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Start Over Author "Yi-Han Wu" Publisher elsevier bv
2 results on '"Yi-Han Wu"'

1. pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide

Author

Jia, Xin Li, Meng, Jiao Zhang, Jin, Feng Shi, Sheng, Peng Wang, Xue, Mei Zhong, Yi, Han Wu, Yan, Qu, Hui, Le Gao, and Jin, Ming Zhang

Subjects
Pharmaceutical Science
Abstract

Since pro-inflammatory macrophages take on a critical significance in the pathophysiology of rheumatoid arthritis (RA), the therapeutics to affect macrophages may receive distinct anti-RA effects. However, the therapeutic outcomes are still significantly impeded, which is primarily due to the insufficient drug delivery at the arthritic site. In this study, the macrophage-targeting and pH stimuli-responsive nano-polyelectrolyte complexes were designed for the efficient targeted delivery of triptolide (TP/PNPs) on the arthritic site. The anionic and cationic amphiphilic copolymers, i.e., hyaluronic acid-g-vitamin E succinate (HA-VE) and the quaternized poly (β-amino ester) (QPBAE-C

Published
2023

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