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Accurate nationwide spatiotemporal distribution of ambient ozone product is critical for environment & health departments and for researches to investigate the influence of ozone for epidemiological studies. Our hybrid method, the novel CAMS (The Copernicus Atmosphere Monitoring Service) ozone improvement (CAO3_I) method, is the first attempt to predict ambient ozone by improving CAMS ozone (CAO3) products. For this novel framework, the SVM (Support Vector Machine) has been adopted for classification through the most significant regional ozone patterns which were extracted through the REOF (Rotated Empirical Orthogonal Function) technique. For each classified region, meteorological data, geographical data, CAMS ozone and ground-sites ozone are fed into random forest for regional regulation training and prediction. The CAO3_I method has shown its great feasibility in daily ozone surface distribution prediction. Based on daily averaged ozone concentrations for each station (STO3), the performance of CAO3 products (R2 = 0.35, RMSE = 25.77 μg/m3, MAPE = 42.06) have significantly improved to CAO3_I (R2 = 0.81, RMSE = 14.10 μg/m3, MAPE = 22.37), which shows above 97.4% R2 and RMSE have been improved. Our model is also capable to predict high level ozone concentrations in summer where the R2 has improved from 0.37 (for CAO3) to 0.81. In comparison with ground monitoring stations, the CAMS ozone improvement results can excellently reflect the distribution of daily ground-level ozone concentration and outperform previous statistical models in predicting ambient O3 concentrations. Therefore, the prediction results and our proposed model can be used for future epidemiological studies and air pollution controlling programs.

The aim of the present study is to evaluate neuroprotective effect of different physical exercises on cognition and behavior function by dopamine and 5-HT in rats of vascular dementia. Forty Sprague-Dawley rats were enrolled in this study and randomly divided into following 5 groups: control group (C group, n = 8), vascular dementia group (VD group, n = 8), treadmill exercise and vascular dementia group (TE-VD group, n = 8), in-voluntary exercise and vascular dementia group (IE-VD group, n = 8), voluntary exercise and vascular dementia group (VE-VD group, n = 8). The rats in TE-VD, IE-VD and VE-VD groups were received different physical exercise interventions, treadmill exercise, voluntary running exercise, involuntary running exercise respectively, total 4 weeks. Next, the rats in VE-VD, IE-VD, TE-VD and VD groups were received bilateral common carotids arteries operation to create vascular dementia model. Then, we use a passive avoid test to evaluate cognition and open field test to evaluate cognition autonomic activity in each group. The level in hippocampal dopamine and 5-HT were detected by microdialysis coupled with high performance liquid chromatography. Behavior results demonstrated that: compared with C group, the cognition in VD group significantly decreased (p0.001); compared with VD group, the cognition in VE-VD, IE-VD and TE-VD groups were significantly increased (p0.001). However, there are no significant difference between VE-VD, IE-VD and TE-VD groups (p0.05). In addition, hippocampal dopamine and 5-HT level significantly decreased in VD group when compared with C group (p0.001); hippocampal dopamine and 5-HT level in VE-VD, IE-VD and TE-VD groups were significantly increased when compared with VD group (p0.05). However, there are no significant difference between VE-VD, IE-VD and TE-VD groups (p0.05). Therefore, we concluded that different physical exercises, included treadmill exercise, in-voluntary exercise and voluntary exercise, all can protect cognition by up-regulate dopamine and 5-HT level in rats of vascular dementia.