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This paper spatially extended the vehicle life-cycle analysis of a single country and developed a new method for vehicle life-cycle analysis by combining a 15-country automotive stock-flow model based on the 15-country automotive lifetime distribution with global multi-regional input-output analysis. From the results, considering that ten of the 15 countries had vehicle lifetimes shorter than the average of 15.8 years: Austria, Canada, Germany, France, the U.K., Ireland, Italy, Japan, South Korea, and the Netherlands, we found that by increasing the average vehicle lifetimes of these 10 countries to the global average of 15.8 years, a reduction of 17 Mt-CO2-eq. from the carbon footprint of the 10 countries could be achieved. In addition, we also revealed that roles of changes in vehicle lifetime and fuel efficiency on global CO2 emissions are vastly different between countries where vehicle lifetimes are longer and those where lifetimes are shorter.

In 1951, the Japanese government introduced a vehicle safety inspection system and this system has an effect of shortening the 'economic' lifetimes of automobiles and increasing CO2 emissions associated with vehicle life-cycle. This study develops an integrated assessment framework by combining dynamic discrete choice analysis with life-cycle environmental accounting analysis based on a dynamic stock model. From the empirical results, we found that (1) the economic lifetime of a Prius in the benchmark model is surprisingly short, 5.07 years, due to the strict car inspection system, and this replacement cycle has contributed to increasing CO2 over time; and (2) abolishing car inspections at the third and fifth years would considerably contribute to reducing life-cycle CO2 emissions associated with Prius sold during the study period, 1997 to 2016, accounting for approximately one million tons-CO2 eq. over 20 years. Thus, we conclude that modifying the regulation policy with a focus on the car inspection system to induce car owners to keep their automobiles longer would have environmental benefits.

Canine glioma is a common brain tumor with poor prognosis despite surgery and/or radiation therapy. Therefore, newer and more effective treatment modalities are needed. Neuregulin 3 (NRG3) has known to be a ligand of ERBB4. This study aimed to investigate the usefulness of the NRG3/ERBB4 signaling cascade as a novel therapeutic target in canine glioma. We found out that microRNA (miR)-190a was downregulated in canine brain tumor tissues, including glioma and meningioma. miR-190a directly targeted NRG3 and inhibited the growth of canine glioma cells. The level of p-Akt, which is a downstream target of ERBB4 signaling, was decreased by transfection with miR-190a. NRG3 silencing also suppressed cell growth and decreased the levels of p-Akt and p-ERK1/2, and NRG3 overexpression exhibited opposed effects in canine glioma J3T-1 cells. The mRNA level of erbb4 was significantly upregulated in glioma tissues compared with that in normal brain tissues and meningioma tissues. Furthermore, compared with gefitinib and lapatinib, afatinib exerted a greater inhibitory effect on the growth of canine glioma cells. In conclusion, NRG3/ERBB4 signaling is negatively regulated by miR-190a and contributes to the growth of canine glioma cells, indicating that it may be a promising therapeutic target in canine glioma.