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A direct numerical simulation database (Zuo et al., J. Fluid Mech. vol. 877, 2019, 167–195) is analyzed to investigate the size of the separation bubble and the relation with the pressure rise in the conical shock wave/turbulent boundary layer interaction. The characteristics of the separation bubbles in the supersonic turbulent boundary layer induced by conical shock waves are discussed. The inviscid reflected conical shock theory is analyzed, to conclude that regular reflection transition to Mach reflection will occur somewhere along the spanwise direction in the interaction zone. Then, the typical shape of a turbulent separation bubble in the conical shock wave/turbulent boundary layer interaction is described. The scaling between the size of the turbulent separation bubble and moderate conical shock intensities is established, giving a potential alternative method to rapidly predict the size of turbulent separation bubbles, especially in the supersonic viscous corrections under condition of boundary layer separation.

BACKGROUND Many studies have examined associations between dietary isoflavones and atherosclerosis, but few used objective biomarkers. OBJECTIVES We examined the associations of isoflavone biomarkers (primary analyses) and equol production (secondary analyses) with the progression of carotid intima-media thickness (cIMT), and whether inflammation, systolic blood pressure (SBP), blood lipids, and sex hormone-binding globulin (SHBG) mediated these associations, in Chinese adults. METHODS This 8.8-y prospective study included 2572 subjects (40-75 y old) from the GNHS (Guangzhou Nutrition and Health Study; 2008-2019). The concentrations of daidzein, genistein, and equol were assayed by an HPLC-tandem MS in serum (n = 2572) at baseline and in urine (n = 2220) at 3-y intervals. The cIMT of the common carotid artery (CCA) and bifurcation segment were measured by B-mode ultrasound every 3 y, and the progressions of cIMT ( ∆cIMT) were estimated using the regression method. RESULTS Multivariable linear mixed-effects models (LMEMs) and ANCOVA revealed that subjects with higher serum isoflavones tended to have lower increases of CCA-cIMT. The mean ± SEM differences in 8.8-y ∆CCA-cIMT between extreme tertiles of serum isoflavones were -17.1 ± 8.4, -20.6 ± 8.3, and -23.3 ± 10.4 μm for daidzein, total isoflavone, and equol (P-trends

Hypersonic non-equilibrium air flows over a laminar double-cone configuration are numerically investigated. In this paper, the effects of thermochemical non-equilibrium gas, chemical non-equilibrium gas, and thermally perfect gas models on the prediction of the wall-surface heat transfer and pressure are investigated. Comparing to the high-enthalpy experimental data, the results of simulations indicate that all models have a similar tendency, and underpredict the length of the separation region, while the heat transfer peaks are overpredicted. The experimental data for surface pressure and heat transfer is insensitive to the choice of the thermally perfect gas model and non-equilibrium thermochemistry models. Quantitatively, the thermochemical non-equilibrium gas and thermally perfect gas models predict the same separation and reattachment locations within the uncertainty in the simulation, but the chemical non-equilibrium gas model predicts a smaller separation region.

The relationship of polyunsaturated fatty acids (PUFAs) with cardiovascular risk is still controversial. We aimed to determine whether erythrocyte n-3 and n-6 PUFAs are related to the risk of carotid atherosclerosis.From 2008 to 2019, baseline erythrocyte n-3 and n-6 PUFAs were determined in a cohort of 4040 Chinese adults (40-75 ys). The intima-media thickness (IMT) at the common carotid artery (CCA) and bifurcation of the carotid artery (BIF) and carotid plaque were assessed using ultrasonography at baseline and every 3 years.During a median follow-up of 8.8 years, we identified the following newly diagnosed cases: 535 cases of CCAIMT thickening, 654 cases of BIFIMT thickening, and 850 cases of carotid plaque. Higher erythrocyte docosahexaenoic acid (DHA) and arachidonic acid (ARA) and lower gamma-linolenic acid (GLA) were associated with decreased risks of BIFIMT thickening. N-3 eicosatrienoic acid (ETrA), docosapentaenoic acid (DPA), and n-6 dodecylthioacetic acid (DTA) presented a significant beneficial association with carotid IMT thickening in the short-term (2.8 y) follow-up (all p trend0.02), although the association was attenuated in the relatively long-term (8.8 y) follow-up. In addition, carotid plaque risk was found to be inversely associated with ETrA and DHA but positively associated with alpha-linolenic acid (ALA). N-6 linolenic acid (LA) and eicosadienoic acid (EDA) were not significantly associated with carotid atherosclerosis risk.Higher erythrocyte very-long-chain n-3 and n-6 PUFAs (especially DHA and ARA) and lower erythrocyte GLA are associated with lower carotid atherosclerosis risk, suggesting potential cardioprotective roles of very-long-chain PUFAs.

In order to evaluate the performance of the slip critical bolted connection of HSS members, 30 specimens fabricated from high strength steel (HSS) (Q550, Q690 and Q890), are tested to investigate the slip factors of shot-blasted surface and rusted surface after blasting. For comparison, a group of specimens fabricated from mild steel Q345 are tested as well. In order to investigate the effect of the steel strength grade on slip factor, the values of hardness, roughness and capacity of plastic deformation of steels with different strength grades are also tested and analyzed. Based on experimental results and friction theory, it is found that with the same blasting treatment, the surface roughness tends to decrease with the increase of steel hardness, which induces the decreasing of the slip factor. Based on the friction mechanism, the slip factor is not only decided by surface roughness, but also can be affected by the capacity of plastic deformation of the contacting materials. With the increasing of plastic deformation capacity of the steel, the slip factor tends to be higher. According to the test results, the suggested slip factor of HSS specimens with blasted surfaces is 0.40. Moreover, for the specimens with rusted surface after blasting, there may be an increment in the slip factor owing to the increased surface roughness by rusting. However, the positive influence of rusting on the slip factor is not recommended to be considered in the connection design due to its instability. Therefore, the recommended slip factor of the specimen with rusted surface after blasting takes the value of 0.40 as well.

Poor cell viability after transplantation has restricted the therapeutic capacity of mesenchymal stem cells (MSCs) for cardiac dysfunction after myocardial infarction (MI). Growth arrest-specific gene 6 (Gas6) encodes a secreted γ-carboxyglutamic acid (Gla)-containing protein that functions in cell growth, adhesion, chemotaxis, mitogenesis and cell survival. In this study, we genetically modified MSCs with Gas6 and evaluated cell survival, cardiac function, and infarct size in a rat model of MI via intramyocardial delivery. Functional studies demonstrated that Gas6 transfer significantly reduced MSC apoptosis, increased survival of MSCs in vitro and in vivo, and that Gas6-engineered MSCs (MSCGas6)-treated animals had smaller infarct size and showed remarkably functional recovery as compared with control MSCs (MSCNull)-treated animals. Mechanistically, Gas6 could enhance phosphatidylinositol 3-kinase (PI3K)/Akt signaling and improve hypoxia-inducible factor-1 alpha (HIF-1α)-driven secretion of four major growth factors (VEGF, bFGF, SDF and IGF-1) in MSCs under hypoxia in an Axl-dependent autocrine manner. The paracrine action of MSCGas6 was further validated by coculture neonatal rat cardiomyocytes with conditioned medium from hypoxia-treated MSCGas6, as well as by pretreatment cardiomyocytes with the specific receptor inhibitors of VEGF, bFGF, SDF and IGF-1. Collectively, our data suggest that Gas6 may advance the efficacy of MSC therapy for post-infarcted heart failure via enhanced Gas6/Axl autocrine prosurvival signaling and paracrine cytoprotective action.

Background: COVID-19 has caused a large number of deaths in a short period and lacks a specific treatment Early identification of poor prognosis patients may f

Background: Several descriptive studies have reported that higher neutrophil count (NC) may be correlated with poor prognosis in patients with confirmed COVID19

Bolt pre-tension is regularly used in the practical case of bearing-type connection. Due to confinement of lap plates, complicate triaxial stress field can be observed near bolt hole, which may affect bearing behavior of the whole connection. Currently, investigations on the related issues are limited. To fill this research gap, this paper presents a combined experimental and numerical study on high strength steel single-bolt connections with bolt pre-tension. Results reveal several meaningful recognitions on the bearing behavior of connection with bolt pre-tension. Firstly, the effect of bolt pre-tension on the final tearout failure mode is negligible. Secondly, distribution of triaxial stress field initiates with a circular pattern and gradually shrinks to a localized pattern between shear fracture lines at ultimate resistance of the connection. Thirdly, out-plane confinement will limit the piling-up of plate material in front of bolt, which will reduce the related bearing resistance. However, increasing bolt grade is still beneficial to the whole connection due to a trade-off between ultimate resistance of the connection and related bearing resistance. Comparison with current code is further conducted. It is found that current Eurocode3 has adequate design safety for connection with bolt pre-tension while extra safety is needed for current AISC 360-16.

High Strength Structural (HSS) steels, with nominal yield strength greater than 450 MPa exhibit phenomena including Lode angle dependence of yield, and accelerated cyclic softening at large strains that cannot be conveniently simulated by existing constitutive models that are developed primarily for conventional strength structural steels. This paper presents an experimental study consisting of 25 coupon scale tests (monotonic and cyclic) as well as 2 large scale cantilever column tests. According to experimental results, a classical combined isotropic and kinematic hardening constitutive model, the Armstrong and Frederick (A-F) model is identified by using the particle swarm optimization (PSO) algorithm. However, the yield plateau region and full-range softening behavior of HSSs under cyclic loading are difficult to be captured by the A-F model. A new constitutive model, termed the HSS-TD model with consideration of the yield plateau and three-stage strength softening, is formulated to simulate the response of HSS steels. The HSS-TD model shows significantly lower errors relative to the conventional A-F model, when assessed relative to test data. Moreover, the limitations of the HSS-TD model including influence of strain history and nonproportional loading are discussed.