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222 results on '"Zanaboni A"'

1. Longitudinal trajectories of anxiety and depression in subjects with different mental disorders after one year in the COVID-19 pandemic

Author

Carmassi, Claudia, primary, Tosato, Sarah, additional, Pedrinelli, Virginia, additional, Bertelloni, Carlo A., additional, Abbate-Daga, Giovanni, additional, Albert, Umberto, additional, Castellini, Giovanni, additional, Luciano, Mario, additional, Menchetti, Marco, additional, Pompili, Maurizio, additional, Sampogna, Gaia, additional, Signorelli, Maria, additional, Massimetti, Gabriele, additional, Fiorillo, Andrea, additional, Fantasia, Sara, additional, Gravina, Davide, additional, Dell'Oste, Valerio, additional, Maselli, Francesca Maria Camilla, additional, Zanaboni, Silvia, additional, Bastanzetti, Vittoria, additional, Ceci, Pietro, additional, Longo, Paola, additional, Burato, Sofia, additional, D'Aietti, Alberto, additional, Faldi, Marco, additional, Marchesoni, Giorgia, additional, Vincenzo, Matteo Di, additional, Rocca, Bianca Della, additional, Possidente, Chiara, additional, Cosentini, Nicola, additional, Berardelli, Isabella, additional, Concerto, Carmen, additional, and Rodolico, Alessandro, additional

Published
2024
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2. An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter study

Author

Kwiatkowski, David M., primary, Alten, Jeffrey A., additional, Mah, Kenneth E., additional, Selewski, David T., additional, Raymond, Tia T., additional, Afonso, Natasha S., additional, Blinder, Joshua J., additional, Coghill, Matthew T., additional, Cooper, David S., additional, Koch, Joshua D., additional, Krawczeski, Catherine D., additional, Morales, David L.S., additional, Neumayr, Tara M., additional, Rahman, A.K.M. Fazlur, additional, Reichle, Garrett, additional, Tabbutt, Sarah, additional, Webb, Tennille N., additional, Borasino, Santiago, additional, Zang, Huaiyu, additional, Winlaw, David, additional, Bailly, David, additional, Goldstein, Stuart, additional, Gist, Katja, additional, Brandewie, Katie L., additional, Bhat, Priya N., additional, Diddle, John W., additional, Ghbeis, Muhammad, additional, Prodhan, Parthak, additional, Garcia, Xiomara, additional, Ramer, Shannon, additional, Albertson, Mindy, additional, Rodriquez, Zahidee, additional, Lukacs, Mary, additional, Gaies, Michael, additional, Freytag, Joshua, additional, Sammons, Amanda, additional, Abraha, Hideat, additional, Butcher, John, additional, Zanaboni, Dominic, additional, Sanchez de Toledo, Joan, additional, Domnina, Yuliya A., additional, Saenz, Lucas, additional, Baust, Tracy, additional, Kluck, Jane, additional, Sasaki, Jun, additional, Raees, Aanish, additional, O'Neil, Erika R., additional, Lasa, Javier J., additional, Phillips, Patrick A., additional, Hock, Kristal M., additional, Valentine, Kevin, additional, Tadphale, Sachin, additional, Buckley, Jason R., additional, Schroeder, Luke, additional, Clarke, Shanelle, additional, Zhang, Wenying, additional, Smith, Andrew, additional, Absi, Mohammed, additional, Askenazi, David J., additional, Duncan, Linda, additional, Bertrandt, Rebecca A., additional, Sosa, Lisa J., additional, O’Neal, Erika R., additional, Doman, Tammy, additional, Viers, Suzanne, additional, Smith, Andrew H., additional, and Bailly, David K., additional

Published
2024
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5. Fluid Accumulation After Neonatal Congenital Cardiac Operation: Clinical Implications and Outcomes

Author

Bailly, David K., primary, Alten, Jeffrey A., additional, Gist, Katja M., additional, Mah, Kenneth E., additional, Kwiatkowski, David M., additional, Valentine, Kevin M., additional, Diddle, J.Wesley, additional, Tadphale, Sachin, additional, Clarke, Shanelle, additional, Selewski, David T., additional, Banerjee, Mousumi, additional, Reichle, Garrett, additional, Lin, Paul, additional, Gaies, Michael, additional, Blinder, Joshua J., additional, Prodhan, Parthak, additional, Garcia, Xiomara, additional, Ramer, Shannon, additional, Albertson, Mindy, additional, Ghbeis, Muhammad B., additional, Cooper, David S., additional, Rodriquez, Zahidee, additional, Lukacs, Mary, additional, Zanaboni, Dominic, additional, Sanchez de Toledo, Joan, additional, Domnina, Yuliya A., additional, Saenz, Lucas, additional, Baust, Tracy, additional, Kluck, Jane, additional, Duncan, Linda, additional, Koch, Joshua D., additional, Freytag, Joshua, additional, Sammons, Amanda, additional, Abraha, Hideat, additional, Butcher, John, additional, Sasaki, Jun, additional, Krawczeski, Catherine D., additional, Bertrandt, Rebecca A., additional, Raymond, Tia T., additional, Buckley, Jason R., additional, Schroeder, Luke, additional, Raees, Aanish, additional, Sosa, Lisa J., additional, Bhat, Priya N., additional, Neumayr, Tara M., additional, Afonso, Natasha S., additional, O’Neal, Erika R., additional, Lasa, Javier J., additional, Phillips, Patrick A., additional, Ardisana, Amy, additional, Gonzalez, Kim, additional, Doman, Tammy, additional, Viers, Suzanne, additional, Zhang, Wenying, additional, Hock, Kristal M., additional, and Borasino, Santiago, additional

Published
2022
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6. Perceived autonomy support in telerehabilitation by people with chronic respiratory disease: a mixed methods study.

Author

Cox, Narelle S., primary, Lee, Joanna YT., additional, McDonald, Christine F., additional, Mahal, Ajay, additional, Alison, Jennifer A., additional, Wootton, Richard, additional, Hill, Catherine J., additional, Zanaboni, Paolo, additional, O’Halloran, Paul, additional, Bondarenko, Janet, additional, Macdonald, Heather, additional, Barker, Kathryn, additional, Crute, Hayley, additional, Mellerick, Christie, additional, Wageck, Bruna, additional, Boursinos, Helen, additional, Lahham, Aroub, additional, Nichols, Amanda, additional, Czupryn, Pawel, additional, Corbett, Monique, additional, Handley, Emma, additional, Burge, Angela T., additional, and Holland, Anne E., additional

Published
2022
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7. Perceived Autonomy Support in Telerehabilitation by People With Chronic Respiratory Disease

Author

Narelle S. Cox, Joanna Y.T. Lee, Christine F. McDonald, Ajay Mahal, Jennifer A. Alison, Richard Wootton, Catherine J. Hill, Paolo Zanaboni, Paul O’Halloran, Janet Bondarenko, Heather Macdonald, Kathryn Barker, Hayley Crute, Christie Mellerick, Bruna Wageck, Helen Boursinos, Aroub Lahham, Amanda Nichols, Pawel Czupryn, Monique Corbett, Emma Handley, Angela T. Burge, and Anne E. Holland

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2022

9. Academic Medical Center Visits by Adolescents Preceding Emergency Department Care for Suicidal Ideation or Suicide Attempt

Author

Joan Giovanni, Arjun Sarin, Kimberly A. Randell, Ashley K. Sherman, Gregory P. Conners, Christina Zanaboni, and Shayla Sullivant

Subjects
Male, medicine.medical_specialty, Adolescent, Suicide, Attempted, Subspecialty, Suicidal Ideation, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, 030225 pediatrics, Health care, Humans, Medicine, Outpatient clinic, 030212 general & internal medicine, Child, Suicidal ideation, Cause of death, Academic Medical Centers, Suicide attempt, business.industry, Emergency department, Family medicine, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Emergency Service, Hospital, business, Risk assessment
Abstract

Objective Suicide is a leading cause of death in children and adolescents, and healthcare encounters relating to suicidal ideation (SI) and suicide attempt (SA) are steadily increasing. Studies examining healthcare utilization by adolescents prior to emergency department (ED) evaluation for SI/SA are lacking and may guide risk assessment. Methods We performed a descriptive study of patients 10 to 18 years evaluated for SI/SA in either of our 2 academic, pediatric EDs between January 1 and December 31, 2016. We quantified and characterized healthcare encounters in the year preceding ED evaluation for SI/SA by obtaining data from the electronic health record. Results We identified 599 patients with an index ED visit for evaluation of SI/SA. Mean age was 14.1 years (SD 2.0 years); 69.8% female, 61.9% White, 55.4% publicly insured. Fifty-six percent (336/599) had at least one previous encounter within our healthcare system in the year preceding their index ED visit (median 3, maximum 40, IQR: 2, 7), most commonly among Black/African American and Hispanic adolescents. Among all patients we identified 1409 previous encounters, and 55.4% (780/1409) occurred within 6 months of the index ED visit. Sixty-two percent (880/1409) of previous encounters were to an outpatient clinic, primarily nonmental health, subspecialty clinics. Conclusions Adolescent healthcare encounters in the year preceding ED evaluation for SI/SA occur in a variety of settings. A broad approach to suicide risk screening may improve opportunities for early identification and intervention.

Published
2021

11. Epidemiology of Neonatal Acute Kidney Injury After Cardiac Surgery Without Cardiopulmonary Bypass

Author

Sasaki, Jun, primary, Rodriguez, Zahidee, additional, Alten, Jeffrey A., additional, Rahman, AKM Fazlur, additional, Reichle, Garrett, additional, Lin, Paul, additional, Banerjee, Mousumi, additional, Selewski, David, additional, Gaies, Michael, additional, Hock, Kristal M., additional, Borasino, Santiago, additional, Gist, Katja M., additional, Prodhan, Parthak, additional, Garcia, Xiomara, additional, Ramer, Shannon, additional, Sherman, Mindy, additional, Ghbeis, Muhammad B., additional, Clarke, Shanelle A., additional, Lukacs, Mary, additional, Zanaboni, Dominic, additional, Sanchez de Toledo, Joan, additional, Domnina, Yuliya A., additional, Saenz, Lucas, additional, Baust, Tracy, additional, Kluck, Jane, additional, Duncan, Linda, additional, Koch, Joshua D., additional, Diddle, J. Wesley, additional, Freytag, Joshua, additional, Harris, Amanda, additional, Abraha, Hideat, additional, Butcher, John, additional, Tadphale, Sachin D., additional, Krawczeski, Catherine D., additional, Kwiatkowski, David M., additional, Raymond, Tia T., additional, Burton, Grant L., additional, Das, Ashima, additional, Shan, Tajas, additional, Buckley, Jason R., additional, Schroeder, Luke, additional, Raees, Aanish, additional, Guidry, Bradley, additional, Sosa, Lisa J., additional, Bailly, David K., additional, Valentine, Kevin M., additional, Bhat, Priya N., additional, Neumayr, Tara M., additional, Afonso, Natasha S., additional, O’Neal, Erika R., additional, Lasa, Javier J., additional, Huskey, Jordan L., additional, Phillips, Patrick A., additional, Ardisana, Amy, additional, Gonzalez, Kim, additional, Columb, Eric, additional, Domar, Tammy, additional, and Viers, Suzanne, additional

Published
2022
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13. EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count

Author

Stefania Paolucci, Irene Cassaniti, Federica Novazzi, Loretta Fiorina, Antonio Piralla, Giuditta Comolli, Raffaele Bruno, Renato Maserati, Roberto Gulminetti, Stefano Novati, Francesco Mojoli, Fausto Baldanti, R Bruno, M Mondelli, E Brunetti, A Di Matteo, E Seminari, L Maiocchi, V Zuccaro, L Pagnucco, B Mariani, S Ludovisi, R Lissandrin, A Parisi, P Sacchi, SFA Patruno, G Michelone, R Gulminetti, D Zanaboni, S Novati, R Maserati, P Orsolini, M Vecchia, M Sciarra, E Asperges, M Colaneri, A Di Filippo, M Sambo, S Biscarini, M Lupi, S Roda, TC Pieri, I Gallazzi, M Sachs, P Valsecchi, S Perlini, C Alfano, M Bonzano, F Briganti, G Crescenzi, AG Falchi, R Guarnone, B Guglielmana, E Maggi, I Martino, P Pettenazza, S Pioli di Marco, F Quaglia, A Sabena, F Salinaro, F Speciale, I Zunino, M De Lorenzo, G Secco, L Dimitry, G Cappa, I Maisak, B Chiodi, M Sciarrini, B Barcella, F Resta, L Moroni, G Vezzoni, L Scattaglia, E Boscolo, C Zattera, MF Tassi, V Capozza, D Vignaroli, M Bazzini, G Iotti, F Mojoli, M Belliato, L Perotti, S Mongodi, G Tavazzi, G Marseglia, A Licari, I Brambilla, D Barbarini, A Bruno, P Cambieri, G Campanini, C. Cavanna, G Comolli, M Corbella, R Daturi, M Furione, P Marone, E Monzillo, S Paolucci, M Parea, E Percivalle, A Piralla, F Rovida, A Sarasini, M Zavattoni, G Adzasehoun, M Ardizzone, L Bellotti, V Brunco, E Cabano, G Casali, L Capella, D Devitis, L Dossena, G Frisco, G Garbagnoli, F Gardellini, A Girello, A Guerrizio, V Landini, C Lucchelli, V Maliardi, P Piemontese, S Pezzaia, M Premoli, C Rebuffa, C Zanello, J Bagnarino, F Bergami, A Bonetti, G Caneva, I Cassaniti, A Corcione, R Di Martino, A Di Napoli, A Ferrari, G Ferrari, L Fiorina, A Gallone, F Giardina, A Girardi, A Mercato, C Merla, F Novazzi, G Ratano, B Rossi, G Saveriaempillai, IM Sciabica, M Tallarita, E Vecchio Nepita, J Vitali, A Cerino, S Varchetta, B Oliviero, S Mantovani, D Mele, M Calvi, M Tizzoni, C Nicora, A Triarico, V Petronella, C Marena, A Muzzi, P Lago, S Cutti, V Novelli, F Comandatore, G BatistiBiffignandi, S Gaiarsa, M Rettani, and C Bandi

Subjects
Male, 0301 basic medicine, Human cytomegalovirus, Herpesvirus 4, Human, Epstein-Barr Virus Infections, viruses, Lymphocyte, COVID-19, EBV DNA, Lymphocyte subpopulation, Aged, Aged, 80 and over, CD8-Positive T-Lymphocytes, DNA, Viral, Female, Humans, Intensive Care Units, Killer Cells, Natural, Lymphocyte Count, Lymphocyte Subsets, Middle Aged, Opportunistic Infections, Real-Time Polymerase Chain Reaction, SARS-CoV-2, Viral Load, law.invention, 0302 clinical medicine, law, 80 and over, Killer Cells, Cytotoxic T cell, Viral, 030212 general & internal medicine, biology, musculoskeletal, neural, and ocular physiology, General Medicine, Intensive care unit, Infectious Diseases, medicine.anatomical_structure, Natural, Human herpesvirus 6, Human, Microbiology (medical), 030106 microbiology, macromolecular substances, Article, Virus, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, medicine, lcsh:RC109-216, Parvovirus, business.industry, Herpesvirus 4, DNA, biology.organism_classification, medicine.disease, nervous system, Immunology, business, CD8
Abstract

Highlights • EBV reactivation was observed in patients with COVID-19. • NK + and CD8 + T cell reduction was related to the severity of COVID-19 infection. • An increase of B cells in patients with severe symptoms was documented., Objectives The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity. Methods A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry. Results Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p

Published
2021

14. Point-of-Care Ultrasound Diagnosis of Cesarean Scar Ectopic Pregnancy: A Case Series

Author

Ryan C. Gibbons, Mark A. Magee, Allison Zanaboni, and Thomas G. Costantino

Subjects
medicine.medical_specialty, Point-of-Care Systems, Cesarean Scar Pregnancy, Early pregnancy factor, Maternal morbidity, 030218 nuclear medicine & medical imaging, Cicatrix, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, parasitic diseases, medicine, Humans, Effective treatment, Intensive care medicine, Ultrasonography, 030219 obstetrics & reproductive medicine, Ectopic pregnancy, biology, Cesarean Section, business.industry, Point of care ultrasound, Incidence (epidemiology), Emergency department, medicine.disease, Pregnancy, Ectopic, Emergency Medicine, biology.protein, Female, business
Abstract

Background A cesarean scar pregnancy (CSP) is a clinically important form of ectopic pregnancy that carries a high risk of maternal morbidity and mortality. As the rate of cesarean sections has risen, this diagnosis is becoming an increasingly important consideration for providers caring for patients in early pregnancy. Case Report We present three cases of CSPs in which point-of-care ultrasound expedited the diagnosis and treatment in the emergency department. Why Should an Emergency Physician Be Aware of This? Given the risks of an undiagnosed CSP, the increasing incidence of CSP, and the number of effective treatment options available in early gestation, the prompt and accurate diagnosis of CSP remains crucial to its successful management. As such, it is an important diagnosis for the emergency physician to consider when evaluating a patient in early pregnancy.

Published
2021

15. Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior

Author

Chiara Demartini, Rosaria Greco, Miriam Francavilla, Anna Maria Zanaboni, and Cristina Tassorelli

Subjects
Male, Rats, Sprague-Dawley, Disease Models, Animal, Nitroglycerin, Behavioral Neuroscience, Hyperalgesia, Formaldehyde, Migraine Disorders, Animals, Pain, Experimental and Cognitive Psychology, Rats
Abstract

Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms. Emotional-affective aspects are important components of pain, but so far they have been little explored in animal models of migraine. In this study, we aimed to explore the correlation between trigeminal hyperalgesia and affective status or behavioral components in a migraine-specific animal model. Male Sprague-Dawley rats were treated with nitroglycerin (10 mg/kg, i.p.) or its vehicle. Four hours later, anxiety, motor/exploratory behavior and grooming (a nociception index) were evaluated with the open field test. Rats were then exposed to formalin in the orofacial region to evaluate trigeminal hyperalgesia. The data analysis shows an inverse correlation between trigeminal hyperalgesia and motor or exploratory behavior, and a positive association with anxiety-like behavior or self-grooming. These findings further expand on the translational value of the migraine-specific model based on nitroglycerin administration and prompt additional parameters that can be investigated to explore migraine disease in its complexity.

Published
2022

17. Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally-induced migraine attacks

Author

De Icco, Roberto, primary, Greco, Rosaria, additional, Demartini, Chiara, additional, Zanaboni, Anna Maria, additional, Reggiani, Angelo, additional, Realini, Natascia, additional, Allena, Marta, additional, Martinelli, Daniele, additional, Putortì, Alessia, additional, Ahmad, Lara, additional, Corrado, Michele, additional, Grillo, Valentina, additional, Sances, Grazia, additional, and Tassorelli, Cristina, additional

Published
2021
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20. Corrigendum to ‘Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study’ (Br J Anaesth 2021; 126: 1173–81)

Author

Disma, Nicola, primary, Virag, Katalin, additional, Riva, Thomas, additional, Kaufmann, Jost, additional, Engelhardt, Thomas, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Kerovec Sorić, Ivana, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Nouette Gaulain, Karine, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau, Caroline, additional, Magne, Cécile, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, de la Brière, François, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Wolfler, Andrea, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Zanaboni, Clelia, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Bilotta, Federico, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Puric Racic, Selena, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Pirtovšek Štupnik, Špela, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, González Serrano, Cristina, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, Martínez García, Ernesto, additional, Tormo de las Heras, Carolina, additional, Troncoso Montero, Pablo, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Suarez Comas, Montserrat, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pérez Pardo, Osvaldo, additional, Sierra Biddle, Natalia, additional, Suárez Castaño, Ceferina, additional, Villalobos Rico, María Isabel, additional, Manrique Muñoz, Susana, additional, García Martínez, Irene, additional, Montferrer Estruch, Nuria, additional, Vilardell Ortíz, Elena, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Wolfe Barry, Juliet, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Scalia Catenacci, Stefano, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

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2021
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21. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Author

Disma, Nicola, primary, Virag, Katalin, additional, Riva, Thomas, additional, Kaufmann, Jost, additional, Engelhardt, Thomas, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Kerovec Sorić, Ivana, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Nouette Gaulain, Karine, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau, Caroline, additional, Magne, Cécile, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, de la Brière, François, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Wolfler, Andrea, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Zanaboni, Clelia, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Bilotta, Federico, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Puric Racic, Selena, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Pirtovšek Štupnik, Špela, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, González Serrano, Cristina, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, Martínez García, Ernesto, additional, Tormo de las Heras, Carolina, additional, Troncoso Montero, Pablo, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Suarez Comas, Montserrat, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pérez Pardo, Osvaldo, additional, Sierra Biddle, Natalia, additional, Suárez Castaño, Ceferina, additional, Villalobos Rico, María Isabel, additional, Manrique Muñoz, Susana, additional, García Martínez, Irene, additional, Montferrer Estruch, Nuria, additional, Vilardell Ortíz, Elena, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Wolfe Barry, Juliet, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Scalia Catenacci, Stefano, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

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2021
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22. Impact of COVID-19 pandemic in pediatric patients with epilepsy with neuropsychiatric comorbidities: A telemedicine evaluation

Author

Elena Ballante, Serena Grumi, Martina Paola Zanaboni, Ludovica Pasca, Costanza Varesio, Martina Totaro, and Valentina De Giorgis

Subjects
Male, Parents, medicine.medical_specialty, Adolescent, Clinical Neurology, CBCL, Child Behavior Disorders, Anxiety, Neuropsychiatric comorbidities, Article, Cohort Studies, 03 medical and health sciences, Epilepsy, Behavioral Neuroscience, 0302 clinical medicine, Surveys and Questionnaires, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Child, Child Behavior Checklist, Psychiatry, Depression (differential diagnoses), Learning disabilities, Depression, business.industry, Mental Disorders, COVID-19, medicine.disease, Telemedicine, Neurology, Communicable Disease Control, Cohort, Female, Observational study, Neurology (clinical), medicine.symptom, business, Neurocognitive, 030217 neurology & neurosurgery
Abstract

Objective The objective of this study was to evaluate care needs, emotional and behavioral changes, and parental stress indices in a cohort of pediatric patients with epilepsy with neurocognitive and emotional comorbidities at the time of the coronavirus disease 2019 (COVID-19) pandemic. Methods This is a prospective observational study involving pediatric patients with epilepsy with neurocognitive and emotional comorbidities. Included patients were admitted to our hospital between August 2019 and February 2020 for epilepsy and neuropsychiatric assessment, and Child Behavior Checklist (CBCL) questionnaires were filled in by parents. Those patients and their families accepted to participate in a phone follow-up visit in April–May 2020 and to refill CBCL and Parenting Stress Index–Short Form (PSI-SF) questionnaires. Descriptive statistics for demographic and clinical data, CBCL questionnaire scores before and during the COVID-19 pandemic, and PSI-SF scores have been computed. Moreover, results of a short phone survey on the psychological burden during COVID lockdown have been reported. Results This study provides the parental-proxy report of emotional and behavioral profile changes of 23 pediatric patients with epilepsy and neurocognitive and emotional comorbidities during the COVID-19 pandemic. Concerns for therapy monitoring at the time of lockdown emerged in 43% of families, and 30% of patients showed worries for an altered contact with the referring medical team. Patients with neurocognitive comorbidities were more likely to exhibit behavioral problems, especially externalizing problems compared with patients with a diagnosis of anxiety/depression. Conclusion Our data suggest the importance to monitor disease trajectory and behavior and affective symptoms with telehealth strategies to provide effective care to patients and their families., Highlights • COVID-19 pandemic changed the usual healthcare assistance in patients with epilepsy and neuropsychiatric comorbidities • The psychological burden related to the disease might worsen patients and their families' functional profile • Affective symptoms and behavior should be investigated during and after the COVID-19 pandemic in at-risk patients • Special attention should be payed to patients’ families to modulate a suitable emergency teleassistance and support strategy

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2021
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23. Patients with chronic hepatitis C receiving treatment with direct acting antivirals: How is this population changing?

Author

Lombardi, Andrea, primary, Colaneri, Marta, additional, Vijayagopal, Kesav Aditya, additional, Sambo, Margherita, additional, Legnazzi, Patrizia, additional, Sacchi, Paolo, additional, Zuccaro, Valentina, additional, Maiocchi, Laura, additional, Maserati, Renato, additional, Gulminetti, Roberto, additional, Pagnucco, Layla, additional, Novati, Stefano, additional, Zanaboni, Domenico, additional, Michelone, Giuseppe, additional, Ludovisi, Serena, additional, Mondelli, Mario U., additional, and Bruno, Raffaele, additional

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2021
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24. EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count

Author

Paolucci, Stefania, primary, Cassaniti, Irene, additional, Novazzi, Federica, additional, Fiorina, Loretta, additional, Piralla, Antonio, additional, Comolli, Giuditta, additional, Bruno, Raffaele, additional, Maserati, Renato, additional, Gulminetti, Roberto, additional, Novati, Stefano, additional, Mojoli, Francesco, additional, Baldanti, Fausto, additional, Bruno, R, additional, Mondelli, M, additional, Brunetti, E, additional, Di Matteo, A, additional, Seminari, E, additional, Maiocchi, L, additional, Zuccaro, V, additional, Pagnucco, L, additional, Mariani, B, additional, Ludovisi, S, additional, Lissandrin, R, additional, Parisi, A, additional, Sacchi, P, additional, Patruno, SFA, additional, Michelone, G, additional, Gulminetti, R, additional, Zanaboni, D, additional, Novati, S, additional, Maserati, R, additional, Orsolini, P, additional, Vecchia, M, additional, Sciarra, M, additional, Asperges, E, additional, Colaneri, M, additional, Di Filippo, A, additional, Sambo, M, additional, Biscarini, S, additional, Lupi, M, additional, Roda, S, additional, Pieri, TC, additional, Gallazzi, I, additional, Sachs, M, additional, Valsecchi, P, additional, Perlini, S, additional, Alfano, C, additional, Bonzano, M, additional, Briganti, F, additional, Crescenzi, G, additional, Falchi, AG, additional, Guarnone, R, additional, Guglielmana, B, additional, Maggi, E, additional, Martino, I, additional, Pettenazza, P, additional, Pioli di Marco, S, additional, Quaglia, F, additional, Sabena, A, additional, Salinaro, F, additional, Speciale, F, additional, Zunino, I, additional, De Lorenzo, M, additional, Secco, G, additional, Dimitry, L, additional, Cappa, G, additional, Maisak, I, additional, Chiodi, B, additional, Sciarrini, M, additional, Barcella, B, additional, Resta, F, additional, Moroni, L, additional, Vezzoni, G, additional, Scattaglia, L, additional, Boscolo, E, additional, Zattera, C, additional, Tassi, MF, additional, Capozza, V, additional, Vignaroli, D, additional, Bazzini, M, additional, Iotti, G, additional, Mojoli, F, additional, Belliato, M, additional, Perotti, L, additional, Mongodi, S, additional, Tavazzi, G, additional, Marseglia, G, additional, Licari, A, additional, Brambilla, I, additional, Barbarini, D, additional, Bruno, A, additional, Cambieri, P, additional, Campanini, G, additional, Cavanna, C., additional, Comolli, G, additional, Corbella, M, additional, Daturi, R, additional, Furione, M, additional, Marone, P, additional, Monzillo, E, additional, Paolucci, S, additional, Parea, M, additional, Percivalle, E, additional, Piralla, A, additional, Rovida, F, additional, Sarasini, A, additional, Zavattoni, M, additional, Adzasehoun, G, additional, Ardizzone, M, additional, Bellotti, L, additional, Brunco, V, additional, Cabano, E, additional, Casali, G, additional, Capella, L, additional, Devitis, D, additional, Dossena, L, additional, Frisco, G, additional, Garbagnoli, G, additional, Gardellini, F, additional, Girello, A, additional, Guerrizio, A, additional, Landini, V, additional, Lucchelli, C, additional, Maliardi, V, additional, Piemontese, P, additional, Pezzaia, S, additional, Premoli, M, additional, Rebuffa, C, additional, Zanello, C, additional, Bagnarino, J, additional, Bergami, F, additional, Bonetti, A, additional, Caneva, G, additional, Cassaniti, I, additional, Corcione, A, additional, Di Martino, R, additional, Di Napoli, A, additional, Ferrari, A, additional, Ferrari, G, additional, Fiorina, L, additional, Gallone, A, additional, Giardina, F, additional, Girardi, A, additional, Mercato, A, additional, Merla, C, additional, Novazzi, F, additional, Ratano, G, additional, Rossi, B, additional, Saveriaempillai, G, additional, Sciabica, IM, additional, Tallarita, M, additional, Vecchio Nepita, E, additional, Vitali, J, additional, Cerino, A, additional, Varchetta, S, additional, Oliviero, B, additional, Mantovani, S, additional, Mele, D, additional, Calvi, M, additional, Tizzoni, M, additional, Nicora, C, additional, Triarico, A, additional, Petronella, V, additional, Marena, C, additional, Muzzi, A, additional, Lago, P, additional, Cutti, S, additional, Novelli, V, additional, Comandatore, F, additional, BatistiBiffignandi, G, additional, Gaiarsa, S, additional, Rettani, M, additional, and Bandi, C, additional

Published
2021
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25. Severe acute respiratory syndrome coronavirus 2 RNA contamination of inanimate surfaces and virus viability in a health care emergency unit

Author

Colaneri, M., Seminari, E., Novati, S., Asperges, E., Biscarini, S., Piralla, A., Percivalle, E., Cassaniti, I., Baldanti, F., Bruno, R., Mondelli, M. U., Brunetti, E., Di Matteo, A., Maiocchi, L., Zuccaro, V., Pagnucco, L., Ludovisi, S., Lissandrin, R., Parisi, A., Sacchi, P., Patruno, S. F. A., Michelone, G., Gulminetti, R., Zanaboni, D., Maserati, R., Orsolini, P., Vecchia, M., Di Filippo, A., Sambo, M., Lupi, M., Roda, S., Pieri, T. C., Gallazzi, I., Sachs, M., Valsecchi, P., Perlini, S., Alfano, C., Bonzano, M., Briganti, F., Crescenzi, G., Falchi, A. G., Guarnone, R., Guglielmana, B., Maggi, E., Martino, I., Pettenazza, P., di Marco, S. P., Quaglia, F., Sabena, A., Salinaro, F., Speciale, F., Zunino, I., de Lorenzo, M., Secco, G., Dimitry, L., Cappa, G., Maisak, I., Chiodi, B., Sciarrini, M., Barcella, B., Resta, F., Moroni, L., Vezzoni, G., Scattaglia, L., Boscolo, E., Zattera, C., Fidel, T. M., Vincenzo, C., Vignaroli, D., Bazzini, M., Iotti, G., Mojoli, F., Belliato, M., Perotti, L., Mongodi, S., Tavazzi, G., Marseglia, G., Licari, A., Brambilla, I., Barbarini, D., Bruno, A., Cambieri, P., Campanini, G., Cavanna, C., Comolli, G., Corbella, M., Daturi, R., Furione, M., Mariani, B., Marone, P., Monzillo, V., Paolucci, S., Parea, M., Rovida, F., Sarasini, A., Zavattoni, M., Adzasehoun, G., Ardizzone, M., Bellotti, L., Brunco, V., Cabano, E., Casali, G., Capella, L., Devitis, D., Dossena, L., Frisco, G., Garbagnoli, G., Gardellini, F., Girello, A., Guerrizio, A., Landini, V., Lucchelli, C., Maliardi, V., Piemontese, P., Pezzaia, S., Premoli, M., Rebuffa, C., Bagnarino, J., Bergami, F., Bonetti, A., Caneva, G., Corcione, A., Di Martino, R., Di Napoli, A., Ferrari, A., Ferrari, G., Fiorina, L., Gallone, A., Giardina, F., Girardi, A., Mercato, A., Novazzi, F., Ratano, G., Rossi, B., Saverimpilla, G., Sciabica, I. M., Tallarita, M., Nepita, E. V., Vitali, J., Cerino, A., Varchetta, S., Oliviero, B., Mantovani, S., Mele, D., Calvi, M., Tizzoni, M., Nicola, C., Triarico, A., Petronella, V., Marena, C., Muzzi, A., Lago, P., Comandatore, F., Biffignandi, G. B., Gaiarsa, S., Rettani, M., and Bandi, C.

Subjects
0301 basic medicine, Microbiology (medical), Environmental contamination, medicine.medical_treatment, 030106 microbiology, Microbiology, Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus-2, Surfaces, Vero E6 cells, Animals, Betacoronavirus, Chlorocebus aethiops, Coronavirus Envelope Proteins, Equipment Contamination, Fomites, Humans, Intensive Care Units, Microbial Viability, RNA-Dependent RNA Polymerase, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Vero Cells, Viral Envelope Proteins, Viral Proteins, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RNA polymerase, medicine, 030212 general & internal medicine, Continuous positive airway pressure, Respiratory system, Gene, Cytopathic effect, business.industry, RNA, General Medicine, Infectious Diseases, chemistry, Vero cell, business
Abstract

Objectives To detect possible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA contamination of inanimate surfaces in areas at high risk of aerosol formation by patients with coronavirus disease 2019 (COVID-19). Methods Sampling was performed in the emergency unit and the sub-intensive care ward. SARS-CoV-2 RNA was extracted from swabbed surfaces and objects and subjected to real-time RT-PCR targeting RNA-dependent RNA polymerase and E genes. Virus isolation from positive samples was attempted in vitro on Vero E6 cells. Results Twenty-six samples were collected and only two were positive for low-level SARS-CoV-2 RNA, both collected on the external surface of continuous positive airway pressure helmets. All transport media were inoculated onto susceptible cells, but none induced a cytopathic effect on day 7 of culture. Conclusions Even though daily contact with inanimate surfaces and patient fomites in contaminated areas may be a medium of infection, our data obtained in real-life conditions suggest that it might be less extensive than hitherto recognized.

Published
2020
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26. Xanthogranulomatous Pyelonephritis: A Complicated Febrile Urinary Tract Infection Detected by Point-of-Care Ultrasound in the Emergency Department

Author

J. Patterson, Ryan C. Gibbons, Allison Zanaboni, Nicole Leonard, Mark A. Magee, and Thomas G. Costantino

Subjects
Adult, medicine.medical_specialty, Point-of-Care Systems, Urinary system, 030232 urology & nephrology, Flank Pain, 03 medical and health sciences, 0302 clinical medicine, Xanthogranulomatous pyelonephritis, Sepsis, Humans, Medicine, Intensive care medicine, Hydronephrosis, Pyelonephritis, Xanthogranulomatous, Ultrasonography, business.industry, Febrile urinary tract infection, Mortality rate, Point of care ultrasound, 030208 emergency & critical care medicine, Emergency department, medicine.disease, Anti-Bacterial Agents, Emergency Medicine, Female, Pyonephrosis, Emergency Service, Hospital, business
Abstract

Background Febrile urinary tract infections (UTIs) include a spectrum of pathologies from uncomplicated pyelonephritis to urosepsis, including xanthogranulomatous pyelonephritis (XGP). Most febrile UTIs are treated with antibiotics alone, but studies indicate nearly 12% of cases of presumed simple pyelonephritis require emergent urologic intervention. How to identify these individuals, while limiting unnecessary advanced imaging and delays in diagnosis, challenges all emergency providers. We review the diagnosis and management of XGP, as well as the evidence regarding the role of renal ultrasound in the identification of complicated presentations of febrile UTIs. Case Report We present a case of XGP, a complicated febrile UTI requiring immediate urologic intervention, diagnosed by point-of-care ultrasound. A 40-year-old female presented in severe sepsis and complaining of flank pain. Prompt bedside ultrasound demonstrated hydronephrosis, expediting definitive urologic treatment via percutaneous nephrostomy tube placement. Why Should an Emergency Physician Be Aware of This? With a mortality rate exceeding 40%, obstructed pyonephrosis requires prompt decompression. Given its exceptional sensitivity for identifying hydronephrosis and ability to detect abscesses and emphysematous changes, we advocate a point-of-care ultrasound–first approach to screen for cases of complicated febrile UTIs in order to expedite treatment and limit radiation in uncomplicated presentations.

Published
2018

31. Double-binding botulinum molecule with reduced muscle paralysis: Evaluation in in vitro and in vivo models of migraine

Author

Andreou, Anna P., primary, Leese, Charlotte, additional, Greco, Rosaria, additional, Demartini, Chiara, additional, Corrie, Eve, additional, Simsek, Deniz, additional, Zanaboni, Anna, additional, Koroleva, Ksenia, additional, Lloyd, Joseph O., additional, Lambru, Giorgio, additional, Doran, Ciara, additional, Gafurov, Oleg, additional, Seward, Elizabeth, additional, Giniatullin, Rashid, additional, Tassorelli, Cristina, additional, and Davletov, Bazbek, additional

Published
2021
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33. A pilot study for investigating the feasibility of supervised machine learning approaches for the classification of pedestrians struck by vehicles

Author

Andrea Sommariva, Claudio Spada, Alberto Blandino, Rosy Cotroneo, Dario Malchiodi, M.B. Casali, Domenico Furci, Anna Maria Zanaboni, and Umberto Genovese

Subjects
Truck, Decision support system, business.industry, Computer science, Accidents, Traffic, Pilot Projects, ComputerApplications_COMPUTERSINOTHERSYSTEMS, General Medicine, Pedestrian, Machine learning, computer.software_genre, Pathology and Forensic Medicine, Artificial Intelligence, Feasibility Studies, Humans, Wounds and Injuries, Supervised Machine Learning, Artificial intelligence, business, Vehicle type, Law, computer, Pedestrians
Abstract

This research focuses on the application of Artificial Intelligence (AI) methodologies to the problem of classifying vehicles involved in lethal pedestrian collisions. Specifically, the vehicle type is predicted on the basis of traumatic injury suffered by casualties, exploiting machine learning algorithms. In the present study, AI-assisted diagnosis was shown to have correct prediction about 70% of the time. In pedestrians struck by trucks, more severe injuries were appreciated in the facial skeleton, lungs, major airways, liver, and spleen as well as in the sternum/clavicle/rib complex, whereas the lower extremities were more affected by fractures in pedestrians struck by cars. Although the distinction of the striking vehicle should develop beyond autopsy evidence alone, the presented approach which is novel in the realm of forensic science, is shown to be effective in building automated decision support systems. Outcomes from this system can provide valuable information after the execution of autoptic examinations supporting the forensic investigation. Preliminary results from the application of machine learning algorithms with real-world datasets seem to highlight the efficacy of the proposed approach, which could be used for further studies concerning this topic.

Published
2021

34. Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally-induced migraine attacks

Author

Lara Ahmad, Michele Corrado, Roberto De Icco, Grazia Sances, Alessia Putortì, Natascia Realini, Rosaria Greco, Angelo Reggiani, Valentina Grillo, Marta Allena, Chiara Demartini, Cristina Tassorelli, Daniele Martinelli, and Anna Maria Zanaboni

Subjects
Palmitoylethanolamide, business.industry, Pharmacology, medicine.disease, chemistry.chemical_compound, medicine.anatomical_structure, Nociception, Neurology, chemistry, Migraine, medicine, Neurology (clinical), business, Sensitization
Published
2021

35. Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)

Author

Bartoletti, Michele, primary, Giannella, Maddalena, additional, Scudeller, Luigia, additional, Tedeschi, Sara, additional, Rinaldi, Matteo, additional, Bussini, Linda, additional, Fornaro, Giacomo, additional, Pascale, Renato, additional, Pancaldi, Livia, additional, Pasquini, Zeno, additional, Trapani, Filippo, additional, Badia, Lorenzo, additional, Campoli, Caterina, additional, Tadolini, Marina, additional, Attard, Luciano, additional, Puoti, Massimo, additional, Merli, Marco, additional, Mussini, Cristina, additional, Menozzi, Marianna, additional, Meschiari, Marianna, additional, Codeluppi, Mauro, additional, Barchiesi, Francesco, additional, Cristini, Francesco, additional, Saracino, Annalisa, additional, Licci, Alberto, additional, Rapuano, Silvia, additional, Tonetti, Tommaso, additional, Gaibani, Paolo, additional, Ranieri, Vito M., additional, Viale, Pierluigi, additional, Raumer, Luigi, additional, Guerra, Luca, additional, Tumietto, Fabio, additional, Cascavilla, Alessandra, additional, Zamparini, Eleonora, additional, Verucchi, Gabriella, additional, Coladonato, Simona, additional, Rubin, Arianna, additional, Ianniruberto, Stefano, additional, Francalanci, Eugenia, additional, Volpato, Francesca, additional, Virgili, Giulio, additional, Rossi, Nicolò, additional, Del Turco, Elena Rosselli, additional, Guardigni, Viola, additional, Fasulo, Giovanni, additional, Dentale, Nicola, additional, Fulgaro, Ciro, additional, Legnani, Giorgio, additional, Campaci, Emanuele, additional, Basso, Cristina, additional, Zuppiroli, Alberto, additional, Passino, Amalia Sanna, additional, Tesini, Giulia, additional, Angelelli, Lucia, additional, Badeanu, Adriana, additional, Rossi, Agostino, additional, Santangelo, Giulia, additional, Dauti, Flovia, additional, Koprivika, Vidak, additional, Roncagli, Nicholas, additional, Tzimas, Ioannis, additional, Liuzzi, Guido Maria, additional, Baxhaku, Irid, additional, Pasinelli, Letizia, additional, Neri, Mattia, additional, Zanaboni, Tommaso, additional, Dell'Omo, Francesco, additional, Vatamanu, Oana, additional, Gori, Alice, additional, Zavatta, Idina, additional, Antonini, Stefano, additional, Pironi, Chiara, additional, Piccini, Elena, additional, Esposito, Luca, additional, Zuccotti, Alessandro, additional, Urbinati, Giacomo, additional, Pratelli, Agnese, additional, Sarti, Alberto, additional, Semprini, Michela, additional, Evangelisti, Enrico, additional, D'Onofrio, Mara, additional, Sasdelli, Giuseppe, additional, Pizzilli, Giacinto, additional, Pierucci, Elisabetta, additional, Rossini, Giada, additional, Vocale, Caterina, additional, Marconi, Lorenzo, additional, Leoni, Maria Cristina, additional, Fronti, Elisa, additional, Guaraldi, Giovanni, additional, Bavaro, Davide, additional, and Laghetti, Paola, additional

Published
2020
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36. Low risk for SARS-CoV2 symptomatic infection and early complications in paediatric patients during the ongoing CoVID19 epidemics in Lombardy

Author

Rovida, F., primary, Cereda, D., additional, Novati, S., additional, Licari, A., additional, Triarico, A., additional, Marseglia, G.L., additional, Bruno, R., additional, Baldanti, F., additional, Mondelli, M., additional, Brunetti, E., additional, Di Matteo, A., additional, Seminari, E., additional, Maiocchi, L., additional, Zuccaro, V., additional, Pagnucco, L., additional, Mariani, B., additional, Ludovisi, S., additional, Lissandrin, R., additional, Parisi, A., additional, Sacchi, P., additional, Patruno, S.F.A., additional, Michelone, G., additional, Gulminetti, R., additional, Zanaboni, D., additional, Maserati, R., additional, Orsolini, P., additional, Vecchia, M., additional, Sciarra, M., additional, Asperges, E., additional, Colaneri, M., additional, Di Filippo, A., additional, Sambo, M., additional, Biscarini, S., additional, Lupi, M., additional, Roda, S., additional, Pieri, T.C., additional, Gallazzi, I., additional, Sachs, M., additional, Valsecchi, P., additional, Perlini, S., additional, Alfano, C., additional, Bonzano, M., additional, Briganti, F., additional, Crescenzi, G., additional, Falchi, A.G., additional, Guarnone, R., additional, Guglielmana, B., additional, Maggi, E., additional, Martino, I., additional, Pettenazza, P., additional, Pioli di Marco, S., additional, Quaglia, F., additional, Sabena, A., additional, Salinaro, F., additional, Speciale, F., additional, Zunino, I., additional, De Lorenzo, M., additional, Secco, G., additional, Dimitry, L., additional, Cappa, G., additional, Maisak, I., additional, Chiodi, B., additional, Sciarrini, M., additional, Barcella, B., additional, Resta, F., additional, Moroni, L., additional, Vezzoni, G., additional, Scattaglia, L., additional, Boscolo, E., additional, Zattera, C., additional, Tassi, M.F., additional, Capozza, V., additional, Vignaroli, D., additional, Bazzini, M., additional, Iotti, G., additional, Mojoli, F., additional, Belliato, M., additional, Perotti, L., additional, Mongodi, S., additional, Tavazzi, G., additional, Marseglia, G., additional, Brambilla, I., additional, Barbarini, D., additional, Bruno, A., additional, Cambieri, P., additional, Campanini, G., additional, Comolli, G., additional, Corbella, M., additional, Daturi, R., additional, Furione, M., additional, Monzillo, E., additional, Paolucci, S., additional, Parea, M., additional, Percivalle, E., additional, Piralla, A., additional, Rovida, F., additional, Sarasini, A., additional, Zavattoni, M., additional, Adzasehoun, G., additional, Bellotti, L., additional, Cabano, E., additional, Casali, G., additional, Dossena, L., additional, Frisco, G., additional, Garbagnoli, G., additional, Girello, A., additional, Landini, V., additional, Lucchelli, C., additional, Maliardi, V., additional, Pezzaia, S., additional, Premoli, M., additional, Bonetti, A., additional, Caneva, G., additional, Cassaniti, I., additional, Corcione, A., additional, Di Martino, R., additional, Di Napoli, A., additional, Ferrari, A., additional, Ferrari, G., additional, Fiorina, L., additional, Giardina, F., additional, Mercato, A., additional, Novazzi, F., additional, Ratano, G., additional, Rossi, B., additional, Sciabica, I.M., additional, Tallarita, M., additional, Vecchio Nepita, E., additional, Calvi, M., additional, Tizzoni, M., additional, Nicora, C., additional, Petronella, V., additional, Marena, C., additional, Muzzi, A., additional, and Lago, P., additional

Published
2020
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39. Information and communications technologies in low and middle-income countries: Survey results on economic development and health

Author

Claudio Dario, Theodoros Karapiperis, Sarah Mccormack, Giorgio Micheletti, Göran Tomson, Laura Delponte, Paolo Zanaboni, Laurent Bonnardot, Gianluca Quaglio, and Giovanni Putoto

Subjects
Economic growth, business.industry, 030503 health policy & services, Health Policy, Biomedical Engineering, Psychological intervention, Developing country, Investment (macroeconomics), Human capital, 03 medical and health sciences, 0302 clinical medicine, Information and Communications Technology, parasitic diseases, Health care, Structured interview, Sustainability, 030212 general & internal medicine, 0305 other medical science, business
Abstract

Background Despite the wide gap between the developed and developing world in terms of ICT access, ICT investment in low and middle-income countries (LMICs) has increased due to the rapid development of mobile services. However, the effects of ICTs in LMICs remain debatable. Methods An online survey was conducted to collect feedback from experts. The questionnaire explored the role of ICTs in the economic development of LMICs, investigated the benefits and limits of e-health, and collected evaluations of past EU initiatives on future development policies. Structured interviews were also carried out with ten of the respondents. Results One hundred and forty-five experts responded to the survey. Health and education were considered to be the two main areas where ICTs can support economic development. Poor infrastructure, lack of political support and human capital, and poor affordability were found to be the main obstacles. The shortcomings of donors in fostering the role of ICTs in LMICs development were identified as sustainability of interventions and lack of a coherent approach. The main benefits of e-health technologies in LMICs are their ability to facilitate health information and increase access to health care. Remote data collection, training for healthcare workers and education are the most effective m-health applications. Poor infrastructure and lack of equipment are considered the main barriers to the use of e-health in LMICs. Limited financial resources and lack of policy and regulatory frameworks might prevent the scaling up of e-health. Conclusions The results of this survey can support decision makers and healthcare managers to better plan and implement ICTs in LMICs and make improved use of European resources for development.

Published
2016

40. Double-binding botulinum molecule with reduced muscle paralysis: Evaluation in in vitro and in vivo models of migraine

Author

Cristina Tassorelli, Rashid Giniatullin, Oleg Gafurov, Anna Zanaboni, Rosaria Greco, Ksenia Koroleva, Eve Corrie, Deniz Simsek, Charlotte Leese, Giorgio Lambru, Anna P. Andreou, Ciara Doran, Elizabeth P. Seward, Bazbek Davletov, Chiara Demartini, and Joseph O Lloyd

Subjects
0301 basic medicine, Male, 0106 biological sciences, medicine.medical_specialty, Neurology, Botulinum Toxins, Migraine Disorders, Stimulation, Neurological disorder, Pharmacology, Toxicology, 01 natural sciences, Rats, Sprague-Dawley, Nitroglycerin, 03 medical and health sciences, 0302 clinical medicine, Chronic Migraine, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Pharmacology (medical), Muscle, Skeletal, Analgesics, 0303 health sciences, Electromyography, business.industry, 010604 marine biology & hydrobiology, 030302 biochemistry & molecular biology, medicine.disease, Rats, 3. Good health, Disease Models, Animal, 030104 developmental biology, Trigeminal Ganglion, Migraine, Calcitonin, Hyperalgesia, Nociceptor, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability. Current oral medications for migraine show variable effects and are frequently associated with intolerable side effects, leading to the dissatisfaction of both patients and doctors. Injectable therapeutics, which include calcitonin gene–related peptide–targeting monoclonal antibodies and botulinum neurotoxin A (BoNT/A), provide a new paradigm for treatment of chronic migraine but are effective only in approximately 50% of subjects. Here, we investigated a novel engineered botulinum molecule with markedly reduced muscle paralyzing properties which could be beneficial for the treatment of migraine. This stapled botulinum molecule with duplicated binding domain—binary toxin-AA (BiTox/AA)—cleaves synaptosomal-associated protein 25 with a similar efficacy to BoNT/A in neurons; however, the paralyzing effect of BiTox/AA was 100 times less when compared to native BoNT/A following muscle injection. The performance of BiTox/AA was evaluated in cellular and animal models of migraine. BiTox/AA inhibited electrical nerve fiber activity in rat meningeal preparations while, in the trigeminovascular model, BiTox/AA raised electrical and mechanical stimulation thresholds in Aδ- and C-fiber nociceptors. In the rat glyceryl trinitrate (GTN) model, BiTox/AA proved effective in inhibiting GTN-induced hyperalgesia in the orofacial formalin test. We conclude that the engineered botulinum molecule provides a useful prototype for designing advanced future therapeutics for an improved efficacy in the treatment of migraine.

Published
2021

41. First evidence of purple pigment production and dyeing in southern Arabia (Sumhuram, Sultanate of Oman) revealed by mass spectrometric and chromatographic techniques

Author

Maria Perla Colombini, Marco Zanaboni, Alexia Pavan, Erika Ribechini, Ilaria Degano, and Josefina Pérez-Arantegui

Subjects
History, Archeology, Molecular composition, Materials Science (miscellaneous), Conservation, HPLC-DAD, LDI-MS, Alizarin, 01 natural sciences, Indigo, Southern Arabia, Pigment, chemistry.chemical_compound, 0601 history and archaeology, Spectroscopy, Dyeing, 060102 archaeology, Purple, Chemistry, 010401 analytical chemistry, Madder, 06 humanities and the arts, Mass spectrometric, Archaeology, Pigment production, 0104 chemical sciences, Organic fraction, Chemistry (miscellaneous), Anthropology, visual_art, visual_art.visual_art_medium, Pottery, General Economics, Econometrics and Finance
Abstract

Archaeological excavations carried out in the ancient settlement of Sumhuram (3rd century BC–5th century AD) in the area of Khor Rori (Dhofar Governorate, southern Oman), brought to light pottery showing a pink-violet substance. In order to reveal the nature of this pink-violet colour, the substance was chemically examined by laser desorption-ionization mass spectrometry (LDI-MS) and high performance liquid chromatography-diode array detection (HPLC-DAD). The analytical investigations provided a detailed molecular composition of the organic fraction of the pink-violet material, highlighting the presence of 6,6′-dibromoindigo, 6-monobromoindigo, 6,6′-dibromoindirubin, 6- and 6′-monobromoindirubin, indigo and indirubin. The results revealed that shellfish purple was the source. In addition, in some of the pottery fragments, alizarin and purpurin, which are the molecular markers of madder type dyestuffs, were also ascertained by LDI-MS. The analytical results enabled us to draw hypotheses not only on the possible function of such vessels as dye baths, but also that, since Sumhuram was one of the most important harbours in southern Arabia during the pre-Islamic time, it was also possibly a centre for the production and trade of purple pigments.

Published
2016

42. Assessment of right ventricular function by feature-tracking echocardiography in conscious healthy dogs

Author

Anna Maria Zanaboni, Claudio Bussadori, I. Spalla, Chiara Locatelli, and Paola Brambilla

Subjects
Male, medicine.medical_specialty, 040301 veterinary sciences, Heart Ventricles, Coefficient of variation, 030204 cardiovascular system & hematology, Free wall, 0403 veterinary science, Correlation, 03 medical and health sciences, Dogs, 0302 clinical medicine, Internal medicine, Heart rate, medicine, Animals, General Veterinary, Ventricular function, business.industry, Significant difference, Reproducibility of Results, 04 agricultural and veterinary sciences, Breed, Echocardiography, Ventricular Function, Right, Cardiology, Feature tracking, Female, business
Abstract

Advanced two-dimensional echocardiographic techniques allow strain (S) analysis of regional function and thus can provide information on regional myocardial deformation. Feature-tracking echocardiography (FTE) is based on a mono-dimensional technology and may offer more detailed information about septal deformation because it can analyse the activity of left- and right-sided septal fibres separately. The present study aimed to quantify global and regional (free wall and septal) right ventricular (RV) longitudinal S and strain rate (SR). We also investigated the relationships of S and SR with age, sex, weight, breed (sighthound breed vs other breeds), and heart rate. Cine loops were acquired from the left apical four-chamber view, optimized for the RV, in 60 dogs. The within-day and between-day intra-observer coefficient of variation for global RV S and SR in normal dogs using FTE was acceptable (

Published
2016

43. Monitoring/characterization of stickies contaminants coming from a papermaking plant – Toward an innovative exploitation of the screen rejects to levulinic acid

Author

Claudia Antonetti, Domenico Licursi, Marco Martinelli, Anna Maria Raspolli Galletti, Marco Zanaboni, and Erika Ribechini

Subjects
Paper, Energy recovery, Levulinic acid, Plastic contaminants, Screen rejects, Waste incineration, Waste Management and Disposal, 0106 biological sciences, Industrial Waste, Stickies, 01 natural sciences, Industrial waste, chemistry.chemical_compound, Waste Management, 010608 biotechnology, Recycling, Cellulose, 040101 forestry, Waste management, Papermaking, cardboard, 04 agricultural and veterinary sciences, Levulinic Acids, Incineration, Cellulose fiber, chemistry, visual_art, visual_art.visual_art_medium, 0401 agriculture, forestry, and fisheries, Environmental science
Abstract

Recycled paper needs a lot of mechanical/chemical treatments for its re-use in the papermaking process. Some of these ones produce considerable rejected waste fractions, such as "screen rejects", which include both cellulose fibers and non-fibrous organic contaminants, or "stickies", these last representing a shortcoming both for the papermaking process and for the quality of the final product. Instead, the accepted fractions coming from these unit operations become progressively poorer in contaminants and richer in cellulose. Here, input and output streams coming from mechanical screening systems of a papermaking plant using recycled paper for cardboard production were sampled and analyzed directly and after solvent extraction, thus confirming the abundant presence of styrene-butadiene rubber (SBR) and ethylene vinyl acetate (EVA) copolymers in the output rejected stream and cellulose in the output accepted one. Despite some significant drawbacks, the "screen reject" fraction could be traditionally used as fuel for energy recovery within the paper mill, in agreement with the integrated recycled paper mill approach. The waste, which still contains a cellulose fraction, can be also exploited by means of the hydrothermal route to give levulinic acid, a platform chemical of very high value added.

Published
2016

44. FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

Author

Chiara Demartini, Cristina Tassorelli, Elena Tumelero, Anna Maria Zanaboni, Angelo Reggiani, Daniele Piomelli, Alessandra Misto, and Rosaria Greco

Subjects
Male, 0301 basic medicine, Migraine Disorders, Vasodilator Agents, Central nervous system, Endogeny, Pharmacology, lcsh:RC321-571, Amidohydrolases, Rats, Sprague-Dawley, Nitroglycerin, 03 medical and health sciences, chemistry.chemical_compound, Trigeminal Caudal Nucleus, 0302 clinical medicine, Animals, Medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Migraine, business.industry, Anandamide, URB597, Endocannabinoid system, Rats, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, nervous system, Neurology, chemistry, Benzamides, Hyperalgesia, Locus coeruleus, lipids (amino acids, peptides, and proteins), Carbamates, medicine.symptom, business, 030217 neurology & neurosurgery, Intracellular
Abstract

Background Fatty-acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (AEA). We previously reported that the peripherally restricted FAAH inhibitor URB937, which selectively increases AEA levels outside the central nervous system, reduces hyperalgesia and c-Fos expression in the trigeminal nucleus caudalis (TNC) and the locus coeruleus in an animal model of migraine based on nitroglycerin (NTG) administration. Aim To further investigate the relevance of FAAH inhibition in the NTG animal model of migraine by testing the effects of the globally active FAAH inhibitor URB597. Methods Our experimental approach involved mapping neuronal c-Fos protein expression, measurement of AEA levels in brain areas and in trigeminal ganglia, evaluation of pain-related behavior and quantification of molecular mediators in rats that received URB597 (2 mg/kg i.p.) either before or after NTG administration (10 mg/kg, i.p.). Results Pre-treatment with URB597 significantly reduced c-Fos immunoreactivity in the TNC and inhibited NTG-induced hyperalgesia in the orofacial formalin test. This behavioral response was associated with a decrease in neuronal nitric oxide synthase, calcitonin gene-related peptide and cytokine gene expression levels in central and peripheral structures. Administration of URB597 after NTG had no such effect. Conclusions The findings suggest that global FAAH inhibition may offer a therapeutic approach to the prevention, but not the abortive treatment, of migraine attacks. Further studies are needed to elucidate the exact cellular and molecular mechanisms underlying the protective effects of FAAH inhibition.

Published
2020

46. Implementation of laparoscopic approach for type B radical hysterectomy: A comparison with open surgical operations

Author

Domenica Lorusso, Antonino Ditto, Maria Luisa Gasparri, Flavia Zanaboni, Fabio Martinelli, Giorgio Bogani, Francesco Raspagliesi, and Violante Di Donato

Subjects
Adult, medicine.medical_specialty, Survival, Adolescent, Operative Time, Uterine Cervical Neoplasms, Length of hospitalization, Laparoscopy, Morbidity, Open surgery, Type II radical hysterectomy, Oncology, Surgery, Hysterectomy, Disease-Free Survival, Young Adult, Postoperative Complications, Humans, Medicine, Radical Hysterectomy, Stage (cooking), Pathological, Modified radical hysterectomy, Aged, Neoplasm Staging, Retrospective Studies, Cervical cancer, medicine.diagnostic_test, business.industry, Carcinoma, General Medicine, Length of Stay, Middle Aged, medicine.disease, Treatment Outcome, Carcinoma, Squamous Cell, Feasibility Studies, Lymph Node Excision, Operative time, Female, Lymph Nodes, business
Abstract

To investigate the safety, feasibility and effectiveness of laparoscopic approach in the management patients undergoing modified radical hysterectomy for early stage cervical cancer.Consecutive data of 157 women who had class II radical hysterectomy, for stage IA2 and stage IB12 cm cervical cancer, were prospectively collected. Data of patients undergoing surgery via laparoscopy (LRH) were compared with those undergoing open surgical operations (RAH). A propensity-matched comparison (1:1) was carried out to minimize as possible selection biases. Post-operative complications were graded per the Clavien-Dindo classification. Five-year survival outcomes were assessed using Kaplan-Meier model.After the exclusion of 37 (23.5%) patients on the basis of propensity-matching, 60 patients undergoing LRH were compared with 60 patients undergoing RAH. No between-group differences in baseline, disease and pathological variables were observed (p0.05). Patients undergoing surgery via laparoscopy experienced longer operative time than patients undergoing RAH; while LRH correlated whit shorter length of hospitalization and lower blood loss in comparison to RAH. Intra- and post-operative complication rate was similar between groups (p = 1.00). The execution of LRH or RAH did not influence site of recurrence (p0.2) as well as survival outcomes, in term of 5-year disease-free (p = 0.29, log-rank test) and overall survivals (p = 0.50, log-rank test).Laparoscopic approach is a safe procedure, upholds the results of RAH, reducing invasiveness of open surgical operations. Further large prospective investigations are warranted.

Published
2015

47. Low CURB-65 is of limited value in deciding discharge of patients with community-acquired pneumonia

Author

Federico Piffer, Paolo Tarsia, Anna Maria Brambilla, Francesco Blasi, Stefano Aliberti, Paula Peyrani, Anna Maria Zanaboni, Valeria Rossetti, Julio A. Ramirez, Roberto Cosentini, Aliberti, S, Ramirez, J, Cosentini, R, Brambilla, A, Zanaboni, A, Rossetti, V, Tarsia, P, Peyrani, P, Piffer, F, and Blasi, F

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Community-acquired pneumonia, Pneumonia severity index, Decision Making, education, Choice Behavior, Sensitivity and Specificity, Severity of Illness Index, Cardiovascular events, Hypoxemia, Predictive Value of Tests, Risk Factors, CURB-65 score, medicine, Humans, Simplified Acute Physiology Score, Intensive care medicine, Aged, Retrospective Studies, MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, business.industry, Medical record, Retrospective cohort study, Pneumonia, medicine.disease, CURB-65, Patient Discharge, humanities, CURB65 score, Community-Acquired Infections, Hospitalization, MED/17 - MALATTIE INFETTIVE, Italy, Site-of-care, Predictive value of tests, Practice Guidelines as Topic, Emergency medicine, Female, Observational study, business
Abstract

Summary Background The relationship between clinical judgment and indications of the CURB-65 score in deciding the site-of-care for patients with community-acquired pneumonia (CAP) has not been fully investigated. The aim of this study was to evaluate reasons for hospitalization of CAP patients with CURB-65 score of 0 and 1. Methods An observational, retrospective study of consecutive CAP patients was performed at the Fondazione Ca Granda, Milan, Italy, between January 2005 and December 2006. The medical records of hospitalized patients with CAP having a CURB-65 score of 0 and 1 were identified and reviewed to determine whether there existed a clinical basis to justify hospitalization. Results Among the 580 patients included in the study, 218 were classified with a CURB-65 score of 0 or 1. Among those, 127 were hospitalized, and reasons that justified hospitalization were found in 104 (83%) patients. Main reasons for hospitalization included the presence of hypoxemia on admission (35%), failure of outpatient therapy (14%) and the presence of cardiovascular events on admission (9.7%). Used as the sole indicator for inappropriate hospitalization, the CURB-65 score had a poor positive predictive value of 52%. Conclusions Although the CURB-65 has been proposed as a tool to guide the site of care decision by international guidelines, this score is not ideal by itself, and should not be regarded as providing decision support information if a score of 0 and 1 is present. In CAP patients with CURB-65 scores of 0 or 1, further evaluations should be performed and completed by clinical judgment.

Published
2011

48. Combination of deferasirox and deferoxamine in clinical practice: An alternative scheme of chelation in thalassemia major patients

Author

Mirella Fraquelli, Laura Zanaboni, Alberto Roghi, Maria Domenica Cappellini, Elena Cassinerio, Lorena Duca, Erika Poggiali, and Nicola Orofino

Subjects
Adult, Male, medicine.medical_specialty, Iron Overload, Thalassemia, Deferoxamine, Benzoates, Gastroenterology, chemistry.chemical_compound, Internal medicine, medicine, Humans, Chelation therapy, Molecular Biology, biology, business.industry, beta-Thalassemia, Deferasirox, Cell Biology, Hematology, Triazoles, medicine.disease, Chelation Therapy, Surgery, Ferritin, Treatment Outcome, Tolerability, chemistry, Concomitant, biology.protein, Molecular Medicine, Drug Therapy, Combination, Female, Deferiprone, business, medicine.drug
Abstract

The availability of three iron chelators improved the scenario of chelation therapy for transfusion-dependent thalassemia (TDT) patients, allowing tailoring of drugs according to the goals expected for each patient. The use of Deferiprone/Deferoxamine (DFP/DFO) combined in different schemes has been reported since many years. Only recently data from combination of Deferasirox/Deferoxamine (DFX/DFO) have been reported showing that it can be safe and efficacious to remove iron overload, particularly in patients who do not respond adequately to a single chelating agent. We investigated the efficacy, tolerability and safety of combined DFX/DFO in thalassemia major patients. Ten TDT patients have started DFX/DFO for different reasons: 1) lack of efficacy in removing liver/cardiac iron with monotherapy; 2) agranulocytosis on DFP; and 3) adverse events with elevated doses of monotherapies. The study design included: cardiac and hepatic T2* magnetic resonance (CMR), transient elastography evaluation (Fibroscan), biochemical evaluation, and audiometric and ocular examinations. The drugs' starting doses were: DFO 32 ± 4 mg/kg/day for 3-4 days a week and DFX 20 ± 2 mg/kg/day. Seven patients completed the one-year follow-up period. At baseline the mean pre-transfusional Hb level was 9.4 ± 0.4 g/dl, the mean iron intake was 0.40 ± 0.10mg/kg/day, the median ferritin level was 2254 ng/ml (range 644-17,681 ng/ml). Data available at 1 year showed no alteration of renal/hepatic function and no adverse events. A marked reduction in LIC (6.54 vs 11.44 mg/g dw at baseline) and in median ferritin (1346 vs 2254 ng/ml at baseline) was achieved. A concomitant reduction of non-transferrin-bound iron (NTBI) at six months was observed (2.1 ± 1.0 vs 1.7 ± 1.2 μM). An improvement in cardiac T2* values was detected (26.34 ± 15.85 vs 19.85 ± 12.06 at baseline). At 1 year an increased dose of DFX was administered (27 ± 6 mg/kg/day vs 20 ± 2 mg/kg/day at baseline, p=0.01) with a stable dose of DFO (32 ± 4 mg/kg/day). Combined or alternated DFX/DFO can be considered when monotherapy is not able to remove the iron overload or in the presence of adverse events.

Published
2014

49. Thalassemic osteopathy: A new marker of bone deposition

Author

Lorena Airaghi, Maria Domenica Cappellini, Stella Forti, Fabio Massimo Ulivieri, Marina Baldini, Laura Zanaboni, Alessia Marcon, and A. Orsatti

Subjects
Adult, Male, medicine.medical_specialty, Bone disease, Osteocalcin, Osteoporosis, Bone tissue, Collagen Type I, Bone resorption, Bone remodeling, Young Adult, Absorptiometry, Photon, Bone Density, Internal medicine, medicine, Humans, Molecular Biology, biology, business.industry, beta-Thalassemia, Cell Biology, Hematology, Middle Aged, medicine.disease, Peptide Fragments, Osteopenia, Bone Diseases, Metabolic, medicine.anatomical_structure, Endocrinology, biology.protein, Molecular Medicine, Photon absorptiometry, Female, business, Biomarkers, Procollagen
Abstract

Osteopathy represents a prominent cause of morbidity in patients with beta-thalassemia major (TM) and manifests as osteopenia/osteoporosis. Biochemical turnover markers (BTMs) are considered a useful, non-invasive tool for the clinical follow-up of osteoporotic patients; they can provide a dynamic view of the remodeling process and give information on the metabolic activity of bone tissue as well as on the pathogenesis of bone loss. The amino-terminal pro-peptide of type I procollagen (P1NP) is a recently introduced marker that is considered the most sensitive index of bone formation. Although demonstrated in several categories of patients with bone disease, there is little information on the clinical usefulness of this bone formation index in thalassemic patients. We evaluated the P1NP levels of 53 adult patients with b-thalassemia major (21 males and 32 females, mean age 34.5 ± 5.7, range 22-46 years) and associated osteopathy. We investigated the correlation between P1NP and bone condition as examined by dual X-ray photon absorptiometry and with BTMs expressing bone resorption and bone mineralization (carboxyterminal collagen cross-linked (CTX) terminal regions of type I collagen and osteocalcin, respectively). P1NP serum levels were correlated with CTX levels (r=0.545, p

Published
2014

50. Percutaneous and surgical treatment of pyogenic liver abscesses: Observation over a 21-year period in 148 patients

Author

D. Zanaboni, Rosario Gulizia, Carlo Filice, Giovanna Ferraioli, F.P. Tinozzi, Enrico Brunetti, A. L. Garlaschelli, Calogero Cammà, FERRAIOLI G, GARLASCHELLI A, ZANABONI D, GULIZIA R, BRUNETTI E, TINOZZI FP, CAMMA' C, and FILICE C

Subjects
Adult, Male, medicine.medical_specialty, Percutaneous, Punctures, percutaneous, surgical treatment, phyogenic liver abscess, medicine, Humans, Abscess, Surgical treatment, Multiple abscesses, Aged, Retrospective Studies, Aged, 80 and over, Pyogenic liver abscess, Hepatology, business.industry, Significant difference, Gastroenterology, Retrospective cohort study, Length of Stay, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Liver Abscess, Pyogenic, Drainage, Female, Morbidity, business, Liver abscess
Abstract

Percutaneous drainage of pyogenic liver abscess has become first-line treatment. In the past surgical drainage was preferred in some centres.The aim of this retrospective study was to assess the effectiveness of percutaneous treatments and surgical drainage, in terms of treatment success, hospital stay and costs.Data of 148 patients (90 males; 58 females; mean age, 61 yrs; range, 30-86 yrs) were retrospectively analysed.Patients' outcomes, including the length of hospital stay, procedure-related complications, treatment failure and death, were recorded. Multiple logistic regression model was used for statistical analysis.One hundred and four patients (83 with solitary and 21 with multiple abscesses) were treated percutaneously, either by needle aspiration (91 patients) or catheter drainage (13 patients) depending on the abscess's size, and 44 patients (30 with solitary and 14 with multiple abscesses) were treated surgically. There was no statistically significant difference in patients' demographics or abscess characteristics between groups. Hospital stay was longer, and costs were higher in patients treated surgically (p0.001). There was statistically significant difference in morbidity rate between groups (p0.001). No death occurred in both groups.Percutaneous and surgical treatment of pyogenic liver abscesses are both effective, nevertheless percutaneous drainage carries lower morbidity and is cheaper.

Published
2008

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