129 results on '"Worek, Franz"'
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2. Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents
3. The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms – Structure optimization
4. Disulfide-adducts with cysteine residues in human serum albumin prove exposure to malodorous mercaptans in vitro
5. Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor
6. Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication
7. Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption
8. Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships
9. MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor
10. The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds.
11. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
12. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
13. Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro
14. Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
15. Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample
16. Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase
17. Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks
18. A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds
19. Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by 31P-NMR spectroscopy
20. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents
21. Human small bowel as model for poisoning with organophosphorus compounds
22. The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM)
23. Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro
24. Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman
25. Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase
26. Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
27. Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl
28. Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models
29. Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM
30. Alteration of miRNA expression in a sulfur mustard resistant cell line
31. The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study
32. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
33. Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor
34. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism
35. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis
36. Development of a sensitive, generic and easy to use organophosphate skin disclosure kit
37. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning
38. Blaptica dubia as sentinels for exposure to chemical warfare agents – a pilot study
39. Oximes in organophosphate poisoning: 60 years of hope and despair
40. In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications
41. Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
42. Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum
43. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit—Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds
44. Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds
45. Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics
46. Anesthetic actions of thiopental remain largely unaffected during cholinergic overstimulation in cultured cortical networks
47. Catalytic bioscavengers in nerve agent poisoning: A promising approach?
48. Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
49. Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord—skeletal muscle cocultures
50. Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report
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