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Your search keyword '"Yang, Liang-Yo"' showing total 21 results
Start Over Author "Yang, Liang-Yo" Publisher elsevier bv
21 results on '"Yang, Liang-Yo"'

1. LPS priming-induced immune tolerance mitigates LPS-stimulated microglial activation and social avoidance behaviors in mice

Author

Charoensaensuk, Vichuda, primary, Huang, Bor-Ren, additional, Huang, Sian-Ting, additional, Lin, Chingju, additional, Xie, Sheng-Yun, additional, Chen, Chao-Wei, additional, Chen, Yen-Chang, additional, Cheng, Han-Tsung, additional, Liu, Yu-Shu, additional, Lai, Sheng-Wei, additional, Shen, Ching-Kai, additional, Lin, Hui-Jung, additional, Yang, Liang-Yo, additional, and Lu, Dah-Yuu, additional

Published
2024
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3. Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-ζ to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression

Author

Hung-Jen Lin, Chih Yang Huang, Ping-Ling Chiu, Yung-Ming Chang, Yang Liang-Yo, Ray-Jade Chen, Wei Wen Kuo, Hsiang-Yen Huang, Cecilia Hsuan Day, Ramasamy Mahendran, and V. Vijaya Padma

Subjects
Male, Cardiac function curve, Cardiotonic Agents, Cardiomegaly, Hydrophobia, Pharmacology, Rats, Inbred WKY, Receptor, IGF Type 2, Cell Line, Muscle hypertrophy, chemistry.chemical_compound, Rats, Inbred SHR, Drug Discovery, medicine, Animals, cvg, Protein kinase A, Heat-Shock Proteins, Protein Kinase C, Protein kinase C, Solanum nigrum, Dose-Response Relationship, Drug, Plant Extracts, business.industry, Angiotensin II, cvg.computer_videogame, medicine.disease, Rats, Disease Models, Animal, Calphostin C, chemistry, Heart failure, Hypertension, business, Myoblasts, Cardiac, Transcription Factors
Abstract

Ethnopharmacological relevance Solanum nigrum, commonly known as Makoi or black shade has been traditionally used in Asian countries and other regions of world to treat liver disorders, diarrhoea, inflammatory conditions, chronic skin ailments (psoriasis and ringworm), fever, hydrophobia, painful periods, eye diseases, etc. It has been observed that S. nigrum contains substances, like steroidal saponins, total alkaloid, steroid alkaloid, and glycoprotein, which show anti-tumor activity. However; there is no scientific evidence of the efficacy of S. nigrum in the treatment of cardiac hypertrophy. Aim To investigate the ability of S. nigrum to attenuate Angiotensin II - induced cardiac hypertrophy and improve cardiac function through the suppression of protein kinase PKC-ζ and Mel-18-IGF-IIR signaling leading to the restoration of HSF2 desumolyation. Materials and methods Cardiomyoblast cells (H9c2) were challenged with 100 nM Angiotensin-II (AngII) for 24 h and were then treated with different concentration of S.nigrum or Calphostin C for 24 h. The hypertrophic effect in cardiomyoblast cells were determined by immunofluorescence staining and the modulations in hypertrophic protein marker along with Protein Kinase C-ζ, MEL18, HSF2, and Insulin like growth factor II (IGFIIR), markers were analyzed by western blotting. In vivo experiments were performed using 12 week old male Wistar Kyoto rats (WKY) and Spontaneously hypertensive rats (SHR) separated into five groups. [1]Control WKY, [2] WKY –100 mg/kg of S.nigrum treatment, [3] SHR, [4] SHR-100 mg/kg of S.nigrum treatment, [5] SHR-300 mg/kg of S.nigrum treatment. S. nigrum was administered intraperitoneally for 8 week time interval. Results Western blotting results indicate that S. nigrum significantly attenuates AngII induced cardiac hypertrophy. Furthermore, actin staining confirmed the ability of S. nigrum to ameliorate AngII induced cardiac hypertrophy. Moreover, S. nigrum administration suppressed the hypertrophic signaling mediators like Protein Kinase C-ζ, Mel-18, and IGFIIR in a dose-dependent manner and HSF2 activation (restore deSUMOlyation) that leads to downregulation of IGF-IIR expression. Additionally in vivo experiments demonstrate the reduced heart sizes of S. nigrum treated SHRs rats when compared to control WKY rats. Conclusion Collectively, the data reveals the cardioprotective effect of S. nigrum inhibiting PKC-ζ with alleviated IGF IIR level in the heart that profoundly remits cardiac hypertrophy for hypertension-induced heart failure.

Published
2022

12. Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine

Author

Lin, Jia-Wei, primary, Shih, Chwen-Ming, additional, Chen, Yen-Chou, additional, Lin, Chien-Min, additional, Tsai, Jo-Ting, additional, Chiang, Yung-Hsiao, additional, Shih, Raymond, additional, Chiu, Pei-Ling, additional, Hung, Kuo-Sheng, additional, Yeh, Yi-Shian, additional, Wei, Li, additional, Chiu, Wen-Ta, additional, and Yang, Liang-Yo, additional

Published
2009
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