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The role of visible light on longevity is incompletely understood. Here we show the effect of visible light in Drosophila melanogaster is wavelength specific. Life span was significantly extended by green light, whereas blue light reduced longevity dramatically, and minor impact was observed with red light. While oxidative stress, heat stress, or caloric restriction does not contribute to the beneficial effect of green light, our study found that the life span extension effect of green light might be mediated by microbiota or photosensitive micronutrients in food medium. In conclusion, we report that green light can extend longevity and present the potential of light as a noninvasive therapy for aging-related diseases.

The growing complexity of modern Cyber-Physical Systems (CPS) and the frequent communication between their components make them vulnerable to malicious attacks. As a result, secure state estimation is a critical requirement for the control of these systems. Many existing secure state estimation methods suffer from combinatorial complexity which grows with the number of states and sensors in the system. This complexity can be mitigated using optimization-based methods that relax the original state estimation problem, although at the cost of optimality as these methods often identify attack-free sensors as attacked. In this paper, we propose a new optimal graph-search algorithm to correctly identify malicious attacks and to securely estimate the states even in large-scale CPS modeled as linear time-invariant systems. The graph consists of layers, each one containing two nodes capturing a truth assignment of any given sensor, and directed edges connecting adjacent layers only. Then, our algorithm searches the layers of this graph incrementally, favoring directions at higher layers with more attack-free assignments, while actively managing a repository of nodes to be expanded at later iterations. The proposed search bias and the ability to revisit nodes in the repository and self-correct, allow our graph-search algorithm to reach the optimal assignment faster and tackle larger problems. We show that our algorithm is complete and optimal provided that process and measurement noises do not dominate the attack signal. Moreover, we provide numerical simulations that demonstrate the ability of our algorithm to correctly identify attacked sensors and securely reconstruct the state. Our simulations show that our method outperforms existing algorithms both in terms of optimality and execution time., Comment: 16 pages, 10 figures