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Major limitations for conventional FFR measurement using a pressure wire (PW) include the suboptimal handling characteristics and needs for occasional disconnecting and reconnecting of the PW. To address these limitations, a piezoresistive-sensor equipped pressure microcatheter (PMC), with a profile

An automated framework for detecting lumen and media-adventitia borders in intravascular ultrasound images was developed on the basis of an adaptive region-growing method and an unsupervised clustering method. To demonstrate the capability of the framework, linear regression, Bland-Altman analysis and distance analysis were used to quantitatively investigate the correlation, agreement and spatial distance, respectively, between our detected borders and manually traced borders in 337 intravascular ultrasound images in vivo acquired from six patients. The results of these investigations revealed good correlation (r = 0.99), good agreement (>96.82% of results within the 95% confidence interval) and small average distance errors (lumen border: 0.08 mm, media-adventitia border: 0.10 mm) between the borders generated by the automated framework and the manual tracing method. The proposed framework was found to be effective in detecting lumen and media-adventitia borders in intravascular ultrasound images, indicating its potential for use in routine studies of vascular disease.

The Combo drug-eluting stent (OrbusNeich Medical, Inc, Fort Lauderdale, FL) has an abluminal sirolimus-eluting bioabsorbable polymer and a luminal CD34+ antibody designed to capture endothelial progenitor cells to promote early re-endothelialization. This is the first prospective study to evaluate