9 results on '"Yin-Jia Cheng"'
Search Results
2. Infection-activated lipopeptide nanotherapeutics with adaptable geometrical morphology for in vivo bacterial ablation
- Author
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Qi-Hang Yu, Rong Huang, Kai-Yue Wu, Xiao-Le Han, Yin-Jia Cheng, Wen-Long Liu, Ai-Qing Zhang, and Si-Yong Qin
- Subjects
Biomaterials ,Biomedical Engineering ,General Medicine ,Molecular Biology ,Biochemistry ,Biotechnology - Abstract
The nonselective membrane disruption of antimicrobial peptides (AMPs) helps in combating the antibacterial resistance. But their overall positive charges lead to undesirable hemolysis and toxicity toward normal living cells, as well as the rapid clearance from blood circulation. In consequence, developing smart AMPs to optimize the antimicrobial outcomes is highly urgent. Relying on the local acidity of microbial infection sites, in this work, we designed an acidity-triggered charge reversal nanotherapeutics with adaptable geometrical morphology for bacterial targeting and optimized therapy. C
- Published
- 2022
3. Biomedical applications of functional peptides in nano-systems
- Author
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Jun Feng, Si-Yong Qin, Yin-Jia Cheng, Shi-Bo Wang, Chi Zhang, Xian-Zheng Zhang, and Lei Rong
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Polymers and Plastics ,Chemistry ,technology, industry, and agriculture ,Tumor therapy ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Colloid and Surface Chemistry ,Materials Chemistry ,0210 nano-technology ,Function (biology) - Abstract
During the past decades, functionalized nano-systems were believed in holding the bright future of the nanomaterials in biomedical applications. Due to their excellent biocompatibility, biodegradation capability, and biological activity, functional peptides have been vastly used solitary or employed as functional components in nano-systems for disease treatments. This review focuses on the recent advances on the use of functional peptides as a toolbox to construct various delivery nano-systems for tumor treatments. Arising from the special function contributed to the nano-systems, the functional peptides are mainly divided into three groups, cell-targeting peptides (CTPs), cell-penetrating peptides (CPPs), and environment-sensitive peptides. Within each group, their usage in both organic and inorganic systems is discussed. In particular, strategies used to generate promising therapeutic nano-systems for efficient tumor treatment are also highlighted.
- Published
- 2018
4. Morphology control of self-deliverable nanodrug with enhanced anticancer efficiency
- Author
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Zhi-Wei Jiang, Aiqing Zhang, Yi-Han Ma, Yin-Jia Cheng, and Si-Yong Qin
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Drug ,Cell Survival ,media_common.quotation_subject ,Sonication ,Cancer therapy ,Drug release kinetics ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Mice ,Colloid and Surface Chemistry ,Confocal imaging ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Particle Size ,Physical and Theoretical Chemistry ,media_common ,Dose-Response Relationship, Drug ,Chemistry ,Surfaces and Interfaces ,General Medicine ,021001 nanoscience & nanotechnology ,Antineoplastic Agents, Phytogenic ,Endocytosis ,0104 chemical sciences ,Morphology control ,Drug Liberation ,Kinetics ,Nanomedicine ,Drug release ,Biophysics ,Nanoparticles ,Camptothecin ,0210 nano-technology ,HeLa Cells ,Biotechnology ,medicine.drug - Abstract
The morphology of nanomedicines has a large influence on the anticancer efficiency of therapeutic agents in biological systems. In this study, camptothecin (CPT)-based nanodrugs with helical and spherical shapes were simply built without the need of any additional carriers. Self-deliverable spherical nanodrug represented a therapeutic advantage over the helical one, which was uncovered from the in vitro toxicity assay. Confocal imaging study indicated that the better outcome of spherical nanodrug was ascribed to the faster cellular uptake. With the aid of sonication treatment, helical nanodrugs with different lengths (HD-1, HD-2, HD-3, HD-4) were created. In comparing with the longest HD-1, the drug release kinetics indicated that the shortest HD-4 exhibited a 20% elevation in cumulative drug release at the first 10 h. The internalized drug amount of HD-4 was three-fold higher than that of HD-1 after the cultivation with 4T1 cells for 2 h. These results demonstrated that the anticancer efficacy of helical nanodrugs was inversely proportional to their lengths. The strategy demonstrated here presents great promise for the preparation of nanodrugs with suitable morphology for cancer therapy.
- Published
- 2018
5. Synergistic effect between a novel silane-containing hyperbranched polyphosphamide and ammonium polyphosphate on the flame retardancy and smoke suppression of polypropylene composites
- Author
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Wei Liu, Aiqing Zhang, Xiaosui Chen, Hongfu Zhou, Yi-Han Ma, and Yin-Jia Cheng
- Subjects
Polypropylene ,Polymers and Plastics ,Chemistry ,Composite number ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Silane ,0104 chemical sciences ,chemistry.chemical_compound ,Hydrolysis ,Chemical engineering ,Mechanics of Materials ,Triethoxysilane ,Materials Chemistry ,Thermal stability ,Char ,0210 nano-technology ,Ammonium polyphosphate - Abstract
A novel hyperbranched polyphosphamide with abundant terminal groups of silane (HBPPA-Si) was synthesized from phosphorus oxychloride (POCl3), 4, 4′-diaminodiphenylmethane (DDM) and (3-aminopropyl) triethoxysilane (APTES), which had high thermal stability with a residual weight of 44.0 wt% at 800°C in nitrogen atmosphere. By incorporating 25 wt% of APP and HBPPA-Si with an optimum mass ratio of 1:1 into polypropylene (PP) composites, the PP/APP/HBPPA-Si composite reached V-0 rating at the UL-94 test and also obtained a maximum LOI value of 27.5%. Meanwhile, their peak heat release rates (PHRR), total heat release (THR), and total smoke production (TSP) reduced dramatically by 72.5%, 35.8%, and 62.7% respectively, when compared with virgin PP. The improved flame retardancy and smoke suppression of PP/APP/HBPPA-Si composite were ascribed to their excellent synergistic effect working efficiently in both condensed-phase and gas-phase actions. It is noticeable that the high-quality and high-quantity char residue possessing thermal-stable P- and Si-containing cross-linked structures can shield the underlying polymeric materials from further hydrolysis and simultaneously insulate the volatile fuel and heat transfer. Moreover, the weak polar silane shell of HBPPA-Si improved the interfacial compatibility of APP within the PP matrix, leading to enhanced mechanical properties with increasing HBPPA-Si concentration.
- Published
- 2020
6. Functional mesoporous silica nanoparticles (MSNs) for highly controllable drug release and synergistic therapy
- Author
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Xian-Zheng Zhang, Xiao-Ding Xu, Dong-Bing Cheng, Yin-Jia Cheng, Ren-Xi Zhuo, Xuan Zeng, and Feng He
- Subjects
Cell Survival ,Cancer therapy ,Nanoparticle ,Peptide ,Nanotechnology ,Cell-Penetrating Peptides ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Colloid and Surface Chemistry ,X-Ray Diffraction ,Chlorocebus aethiops ,Spectroscopy, Fourier Transform Infrared ,medicine ,Animals ,Humans ,Doxorubicin ,Physical and Theoretical Chemistry ,chemistry.chemical_classification ,Cell Membrane ,Drug Synergism ,Surfaces and Interfaces ,General Medicine ,Mesoporous silica ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Glutathione ,Endocytosis ,Mitochondria ,0104 chemical sciences ,Drug Liberation ,chemistry ,Delayed-Action Preparations ,COS Cells ,Thermogravimetry ,Drug delivery ,Cancer cell ,Drug release ,Nanoparticles ,0210 nano-technology ,Porosity ,HeLa Cells ,Biotechnology ,medicine.drug - Abstract
Synergistic therapy involving two or more therapeutic agents with different anticancer mechanisms represents a promising approach to eradicate chemotherapy-refractory cancers. However, the preparation of a synergistic therapy platform generally involves complicated procedures to encapsulate different therapeutic agents and thereby increases the purification difficulty. In this work, we reported a simple but robust strategy to prepare a highly controllable drug delivery system (DDS) for synergistic cancer therapy. To construct this robust DDS, mesoporous silica nanoparticles (MSNs) were employed as a nanoplatform to encapsulate anticancer drug doxorubicin (DOX). After using a tumor-targeting cellular membrane-penetrating peptide (TCPP) and a mitochondria-targeting therapeutic peptide (TPP) to seal the surface pores via disulfide bonds, these newly developed MSNs can target cancer cells, penetrate cell membrane and rapidly release anticancer drug and mitochondria-targeted peptide in cytoplasm, inducing a remarkable synergistic anticancer effect. The new design concept reported here will promote the development of targeted and smart DDSs for synergistic cancer therapy.
- Published
- 2016
7. The Unique Spatial-Temporal Treatment Failure Patterns of Adjuvant Gefitinib Therapy: A Post Hoc Analysis of the ADJUVANT Trial (CTONG 1104)
- Author
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Xu, Song-Tao, primary, Xi, Jun-Jie, additional, Zhong, Wen-Zhao, additional, Mao, Wei-Min, additional, Wu, Lin, additional, Shen, Yi, additional, Liu, Yong-Yu, additional, Chen, Chun, additional, Cheng, Ying, additional, Xu, Lin, additional, Wang, Jun, additional, Fei, Ke, additional, Li, Xiao-Fei, additional, Li, Jian, additional, Huang, Cheng, additional, Liu, Zhi-Dong, additional, Xu, Shun, additional, Chen, Ke-Neng, additional, Xu, Shi-Dong, additional, Liu, Lun-Xu, additional, Yu, Ping, additional, Wang, Bu-Hai, additional, Ma, Hai-Tao, additional, Yan, Hong-Hong, additional, Yang, Xue-Ning, additional, Zhang, Yong-Xing, additional, Yin, Jia-Cheng, additional, Wang, Qun, additional, and Wu, Yi-Long, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release
- Author
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Yin Lv, You-Mei Li, Yin-Jia Cheng, Tao Jiang, Ren-Xi Zhuo, and Feng He
- Subjects
Proton Magnetic Resonance Spectroscopy ,Sus scrofa ,Hydrazone ,Conjugated system ,Micelle ,Polyethylene Glycols ,HeLa ,Surface-Active Agents ,Colloid and Surface Chemistry ,Amphiphile ,polycyclic compounds ,Animals ,Humans ,Organic chemistry ,Prodrugs ,Particle Size ,Physical and Theoretical Chemistry ,Micelles ,chemistry.chemical_classification ,Polycarboxylate Cement ,Cell Death ,biology ,organic chemicals ,Hydrazones ,technology, industry, and agriculture ,Surfaces and Interfaces ,General Medicine ,Hydrogen-Ion Concentration ,Prodrug ,biology.organism_classification ,Controlled release ,Combinatorial chemistry ,carbohydrates (lipids) ,chemistry ,Doxorubicin ,Delayed-Action Preparations ,Linker ,HeLa Cells ,Biotechnology - Abstract
Novel amphiphilic polycarbonates-graft-doxorubicin (mPEG-b-P(ATMC-co-DTC)-g-DOX) were successfully designed and synthesized for pH-triggered intercellular drug release in cancer cells. The amphiphilic block copolymer, mPEG-b-P(ATMC-co-DTC), was synthesized in bulk using immobilized porcine pancreas lipase (IPPL) as the catalyst. After allyl epoxidation of ATMC units, DOX was covalently conjugated to the hydrophobic polycarbonates block through a hydrazone linkage. The resulting mPEG-b-P(ATMC-co-DTC)-g-DOX prodrugs could self-assemble to form nano-sized micelles in aqueous solution, while DOX contents in the hydrophobic core were 9.9 and 12.5 wt.%. DOX release rate from the prodrug micelles increased in acidic medium due to the acid-cleavable hydrazone linkage between the DOX and polycarbonates. MTT assays demonstrated that DOX prodrug micelles in this study showed effective cytotoxic effects to HeLa cells. Furthermore, confocal laser scanning microscopy (CLSM) observations also revealed that mPEG-b-P(ATMC-co-DTC)-g-DOX prodrugs could efficiently deliver and release DOX into the nuclei of HeLa cells.
- Published
- 2013
9. A copper(II)–gadolinium(III) heterometallic MOF: Synthesis, structure, and electrochemical property
- Author
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Yin, Jia-Cheng, primary, Qin, Tian-Zhu, additional, Hu, Chao, additional, He, Gui-Mei, additional, Zhao, Bo-Wei, additional, Zhang, Chi, additional, and Wang, Juan, additional
- Published
- 2017
- Full Text
- View/download PDF
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