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591 results on '"Wei, Long"'

12. Diversity and genetic characterization of orthohantavirus from small mammals and humans during 2012–2022 in Hubei Province, Central China

Author

Chen, Jin-tao, primary, Zhan, Jian-bo, additional, Zhu, Ming-chao, additional, Li, Kai-ji, additional, Liu, Man-qing, additional, Hu, Bin, additional, Cai, Kun, additional, Xiong, Hai-rong, additional, Chen, Shu-liang, additional, Tan, Wei-long, additional, Chen, Liang-jun, additional, and Hou, Wei, additional

Published
2024
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24. Clinical and genetic investigation in patients with permanent congenital hypothyroidism

Author

Lingna, Zhou, Shuang, Liu, Wei, Long, Lei-Lei, Wang, and Bin, Yu

Subjects
Biochemistry (medical), Clinical Biochemistry, General Medicine, Biochemistry
Abstract

Permanent congenital hypothyroidism (CH) is usually a more severe type of CH. However, the molecular etiology and clinical features of permanent CH remain unclear.We recruited 42 patients who were diagnosed with CH and followed-up after diagnosis. Demographic information and data at diagnosis and treatment were recorded. Genetic analyses were performed using whole exome sequencing. Based on the presence or absence of variants and differences in clinical features, we grouped the study participants and analyzed their characteristics.A total of 29 patients (69.0 %) were identified as having variants potentially related to their disease. Among the 24 patients with normal-sized thyroid gland-in-situ (GIS) or goiter, 23 (95.8 %, P 0.001) had variants. This is compared to 18 patients with thyroid dysgenesis (TD), of which six (33.3 %) had genetic variants. We detected 55 variants in six genes, the most frequently mutated gene being DUOX2 (70.9 %). Biallelic DUOX2 variants were detected in 14 of 24 (58.3 %) GIS or goiter patients. Compared to the cases with variants, the L-T4 dose at 2 and 3 years of age and current dose were higher in the unmutated cases. At 2 years of age, patients with TD required higher doses of L-T4 supplementation. Patients with DUOX2 variants showed lower doses of L-T4 being required at 2 and 3 years of age and current. Furthermore, patients with GIS or goiter with DUOX2 variants showed lower doses of L-T4.Patients with CH, whether TD or GIS or goiter, are at risk of developing a permanent condition. Compared with patients with TD, the detection of variants was higher in patients with GIS or goiter. The most frequently mutated gene was DUOX2, with a biallelic type. Patients with TD required higher doses of L-T4 supplementation with age, whereas those patients with the DUOX2 variant required relatively lower doses.

Published
2023

26. Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage

Author

Wei-Long Zheng, Jennifer A. Kim, Jonathan Elmer, Sahar F. Zafar, Manohar Ghanta, Valdery Moura Junior, Aman Patel, Eric Rosenthal, and M. Brandon Westover

Subjects
Neurology, Physiology (medical), Brain, Humans, Electroencephalography, Cerebral Infarction, Neurology (clinical), Subarachnoid Hemorrhage, Article, Sensory Systems, Brain Ischemia
Abstract

OBJECTIVE: Delayed cerebral ischemia (DCI) is a leading complication of aneurysmal subarachnoid hemorrhage (SAH) and electroencephalography (EEG) is increasingly used to evaluate DCI risk. Our goal is to develop an automated DCI prediction algorithm integrating multiple EEG features over time. METHODS: We assess 113 moderate to severe grade SAH patients to develop a machine learning model that predicts DCI risk using multiple EEG features. RESULTS: Multiple EEG features discriminate between DCI and non-DCI patients when aligned either to SAH time or to DCI onset. DCI and non-DCI patients have significant differences in alpha-delta ratio (0.08 vs 0.05, p < 0.05) and percent alpha variability (0.06 vs 0.04, p < 0.05), Shannon entropy (p < 0.05) and epileptiform discharge burden (205 vs 91 discharges per hour, p < 0.05) based on whole brain and vascular territory averaging. Our model improves predictions by emphasizing the most informative features at a given time with an area under the receiver-operator curve of 0.73, by day 5 after SAH and good calibration between 48–72 hours (calibration error 0.13). CONCLUSIONS: Our proposed model obtains good performance in DCI prediction. SIGNIFICANCE: We leverage machine learning to enable rapid, automated, multi-featured EEG assessment and has the potential to increase the utility of EEG for DCI prediction.

Published
2022

30. High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage

Author

Jonathan Elmer, Sahar F. Zafar, Manohar Ghanta, Wei-Long Zheng, Valdery Moura Junior, Jennifer A. Kim, M. Brandon Westover, Jin Jing, Aman B. Patel, Eric Rosenthal, Emily J. Gilmore, and Lawrence J. Hirsch

Subjects
Moderate to severe, Periodicity, medicine.medical_specialty, Subarachnoid hemorrhage, Ischemia, Electroencephalography, 050105 experimental psychology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Retrospective analysis, Humans, 0501 psychology and cognitive sciences, cardiovascular diseases, Retrospective Studies, Receiver operating characteristic, medicine.diagnostic_test, business.industry, 05 social sciences, Cerebral Infarction, Subarachnoid Hemorrhage, medicine.disease, Sensory Systems, nervous system diseases, Neurology, Cardiology, Biomarker (medicine), Neurology (clinical), business, Complication, 030217 neurology & neurosurgery
Abstract

Objective To investigate whether epileptiform discharge burden can identify those at risk for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Methods Retrospective analysis of 113 moderate to severe grade SAH patients who had continuous EEG (cEEG) recordings during their hospitalization. We calculated the burden of epileptiform discharges (ED), measured as number of ED per hour. Results We find that many SAH patients have an increase in ED burden during the first 3–10 days following rupture, the major risk period for DCI. However, those who develop DCI have a significantly higher hourly burden from days 3.5–6 after SAH vs. those who do not. ED burden is higher in DCI patients when assessed in relation to the onset of DCI (area under the receiver operator curve 0.72). Finally, specific trends of ED burden over time, assessed by group-based trajectory analysis, also help stratify DCI risk. Conclusions These results suggest that ED burden is a useful parameter for identifying those at higher risk of developing DCI after SAH. The higher burden rate associated with DCI supports the theory of metabolic supply-demand mismatch which contributes to this complication. Significance ED burden is a novel biomarker for predicting those at high risk of DCI.

Published
2022

32. 3,4-Dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs act as potential AMPA receptor potentiators with antidepressant activity

Author

wei, Long, primary, Qi, Xueyu, additional, Yu, Xueli, additional, Zheng, Yanghao, additional, Luo, Xing, additional, Wei, Yingying, additional, Ni, Peiyan, additional, Zhao, Liansheng, additional, Wang, Qiang, additional, Ma, Xiaohong, additional, Deng, Wei, additional, Guo, Wanjun, additional, Hu, Xun, additional, and Li, Tao, additional

Published
2023
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36. A novel multi-anode MCP-PMT with Cherenkov radiator window

Author

Ma, Lishuang, primary, Chen, Lingyue, additional, Chai, Pei, additional, Liang, Zehong, additional, Huang, Guorui, additional, Hu, Jun, additional, Han, Xiaorou, additional, Hua, Zhehao, additional, Huang, XianChao, additional, Jin, Muchun, additional, Jiang, Xiaoshan, additional, Jin, Zhen, additional, Liu, Shulin, additional, Pan, Weiyan, additional, Qian, Sen, additional, Ren, Ling, additional, Si, Shuguang, additional, Sun, Jianning, additional, Wei, Long, additional, Wu, Qi, additional, Wang, Tianyi, additional, Wang, Xingchao, additional, Wang, Yifang, additional, Wang, Yingjie, additional, Wang, Zhile, additional, Wang, Zhi, additional, Wang, Ning, additional, Wu, Kai, additional, Yan, Xiongbo, additional, Zhang, Haoda, additional, and Zhang, Zhiming, additional

Published
2023
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43. Overestimate of remediation efficiency due to residual sodium persulfate in PAHs contaminated soil and a solution

Author

Yuanqiang Yang, Zhonghua Wei, Wei Long, Linqian Li, Jianhao Tong, Jingli Pang, Wu Jianxun, Jiyan Shi, and Liping He

Subjects
Environmental Engineering, Sulfates, Environmental remediation, Extraction (chemistry), General Medicine, Persulfate, Residual, Soil remediation, Sodium Compounds, Soil contamination, Sodium persulfate, Soil, chemistry.chemical_compound, Recovery rate, chemistry, Environmental chemistry, Soil Pollutants, Environmental Chemistry, Polycyclic Aromatic Hydrocarbons, Environmental Restoration and Remediation, General Environmental Science
Abstract

Oxidation remediation is a commonly used technology for PAHs contaminated soil presently, but the overestimate of efficiency due to ongoing remediation by residual oxidants during extraction and testing has not been paid enough attention. In this study, persulfate was activated by Fe(II) to investigate the effects of residual oxidants on PAHs removal during detection process and the elimination effects of adding Na2SO3 and extending sampling time on residual oxidants. Results verified that the residual oxidants removed PAHs in extraction process, making the results lower than the actual values: the detection recovery rate η of ∑PAHs and 3-6 ring PAHs ranged from 24.3% (25% Na2S2O8 treatment) to 87.4% (5% Na2S2O8+4/4Fe2+ treatment), 20.1%-99.0%, 28.9%-87.9%, 20.8%-89.4%, and 18.6%-76.9%, respectively. After adding Na2SO3, the accuracy of detection results increased significantly: the η of ∑PAHs and 3-6 ring PAHs increased to 64.1%-96.5%, 58.8%-95.5%, 73.8%-114.4%, 60.6%-95.6%, and 45.4%-77.1%, respectively. After 49 days of adding oxidants, residual oxidants had no considerable effect on the detection of PAHs, indicating it was appropriate to start soil remediation verification sampling49 days after the remediation was completed. The observed results will help scientific evaluation of the remediation effects of chemical oxidation on organic contaminated soil.

Published
2022

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