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Your search keyword '"Wikström, Johan"' showing total 29 results
Start Over Author "Wikström, Johan" Publisher elsevier bv
29 results on '"Wikström, Johan"'

7. The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care

Author

Pavel Radu, Frithiof Robert, Zetterberg Henrik, Fällmar David, Rostami Elham, Blennow Kaj, Jackmann Sven, Westman Gabriel, Kumlien Eva, Hultström Michael, Wikström Johan, Ashton Nicholas J, Lipcsey Miklos, and Virhammar Johan

Subjects
Neurologi, UCHL1, ubiquitin carboxy-terminal hydrolase L1, Intraclass correlation, GFAp, glial fibrillary acidic protein, law.invention, Correlation, PCR, polymerase chain reaction, law, Medicine, IL-6, interleukin-6, COVID-19, coronavirus disease 2019, Neuroradiology, t-tau, total tau, Radiological and Ultrasound Technology, Brain, NIH, national institute of health, ICU, intensive care unit, Intensive care unit, Nerases, neuroradiological severity scale, Neurology, Cohort, CRP, C-reactive protein, Ubiquitin Thiolesterase, Radiology, Nuclear Medicine and Medical Imaging, MRI, medicine.medical_specialty, Critical Care, Coronavirus disease 2019 (COVID-19), Article, NfL, neurofilament light chain, Intensive care, Internal medicine, Severity scale, Humans, Glasgow Coma Scale, Radiology, Nuclear Medicine and imaging, SARS-CoV-2, business.industry, COVID-19, SWI, susceptibility weighted imaging, GCS, Glasgow Coma Scale, ADEM, acute disseminating encephalomyelitis, Radiologi och bildbehandling, Neurology (clinical), business, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, Biomarkers
Abstract

Background and purpose A wide range of neuroradiological findings has been reported in patients with coronavirus disease 2019 (COVID-19), ranging from subcortical white matter changes to infarcts, haemorrhages and focal contrast media enhancement. These have been descriptively but inconsistently reported and correlations with clinical findings and biomarkers have been difficult to extract from the literature. The purpose of this study was to quantify the extents of neuroradiological findings in a cohort of patients with COVID-19 and neurological symptoms, and to investigate correlations with clinical findings, duration of intensive care and biomarkers in blood. Material and methods Patients with positive SARS-CoV-2 and at least one new-onset neurological symptom were included from April until July 2020. Nineteen patients were examined regarding clinical symptoms, biomarkers in blood and MRI of the brain. In order to quantify the MRI findings, a semi-quantitative neuroradiological severity scale was constructed a priori, and applied to the MR images by two specialists in neuroradiology. Results and conclusions The score from the severity scale correlated significantly with blood biomarkers of CNS injury (glial fibrillary acidic protein, total-tau, ubiquitin carboxyl-terminal hydrolase L1) and inflammation (C-reactive protein), Glasgow Coma Scale score, and the number of days spent in intensive care. The underlying radiological assessments had inter-rater agreements of 90.5%/86% (for assessments with 2/3 alternatives). Total intraclass correlation was 0.80. Previously reported neuroradiological findings in COVID-19 have been diverse and heterogenous. In this study, the extent of findings in MRI examination of the brain, quantified using a structured report, shows correlation with relevant biomarkers.

Published
2022
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8. Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Author

Dubol, Manon, primary, Immenschuh, Jana, additional, Jonasson, My, additional, Takahashi, Kayo, additional, Niwa, Takashi, additional, Hosoya, Takamitsu, additional, Roslin, Sara, additional, Wikström, Johan, additional, Antoni, Gunnar, additional, Watanabe, Yasuyoshi, additional, Lubberink, Mark, additional, Biegon, Anat, additional, Sundström-Poromaa, Inger, additional, and Comasco, Erika, additional

Published
2023
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10. The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care

Author

Fällmar, David, primary, Rostami, Elham, additional, Kumlien, Eva, additional, Ashton, Nicholas J., additional, Jackmann, Sven, additional, Pavel, Radu, additional, Blennow, Kaj, additional, Hultström, Michael, additional, Lipcsey, Miklos, additional, Frithiof, Robert, additional, Westman, Gabriel, additional, Zetterberg, Henrik, additional, Wikström, Johan, additional, and Virhammar, Johan, additional

Published
2022
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13. Increased cerebral biomarkers in plasma and decreased intracerebral magnesium levels are correlated to an impaired blood brain barrier in vitro in preeclampsia

Author

Friis, Therese, primary, Wikström, Anna-Karin, additional, Acurio, Jesenia, additional, Leon, Jose, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Nelander, Maria, additional, Åkerud, Helena, additional, Kaihola, Helena, additional, Cluver, Catherine, additional, Wikström, Johan, additional, Torres-Vergara, Pablo, additional, Bergman, Lina, additional, and Escudero, Carlos, additional

Published
2019
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16. Relation between Cardiovascular Disease Risk Markers and Brain Infarcts Detected by Magnetic Resonance Imaging in an Elderly Population

Author

Nylander, Ruta, primary, Lind, Lars, additional, Wikström, Johan, additional, Lindahl, Bertil, additional, Venge, Per, additional, Larsson, Anders, additional, Ärnlöv, Johan, additional, Berglund, Lars, additional, Ahlström, Håkan, additional, Johansson, Lars, additional, and Larsson, Elna-Marie, additional

Published
2015
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23. OP003. Placental perfusion in normal pregnancy and in early and late preeclampsia: A magnetic resonance imaging study

Author

Weis Jan, Wikström Anna-Karin, Otriz-Nieto Francisco, Sohlberg Sara, Olovsson Matts, Wikström Johan, Lutvica Ajlana, and Lindgren Peter

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Gestational age, Magnetic resonance imaging, Normal pregnancy, Placental disease, medicine.disease, Pathophysiology, Preeclampsia, Endocrinology, Internal medicine, Internal Medicine, medicine, Cardiology, business, Perfusion, Gestational length
Abstract

Placental perfusion is of key interest for the understanding of the pathophysiology of different types of preeclampsia (PE). With magnetic resonance imaging (MRI) perfusion can be estimated non-invasively by calculation of the tissue perfusion fraction from a diffusion weighted sequence (DWI).Our primary aim was to investigate if women with early or late PE have different placental perfusion compared with normal pregnancies. A secondary aim was to investigate if placental perfusion changes with increased gestational length in normal pregnancy.5 women with early PE (34weeks), 8 women with late PE (⩾34weeks), and 19 women with normal pregnancies were included. All women underwent an MRI examination including a DWI sequence at 1.5T. The perfusion fraction was calculated.Women with early PE had a lower placental perfusion fraction (p=0.002) and women with late PE had a higher placental perfusion fraction (p=0.012) than gestational age matched women with normal pregnancies. The placental perfusion fraction decreased with increased gestational length in normal pregnancies (p=0.001).Our finding of reduced placental perfusion in early, but not late PE is in agreement with the hypothesis that early and late PE have partly different pathophysiology, where early PE is a mainly placental disease. The placental perfusion, as estimated by the perfusion fraction, decreased with increased gestational length in normal pregnancies.

Published
2013
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