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5. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

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Pham, Tài, primary, Heunks, Leo, additional, Bellani, Giacomo, additional, Madotto, Fabiana, additional, Aragao, Irene, additional, Beduneau, Gaëtan, additional, Goligher, Ewan C, additional, Grasselli, Giacomo, additional, Laake, Jon Henrik, additional, Mancebo, Jordi, additional, Peñuelas, Oscar, additional, Piquilloud, Lise, additional, Pesenti, Antonio, additional, Wunsch, Hannah, additional, van Haren, Frank, additional, Brochard, Laurent, additional, Laffey, John G, additional, Abrough, Fekri, additional, Acharya, Subhash P, additional, Amin, Pravin, additional, Arabi, Yaseen, additional, Bauer, Philippe, additional, Beitler, Jeremy, additional, Berkius, Johan, additional, Bugedo, Guillermo, additional, Camporota, Luigi, additional, Cerny, Vladimir, additional, Cho, Young-Jae, additional, Clarkson, Kevin, additional, Estenssoro, Elisa, additional, Goligher, Ewan, additional, Gritsan, Alexey, additional, Hashemian, Seyed Mohammadreza, additional, Hermans, Greet, additional, Heunks, Leo M, additional, Jovanovic, Bojan, additional, Kurahashi, Kiyoyasu, additional, Matamis, Dimitrios, additional, Moerer, Onnen, additional, Molnar, Zsolt, additional, Ozyilmaz, Ezgi, additional, Panka, Bernardo, additional, Papali, Alfred, additional, Peñuelas, Óscar, additional, Perbet, Sébastien, additional, Qiu, Haibo, additional, Razek, Assem Abdel, additional, Rittayamai, Nuttapol, additional, Roldan, Rollin, additional, Serpa Neto, Ary, additional, Szuldrzynski, Konstanty, additional, Talmor, Daniel, additional, Tomescu, Dana, additional, Van Haren, Frank, additional, Villagomez, Asisclo, additional, Zeggwagh, Amine Ali, additional, Abe, Toshikazu, additional, Aboshady, Abdelrhman, additional, Acampo-de Jong, Melanie, additional, Acharya, Subhash, additional, Adderley, Jane, additional, Adiguzel, Nalan, additional, Agrawal, Vijay Kumar, additional, Aguilar, Gerardo, additional, Aguirre, Gaston, additional, Aguirre-Bermeo, Hernan, additional, Ahlström, Björn, additional, Akbas, Türkay, additional, Akker, Mustafa, additional, Al Sadeh, Ghamdan, additional, Alamri, Sultan, additional, Algaba, Angela, additional, Ali, Muneeb, additional, Aliberti, Anna, additional, Allegue, Jose Manuel, additional, Alvarez, Diana, additional, Amador, Joaquin, additional, Andersen, Finn H, additional, Ansari, Sharique, additional, Apichatbutr, Yutthana, additional, Apostolopoulou, Olympia, additional, Arellano, Daniel, additional, Arica, Mestanza, additional, Arikan, Huseyin, additional, Arinaga, Koichi, additional, Arnal, Jean-Michel, additional, Asano, Kengo, additional, Asín-Corrochano, Marta, additional, Avalos Cabrera, Jesus Milagrito, additional, Avila Fuentes, Silvia, additional, Aydemir, Semih, additional, Aygencel, Gulbin, additional, Azevedo, Luciano, additional, Bacakoglu, Feza, additional, Badie, Julio, additional, Baedorf Kassis, Elias, additional, Bai, Gabriela, additional, Balaraj, Govindan, additional, Ballico, Bruno, additional, Banner-Goodspeed, Valerie, additional, Banwarie, Preveen, additional, Barbieri, Rosella, additional, Baronia, Arvind, additional, Barrett, Jonathan, additional, Barrot, Loïc, additional, Barrueco-Francioni, Jesus Emilio, additional, Barry, Jeffrey, additional, Bawangade, Harshal, additional, Beavis, Sarah, additional, Beck, Eduardo, additional, Beehre, Nina, additional, Belenguer Muncharaz, Alberto, additional, Belliato, Mirko, additional, Bellissima, Agrippino, additional, Beltramelli, Rodrigo, additional, Ben Souissi, Asma, additional, Benitez-Cano, Adela, additional, Benlamin, Mohamed, additional, Benslama, Abdellatif, additional, Bento, Luis, additional, Benvenuti, Daniela, additional, Bernabe, Laura, additional, Bersten, Andrew, additional, Berta, Giacomo, additional, Bertini, Pietro, additional, Bertram-Ralph, Elliot, additional, Besbes, Mohamed, additional, Bettini, Lisandro Roberto, additional, Beuret, Pascal, additional, Bewley, Jeremy, additional, Bezzi, Marco, additional, Bhakhtiani, Lakshay, additional, Bhandary, Rakesh, additional, Bhowmick, Kaushik, additional, Bihari, Shailesh, additional, Bissett, Bernie, additional, Blythe, David, additional, Bocher, Simon, additional, Boedjawan, Narain, additional, Bojanowski, Christine M, additional, Boni, Elisa, additional, Boraso, Sabrina, additional, Borelli, Massimo, additional, Borello, Silvina, additional, Borislavova, Margarita, additional, Bosma, Karen J, additional, Bottiroli, Maurizio, additional, Boyd, Owen, additional, Bozbay, Suha, additional, Briva, Arturo, additional, Bruel, Cédric, additional, Bruni, Andrea, additional, Buehner, Ulrike, additional, Bulpa, Pierre, additional, Burt, Karen, additional, Buscot, Mathieu, additional, Buttera, Stefania, additional, Cabrera, Jorge, additional, Caccese, Roberta, additional, Caironi, Pietro, additional, Canchos Gutierrez, Ivan, additional, Canedo, Nancy, additional, Cani, Alma, additional, Cappellini, Iacopo, additional, Carazo, Jesus, additional, Cardonnet, Luis Pablo, additional, Carpio, David, additional, Carriedo, Demetrio, additional, Carrillo, Ramón, additional, Carvalho, João, additional, Caser, Eliana, additional, Castelli, Antonio, additional, Castillo Quintero, Manuel, additional, Castro, Heloisa, additional, Catorze, Nuno, additional, Cengiz, Melike, additional, Cereijo, Enrique, additional, Ceunen, Helga, additional, Chaintoutis, Christos, additional, Chang, Youjin, additional, Chaparro, Gustavogcha, additional, Chapman, Carmel, additional, Chau, Simon, additional, Chavez, Cecilia Eugenia, additional, Chelazzi, Cosimo, additional, Chelly, Jonathan, additional, Chemouni, Frank, additional, Chen, Kai, additional, Chena, Ariel, additional, Chiarandini, Paolo, additional, Chilton, Phil, additional, Chiumello, Davide, additional, Chou-Lie, Yvette, additional, Chudeau, Nicolas, additional, Cinel, Ismail, additional, Cinnella, Gilda, additional, Clark, Michele, additional, Clark, Thomas, additional, Clementi, Stefano, additional, Coaguila, Luis, additional, Codecido, Alexis Jaspe, additional, Collins, Amy, additional, Colombo, Riccardo, additional, Conde, Juan, additional, Consales, Guglielmo, additional, Cook, Tim, additional, Coppadoro, Andrea, additional, Cornejo, Rodrigo, additional, Cortegiani, Andrea, additional, Coxo, Cristina, additional, Cracchiolo, Andrea Neville, additional, Crespo Ramirez, Mónica, additional, Crova, Philippe, additional, Cruz, José, additional, Cubattoli, Lucia, additional, Çukurova, Zafer, additional, Curto, Francesco, additional, Czempik, Piotr, additional, D'Andrea, Rocco, additional, da Silva Ramos, Fernando, additional, Dangers, Laurence, additional, Danguy des Déserts, Marc, additional, Danin, Pierre-Eric, additional, Dantas, Fabianne, additional, Daubin, Cédric, additional, Dawei, Wu, additional, de Haro, Candelaria, additional, de Jesus Montelongo, Felipe, additional, De Mendoza, Diego, additional, de Pablo, Raúl, additional, De Pascale, Gennaro, additional, De Rosa, Silvia, additional, Decavèle, Maxens, additional, Declercq, Pierre-Louis, additional, Deicas, Alberto, additional, del Carmen Campos Moreno, María, additional, Dellamonica, Jean, additional, Delmas, Benjamin, additional, Demirkiran, Oktay, additional, Demirkiran, Hilmi, additional, Dendane, Tarek, additional, di Mussi, Rossella, additional, Diakaki, Chrysi, additional, Diaz, Anatilde, additional, Diaz, Willy, additional, Dikmen, Yalim, additional, Dimoula, Aikaterini, additional, Doble, Patricia, additional, Doha, Nagwa, additional, Domingos, Guilherme, additional, Dres, Martin, additional, Dries, David, additional, Duggal, Abhijit, additional, Duke, Graeme, additional, Dunts, Pavel, additional, Dybwik, Knut, additional, Dykyy, Maksym, additional, Eckert, Philippe, additional, Efe, Serdar, additional, Elatrous, Souheil, additional, Elay, Gülseren, additional, Elmaryul, Abubaker S, additional, Elsaadany, Mohamed, additional, Elsayed, Hany, additional, Elsayed, Samar, additional, Emery, Malo, additional, Ena, Sébastien, additional, Eng, Kevin, additional, Englert, Joshua A, additional, Erdogan, Elif, additional, Ergin Ozcan, Perihan, additional, Eroglu, Ege, additional, Escobar, Miguel, additional, Esen, Figen, additional, Esen Tekeli, Arzu, additional, Esquivel, Alejandro, additional, Esquivel Gallegos, Helbert, additional, Ezzouine, Hanane, additional, Facchini, Alberto, additional, Faheem, Mohammad, additional, Fanelli, Vito, additional, Farina, Maria Fernanda, additional, Fartoukh, Muriel, additional, Fehrle, Lutz, additional, Feng, Feng, additional, Feng, Yufeng, additional, Fernandez, Irene, additional, Fernandez, Borja, additional, Fernandez-Rodriguez, Maria Lorena, additional, Ferrando, Carlos, additional, Ferreira da Silva, Maria João, additional, Ferreruela, Mireia, additional, Ferrier, Janet, additional, Flamm Zamorano, Matias Jesús, additional, Flood, Laura, additional, Floris, Leda, additional, Fluckiger, Martin, additional, Forteza, Catalina, additional, Fortunato, Antonella, additional, Frans, Eric, additional, Frattari, Antonella, additional, Fredes, Sebastian, additional, Frenzel, Tim, additional, Fumagalli, Roberto, additional, Furche, Mariano Andres, additional, Fusari, Maurizio, additional, Fysh, Edward, additional, Galeas-Lopez, Juan Luis, additional, Galerneau, Louis-Marie, additional, Garcia, Analía, additional, Garcia, María Fernanda, additional, Garcia, Elisabet, additional, Garcia Olivares, Pablo, additional, Garlicki, Jaroslaw, additional, Garnero, Aude, additional, Garofalo, Eugenio, additional, Gautam, Prabha, additional, Gazenkampf, Andrey, additional, Gelinotte, Stéphanie, additional, Gelormini, Domenico, additional, Ghrenassia, Etienne, additional, Giacomucci, Angelo, additional, Giannoni, Robert, additional, Gigante, Andrea, additional, Glober, Nancy, additional, Gnesin, Paolo, additional, Gollo, Yari, additional, Gomaa, Dina, additional, Gomero Paredes, Rosita, additional, Gomes, Rui, additional, Gomez, Raúl Alejandro, additional, Gomez, Oscar, additional, Gomez, Aroa, additional, Gondim, Louise, additional, Gonzalez, Manuel, additional, Gonzalez, Isabel, additional, Gonzalez-Castro, Alejandro, additional, Gordillo Romero, Orlando, additional, Gordo, Federico, additional, Gouin, Philippe, additional, Graf Santos, Jerónimo, additional, Grainne, Rooney, additional, Grando, Matilde, additional, Granov Grabovica, Sanja, additional, Grasso, Salvatore, additional, Grasso, Rinaldo, additional, Grimmer, Lisa, additional, Grissom, Colin, additional, Gu, Qing, additional, Guan, Xiang-Dong, additional, Guarracino, Fabio, additional, Guasch, Neus, additional, Guatteri, Luca, additional, Gueret, Renaud, additional, Guérin, Claude, additional, Guerot, Emmanuel, additional, Guitard, Pierre-Gildas, additional, Gül, Fethi, additional, Gumus, Ayca, additional, Gurjar, Mohan, additional, Gutierrez, Patricia, additional, Hachimi, Abdelhamid, additional, Hadzibegovic, Adi, additional, Hagan, Samantha, additional, Hammel, Clare, additional, Han Song, Joo, additional, Hanlon, Gabrielle, additional, Heines, Serge, additional, Henriksson, Johanna, additional, Herbrecht, Jean-Etienne, additional, Heredia Orbegoso, Gabriel Omar, additional, Hermon, Andrew, additional, Hernandez, Rosana, additional, Hernandez, Carmen, additional, Herrera, Luis, additional, Herrera-Gutierrez, Manuel, additional, Hidalgo, Juan, additional, Hill, Dianne, additional, Holmquist, Dagmar, additional, Homez, Marcela, additional, Hongtao, Xia, additional, Hormis, Anil, additional, Horner, Daniel, additional, Hornos, M Carmen, additional, Hou, Meihong, additional, House, Stacy, additional, Housni, Brahim, additional, Hugill, Keith, additional, Humphreys, Sally, additional, Humbert, Louis, additional, Hunter, Stephanie, additional, Hwa Young, Lee, additional, Iezzi, Nicolas, additional, Ilutovich, Santiago, additional, Inal, Volkan, additional, Innes, Richard, additional, Ioannides, Panagiotis, additional, Iotti, Giorgio Antonio, additional, Ippolito, Mariachiara, additional, Irie, Hiromasa, additional, Iriyama, Hiroki, additional, Itagaki, Taiga, additional, Izura, Javier, additional, Izza, Santiago, additional, Jabeen, Rakhshanda, additional, Jamaati, Hamidreza, additional, Jamadarkhana, Sunil, additional, Jamoussi, Amira, additional, Jankowski, Milosz, additional, Jaramillo, Luis Alberto, additional, Jeon, Kyeongman, additional, Jeong Lee, Seok, additional, Jeswani, Deepak, additional, Jha, Simant, additional, Jiang, Liangyan, additional, Jing, Chen, additional, Jochmans, Sébastien, additional, Johnstad, Bror Anders, additional, Jongmin, Lee, additional, Joret, Aurélie, additional, Junhasavasdikul, Detajin, additional, Jurado, Maria Teresa, additional, Kam, Elisa, additional, Kamohara, Hidenobu, additional, Kane, Caroline, additional, Kara, Iskender, additional, Karakurt, Sait, additional, Karnjanarachata, Cherdkiat, additional, Kataoka, Jun, additional, Katayama, Shinshu, additional, Kaushik, Shuchi, additional, Kelebek Girgin, Nermin, additional, Kerr, Kathryn, additional, Kerslake, Ian, additional, Khairnar, Prakash, additional, Khalid, Abidi, additional, Khan, Akram, additional, Khanna, Ashish K, additional, Khorasanee, Reza, additional, Kienhorst, Dieneke, additional, Kirakli, Cenk, additional, Knafelj, Rihard, additional, Kol, Mark Kol, additional, Kongpolprom, Napplika, additional, Kopitko, Csaba, additional, Korkmaz Ekren, Pervin, additional, Kubisz-Pudelko, Agnieszka, additional, Kulcsar, Zoltan, additional, Kumasawa, Junji, additional, Kuriyama, Akira, additional, Kutchak, Fernanda, additional, Labarca, Eduardo, additional, Labat, Françoise, additional, Laborda, César, additional, Laca Barrera, Manuel Alberto, additional, Lagache, Laurie, additional, Landaverde Lopez, Antonio, additional, Lanspa, Michael, additional, Lascari, Valeria, additional, Le Meur, Matthieu, additional, Lee, Su Hwan, additional, Lee, Young Ju, additional, Lee, Jinwoo, additional, Lee, Won-Yeon, additional, Lee, Jarone, additional, Legernaes, Terje, additional, Leiner, Tamaas, additional, Lemiale, Virginie, additional, Leonor, Tiago, additional, Lepper, Philipp M, additional, Li, Dahuan, additional, Li, Hongbin, additional, Li, Oleg, additional, Lima, Ana Raquel, additional, Lind, Dan, additional, Litton, Edward, additional, Liu, Ning, additional, Liu, Ling, additional, Liu, Jialin, additional, Llitjos, Jean-François, additional, Llorente, Beatriz, additional, Lopez, Rodolfo, additional, Lopez, Claudia Elizabeth, additional, Lopez Nava, Claudia, additional, Lovazzano, Pablo, additional, Lu, Min, additional, Lucchese, Francesca, additional, Lugano, Manuela, additional, Lugo Goytia, Gustavo, additional, Luo, Hua, additional, Lynch, Ceri, additional, Macheda, Sebastiano, additional, Madrigal Robles, Victor Hugo, additional, Maggiore, Salvatore Maurizio, additional, Magret Iglesias, Mònica, additional, Malaga, Peter, additional, Mallapura Maheswarappa, Harish, additional, Malpartida, Guillermo, additional, Malyarchikov, Andrey, additional, Mansson, Helena, additional, Manzano, Anaid, additional, Marey, Ismael, additional, Marin, Nathalie, additional, Marin, Maria del Carmen, additional, Markman, Eliana, additional, Martin, Felix, additional, Martin, Alex, additional, Martin Dal Gesso, Cristina, additional, Martinez, Felipe, additional, Martínez-Fidalgo, Conchita, additional, Martin-Loeches, Ignacio, additional, Mas, Arantxa, additional, Masaaki, Sakuraya, additional, Maseda, Emilio, additional, Massa, Eleni, additional, Mattsson, Anna, additional, Maugeri, Jessica, additional, McCredie, Victoria, additional, McCullough, James, additional, McGuinness, Shay, additional, McKown, Andrew, additional, Medve, László, additional, Mei, Chengqing, additional, Mellado Artigas, Ricard, additional, Mendes, Vitor, additional, Mervat, Mohamed Khalaf Ebraheim, additional, Michaux, Isabelle, additional, Mikhaeil, Michael, additional, Milagros, Olga, additional, Milet, Igor, additional, Millan, Maria Teresa, additional, Minwei, Zhang, additional, Mirabella, Lucia, additional, Mishra, Sanghamitra, additional, Mistraletti, Giovanni, additional, Mochizuki, Katsunori, additional, Moghal, Arif, additional, Mojoli, Francesco, additional, Molin, Alexandre, additional, Montiel, Raquel, additional, Montini, Luca, additional, Monza, Gianmario, additional, Mora Aznar, Maria, additional, Morakul, Sunthiti, additional, Morales, Maria, additional, Moreno Torres, Daniel, additional, Morocho Tutillo, Diego Rolando, additional, Motherway, Catherine, additional, Mouhssine, Doumiri, additional, Mouloudi, Eleni, additional, Muñoz, Tapia, additional, Munoz de Cabo, Carlos, additional, Mustafa, Mohamed, additional, Muthuchellappan, Radhakrishnan, additional, Muthukrishnan, Muraleekrishnan, additional, Muttini, Stefano, additional, Nagata, Isao, additional, Nahar, Dick, additional, Nakanishi, Misuzu, additional, Nakayama, Izumi, additional, Namendys-Silva, Silvio Antonio, additional, Nanchal, Rahul, additional, Nandakumar, Sivakumar, additional, Nasi, Alessandra, additional, Nasir, Kamal, additional, Navalesi, Paolo, additional, Naz Aslam, Tayyba, additional, Nga Phan, Thuy, additional, Nichol, Alistair, additional, Niiyama, Shuhei, additional, Nikolakopoulou, Sofia, additional, Nikolic, Elena, additional, Nitta, Kenichi, additional, Noc, Marko, additional, Nonas, Stephanie, additional, Nseir, Saad, additional, Nur Soyturk, Ayse, additional, Obata, Yukako, additional, Oeckler, Richard, additional, Oguchi, Moe, additional, Ohshimo, Shinichiro, additional, Oikonomou, Marina, additional, Ojados, Agueda, additional, Oliveira, Maria Teresa, additional, Oliveira Filho, Wilson, additional, Oliveri, Carlo, additional, Olmos, Aitor, additional, Omura, Kazuya, additional, Orlandi, Maria Cristina, additional, Orsenigo, Francesca, additional, Ortiz-Ruiz De Gordoa, Laura, additional, Ota, Kei, additional, Ovalle Olmos, Rainier, additional, Öveges, Nándo, additional, Oziemski, Peter, additional, Ozkan Kuscu, Ozlem, additional, Pachas Alvarado, Fernando, additional, Pagella, Gonzalo, additional, Palaniswamy, Vijayanand, additional, Palazon Sanchez, Eugenio Luis, additional, Palmese, Salvatore, additional, Pan, Guojun, additional, Pan, Wensen, additional, Papanikolaou, Metaxia, additional, Papavasilopoulou, Theonymfi, additional, Parekh, Ameet, additional, Parke, Rachael, additional, Parrilla, Francisco J, additional, Parrilla, Dácil, additional, Pasha, Taha, additional, Pasin, Laura, additional, Patão, Luis, additional, Patel, Mayur, additional, Patel, Grisma, additional, Pati, Basanta Kumar, additional, Patil, Jayaprakash, additional, Pattnaik, Saroj, additional, Paul, Daniel, additional, Pavesi, Maurizio, additional, Pavlotsky, Vanesa Alejandra, additional, Paz, Graciela, additional, Paz, Enrique, additional, Pecci, Elisabetta, additional, Pellegrini, Carlos, additional, Peña Padilla, Andrea Gabriela, additional, Perchiazzi, Gaetano, additional, Pereira, Tiago, additional, Pereira, Vera, additional, Perez, Manuel, additional, Perez Calvo, Cesar, additional, Perez Cheng, Meisy, additional, Perez Maita, Ronald, additional, Pérez-Araos, Rodrigo, additional, Perez-Teran, Purificación, additional, Perez-Torres, David, additional, Perkins, Gavin, additional, Persona, Paolo, additional, Petnak, Tananchai, additional, Petrova, Marina, additional, Pham, Tai, additional, Philippart, François, additional, Picetti, Edoardo, additional, Pierucci, Elisabetta, additional, Piervincenzi, Edoardo, additional, Pinciroli, Riccardo, additional, Pintado, Maria-Consuelo, additional, Piraino, Thomas, additional, Piras, Stephanie, additional, Piras, Claudio, additional, Pirompanich, Pattarin, additional, Pisani, Luigi, additional, Platas, Enrique, additional, Plotnikow, Gustavo, additional, Porras, Willy, additional, Porta, Virginia, additional, Portilla, Mariana, additional, Portugal, José, additional, Povoa, Pedro, additional, Prat, Gwenael, additional, Pratto, Romina, additional, Preda, Gabriel, additional, Prieto, Isidro, additional, Prol-Silva, Estefania, additional, Pugh, Richard, additional, Qi, Yupeng, additional, Qian, Chuanyun, additional, Qin, Tiehe, additional, Qu, Hongping, additional, Quintana, Teobaldo, additional, Quispe Sierra, Rosari, additional, Quispe Soto, Rocio, additional, Rabbani, Raihan, additional, Rabee, Mohamed, additional, Rabie, Ahmed, additional, Rahe Pereira, Maria Augusta, additional, Rai, Ashish, additional, Raj Ashok, Sundar, additional, Rajab, Mostafa, additional, Ramdhani, Navin, additional, Ramey, Elizabeth, additional, Ranieri, Marco, additional, Rathod, Darshana, additional, Ray, Banambar, additional, Redwanul Huq, Shihan Mahmud, additional, Regli, Adrian, additional, Reina, Rosa, additional, Resano Sarmiento, Natalia, additional, Reynaud, Faustine, additional, Rialp, Gemma, additional, Ricart, Pilar, additional, Rice, Todd, additional, Richardson, Angus, additional, Rieder, Marcelo, additional, Rinket, Martin, additional, Rios, Fernando, additional, Risso Vazquez, Alejandro, additional, Riva, Ivano, additional, Rivette, Monaly, additional, Roca, Oriol, additional, Roche-Campo, Ferran, additional, Rodriguez, Covadonga, additional, Rodriguez, Gabriel, additional, Rodriguez Gonzalez, Daniel, additional, Rodriguez Tucto, Xandra Yanina, additional, Rogers, Angela, additional, Romano, María Elena, additional, Rørtveit, Linda, additional, Rose, Alastair, additional, Roux, Damien, additional, Rouze, Anahita, additional, Rubatto Birri, Paolo Nahuel, additional, Ruilan, Wang, additional, Ruiz Robledo, Aldana, additional, Ruiz-Aguilar, Antonio Luis, additional, Sadahiro, Tomohito, additional, Saez, Ignacio, additional, Sagardia, Judith, additional, Saha, Rajnish, additional, Saha, Rohit, additional, Saiphoklang, Narongkorn, additional, Saito, Shigeki, additional, Salem, Maie, additional, Sales, Gabriele, additional, Salgado, Patricia, additional, Samavedam, Srinivas, additional, Sami Mebazaa, Mhamed, additional, Samuelsson, Line, additional, San Juan Roman, Nandyelly, additional, Sanchez, Patricia, additional, Sanchez-Ballesteros, Jesus, additional, Sandoval, Yazcitk, additional, Sani, Emanuele, additional, Santos, Martin, additional, Santos, Carla, additional, Sanui, Masamitsu, additional, Saravanabavan, Lakshmikanthcharan, additional, Sari, Sema, additional, Sarkany, Agnes, additional, Sauneuf, Bertrand, additional, Savioli, Monica, additional, Sazak, Hilal, additional, Scano, Riccardo, additional, Schneider, Francis, additional, Schortgen, Frédérique, additional, Schultz, Marcus J, additional, Schwarz, Gabriele Leonie, additional, Seçkin Yücesoy, Faruk, additional, Seely, Andrew, additional, Seiler, Frederik, additional, Seker Tekdos, Yasemin, additional, Seok Chan, Kim, additional, Serano, Luca, additional, Serednicki, Wojciech, additional, Setten, Mariano, additional, Shah, Asim, additional, Shah, Bhagyesh, additional, Shang, You, additional, Shanmugasundaram, Pradeep, additional, Shapovalov, Konstantin, additional, Shebl, Eman, additional, Shiga, Takuya, additional, Shime, Nobuaki, additional, Shin, Phil, additional, Short, Jack, additional, Shuhua, Chen, additional, Siddiqui, Sughrat, additional, Silesky Jimenez, Juan Ignacio, additional, Silva, Daniel, additional, Silva Sales, Betania, additional, Simons, Koen, additional, Sjøbø, Brit Ågot, additional, Slessor, David, additional, Smiechowicz, Jakub, additional, Smischney, Nathan, additional, Smith, Paul, additional, Smith, Tim, additional, Smith, Mark, additional, Snape, Sarah, additional, Snyman, Lindi, additional, Soetens, Filiep, additional, Sook Hong, Kyung, additional, Sosa Medellin, Miguel Ángel, additional, Soto, Giovanna, additional, Souloy, Xavier, additional, Sousa, Elsa, additional, Sovatzis, Stefania, additional, Sozutek, Didem, additional, Spadaro, Savino, additional, Spagnoli, Marco, additional, Spångfors, Martin, additional, Spittle, Nick, additional, Spivey, Mike, additional, Stapleton, Andrew, additional, Stefanovic, Branislava, additional, Stephenson, Lorraine, additional, Stevenson, Elizabeth, additional, Strand, Kristian, additional, Strano, Maria Teresa, additional, Straus, Slavenka, additional, Sun, Chenliang, additional, Sun, Rongqing, additional, Sundaram, Venkat, additional, SunPark, Tai, additional, Surlemont, Elisabeth, additional, Sutherasan, Yuda, additional, Szabo, Zsuzsanna, additional, Tainter, Christopher, additional, Takaba, Akihiro, additional, Tallott, Mandy, additional, Tamasato, Tamasato, additional, Tang, Zhanhong, additional, Tangsujaritvijit, Viratch, additional, Taniguchi, Leandro, additional, Taniguchi, Daisuke, additional, Tarantino, Fabio, additional, Teerapuncharoen, Krittika, additional, Temprano, Susana, additional, Terragni, Pierpaolo, additional, Terzi, Nicolas, additional, Thakur, Anand, additional, Theerawit, Pongdhep, additional, Thille, Arnaud W, additional, Thomas, Matt, additional, Thungtitigul, Poungrat, additional, Thyrault, Martial, additional, Tilouch, Nejla, additional, Timenetsky, Karina, additional, Tirapu, Juna, additional, Todeschini, Manuel, additional, Tomas, Roser, additional, Tomaszewski, Christian, additional, Tonetti, Tommaso, additional, Tonnelier, Alexandre, additional, Trinder, John, additional, Trongtrakul, Konlawij, additional, Truwit, Jonathon, additional, Tsuei, Betty, additional, Tulaimat, Aiman, additional, Turan, Sema, additional, Turkoglu, Melda, additional, Tyagi, Sanjeev, additional, Ubeda, Alejandro, additional, Vagginelli, Federica, additional, Valenti, María Florencia, additional, Vallverdu, Imma, additional, Van Axel, Alisha, additional, van den Hul, Ingrid, additional, van der Hoeven, Hans, additional, Van Der Meer, Nardo, additional, Vanhoof, Marc, additional, Vargas-Ordoñez, Mónica, additional, Vaschetto, Rosanna, additional, Vascotto, Ettore, additional, Vatsik, Maria, additional, Vaz, Ana, additional, Vazquez-Sanchez, Antonia, additional, Ventura, Sara, additional, Vermeijden, Jan Wytze, additional, Vidal, Anxela, additional, Vieira, Jocyelle, additional, Vilela Costa Pinto, Bruno, additional, Villagra, Ana, additional, Villegas Succar, Cristina, additional, Vinorum, Ole Georg, additional, Vitale, Giovanni, additional, Vj, Ramesh, additional, Vochin, Ana, additional, Voiriot, Guillaume, additional, Volta, Carlo Alberto, additional, von Seth, Magnus, additional, Wajdi, Maazouzi, additional, Walsh, Don, additional, Wang, Shouhong, additional, Wardi, Gabriel, additional, Ween-Velken, Nils Christian, additional, Wei, Bi-Lin, additional, Weller, Dolf, additional, Welsh, Deborah, additional, Welters, Ingeborg, additional, Wert, Michael, additional, Whiteley, Simon, additional, Wilby, Elizabeth, additional, Williams, Erin, additional, Williams, Karen, additional, Wilson, Antoinette, additional, Wojtas, Jadwiga, additional, Won Huh, Jin, additional, Wrathall, David, additional, Wright, Christopher, additional, Wu, Jian-Feng, additional, Xi, Guo, additional, Xing, Zheng-Jiang, additional, Xu, Hongyang, additional, Yamamoto, Kotaro, additional, Yan, Jie, additional, Yáñez, Julio, additional, Yang, Xiaobo, additional, Yates, Elliot, additional, Yazicioglu Mocin, Ozlem, additional, Ye, Zhenglong, additional, Yildirim, Fatma, additional, Yoshida, Norifumi, additional, Yoshido, Hector Higo Leon, additional, Young Lee, Bo, additional, Yu, Rongguo, additional, Yu, Gong, additional, Yu, Tao, additional, Yuan, Boyun, additional, Yuangtrakul, Nadwipa, additional, Yumoto, Tetsuya, additional, Yun, Xie, additional, Zakalik, Graciela, additional, Zaki, Ahmad, additional, Zalba-Etayo, Begoña, additional, Zambon, Massimo, additional, Zang, Bin, additional, Zani, Gianluca, additional, Zarka, Jonathan, additional, Zerbi, Simone Maria, additional, Zerman, Avsar, additional, Zetterquist, Harald, additional, Zhang, Jiuzhi, additional, Zhang, Hongwen, additional, Zhang, Wei, additional, Zhang, Guoxiu, additional, Zhang, Weixin, additional, Zhao, Hongsheng, additional, Zheng, Jia, additional, Zhu, Bin, additional, and Zumaran, Ronald, additional

Published
2023
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6. The quality attribute of watershed ecosystem is more important than the landscape attribute in controlling erosion of red soil in southern China

Author

Yingcong Ye, Qing Zhu, Xi Guo, Shiyu Liu, Wenbo Cai, Jun Wu, and Jiaxin Guo

Subjects
Watershed, media_common.quotation_subject, Soil Science, Spatial heterogeneity, Erosion, Environmental science, Quality (business), Ecosystem, Physical geography, Scale (map), Red soil, Soil conservation, Agronomy and Crop Science, Nature and Landscape Conservation, Water Science and Technology, media_common
Abstract

Landscape and quality attributes are major ecosystem characteristics closely associated with soil conservation service (SCS). However, the intrinsic mechanisms by which these two attributes influence SCS are still unclear. Therefore, this study quantitatively analyzed the landscape pattern, ecological quality, and SCS in the Lianshui River watershed (a typical soil and water loss area of red soil in southern China) and its sub-watersheds in 2019. The boosted regression tree model was used to explore the influence of 15 factors (i.e., landscape and quality attributes) on SCS at the sub-watershed scale. According to the results, compared with the landscape attribute, the quality attribute of the watershed ecosystem could better explain the spatial heterogeneity of SCS across 66 sub-watersheds. The overall degree of influence of five quality factors on SCS reached 57.81%, with the highest being the normalized differential build-up and bare soil index (NDBSI), at 25.11%. Among 10 landscape factors, aggregation had the greatest influence on SCS, at 28.64%. The relationships between key influencing factors and SCS were non-monotonic and non-linear, with threshold effects. For example, NDBSI values of 0.18–0.41 had a positive influence on SCS, while NDBSI values of 0.41–0.65 had a negative influence on SCS. The findings broaden our understanding of the response of SCS to changes in landscape and quality attributes at the sub-watershed scale, and could offer comprehensive support for soil erosion management in the watershed ecosystem.

Published
2022

7. The thrombodynamic ratio as a predictor of 28-day mortality in sepsis patients

Author

Xi Guo, Xin-Yan Shuai, Tian-Tian Cai, Zhi-Yang Wu, Da-Wei Wu, and Shi-Fang Ding

Subjects
Hospitalization, Sepsis, Biochemistry (medical), Clinical Biochemistry, Humans, General Medicine, Prognosis, Biochemistry, Proportional Hazards Models, Retrospective Studies
Abstract

The thrombodynamic ratio (TDR) as a composite thromboelastography (TEG) parameter, has been proven to be valuable in multiple diseases. However, the association between TDR and mortality in sepsis has not been studied.One hundred forty-one patients were enrolled in this retrospectively study. TEG was performed immediately at admission. Two cox proportional hazards models were developed for the prediction of 28-day mortality. The C statistic, continuous net reclassification index (cNRI) and integrated discriminatory index (IDI) were calculated to compare the discrimination performance of clinical models with and without the TDR value. The integrated calibration index (ICI) and E50 were calculated to compare the calibration.Patients with lower TDR were more likely to have organ impairments and increased 28-day mortality. The TDR value improved discrimination performance in both Model 1 (C statistic, 0.745 vs 0.735; cNRI 19.4%, p = 0.044; IDI 5.6%, p = 0.012) and Model 2 (C statistic, 0.761 vs 0.751; IDI, 5.1%, p = 0.012). Compared to the calibration curve of Model 1 without TDR, addition of TDR displayed better calibration (ICI, 0.023; E50, 0.021).TDR value significantly predicts 28-day mortality in patients with sepsis and could improve the discrimination and calibration performance of clinical prediction models.

Published
2022

11. Plant Defensin Gene Pfpdf2 from Perilla Frutescens Confers High-Level Resistance to Alternaria Brassicae And Botrytis Cinerea In Brassica Napus

Author

Huaxiang Xu, Xi Guo, Huiyang Bai, Jie Yu, Huimin Shi, Junxing Lu, Bo Zhu, and Tao Zhang

Abstract

Background Plant defensins (PDF) are a group of small cysteine-rich peptides with broad-spectrum antimicrobial activity that play important roles in the response of plant to abiotic stresses.Results In this study, Perilla frutescens PDF (PfPDF) genes were identified and functionally characterized. A total of 6 PfPDF genes were successfully cloned. Characterization analysis revealed that all PfPDF genes consisted of 2 exons and 1 intron and encoded 73 ~ 88 amino acids, each of which contained 8 cysteine residues. Phylogenetic analyses indicated that all PfPDFs were members of the PDF type I family. The expression of PfPDF genes showed wide tissue specificity. PfPDF1, PfPDF2 and PfPDF4 were expressed in stems, leaves, flowers and seeds, and PfPDF3 was expressed in leaves and seeds, while PfPDF5 and PfPDF6 were only expressed in seeds. Subsequently, PfPDF2, which was highly expressed in seeds, was transformed into Brassica napus to obtain transgenic plants. The total yield of transgenic B. napus was comparable to that of wild-type. Moreover, an in vitro antifungal bioactivity test on leaves revealed that the resistance to Alternaria brassicae and Botrytis cinerea was enhanced significantly in PfPDF2-overexpressing B. napus compared to that of the wild type. Analysis of differentially expressed genes in wild-type and transgenic B. napus showed that photosynthesis, fatty acid biosynthesis and metabolism pathways were significantly activated.Conclusions Overall, this study identified and characterized PDF genes from P. frutescens for the first time and clarified that PfPDF2 could be applied to produce crops with higher resistance to pathogens, providing unique insights and new genetic resources for molecular breeding.

Published
2023

20. AMH inhibits androgen production in human theca cells

Author

Minghui, Chen, Xi, Guo, Yiping, Zhong, Yang, Liu, Bing, Cai, Rihan, Wu, Chuan, Huang, and Canquan, Zhou

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Molecular Medicine, Cell Biology, Molecular Biology, Biochemistry
Abstract

Both excessive ovarian production of AMH and androgen are important features of polycystic ovary syndrome (PCOS). Present study aimed to explore the direct effect of AMH on androgen production in human theca cells. Primary cultured human theca cells were treated with AMH, an ALK2 (the BMP type 1 receptor) inhibitor and an ALK5 (the TGFβ type 1 receptor) inhibitor. AMH significantly suppresses the expression of the androgen synthesis-related enzyme CYP17A1 and reduces the production of androstenedione and testosterone in normal human theca cells and PCOS theca cells. Inhibitors of ALK2/3 and ALK5 antagonize the effect of AMH on the expression of CYP17A1. Although both ALK5 and ALK2 interact with AMHR2 in the presence of AMH, AMH activated neither TGFβR-Smads (Smad 2/3) nor BMPR-Smads (Smad 1/5/8). Our data suggested that AMH suppresses androgen synthesis-related enzyme CYP17A1 expression and inhibits androgen production in human theca cells, which process may be mediated by ALK2 and ALK5.

Published
2023

23. Specific Microglial Subtypes and Inflammatory Mechanisms in Early Diabetic Retinopathy

Author

Yan Wang, Yuxi Zhang, Xiongyi Yang, Libing Hong, Zhuohang Xie, Lin Chen, Ke Xiong, Wenmin Jiang, Siyu Yang, Meiping Lin, Xi Guo, Qiumo Li, Xiaoqing Deng, Yanhui Lin, Mingzhe Cao, Guoguo Yi, and Min Fu

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

27. Genome-wide analysis of DGAT gene family in Perilla frutescens and functional characterization of PfDGAT2-2 and PfDGAT3-1 in Arabidopsis

Author

Huaxiang Xu, Dan Li, Youjin Hao, Xi Guo, Junxing Lu, and Tao Zhang

Subjects
History, Polymers and Plastics, Arabidopsis, Perilla frutescens, Plant Science, General Medicine, Industrial and Manufacturing Engineering, Seeds, Genetics, Plant Oils, Diacylglycerol O-Acyltransferase, Business and International Management, Agronomy and Crop Science, Phylogeny, Triglycerides
Abstract

Diacylglycerol acyltransferase (DGAT) is the rate-limiting enzyme that catalyzes the final step in triacylglycerol biosynthesis, however, members of DGAT gene family of Perilla frutescens has not yet been identified and characterized. In this study, a total of 20 PfDGAT genes were identified from the genome of Perilla frutescens and were divided into four groups (PfDGAT1, PfDGAT2, PfDGAT3, PfWS/DGAT) according to their phylogenetic relationships. These were unevenly distributed across the 12 chromosomes. Sequence analysis revealed that PfDGAT members of the same subfamily have highly conserved gene structures, protein motifs and cis-acting elements in their promoters. Gene duplication analysis showed that random duplication and segmental duplication contributed to the expansion of the DGAT family in P. frutescens. RNA-seq and qRT-PCR analysis suggested that they may play a role in the growth and development of Perilla, especially in the accumulation of seed oil. Compared with the wild-type, seed length, width, and 1000-seed weight of transgenic PfDGAT2-2 and PfDGAT3-1 Arabidopsis were significantly increased, as well as the seed oil content increased by 7.36-15.83 %. Over-expression of PfDGAT2-2 could significantly increase the content of C18:3 and C20:1 in Arabidopsis, while over-expression of PfDGAT3-1 could significantly enhance the content of C18:2 and C18:3. In conclusion, in this study the characteristics and potential functions of the PfDGAT family members were elucidated. Our findings provided basic information for further functional studies and helped to increase the yield and quality of Perilla oil.

Published
2022

32. Structural Elucidation and genetic identification of the O-antigen from a novel serogroup of Escherichia coli strain 2017LL031

Author

Chunjun Qin, Bin Hu, Yujuan Xu, Changqing Zhao, Wei Hao, Jing Wang, Xi Guo, Renpeng Li, Jing Hu, and Jian Yin

Subjects
Multigene Family, Organic Chemistry, Escherichia coli, O Antigens, General Medicine, Serogroup, Biochemistry, Analytical Chemistry
Abstract

The O-antigen is an important virulence factor involved in the survival, virulence and invasion of bacteria. The bacterial serological types are highly dependent on these surface-exposed and structurally unique O-antigen structures. In this work, the structure of O-antigen from an Escherichia coli strain 2017LL031 was elucidated as a hexasaccharide repeating unit: →3)-[β-D-Glcp-(1 → 2)]-α-L-Rhap-(1 → 3)-[α-D-Quip-(1 → 3)-α-D-GlcpA-(1 → 2)]-β-L-Fucp-(1 → 3)-β-D-GlcpNAc-(1→, which is completely different from all known E. coli serogroups. The O-antigen gene cluster (O-AGC) of 2017LL031 was also analyzed and correlates well to its O-Ag. Moreover, the O-AGC of 2017LL031 was deleted and its role in O-Ag biosynthesis was confirmed experimentally. Taken together, our results present that a novel E.coli serotype 2017LL031 is identified.

Published
2022

34. Crocin attenuation of neurological deficits in a mouse model of intracerebral hemorrhage

Author

Youping Li, Lu Ma, Chao You, Xin Qi, Yang Wei, Meng Tian, Xi Guo, Zhongxin Duan, Dayong Wu, and Hao Li

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, Brain Edema, Pharmacology, Antioxidants, Crocin, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, medicine, Animals, Collagenases, cardiovascular diseases, Saline, Cerebral Hemorrhage, Intracerebral hemorrhage, chemistry.chemical_classification, Reactive oxygen species, business.industry, General Neuroscience, Brain, Histology, medicine.disease, Carotenoids, nervous system diseases, Mice, Inbred C57BL, Stroke, Heme oxygenase, Disease Models, Animal, 030104 developmental biology, chemistry, Nerve Degeneration, Immunohistochemistry, Nervous System Diseases, Reactive Oxygen Species, business, Heme Oxygenase-1, 030217 neurology & neurosurgery
Abstract

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke that is associated with high morbidity and mortality. However, up to now, there are no effective prevention methods or specific therapies to improve its clinical outcomes. Herein, we explore preliminarily the efficacy of crocin, a carotenoid extracted from the stigma of saffron known for its anti-oxidation and free radical scavenging activities, in a mouse ICH model induced with collagenase infusion. Crocin or saline was administrated 6 h after ICH and then every 12 h for up to 7 days. Neurological scores were examined on days 1, 3, and 7 after ICH. Mice were sacrificed after1, 3, and 7 days of crocin treatment for examination of histology and immunohistochemistry. The results showed that oral administration of crocin attenuated the neurological deficits and reduced the myelin loss, neuron degeneration, iron deposition, reactive oxygen species (ROS) production and heme oxygenase-1 (HO-1) expression in the early stage of ICH, making it potential to be an ideal candidate for medical therapy of ICH in clinic.

Published
2019

35. Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage

Author

Xi Guo, Xin Qi, Meng Tian, Chao You, Fan Zhang, Lu Ma, Yang Wei, Zhongxin Duan, and Hao Li

Subjects
Male, Iron Overload, medicine.medical_treatment, Deferoxamine, Pharmacology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Collagenases, Saline, Survival rate, Myelin Sheath, Survival analysis, Chelating Agents, Intracerebral hemorrhage, business.industry, Therapeutic effect, medicine.disease, Immunohistochemistry, Survival Analysis, Rats, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Nerve Degeneration, Brain Stem Hemorrhage, Traumatic, Surgery, Neurology (clinical), Neuron, Nervous System Diseases, Reactive Oxygen Species, business, Heme Oxygenase-1, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background Brainstem hemorrhage (BSH) is the most dangerous and devastating subtype of intracerebral hemorrhage and is associated with high morbidity and mortality. However, to date, no effective prevention methods or specific therapies have been available to improve its clinical outcomes. We preliminarily explored the efficacy of deferoxamine (DFO), a clinical chelator known for its iron-scavenging activities, in a rat model of BSH induced with collagenase infusion. Methods DFO or saline was administrated 6 hours after BSH induction and then every 12 hours for ≤7 days. The survival curve of the rats was created, and the neurological scores were examined on days 1, 3, and 7 after BSH. The rats were sacrificed after 1, 3, and 7 days of DFO treatment for histological examination and immunohistochemistry. Results The results showed that administration of DFO delayed erythrocytes lysis, reduced iron deposition, reduced reactive oxygen species generation, reduced heme oxygenase-1 expression, and alleviated brain injury such as neuron degeneration and myelin sheath injury. However, DFO did not improve the survival rate and neurobehavioral outcomes in this model. Conclusions Administration of DFO had limited therapeutic effects on collagenase-induced brainstem hemorrhage in rats. Some potential explanations were proposed, and more preclinical work is required to clarify the controversial curative effect of DFO in ICH.

Published
2019

36. Spatiotemporal variation of soil heavy metals in farmland influenced by human activities in the Poyang Lake region, China

Author

Xi Guo, Yefeng Jiang, and Yingcong Ye

Subjects
Hydrology, Pollution, geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, media_common.quotation_subject, Heavy metals, 04 agricultural and veterinary sciences, 01 natural sciences, Sill, Soil water, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, Spatial variability, Soil heavy metals, China, Environmental quality, 0105 earth and related environmental sciences, Earth-Surface Processes, media_common
Abstract

The problem of heavy metal pollution in farmland has elicited growing concern in the Poyang Lake region, which includes the largest freshwater lake in China and serves as the country's commodity grain base. Here we determined soil As, Cr, and Hg concentrations and characterized their spatiotemporal distributions in the Poyang Lake region using data from 85 and 208 sampling locations that were respectively obtained by the farmland environmental quality surveys conducted in 1983 and 2010. The results showed that the average concentrations of these metals significantly increased from 10.72, 63.25, and 0.10 mg kg−1 in 1983 to 12.14, 84.06, and 0.13 mg kg−1 in 2010, respectively. From 1983 to 2010, the average As and Cr concentrations were higher and the Hg concentration was lower than background values, all of which met China's Soil Environmental Quality Standard (GB 15618-2018). Over the same period, the nugget/sill ratio for soil As and Cr each decreased but it increased for Hg, while for all three metals their ranges of the nugget/sill ratio increased. Spatial variation in soil of As, Cr, and Hg was mainly controlled by geological environment in 1983, whereas it was affected by human activities in 2010. To support the twin goals of sustainable utilization of farmland soils and food security, we should pay more attention to farmland pollution (e.g., heavy metals)—healthy soils for a healthy life.

Published
2019

37. Interactions of oligochitosan with blood components

Author

Tong Sun, Hong Tan, Hao Li, Meng Tian, Xi Guo, Lu Ma, Rui Zhong, Junwen Guan, Chao You, and Zhipeng Gu

Subjects
Blood Platelets, Erythrocytes, Platelet Aggregation, Oligosaccharides, Chitin, 02 engineering and technology, Hemolysis, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Coagulation testing, medicine, Humans, Platelet, Platelet activation, Hydrogen peroxide, Blood Coagulation, Complement Activation, Molecular Biology, 030304 developmental biology, Chitosan, 0303 health sciences, Ethanol, Complement System Proteins, Hydrogen Peroxide, General Medicine, Carbon-13 NMR, Platelet Activation, 021001 nanoscience & nanotechnology, medicine.disease, chemistry, Coagulation system, Biophysics, 0210 nano-technology
Abstract

Oligochitosan (OCHI) is known to have some specific biological activities. However, its interactions with blood components and related correlation with molecular structures remains to be clarified due to its growing use in biomedical areas. Herein, a series of OCHI were prepared by hydrogen peroxide induced degradation combined fractionation in ethanol solutions and their molecular structures were characterized by GPC, FTIR, 1H and 13C NMR, and then the interactions of the prepared OCHI with blood components, including red blood cells (hemolysis, deformability, and aggregation), coagulation system, complement (C3a, and C5a activation), and platelet (activation, and aggregation), were investigated. For red blood cells, OCHI has a quite low risk of hemolysis in a dose- and MW-dependent manner and the deformability and aggregation were observed in its high MW fraction. The coagulation tests revealed that OCHI is capable of a mild anticoagulation through blocking the intrinsic pathway and the anticoagulation corresponding MW was identified. In terms of complement, OCHI could inhibit C3a in a dose-dependent manner and activate C5a with its high MW fraction. In addition, there is no significant effect of OCHI on platelet activation and aggregation. Based on above results, the interactions related mechanism was discussed and proposed.

Published
2019

38. Structure elucidation and gene cluster annotation of the O-antigen of Vibrio cholerae O100 containing two rarely occurred amino sugar derivatives

Author

Andrei V. Filatov, Alexander S. Shashkov, Xi Guo, Andrei V. Perepelov, Bin Li, and Sofia N. Senchenkova

Subjects
Models, Molecular, Amino sugar, Stereochemistry, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, Analytical Chemistry, Antigen, Gene cluster, medicine, Nuclear Magnetic Resonance, Biomolecular, Vibrio cholerae, Gene, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, O Antigens, Amino Sugars, Molecular Sequence Annotation, Sequence Analysis, DNA, General Medicine, 0104 chemical sciences, Carbohydrate Sequence, chemistry, Multigene Family, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

O-polysaccharide (O-antigen) was isolated from the lipopolysaccharide of Vibrio cholerae O100 and studied by component analyses and 1D and 2D NMR spectroscopy. The following structure of the O-polysaccharide was established: →3)-β- d -QuipNAc4N(dHh)-(1 → 3)-α- d -Fucp4N(RHb)-(1 → 3)-α- l -FucpNAc-(1→ where Hb and dHh indicate 3-hydroxybutanoyl and 3,5-dihydroxyhexanoyl, respectively. The O-antigen gene cluster of V. cholerae O100 has been sequenced. The gene functions were tentatively assigned by comparison with sequences in the available databases and found to be in agreement with the OPS structure.

Published
2019

39. Nitrogen doped porous carbon polyhedral supported Fe and Ni dual-metal single-atomic catalysts: template-free and metal ligand-free sysnthesis with microwave-assistance and d-band center modulating for boosted ORR catalysis in zinc-air batteries

Author

Biao Wang, Jie Tang, Xiaohua Zhang, Min Hong, Haokun Yang, Xi Guo, Song Xue, Cuicui Du, Zhixiao Liu, and Jinhua Chen

Subjects
General Chemical Engineering, Environmental Chemistry, General Chemistry, Industrial and Manufacturing Engineering
Published
2022

44. Cu embedded Co oxides and its fenton-like activity for metronidazole degradation over a wide pH range: Active sites of Cu doped Co3O4 with {1 1 2} exposed facet

Author

Xiao Xi Guo, Shishuai Shi, Ke Wang, Ruixue Zhang, Bo Hu, Huanhuan Wang, Yun Tian, Mai Guo, Bolan Li, and Yi-Fan Han

Subjects
Facet (geometry), Materials science, General Chemical Engineering, Inorganic chemistry, General Chemistry, Cu doped, Redox, Industrial and Manufacturing Engineering, Dissociation (chemistry), Catalysis, Ph range, Environmental Chemistry, Degradation (geology), Bimetallic strip
Abstract

Cu-Co bimetallic catalysts show excellent performance for metronidazole (MNZ) degradation in a Fenton-like reaction, a near complete conversion was achieved. Cu doped Co3O4 with {112} exposed facet has proved to promote the oxidation of Co2+ to Co3+ in Cu-CoOx. The surface Cu+ on {112}-enclosed Co3O4 was identified as the main active species for the reaction and its concentration counts a lot in performance. The Cu+ with raised d-band center under Co-Cu synergistic interaction has boosted the dissociation of H2O2 into •OH with stronger electron donation to H2O2 and elongated O-O bond. Meanwhile, the accelerated redox process especially for Cu on the {112} facet of Co3O4 with a faster electron transfer rate also contributed to the excellent performance. The optimization of operational parameters of Co1Cu2 in MNZ removal with investigation of degradation pathway were also thoroughly performed.

Published
2022

45. E3 ubiquitin ligase mind bomb 1 overexpression reduces apoptosis and inflammation of cardiac microvascular endothelial cells in coronary microvascular dysfunction

Author

Xiao-Fei, Qin, Ying-Guang, Shan, Jing-Hong, Gao, Feng-Xiang, Li, and Yu-Xi, Guo

Subjects
Inflammation, Rats, Sprague-Dawley, Ubiquitin-Protein Ligases, Animals, Endothelial Cells, Apoptosis, Heart, Cell Biology, Cells, Cultured, Rats
Abstract

The apoptosis and inflammation in cardiac microvascular endothelial cells (CMECs) promote the development of coronary microvascular dysfunction (CMD). The present study aimed to explore the role of E3 ubiquitin ligase mind bomb 1 (MIB1) in the apoptosis and inflammation in CMECs during CMD.In vivo, CMD in rats was induced by sodium laurate injection. In vitro, rat primary CMECs were stimulated by homocysteine (Hcy). The apoptosis of CMECs was measured using flow cytometry. The inflammation of CMECs was evaluated by the level of tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β). The interplay between MIB1 and mitogen-activated protein kinase kinase kinase 5 (map3k5, also called ASK1) was measured using Co-immunoprecipitation.MIB1 expression was decreased and ASK1 expression was increased in the heart tissues of CMD rats and Hcy-treated CMECs. MIB1 overexpression decreased fibrinogen-like protein 2 (FGL2) secretion, inflammation, and apoptosis induced by Hcy in CMECs. Meanwhile, MIB1 overexpression decreased the protein levels of ASK1 and p38, while not affected ASK1 mRNA levels. The following mechanism experiments revealed that MIB1 downregulated ASK1 expression by increasing its ubiquitination. ASK1 overexpression reversed the inhibitory effect of MIB1 on FGL2 secretion, apoptosis, inflammation, and p38 activation in Hcy-treated CMECs. In CMD rats, MIB1 overexpression partly retarded CMD progression, manifesting as increased coronary capillary density and decreased microthrombi formation.MIB1 overexpression relieved apoptosis and inflammation of CMECs during CMD by targeting the ASK1/p38 pathway.

Published
2022

46. Mussel-inspired dual-crosslinked polyamidoxime photothermal hydrogel with enhanced mechanical strength for highly efficient and selective uranium extraction from seawater

Author

Jie Wang, Zuji Xie, Shuai Tang, Ruoqian Zhang, Yinjiang Liu, Yihui Yuan, Ning Wang, Anping Gu, Hui Wang, Mengwei Chen, Tao Liu, and Xi Guo

Subjects
Materials science, General Chemical Engineering, Extraction (chemistry), Stacking, Ionic bonding, Sorption, General Chemistry, Photothermal therapy, Industrial and Manufacturing Engineering, Adsorption, Chemical engineering, Ultimate tensile strength, Environmental Chemistry, Seawater
Abstract

The efficient development of selective adsorbents for uranium extraction from seawater is necessary for their potential application in nuclear power generation. The amidoxime-based adsorbents have been recognized as the potential candidates, whereas they still suffer from a much higher affinity towards V(V) present in the seawater over U(VI), leading to the extremely limited commercial use. In this work, we develop a novel mussel-inspired photothermal polyamidoxime (PAO) hydrogel adsorbent, in which polydopamine (PDA) chains are linked to PAO (PDA-PAO) via Michael addition. Dual-crosslinked Fe@PDA-PAO hydrogel structure is constructed by noncovalent bonds between the catechol of PDA chains (e.g. π-π stacking and hydrogen bonds) as well as ionic coordination of Fe3+. PDA contributes to the improved hydrophilicity and high photothermal conversion efficiency. As a result, after immersing in real seawater for 6 weeks, light-irradiated Fe@PDA-PAO hydrogel delivers high uranium sorption capacity (12.67 mg-U/g-Ads) together with high U/V mass ratios (1.17), which are superior to currently available hydrogel adsorbents. Meanwhile, Fe3+ coordination endows Fe@PDA-PAO hydrogel with excellent tensile strength and self-recovery ability, which are of great significance to withstand the harsh conditions of ocean environment for practical applications. The results presented here reveal that Fe@PDA-PAO hydrogel holds tremendous potential for practical applications in the uranium-selective extraction from seawater.

Published
2022

47. Study on the quantification method of water pollution ecological compensation standard based on emergy theory

Author

Xi Guo, Zening Wu, Danyang Di, Wang Huiliang, and Cuimei Lv

Subjects
Pollutant, Ecological economics, 010504 meteorology & atmospheric sciences, Ecology, Sluice, General Decision Sciences, 010501 environmental sciences, 01 natural sciences, Compensation (engineering), Emergy, Environmental science, Water quality, Water pollution, Ecology, Evolution, Behavior and Systematics, Analysis method, 0105 earth and related environmental sciences
Abstract

Water pollution compensation is one of the important economic means of water pollution control and management, and the quantification of compensation standard is the key link in the implementation of water pollution ecological compensation. Because the ecological compensation refers to ecological environment, society and economy at the same time, the emergy analysis method of ecological economics was introduced to the quantification study of water pollution ecological compensation standard to overcome the shortcomings of traditional methods, and the ecological economic value of pollutants dilution water is defined as water pollution ecological compensation standard In the process, the key pollutants in river was confirmed by water quality assessment, then the water dilution model was built and the dilution water amount when pollutant concentration meeting the standards of water quality section was determined on the basis of purification of key pollutants. Using the Qingyi River as an example, the water pollution compensation standard of the key pollutants (NH3-N and COD) were calculated, which showed that the comprehensive compensation standard of NH3-N are all higher than COD in six control section. Among them, the highest comprehensive compensation standard is 93.99 yuan/t in Heshang Bridge (Changge City), the next one is 74.07 yuan/t in Hutuo sluice, and Zengfumiao Village is without compensation. Therefore, the pollutant discharge levels are different in different section, and then their compensation standards are different. To sum up, the economic, social and ecological losses caused by water pollution were considered synthetically and the emergy method for the accurate quantification of water pollution ecological compensation standard was provided.

Published
2018

48. Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor

Author

Xi Mu, Lu-Yao Chen, Richard J. Ward, Qian Hao, Nan Wu, Xiao-Xi Guo, Ying Liu, Li Ma, Su An, Tian-Rui Xu, Qiu-Lan Li, Hong Zeng, and Yang Yang

Subjects
0301 basic medicine, Cannabinoid receptor, medicine.medical_treatment, Biosensing Techniques, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Rimonabant, Fluorescence Resonance Energy Transfer, medicine, Humans, Extracellular Signal-Regulated MAP Kinases, Cannabinoid Receptor Antagonists, G protein-coupled receptor, Cannabinoid Receptor Agonists, Chemistry, Kinase, food and beverages, Cell Biology, Kinetics, 030104 developmental biology, Förster resonance energy transfer, Gene Expression Regulation, Biophysics, Phosphorylation, lipids (amino acids, peptides, and proteins), Cannabinoid, 030217 neurology & neurosurgery, Intracellular, Protein Binding, medicine.drug
Abstract

The cannabinoid receptor 1 (CB1) is mainly expressed in the nervous system and regulates learning, memory processes, pain and energy metabolism. However, there is no way to directly measure its activation. In this study, we constructed a CB1 intramolecular fluorescence resonance energy transfer (FRET) sensor, which could measure CB1 activation by monitoring structural changes between the third intracellular loop and the C-terminal tail. CB1 agonists induced a time- and concentration-dependent increase in the FRET signal, corresponding to a reduction in the distance between the third intracellular loop and the C-terminal tail. This, in turn, mobilized intracellular Ca2+, inhibited cAMP accumulation, and increased phosphorylation of the ERK1/2 MAP kinases. The activation kinetics detected using this method were consistent with those from previous reports. Moreover, the increased FRET signal was markedly inhibited by the CB1 antagonist rimonabant, which also reduced phosphorylation of the ERK1/2 MAP kinases. We mutated a single cysteine residue in the sensor (at position 257 or 264) to alanine. Both mutation reduced the agonist-induced increase in FRET signal and structural changes in the CB1 receptor, which attenuated phosphorylation of the ERK1/2 MAP kinases. In summary, our sensor directly assesses the kinetics of CB1 activation in real-time and can be used to monitor CB1 structure and function.

Published
2018

49. Spatio-temporal distribution of soil nitrogen in Poyang lake ecological economic zone (South-China)

Author

Ye-Feng Jiang, Lei Rao, Yi Han, Kai Sun, and Xi Guo

Subjects
Driving factors, Pollution, Topsoil, Environmental Engineering, Soil test, business.industry, media_common.quotation_subject, 04 agricultural and veterinary sciences, 010501 environmental sciences, 01 natural sciences, Manure, Soil survey, Agronomy, Agriculture, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental Chemistry, Environmental science, business, Waste Management and Disposal, Organic fertilizer, 0105 earth and related environmental sciences, media_common
Abstract

Revealing the spatio-temporal distribution of soil nitrogen (N) contributes to N management and prevention of N pollution. The objective of this work is to study the spatio-temporal distribution of soil N and their driving factors in the topsoil (0–20 cm) of farmland in Yugan county, China in 1982 and 2012. Data were collected from 200 sampling sites of the second national soil survey in Yugan in 1982 and 423 sampling sites of the soil testing and formula fertilization project in 2012. On average total N (TN) and available N (AN) significantly increased from 1.50 g kg−1 and 153.04 mg kg−1 in 1982 to 1.58 g kg−1 and 179.75 mg kg−1 in 2012, respectively. The distance of spatial autocorrelation for TN increased from 2.79 to 6.18 km and from 2.97 to 18.00 km for AN from 1982 to 2012. The nugget/sill ratio for TN (0.472 in 1982 and 0.581 in 2012) indicated that soil TN driving by natural characteristics in 1982 to human activities in 2012. The nugget/sill ratio for soil AN (0.471 in 1982 and 0.688 in 2012) indicated that soil AN is more influenced by human activities. The major factors driving the spatio-temporal distribution of soil N was N application rate. To promote the sustainable development of agriculture and eco-environment, we should improve the awareness of farmers on chemical fertilizers (particularly N) and the level of N fertilizer management, increase the use of manure and organic fertilizer and facilitate rational fertilization by farmers.

Published
2018

50. An energy-efficient composite by using expanded graphite stabilized paraffin as phase change material

Author

Xi Guo, Shaodi Zhang, and Jinzhen Cao

Subjects
Thermogravimetric analysis, Materials science, 020209 energy, Wood flour, 02 engineering and technology, 021001 nanoscience & nanotechnology, Phase-change material, Differential scanning calorimetry, Mechanics of Materials, 0202 electrical engineering, electronic engineering, information engineering, Ceramics and Composites, Graphite, High-density polyethylene, Composite material, 0210 nano-technology, Thermal analysis, Diffractometer
Abstract

Thermal energy storage (TES) composites were prepared by employing expanded graphite (EG) stabilized paraffin as phase change material (PCM) and wood flour/high density polyethylene (WF/HDPE) as matrix. The morphology and structure of EG and form-stable phase change material (FSPCM) were investigated by scanning electron microscopy (SEM), X-ray diffractometer (XRD) and mercury intrusion porosimetry. The fabricated TES composites with different FSPCM types and contents were characterized by differential scanning calorimetry (DSC), thermogravimetric (TG), infrared thermography and laserflash thermal analysis. Physical and mechanical strength were also evaluated. The results showed that: (1) the EG had abundant pores and most of the pores were below 26 μm, the EG stabilized paraffin material showed perfect stability without any chemical reactions; (2) thermal performance indicated that the TES composites had efficient temperature-regulated ability, but thermal durability need to be further enhanced; (3) addition of paraffin and EG destroyed the interface bonding of the TES composites and mechanical properties appeared slight decrease; (4) the satisfying thermal performance and acceptable mechanical property indicating the TES composites can be used as building material for temperature conditioning.

Published
2018

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