1. Optic Disc Rotation as a Clue for Predicting Visual Field Progression in Myopic Normal-Tension Glaucoma
- Author
-
Mi Sun Sung, Yeon Soo Kang, Sang Woo Park, and Hwan Heo
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Intraocular pressure ,Rotation ,genetic structures ,Optic Disk ,Optic disk ,Glaucoma ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Ophthalmology ,Normal tension glaucoma ,Myopia ,medicine ,Humans ,Eye Abnormalities ,Low Tension Glaucoma ,Dioptre ,Aged ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Middle Aged ,medicine.disease ,eye diseases ,Visual field ,030104 developmental biology ,medicine.anatomical_structure ,Disease Progression ,030221 ophthalmology & optometry ,Optometry ,Female ,sense organs ,Visual Fields ,business ,Optic disc - Abstract
Purpose To investigate factors associated with visual field (VF) progression in myopic normal-tension glaucoma (NTG) and to determine the relationship between optic disc rotation and VF progression. Design Retrospective, observational study. Subjects Ninety-two patients with myopic NTG, with VF loss confined to a single hemifield, who were followed up over a 2-year period. Methods Systemic and ocular findings such as optic disc tilt and optic disc rotation were evaluated. The eyes with optic disc rotation accompanying a corresponding VF defect were defined as those with correspondence. Visual field progression was defined by Early Manifest Glaucoma Trial criteria. The Cox proportional hazards model was used to determine the risk factors for VF progression. Main Outcome Measures Progression of VF. Results The mean age of subjects was 37.83±10.89 years, mean spherical equivalent refractive error was −5.51±3.37 diopters, and mean axial length was 26.18±1.79 mm. Mean follow-up duration was 55.78±30.12 months. Among 92 eyes, 37 showed VF progression. A multivariate Cox proportional hazard model revealed that percentage reduction in intraocular pressure (IOP) from baseline (hazard ratio [HR], 0.965; P = 0.013), optic disc hemorrhage (HR, 2.623; P = 0.019), and optic disc rotation–VF defect correspondence (HR, 0.441; P = 0.016) were associated with VF progression in myopic NTG eyes. Conclusions In addition to the percentage reduction in IOP from baseline and optic disc hemorrhage, optic disc rotation–VF defect correspondence may be an important prognostic factor for patients with myopic NTG.
- Published
- 2016
- Full Text
- View/download PDF