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Your search keyword '"Zhong, Zheng"' showing total 549 results
Start Over Author "Zhong, Zheng" Publisher elsevier bv
549 results on '"Zhong, Zheng"'

26. The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice

Author

Li, Zheng-Fa, primary, Feng, Jia-Kun, additional, Zhao, Xiao-Chen, additional, Liu, Wei, additional, Gu, Shi-An, additional, Li, Rui, additional, Lu, Yang-Liu, additional, Mao, Rui-Jiao, additional, Xia, Li-Ling, additional, Dong, Lu-Lu, additional, Zhang, Li-Wen, additional, Ruan, Jing-Yan, additional, Liu, Jiao, additional, Li, Guang-Fen, additional, Li, Tao, additional, Sun, Rong, additional, Qiu, Shui-Lan, additional, Zheng, Zhong-Zheng, additional, and Dong, Ting, additional

Published
2023
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29. Fabrication of Biologically Inspired Electrospun Collagen/Silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair

Author

Jianjun Wu, Shengxuan Wang, Zhong Zheng, and Jianbao Li

Subjects
Biomaterials, Biomedical Engineering, Developmental Biology
Abstract

Bone disease and disorder treatment might be difficult because of its complicated nature. Millions of patients each year need bone substitutes that may help them recover quickly from a variety of illnesses. Synthetic bone replacements that mirror the structural, chemical, and biological features of bone matrix structure will be very helpful and in high demand. In this research, the inorganic bioactive glass nanoparticles matrixed with organic collagen and silk fibroin structure (COL/SF/CaO-SiO

Published
2022

32. Corrigendum to “Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation” [Int. Immunopharmacol. 93 (2021) 107165]

Author

Zhang, Yuan-xiang, primary, Zhang, Xiao-tong, additional, Li, Hong-jin, additional, Zhou, Tao-feng, additional, Zhou, An-cheng, additional, Zhong, Zheng-ling, additional, Liu, Yan-hao, additional, Yuan, Li-li, additional, Zhu, Hao-yu, additional, Luan, Di, additional, and Tong, Jiu-cui, additional

Published
2023
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36. Computed Tomography Angiography and Three-Dimensional Reconstruction of Renal Arteries in Diagnosing the Bleedings After Mini-Percutaneous Nephrolithotomy: A Single-center Experience of 7 Years

Author

Bin-Bin, Yang, Wan-Zhang, Liu, Jia-Pei, Ying, Chang, Li, Ting, Huang, Jing-Yu, Shi, Zhong, Zheng, He-Sheng, Yuan, Jia-Sheng, Hu, Yue, Cheng, and Jun-Hai, Qian

Subjects
Renal Artery, Imaging, Three-Dimensional, Computed Tomography Angiography, Urology, Arteriovenous Fistula, Multidetector Computed Tomography, Humans, Angiography, Digital Subtraction, Hemorrhage, Nephrolithotomy, Percutaneous, Aneurysm, False, Nephrostomy, Percutaneous, Retrospective Studies
Abstract

This study aimed to investigate the role of computed tomography angiography (CTA) and three-dimensional (3D) reconstruction of renal arteries in the evaluation of bleeding after mini- percutaneous nephrolithotomy (PCNL).Thirty-one consecutive patients with continuous renal hemorrhage after mini-PCNL were enrolled from January 2015 to January 2022. Demographic and clinical data were retrospectively recorded and analyzed. All patients had received CTA evaluation and subsequently digital subtraction angiography (DSA) embolization to manage renal bleeding. CTA and 3D reconstruction of renal arteries were performed using the 320 multi-detector computed tomography technique and the images were evaluated by experienced radiologists. DSA embolization were performed by an interventional radiologist with more than 10 years of experiences.CTA and 3D construction of renal arteries showed 28 cases of vascular lesions (28/31, 90.3%), including 15 cases of pseudoaneurysm (15/28, 53.6%), 9 cases of arteriovenous fistula (9/28, 32.1%), and 4 cases of suspicious bleeding spot (4/28, 14.3%). While DSA revealed 31 cases of vascular lesions (100%), including 15 cases of pseudoaneurysm (15/31, 48.4%), 10 cases of arteriovenous fistula (10/31, 32.3%), 6 cases of bleeding spot and (6/31, 19.4%). The serum creatinine level was elevated slightly before mini-PCNL and after DSA embolization (73.1±18.1 vs 92.1±33.6, P.01). 15 patients (15/31, 48.4%) required blood transfusion, with mean blood transfusion volume of 700 ml ±660 ml (range, 400 ml-1800 ml). The bleeding was controlled without any further severe complications.CTA and 3D reconstruction of renal arteries were safe and effective in diagnosing renal arterial bleedings after mini-PCNL, with a sensitivity of 90.3% and a specificity of 100%.

Published
2022

37. The dynamic evaluation and optimization model for steel enterprise’s energy flow network operations

Author

Zhichun Hu, Zhong Zheng, Kun Hu, Cunsheng Li, and Yun Yang

Subjects
Optimizing energy efficiency, Dynamic evaluation, General Energy, Energy flow, Steam energy flow network, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Steel manufacturing, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In line with the global green steel development, a steel enterprise seeks to reduce its energy consumption by building a scientific, effective evaluation and optimization model for steel manufacturing’s energy utilizations. It highlights the enterprise and the steel sector’s green mainstream. This paper proposes a dynamic evaluation model for energy flow network operations and brings forward evaluation indicators based on analyses of each energy flow’s input and output, and utilization, conversion and loss during the steel manufacturing process. They provide support for making dynamic optimizations for the energy flow network to achieve an optimal operation efficiency. As a result, an optimization model for energy flow network operations has been built and plays a part in guiding the steel enterprise to contribute further to energy conservation and consumption reduction.

Published
2022

39. Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency

Author

Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou, Hui Wang, Da Ma, Zhan-Ting Li, and Dan-Wei Zhang

Subjects
Photosensitizing Agents, Porphyrins, Polymers, Biomedical Engineering, General Medicine, Biochemistry, Biomaterials, Mice, Photochemotherapy, Cell Line, Tumor, Animals, Porosity, Molecular Biology, Biotechnology
Abstract

Since 1995, photodynamic therapy (PDT) has been utilized as an effective method for cancer treatment. However, the residues of photosensitizers in the normal tissues after PDT can be activated by sunlight to cause severe skin phototoxicity, for which currently there are no clinical solutions. As a result, post-PDT patients need to remain out of sunlight for up to five weeks, which produces great living and mental burdens for patients. Herein, we report that a biocompatible porous organic polymer (POP) with average 3.1 nm porosity is able to suppress the skin phototoxicity of clinically used porphyrin-based photodynamic agents (PDAs), including Photofrin, Talaporfin and Hiporfin, through an adsorption-elimination mechanism. Fluorescence titration and dialysis experiments show that POP can adsorb and retain the PDAs at a micromolar concentration. In vivo experiments demonstrate that POP can significantly suppress the skin phototoxicity caused by all the three PDAs without reducing their PDT efficacy. STATEMENT OF SIGNIFICANCE: Up to now, no efficient clinical treatment for the inhibition of post-PDT phototoxicity of clinically used porphyrin-based PDAs is available. In the manuscript, a water-soluble cationic porous organic polymer has been revealed to include three clinically used PDAs. In vivo experiments show that this inclusion remarkably reduces the content of PDAs in mouse skins, leading to significant alleviation of their post-PDT phototoxicity without no negative effect on their PDT efficacy. Thus, this work provides a strategy for overcoming the drawback of clinically used photodynamic agents.

Published
2022

40. A novel strategy for high-specificity, high-sensitivity, and high-throughput study for gut microbiome metabolism of aromatic carboxylic acids

Author

Junpeng Xing, Ningning Zhao, Zhong Zheng, Fengrui Song, Zhiqiang Liu, and Shu Liu

Subjects
chemistry.chemical_compound, Chromatography, Chemistry, Pharmacological research, Stable Isotope Labeling, General Chemistry, Metabolism, Tandem mass spectrometry, Derivatization, Signal amplification, Gut microbiome, Triple quadrupole mass spectrometer
Abstract

Aromatic carboxylic acids (ACAs) may be as transformed key metabolites via gut microbiome for playing better pharmacological effects. However, it's rare to achieve high-specificity, high-sensitivity, and high-throughput detection simultaneously, especially, for tracing trace ACAs in gut microbiome. In this work, firstly, a novel dual-template and double-shelled molecularly imprinted 96-well microplates (DDMIPs) was designed and amplified signal for p-hydroxybenzoic acid (PBA) and 3,4,5-trimethoxycinnamic acid (TMA). Additionally, the DDMIPs and a stable isotope labeling derivatization (SILD) method combined with the ultra-high performance liquid chromatography triple quadrupole tandem mass spectrometry (UHPLC-TQ MS) was firstly stepwise integrated, achieving high-effective, high-sensitive, and high-throughput study of gut microbiome metabolism. The whole strategy showed lower limits of detections (LODs) up to 1000 folds than the traditional method, and revealed a more real metabolism-time profile of PBA and TMA by 3-step signal amplification. The platform also laid the foundation for fast, simple, high-selective, high-effective, and high-throughput metabolism and pharmacological research.

Published
2022

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