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Your search keyword '"Yousif, S"' showing total 27 results
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27 results on '"Yousif, S"'

10. P2.08-02 Outcomes Following Stereotactic Radiosurgery for Syncronous Brain Metastases in Non-Small Cell Lung Cancer

Author

Wilson, F., primary, Yousif, S., additional, Li, Y., additional, Bayman, N., additional, Chan, C., additional, Cobben, D., additional, Colaco, R., additional, Coote, J., additional, Faivre-Finn, C., additional, Gattamaneni, R., additional, Harris, M., additional, Hudson, A., additional, Pemberton, L., additional, Salem, A., additional, Sheikh, H., additional, Tran, A., additional, Whitfield, G., additional, Mcbain, C., additional, and Woolf, D., additional

Published
2019
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13. Role of Helical Nonenhanced Computed Tomography in the Evaluation of Acute Flank Pain

Author

Yousif S. Matani and Mohammed A. Al-Ghazo

Subjects
Adult, Male, medicine.medical_specialty, Flank pain, Adolescent, lcsh:Surgery, Computed tomography, Diagnostic accuracy, Flank Pain, Nephrolithiasis, Sensitivity and Specificity, Phlebolith, medicine, Humans, Renal colic, Medical diagnosis, Child, Stone disease, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Emergency department, lcsh:RD1-811, Middle Aged, haematuria, phlebolith, renal colic, Acute Disease, Female, Surgery, Radiology, medicine.symptom, business, Tomography, Spiral Computed, CT
Abstract

Objective To evaluate the role of helical nonenhanced computed tomography (NECT) in the diagnosis of acute flank pain. Methods Seventy-five consecutive patients were analysed retrospectively for profile, loin pain, urine analysis and NECT findings. Diagnostic accuracy of NECT for urolithiaisis was calculated. The value of combined microhaematuria and NECT in the diagnosis of flank pain was also highlighted. The potential for identifying phleboliths and alternative diagnoses on NECT was also explored. Results There were 46 males and 29 females with an average age of 42.2 years. Forty-four patients presented with acute left flank pain. NECT carries a sensitivity and specificity of 96% for the diagnosis of stone disease. Combined with microhaematuria, NECT has 100% accuracy in picking up urinary tract stones. Conclusion NECT is the first imaging investigation of choice for the evaluation of patients presenting to the emergency department with flank pain and suspected renal colic.

Published
2007
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15. Metabolite–P450 Complex Formation by Methylenedioxyphenyl HIV Protease Inhibitors in Rat and Human Liver Microsomes

Author

Joy A. Nishime, Kari Vastag, Bruce D. Dorsey, Masato Chiba, Joseph P. Vacca, B. M. Kim, Yousif S Sahly, Jiunn H. Lin, and I.-W. Chen

Subjects
Male, Metabolite, Hydroxylation, Biochemistry, Catalysis, Rats, Sprague-Dawley, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, In vivo, Animals, Cytochrome P-450 CYP3A, Humans, HIV Protease Inhibitor, Biotransformation, Chromatography, High Pressure Liquid, Pharmacology, chemistry.chemical_classification, biology, Cytochrome P450, HIV Protease Inhibitors, In vitro, Rats, Isoenzymes, Enzyme, chemistry, Enzyme inhibitor, Microsomes, Liver, biology.protein, Microsome, Aryl Hydrocarbon Hydroxylases, Half-Life
Abstract

P450 complex formation and the unusual pharmacokinetics of methylenedioxyphenyl HIV protease inhibitors were examined by in vitro studies using human and rat liver microsomes and by in vivo oral dosing studies. In vitro spectral studies indicated that the formation of a P450 complex having absorbance maxima at 425 and 456 nm was time and concentration dependent; 27–60% of the total P450 was complexed in dexamethasone-induced rat liver microsomes after a 30-min incubation with 100 μM HIV protease inhibitors. Methoxy substitution on the phenyl ring of the methylenedioxyphenyl moiety increased formation of the P450 complex, whereas chlorine substitution markedly decreased the P450 complexation. Kinetic studies on the P450 complex formation indicated that both methoxy and chlorine substitution affected the maximum complex formation rate ( V max ), while it had little effect on K m values (∼10 μM). This complexation in human liver microsomes was inhibited markedly by an anti-CYP3A1 antibody. Furthermore, the P450 complex formation resulted in a time-dependent loss of CYP3A-catalyzed marker activities (testosterone 2β/6β-hydroxylase) in both rat and human liver microsomes. Collectively, these results point to the involvement of CYP3A isoforms in P450 complexation by methylenedioxyphenyl HIV protease inhibitors. Additionally, after oral administration to rats, one of these HIV protease inhibitors (Compound I ), which complexed P450 to the greatest extent, showed no elimination over a period of 500 min after administration of the highest dose. It is suggested that formation of a quasi-irreversible metabolite–CYP3A complex with methylenedioxyphenyl HIV protease inhibitors was responsible for the CYP3A-selective time-dependent loss of catalytic function and the unusual dose-dependent pharmacokinetics after oral administration.

Published
1998
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