki, additional, Ding, Jingzhong, additional, Elliott, Paul, additional, Esko, Tõnu, additional, Evans, Michele K., additional, Felix, Stephan B., additional, Floyd, James S., additional, Broer, Linda, additional, Grarup, Niels, additional, Guo, Michael H., additional, Guo, Qi, additional, Greinacher, Andreas, additional, Haessler, Jeff, additional, Hansen, Torben, additional, Howson, Joanna M.M., additional, Huang, Wei, additional, Jorgenson, Eric, additional, Kacprowski, Tim, additional, Kähönen, Mika, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Karthikeyan, Savita, additional, Koskeridis, Fotios, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Linneberg, Allan, additional, Liu, Yongmei, additional, Lyytikäinen, Leo-Pekka, additional, Manichaikul, Ani, additional, Matsuda, Koichi, additional, Mohlke, Karen L., additional, Mononen, Nina, additional, Murakami, Yoshinori, additional, Nadkarni, Girish N., additional, Nikus, Kjell, additional, Pankratz, Nathan, additional, Pedersen, Oluf, additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Rich, Stephen S., additional, Rodriguez, Benjamin A.T., additional, Rosen, Jonathan D., additional, Rotter, Jerome I., additional, Schubert, Petra, additional, Spracklen, Cassandra N., additional, Surendran, Praveen, additional, Tang, Hua, additional, Tardif, Jean-Claude, additional, Ghanbari, Mohsen, additional, Völker, Uwe, additional, Völzke, Henry, additional, Watkins, Nicholas A., additional, Weiss, Stefan, additional, Cai, Na, additional, Kundu, Kousik, additional, Watt, Stephen B., additional, Walter, Klaudia, additional, Zonderman, Alan B., additional, Cho, Kelly, additional, Li, Yun, additional, Loos, Ruth J.F., additional, Knight, Julian C., additional, Georges, Michel, additional, Stegle, Oliver, additional, Evangelou, Evangelos, additional, Okada, Yukinori, additional, Roberts, David J., additional, Inouye, Michael, additional, Johnson, Andrew D., additional, Auer, Paul L., additional, Astle, William J., additional, Reiner, Alexander P., additional, Butterworth, Adam S., additional, Ouwehand, Willem H., additional, Lettre, Guillaume, additional, Sankaran, Vijay G., additional, and Soranzo, Nicole, additional

Published
2020
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48. Effects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial

Author

Ponguta, Liliana A., primary, Issa, Ghassan, additional, Aoudeh, Lara, additional, Maalouf, Cosette, additional, Hein, Sascha D., additional, Zonderman, Anna L., additional, Katsovich, Liliya, additional, Khoshnood, Kaveh, additional, Bick, Johanna, additional, Awar, Abir, additional, Nourallah, Sawsan, additional, Householder, Sarah, additional, Moore, Christina C., additional, Salah, Rima, additional, Britto, Pia R., additional, and Leckman, James F., additional

Published
2020
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