10 results on '"Yih-Jyh Lin"'
Search Results
2. Pleural Effusion With Gastric Ulcer
- Author
-
Yih-Jyh Lin, Shih-Chieh Chien, and Hsueh-Chien Chiang
- Subjects
Liver Cirrhosis ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Pleural effusion ,medicine.medical_treatment ,Liver transplantation ,Gastroenterology ,Tacrolimus ,Lymphoma, Primary Effusion ,Internal medicine ,medicine ,Humans ,Stomach Ulcer ,Hepatology ,business.industry ,Liver Neoplasms ,Middle Aged ,medicine.disease ,Liver Transplantation ,Pleural Effusion ,Kidney Failure, Chronic ,Primary effusion lymphoma ,business ,Immunosuppressive Agents - Published
- 2022
3. Cost effectiveness of cancer treatment in Taiwan
- Author
-
Jung-Der Wang, M.C. Hung, Wu Chou Su, Ya Min Cheng, Helen H.W. Chen, Jenn Ren Hsiao, Yan Shen Shan, Jenq Chang Lee, Wu Wei Lai, and Yih Jyh Lin
- Subjects
Adult ,Male ,lifetime survival function ,Cost effectiveness ,medicine.medical_treatment ,Cost-Benefit Analysis ,Taiwan ,Disease ,Gross domestic product ,semiparametric method ,03 medical and health sciences ,0302 clinical medicine ,healthcare expenditure ,Quality of life ,Neoplasms ,Health care ,Per capita ,Medicine ,Humans ,cancer ,030212 general & internal medicine ,Registries ,health care economics and organizations ,Aged ,Mechanical ventilation ,Aged, 80 and over ,cost per quality-adjusted life year ,Medicine(all) ,lcsh:R5-920 ,cost effectiveness ,business.industry ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Respiration, Artificial ,030220 oncology & carcinogenesis ,Quality of Life ,Kidney Failure, Chronic ,Female ,Medical emergency ,Quality-Adjusted Life Years ,Health Expenditures ,business ,lcsh:Medicine (General) ,Demography - Abstract
Background/Purpose This study aims to examine the cost effectiveness of treating major cancers compared with other major illnesses in Taiwan. Methods We collected data on 395,330 patients with cancer, 125,277 patients with end-stage renal disease, and 50,481 patients under prolonged mechanical ventilation during 1998–2007. They were followed for 10–13 years to estimate lifetime survival functions using a semiparametric method. EuroQol five-dimension was used to measure the quality of life for 6189 cancer patients and 1401 patients with other illnesses. The mean utility values and healthcare costs reimbursed by the National Health Insurance were multiplied with the corresponding survival probabilities to estimate quality-adjusted life expectancies and lifetime costs, respectively. Data of 22,344 cancer patients under hospice care (considered as a comparison group) were used to conduct a cost-effectiveness analysis. Sensitivity analysis was conducted by assuming patients without treatment survived for 2 years with a quality of life value of 0.5. Results The costs of care for patients under prolonged mechanical ventilation and those with end-stage renal disease were US$41,780–53,708 per quality-adjusted life year (QALY) and US$18,222–18,465 per QALY, respectively, which are equivalent to 2.17–2.79 gross domestic product (GDP) per capita per QALY and 1.18–1.25 GDP per capita per QALY. The costs of care for the nine different cancers were less than 1 GDP per capita per QALY, with those of lung, esophagus, and liver cancers being the highest. Sensitivity analysis showed the same conclusion. Lifetime risks of six out of nine cancer sites show an increased trend. Conclusion Cancer care in Taiwan seemed cost effective compared with that of other illnesses, but prevention is necessary to make the National Health Insurance more sustainable.
- Published
- 2016
- Full Text
- View/download PDF
4. SUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC
- Author
-
Chien Hsien Lai, Tang K. Tang, Yao Wen Liu, Yih Jyh Lin, Jenq Chang Lee, Wen Chun Hung, Yi-Wen Liu, Liang Yi Hung, Lu Shin Hsu, Shu Ting Yang, Kung Chao Chang, Wen Chang Chang, Chia Jui Yen, and Pey Yi Chang-Liao
- Subjects
Small interfering RNA ,Carcinoma, Hepatocellular ,SUMO-1 Protein ,SUMO protein ,IκB kinase ,Biology ,chemistry.chemical_compound ,NF-KappaB Inhibitor alpha ,Western blot ,medicine ,Humans ,Viral Regulatory and Accessory Proteins ,Protein inhibitor of activated STAT ,Phosphorylation ,Hepatology ,medicine.diagnostic_test ,Tumor Necrosis Factor-alpha ,Liver Neoplasms ,NF-kappa B ,Sumoylation ,NF-κB ,digestive system diseases ,I-kappa B Kinase ,nervous system diseases ,respiratory tract diseases ,HBx ,IκBα ,chemistry ,Trans-Activators ,Cancer research ,I-kappa B Proteins ,Microtubule-Associated Proteins ,therapeutics ,Signal Transduction ,circulatory and respiratory physiology - Abstract
Background & Aims Constitutive activation of NF-κB is an important event involved in chronic inflammation in hepatocellular carcinoma (HCC). CPAP, which plays important roles in centrosomal functions, was previously identified as the transcriptional co-activator of NF-κB. However, the molecular mechanism is unclear. The goal of this study was to investigate the role of CPAP in activating the NF-κB pathway in HCC. Methods SK-Hep1, HuH7, HepG2, HepG2X, Hep3B, and Hep3BX cells with CPAP overexpression or CPAP siRNA were used to evaluate activation of NF-κB under TNF-α stimulation by reporter assay, RT-PCR, Q-PCR, and Western blot analysis. In vivo SUMO modification of CPAP was demonstrated by an in situ PLA assay. Human HCC tissues were used to perform Q-PCR, Western blot, and IHC. Results CPAP siRNA abolished the interaction between IKKβ and NF-κB, whereas overexpression of CPAP enhanced this interaction and finally led to augmented NF-κB activation by increasing the phosphorylation of NF-κB. CPAP could enter nuclei by associating with NF-κB. Furthermore, CPAP was SUMO-1 modified upon TNF-α stimulus, and this is essential for its NF-κB co-activator activity. SUMO-1-deficient CPAP mutant lost its NF-κB co-activator activity and failed to enter nuclei. Importantly, SUMOylated CPAP could synergistically increase the HBx-induced NF-κB activity. Conclusions CPAP is essential for the recruitment of the IKK complex to inactivated NF-κB upon TNF-α treatment. Expression of CPAP was positively correlated with a poor prognosis in HBV-HCC. CPAP has the potential to serve as a therapeutic target for inflammation and inflammation-related diseases.
- Published
- 2013
5. Reappraisal of HLA Antibody Analysis and Crossmatching in Kidney Transplantation
- Author
-
Chung-Jye Hung, Po-Chang Lee, Yih Jyh Lin, T C. Chou, J P. Chuang, and Shen-Shin Chang
- Subjects
Enzyme-Linked Immunosorbent Assay ,Human leukocyte antigen ,Antigen ,Antibody Specificity ,HLA Antigens ,Isoantibodies ,Preoperative Care ,medicine ,Humans ,Hla antibodies ,Elisa method ,False Negative Reactions ,Kidney transplantation ,Retrospective Studies ,HLA-D Antigens ,Transplantation ,biology ,business.industry ,Histocompatibility Testing ,Histocompatibility Antigens Class I ,Follow up studies ,medicine.disease ,Kidney Transplantation ,Disease control ,Immunology ,biology.protein ,Surgery ,Antibody ,business ,Follow-Up Studies - Abstract
Enzyme-linked immunosorbent assay (ELISA) and flow cytometric techniques have been introduced to overcome the limited sensitivity and specificity of the CDC assay. This retrospective study used lambda antigen tray-mixed screening and Luminex HLA class I and II specificity assays to re-examine: (1) the accuracy with which detection of HLA antibody and specificity by ELISA predicts pretransplantation National Institutes of Health (NIH)/Centers for Disease Control and Prevention (CDC) crossmatch; and (2) a comparison of Luminex and ELISA methods to detect HLA antibodies. Sera from 481 patients awaiting kidney transplantation were tested using the ELISA method lambda antigen tray-mixed and using NIH-CDC to determine how well HLA antibodies detected using ELISA predicted crossmatches using CDC. Pretransplantation sera from 48 patients with follow-up data were retested using both ELISA lambda antigen tray-mixed and Luminex to compare the efficacy of the 2 methods.
- Published
- 2009
6. The Clinical Significance of Human Leukocyte Antigen Antibody Development in Kidney Transplantation
- Author
-
Ren-Hao Chan, Chung-Jye Hung, Jung-Der Wang, Yi Lin Chen, Shen-Shun Chang, Yih Jyh Lin, Tsung-Ching Chou, Po-Chang Lee, and W. M. Wang
- Subjects
Graft Rejection ,Time Factors ,Taiwan ,Enzyme-Linked Immunosorbent Assay ,Human leukocyte antigen ,Risk Assessment ,HLA Antigens ,Isoantibodies ,Risk Factors ,Odds Ratio ,medicine ,Humans ,Clinical significance ,Kidney transplantation ,Retrospective Studies ,Transplantation ,biology ,business.industry ,Graft Survival ,Retrospective cohort study ,Immunosuppressive regimen ,medicine.disease ,Kidney Transplantation ,Human leukocyte antigen antibody ,Treatment Outcome ,Renal transplant ,Histocompatibility ,Immunology ,biology.protein ,Surgery ,Antibody ,business ,Immunosuppressive Agents - Abstract
This retrospective study uses the LAT-M (One Lambda Inc., Calif) screen assay to reexamine the impacts (a), of pretransplant human leukocyte antigen (HLA) antibody on long-term graft survival; (b) posttransplant HLA antibody on long-term graft survival and (c) immunosuppressive regimen on posttransplant HLA antibody development.Pretransplant sera from 222 renal transplant recipients and posttransplant sera from 216 renal transplant recipients were studied for the impact of HLA antibody on long-term graft survival.Among the patients who did not display pretransplant HLA antibodies, 85% enjoyed 5-year and 59% 10-year graft survival, whereas the patients who tested positive were 83% and 83% (P = .5596). Among the patients who did not show posttransplant HLA antibodies, 99% enjoyed 5-, 91% 10-, and 65% 15-year graft survival, whereas for the 44 patients who tested positive they were 59%, 44%, and 30%, respectively (P.0001). Patients prescribed cyclosporine + myfortic (odds ratio 0.17, P = .05) or FK + Cellcept (odds ratio 0.36, P = .04) showed the lowest posttransplant HLA antibody development.Both regimens improve graft survival.
- Published
- 2012
7. Induction of Antinociception and Increased Met-Enkephalin Plasma Levels by Cyclosporine and Morphine in Rats: Implications of the Combined Use of Cyclosporine and Morphine and Acute Posttransplant Neuropsychosis
- Author
-
Po-Chang Lee, Chung-Jye Hung, Jih Ing Chuang, Kuei Sen Hsu, Huan Yao Lei, Yih Jyh Lin, and Yu Chuan Tsai
- Subjects
Male ,Met-enkephalin ,medicine.medical_specialty ,Enkephalin, Methionine ,Analgesic ,Peptide hormone ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Postoperative Complications ,Internal medicine ,medicine ,Animals ,Opioid peptide ,Pain, Postoperative ,Transplantation ,Morphine ,business.industry ,Mental Disorders ,beta-Endorphin ,Nociceptors ,Rats ,Analgesics, Opioid ,Endocrinology ,Nociception ,chemistry ,Cyclosporine ,Surgery ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Background. Cyclosporine A (CsA) and morphine have neurotoxic and psychiatric side effects, respectively. Endogenous opiatelike peptides can elicit a number of behavioral responses that mimic the symptoms of psychiatric illness. The purpose of this study was to quantitiate the changes of Met-enkephalin (ME) and β-endorphin (BE) after administration of CsA and morphine in surgery and to assess the antinociceptive effect. Patients and materials. Pain sensitivity, an antinociceptive indicator in rats, was determined with the hotplate test. Plasma ME and BE levels were measured with radioimmunoassays. Results. In normal unoperated rats, CsA induced a profound analgesic effect concomitant with an increased plasma ME level on day 1. Morphine produced an analgesic effect on days 1 and 2, with decreased ME levels on days 2 and 3. Coadministration of CsA and morphine prolonged the analgesia from days 1 to 4 and increased the plasma ME level on day 1. No change in plasma BE level was found. In surgically operated rats, CsA induced an analgesic effect and higher ME levels than those in unoperated rats. Interestingly, the combined use of CsA and morphine prolonged the analgesia and increased plasma ME levels from days 1 to 4, with no significant change in plasma BE levels. Conclusions. Our results showed that CsA can induce antinociception and increase plasma ME levels. This induction can be potentiated by the addition of morphine. Acute neuropsychiatric manifestations in the early posttransplant period might, therefore, be due to induction of ME after coadministration of CsA and morphine.
- Published
- 2002
8. Five-Year Experience of Adoption and Evolution of Laparoscopic Living Donor Nephrectomy: Results From a Center Without Large Volume of Patients
- Author
-
Jen-Pin Chuang, Tsung-Ching Chou, Yih Jyh Lin, P. Y. Chung, Y. S. Lin, Chung-Jye Hung, Shen-Shin Chang, and Po-Chang Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Intraoperative Complication ,Urinary system ,medicine.medical_treatment ,Taiwan ,Renal function ,Nephrectomy ,Body Mass Index ,Living Donors ,medicine ,Humans ,Aged ,Retrospective Studies ,Transplantation ,business.industry ,Postoperative complication ,Perioperative ,Middle Aged ,Kidney Transplantation ,Surgery ,Treatment Outcome ,Creatinine ,Female ,Laparoscopy ,Complication ,business - Abstract
Objectives Despite the advantages of laparoscopic living donor nephrectomy (LDN), this technique is known to have a steep learning curve that makes worldwide adoption challenging, especially in institutions without a large patients volume. Herein, we have reviewed our 5-year experience of adoption and evolution of this surgical technique, examining the donor and recipient outcomes. Methods Between September 2002 and June 2007, 40 LDNs were performed consecutively. Our surgical technique was mainly derived from the University of California San Francisco method. We retrospectively reviewed the donor demographics, operative characteristics, perioperative complication of donors/recipients, and outcomes of donors and recipients. Results Among the 40 cases, 36 (90.0%) were left-sided LDNs. Mean operative time was 335.1 ± 66.9 minutes, blood loss was 303.9 ± 333.2 mL, and warm ischemia time was 243.2 ± 127.0 seconds. Multiple renal arteries required bench arterial reconstruction in 7 (17.5%) donor kidneys. Three renovascular injuries occurred intraoperatively, and 2 (5.0%) required open conversion. The overall postoperative complication rate was 20.0%. Postoperative donor serum creatinine was 1.5 times higher than preoperative serum creatinine. All but one recipient was discharged with adequate renal function. Graft function continues in 36 of the 38 harvested kidneys (94.7%) during the follow-up period. One (2.5%) recipient developed ureteral necrosis, and no recipients developed vascular thrombosis. Conclusions LDNs can be performed with careful adoption and evolution in institutions without a large patient volume. The intraoperative complication rate of LDN can be reduced with experience.
- Published
- 2008
9. 985 COMBINATION OF SERUM BIOCHEMICAL MARKERS FOR EARLY DIAGNOSIS OF HEPATITIS B VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA: ONE STEP BEYOND ALPHA-FETOPROTEIN
- Author
-
San Lin You, Mei Hsuan Lee, Li Yu Wang, C.-L. Jen, Chien-Chuan Chen, Sheng-Nan Lu, Yih Jyh Lin, and Hwai I. Yang
- Subjects
Hepatitis B virus ,Hepatology ,business.industry ,Hepatocellular carcinoma ,Cancer research ,Medicine ,Alpha-fetoprotein ,business ,medicine.disease_cause ,medicine.disease ,Biochemical markers - Published
- 2011
10. 730 CONVENTIONAL SEROMARKERS FOR PREDICTION OF HEPATITIS B VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA: AN EASY-TO-USE RISK SCORE
- Author
-
Mei Hsuan Lee, San Lin You, Li Yu Wang, Chien-Chuan Chen, Sheng-Nan Lu, C.-L. Jen, Hwai I. Yang, and Yih Jyh Lin
- Subjects
Hepatitis B virus ,medicine.medical_specialty ,Framingham Risk Score ,Hepatology ,business.industry ,Internal medicine ,Hepatocellular carcinoma ,medicine ,medicine.disease_cause ,business ,medicine.disease ,Gastroenterology - Published
- 2012
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.