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Your search keyword '"Wang, Yi‐ming"' showing total 85 results
Start Over Author "Wang, Yi‐ming" Publisher elsevier bv
85 results on '"Wang, Yi‐ming"'

28. Comparison of hyper- and hypofractionated radiation schemes with IMRT technique in small cell lung cancer: Clinical outcomes and the introduction of extended LQ and TCP models

Author

Li, Qi-Wen, primary, Qiu, Bo, additional, Wang, Bin, additional, Zhang, Jun, additional, Chen, Li, additional, Zhou, Yin, additional, Qin, Jun-Kun, additional, Guo, Su-Ping, additional, Xie, Wei-Hao, additional, Hui, Zhou-Guang, additional, Liang, Ying, additional, Guo, Jin-Yu, additional, Wang, He, additional, Zhu, Meng, additional, Shen, Wen-Tong, additional, Duan, Long-Yan, additional, Chen, Li-Kun, additional, Zhang, Li, additional, Long, Hao, additional, Wang, Yi-Ming, additional, and Liu, Hui, additional

Published
2019
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30. System Medicine and Translational Medicine

Author

Xie Yuanyuan, Luo Guo-an, Liang Qiong-lin, Fan Xue-Mei, and Wang Yi-ming

Subjects
Harmony (color), medicine.medical_specialty, business.industry, Management science, Systems biology, Alternative medicine, Translational medicine, Pharmacy, Traditional Chinese medicine, Bioinformatics, Systems theory, medicine, Holism, business
Abstract

In this perspective study, the authors introduce the background, goals, and roadmap of Translational Medicine, address the differences between oriental and western medicines, as well as their development tendency, and then discuss the developments in and prospects for the System Medicine. The advantages of Traditional Chinese Medicine (TCM) lie in its guidelines based on the holism and systems theory; its methodology based on the theory as “the harmony between humans and nature” to regulate the body's balance; and its personalized treatment with TCM formulas. However, modernization of TCM still faces some challenges: how to translate the self-explanatory closed system into an receptively open system; how to achieve the combination, integration, and convergence of TCM with other modern sciences and technologies (such as systems biology); how to implement the modern scientific mode, methodologies, and achievements in the study of TCM, and interpret it with data instead words. Although there is a large difference between the oriental and western medicine systems, the trend of complementary development and integration of both is irresistible. We should try to push the progress in the combination, integration, and convergence of oriental and western medicines to welcome the emergence of System Medicines in the 21st century. The development of System Medicine may have following requirements and characteristics: first, the integrated research on medicine and pharmacy requires the “system–system” interaction character between the drug system and biological system; second, the clinical diagnosis system by the combination of disease and syndrome requires an integrative expression, including some quantitative indexes of syndromes in TCM, some pathological and biochemical indexes as well as imaging diagnostic markers in western medicine, and some biomarkers, such as genes, proteins, and metabolites discovered by systems biology studies; third, a clinical-treatment mode based on the correspondence of formula, disease and syndrome requires that the pattern of compound drugs be widely used for the human system by the combination of disease and syndrome, in order to achieve goals known as “correspondence of formula, disease and syndrome, comprehensive management and systematic condition” fourth, the research and development (R&D) mode of new drugs require “participation of physicians and combination of medicine and pharmacy”, which is a route known as “Beside-Bench-Beside” fifth, the representation of compound drugs and human system requires the combination of macroscopic characterization and microcosmic feature, also the combination of qualitative and quantitative analyses.

Published
2011
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31. Prospect on the Composite Drugs Innovation System

Author

Wang Yi-ming, Liang Qiong-lin, Liu Qing-fei, Li Xue, and Luo Guo-an

Subjects
Drug, Global system, business.industry, Management science, media_common.quotation_subject, Innovation system, Pharmacology, Key issues, Synthetic drugs, Clinical trial, Medicine, Clinical efficacy, business, media_common
Abstract

With the analysis of opportunities and challenges for the drug innovation, this research proposed a definition of the composite drug, which means a compatible combination of multiple compounds or multi-group compounds developed under the guidance of multiple therapeutic principles and mechanisms in order to achieve an optimal holistic efficacy. Composite drugs may consist of composite Traditional Chinese Medicine (TCM) and composite synthetic drugs or the combination of the both. The characteristics of composite drug innovation system are the followings: first, its target is the patient, not just a particular disease. Second, it requires the collaboration from physicians and the combination of iatrology and pharmacology. Third, it requires an R&D procedure of clinical experience to animal experiment to clinical trial. Fourth, it requires the development of a comprehensive assessment system for the clinical efficacy. Fifth, it requires developing an integrative system for screening of composite drugs. Sixth, it requires a development of an integrative system with both holistic characterization and specific characterization of the pharmaceutical components group. The current key issues for the innovation of composite TCM drugs are to develop a comprehensive assessment system for the clinical efficacy of TCM, to develop an integrative system for screening of composite drugs according to the characteristics of TCM and to standardize the approaches for the integrative characterizing of composite drugs. As in some demonstrative studies, this research has developed a new approach, Chemomics-integrated Global System Biology based on which a few composite drugs have been developed: one for treatment of ischemic apoplexy using TCM Qingkailing, and another one for treatment of ischemic cardiopathy using TCM Shuanglongfang. The current key issues for the innovation of composite synthetic drugs should focus on how to innovate the notions in order to establish an acknowledged model for the innovation of composite synthetic drugs, to attract physicians to participate in the composite drug innovation in order to establish an R&D procedure of clinical experience to animal experiment to clinical trial, and to strengthen the research of the composite drugs combining TCM and synthetic drugs.

Published
2009
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34. Proteome analysis of Chinese miniswine bone marrow mesenchymal stem cells

Author

Zhang Rongli, Zhao Yanfeng, Ye Nengsheng, Luo Guo-an, Feng Xue, and Wang Yi-ming

Subjects
Gel electrophoresis, Two-dimensional gel electrophoresis, medicine.anatomical_structure, Peptide mass fingerprinting, Chemistry, Proteome, Mesenchymal stem cell, Protein Expression Analysis, medicine, Bone marrow, Proteomics, Molecular biology, Analytical Chemistry
Abstract

The proteome of Chinese miniswine bone marrow mesenchymal stem cells (MSCs) was investigated in this study. Proteins extracted from MSCs were separated by two-dimensional gel electrophoresis (2DE), and about 1600 protein spots were detected using the silver nitrate staining method. 48 proteins were digested by trypsin for mass spectrometry analysis. 37 proteins were successfully identified by peptide mass fingerprinting (PMF). The biological functions of these identified proteins were involved in different cell processes. Proteomics was successfully applied for the protein expression analysis of Chinese miniswine bone marrow MSCs and some useful data were provided for the future study of MSCs.

Published
2006
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35. Immobilization of glucose oxidase in sol–gel matrix and its application to fabricate chemiluminescent glucose sensor

Author

Zhang Xingrong, Luo Guo-an, Li Qingwen, and Wang Yi-ming

Subjects
Detection limit, Chromatography, Immobilized enzyme, biology, Silica gel, Bioengineering, Molecular sieve, humanities, Biomaterials, Matrix (chemical analysis), chemistry.chemical_compound, chemistry, Mechanics of Materials, biology.protein, Glucose oxidase, Biosensor, Sol-gel
Abstract

In this paper, glucose oxidase (GOD) was immobilized in the course of sol–gel process of TEOS, and we cast the GOD-doped sol to different supports (silica gel and molecular sieve) to prepare the GOD columns. It was demonstrated that the activity of GOD remained high in sol–gel matrix. With the application of the GOD column prepared with sol–gel method to a flowing injection chemiluminescent system, glucose could be effectively determined with the linear range of the concentration in 3.5–70 μmol/l and the detection limit was at 0.6 μmol/l.

Published
2000
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36. pH-Response of nanosized MnO2 prepared with solid state reaction route at room temperature

Author

Luo Guo-an, Wang Yi-ming, and Li Qingwen

Subjects
Materials science, Aqueous solution, Solid-state reaction route, Metals and Alloys, Solid-state, Condensed Matter Physics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Chemical engineering, Specific surface area, Electrode, Materials Chemistry, Ph range, Electrical and Electronic Engineering, Thin film, Instrumentation
Abstract

MnO2 was prepared using a novel synthetic route based on the solid state reaction of KMnO4 with MnCl2·4H2O at room temperature. MnO2 powder synthesized with this method was nanosized and had large specific surface area (300 m2/g). The electrode coated with a thin film of MnO2 exhibited a fast, stable pH response in aqueous solution. A linear pH–potential curve was observed over the pH range of 2–12 with a sensitivity of −78.3 mV/pH at room temperature. In addition, its response mechanism was discussed as well in this paper.

Published
1999
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39. Transport Properties of Bovine Serum Albumin in Gold Nanotubule Membrane Modified with Cl−

Author

Hu Ping, Wang Yue-rong, Luo Guo-an, Wang Yi-ming, and Laing Qiong-Lin

Subjects
Detection limit, biology, Chemistry, Phosphate buffered saline, Analytical chemistry, Electroless deposition, Electrochemistry, Analytical Chemistry, Linear relationship, Membrane, visual_art, biology.protein, visual_art.visual_art_medium, Bovine serum albumin, Polycarbonate, Nuclear chemistry
Abstract

Gold nanotubule membranes were prepared by using electroless deposition of gold in the pores and on the surfaces of polycarbonate track-etched membranes, and the membranes were modified with Cl − . An electrochemical method ( i –t) was then developed for studying the transport properties of bovine serum albumin (BSA) in these nanotubule membranes. In phosphate buffer solution (pH 7.4), when an electric field (l V) was applied between the two sides of the membrane, the response current decreased with the adding of BSA solution. The decrement of response current was in a linear relationship with the concentration of BSA in the range of 1.50 × 10 −10 –1.35 × 10 −9 M ( r = 0.9980), and the limit of detection was 9.46×10 −11 M ( S/N = 3).

Published
2007
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