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Your search keyword '"Yu, Lintao"' showing total 22 results
Start Over Author "Yu, Lintao" Publisher elsevier bv
22 results on '"Yu, Lintao"'

1. Establishment and clinical application of A Candidate Reference Measurement Procedure for Quantification of Urinary Vanillylmandelic acid and Homovanillic Acid using ID-LC-MS/MS method

Author

Yu, Lintao, primary, Kang, Shiyue, additional, Cheng, Long, additional, Zhang, Qiaoxuan, additional, Ouyang, Fen, additional, Han, Liqiao, additional, Zhan, Min, additional, Liao, Dezheng, additional, Zhang, Pengwei, additional, Yan, Jun, additional, and Huang, Xianzhang, additional

Published
2024
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2. Measurement of serum uric acid by isotope dilution liquid chromatography tandem mass spectrometry: Modification of a candidate reference measurement method and its clinical application

Author

Yan, Jun, primary, Lin, Haibiao, additional, Xu, Yuzhu, additional, Yu, Lintao, additional, Chen, Song, additional, Zhang, Qiaoxuan, additional, Han, Liqiao, additional, Ou, Yangfen, additional, Zhan, Min, additional, Wang, Jianbing, additional, Ke, Peifeng, additional, Wang, Yunxiu, additional, and Huang, Xianzhang, additional

Published
2022
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8. Research on Spectrum Sharing Algorithm Based on Potential Game Theory

Author

Zhou Yuxuan, Luo Shouzhi, and Yu Lintao

Subjects
Computer Science::Computer Science and Game Theory, Optimization problem, Computer science, Spectrum (functional analysis), 020206 networking & telecommunications, 020302 automobile design & engineering, Throughput, 02 engineering and technology, Interference (wave propagation), Frequency allocation, symbols.namesake, Cognitive radio, 0203 mechanical engineering, Nash equilibrium, 0202 electrical engineering, electronic engineering, information engineering, symbols, General Earth and Planetary Sciences, Potential game, Spectrum sharing, Throughput (business), Algorithm, General Environmental Science, Communication channel
Abstract

Aiming at the problem of dynamic spectrum allocation in cognitive radio network, a novel spectrum allocation sharing algorithm based on improved interference coordination（Non-cooperation Spectrum Sharing Algorithm based on Interference Coordination, NCSSA-IC）is proposed. Firstly, the spectrum allocation problem is transformed into joint optimization problem. Then, the potential game algorithm is used to realize the optimal spectrum allocation scheme. In the stage of allocation, the second users choose the communication channel that can minimize the interference and maximize the throughput of the system, thus achieving the optimal spectrum allocation. Finally, the proposed algorithm is compared with other algorithms verified by spectrum allocation simulation. All the experiment results indicate that the proposed algorithm could converge to Nash equilibrium in a short time, and the total interference of the system is reduced to minimal and the throughput of the user could reach the maximum. Meanwhile the fairness of the users is greatly improved, and the efficient utilization of the spectrum realized.

Published
2018

9. Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease

Author

Ma Qianwen, Zhipei Sang, Wang Huijuan, Wenmin Liu, Wang Keren, Han Xue, Huifang Wang, Yu Lintao, and Ye Mengyao

Subjects
0301 basic medicine, Monoamine Oxidase Inhibitors, Molecular model, Cell Survival, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Phthalimides, 01 natural sciences, Biochemistry, Phthalimide, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Alzheimer Disease, Cell Line, Tumor, Drug Discovery, Cholinesterases, Humans, Amines, Cytotoxicity, Monoamine Oxidase, Molecular Biology, Cholinesterase, Binding Sites, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, In vitro, Protein Structure, Tertiary, 0104 chemical sciences, Molecular Docking Simulation, Kinetics, 030104 developmental biology, Blood-Brain Barrier, Drug Design, biology.protein, Lipinski's rule of five, Molecular Medicine, Cholinesterase Inhibitors, Monoamine oxidase B
Abstract

A series of novel phthalimide-alkylamine derivatives were synthesized and evaluated as multi-functions inhibitors for the treatment of Alzheimer’s disease (AD). The results showed that compound TM - 9 could be regarded as a balanced multi-targets active molecule. It exhibited potent and balanced inhibitory activities against ChE and MAO-B ( hu AChE, hu BuChE, and hu MAO-B with IC 50 values of 1.2 μM, 3.8 μM and 2.6 μM, respectively) with low selectivity. Both kinetic analysis of AChE inhibition and molecular modeling study suggested that TM - 9 binds simultaneously to the catalytic active site and peripheral anionic site of AChE. Interestingly, compound TM - 9 abided by Lipinski’s rule of five. Furthermore, our investigation proved that TM - 9 indicated weak cytotoxicity, and it could cross the blood-brain barrier (BBB) in vitro . The results suggest that compound TM - 9 , an interesting multi-targeted active molecule, offers an attractive starting point for further lead optimization in the drug-discovery process against Alzheimer’s disease.

Published
2017

12. Design, synthesis and biological evaluation of 3,4-dihydro-2(1 H )-quinoline- O -alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease

Author

Yu Lintao, Wanli Pan, Zhipei Sang, Liu Wenmin, Wang Keren, and Ma Qinge

Subjects
0301 basic medicine, Monoamine Oxidase Inhibitors, Swine, Monoamine oxidase, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Alzheimer Disease, Drug Discovery, Animals, Humans, Monoamine Oxidase, Molecular Biology, Butyrylcholinesterase, Cholinesterase, Oxidase test, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Quinoline, Active site, Acetylcholinesterase, 0104 chemical sciences, 030104 developmental biology, Blood-Brain Barrier, Drug Design, Electrophorus, Quinolines, biology.protein, Lipinski's rule of five, Molecular Medicine, Cholinesterase Inhibitors
Abstract

A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase (MAO) A and B, has been synthesized. Novel 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives have been designed using a conjunctive approach that combines the JMC49 and donepezil. The most promising compound TM-33 showed potent and balance inhibitory activities toward ChE and MAO (eeAChE, eqBuChE, hMAO-A and hMAO-B with IC50 values of 0.56μM, 2.3μM, 0.3μM and 1.4μM, respectively) but low selectivity. Both kinetic analysis of AChE inhibition and molecular modeling study suggested that TM-33 binds simultaneously to the catalytic active site and peripheral anionic site of AChE. Furthermore, our investigation proved that TM-33 could cross the blood-brain barrier (BBB) in vitro, and abided by Lipinski's rule of five. The results suggest that compound TM-33, an interesting multi-targeted active molecule, offers an attractive starting point for further lead optimization in the drug-discovery process against Alzheimer's disease.

Published
2017

18. Design, synthesis and evaluation of novel ferulic acid- O -alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

Author

Sang, Zhipei, primary, Pan, Wanli, additional, Wang, Keren, additional, Ma, Qinge, additional, Yu, Lintao, additional, Yang, Yan, additional, Bai, Ping, additional, Leng, Chaoliang, additional, Xu, Qian, additional, Li, Xiaoqing, additional, Tan, Zhenghuai, additional, and Liu, Wenmin, additional

Published
2017
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