1. Comparison of Ivabradine Versus Metoprolol in Early Phases of Reperfused Anterior Myocardial Infarction With Impaired Left Ventricular Function: Preliminary Findings
- Author
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Francesco Giambanco, Giuseppe Vitale, Pietro Di Pasquale, Daniele Torres, Vito Pinto, Filippo Ganci, Giorgio Maringhini, Sergio Cannizzaro, Salvatore Paterna, Sergio Fasullo, Filippo M. Sarullo, Giuseppe Migliore, Fasullo, S, Cannizzaro, S, Maringhini, G, Ganci, F, Giambanco, F, Vitale, G, Pinto, V, Migliore, G, Torres, D, Sarullo, FM, Di Pasquale, P, and Paterna, S
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Myocardial Reperfusion Injury ,Pilot Projects ,Ventricular Dysfunction, Left ,Double-Blind Method ,Internal medicine ,ejection fraction, end systole volume, ivabradine ,medicine ,Humans ,Ivabradine ,cardiovascular diseases ,Myocardial infarction ,Aged ,Metoprolol ,Killip class ,Ejection fraction ,business.industry ,Percutaneous coronary intervention ,Benzazepines ,Middle Aged ,medicine.disease ,surgical procedures, operative ,Conventional PCI ,Cardiology ,Myocardial infarction complications ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,medicine.drug - Abstract
BACKGROUND: beta-blockers in ST-segment elevation myocardial infarction (STEMI) are indicated for patients without a contraindication, particularly in patients with high heart rates (HR) or blood pressures. Epidemiological studies have shown that elevated HR represents a risk factor for cardiovascular morbidity. The study investigates the feasibility, tolerability, and the effects after 30 days of follow-up of ivabradine (IVA) versus metoprolol (METO) in early phases of anterior STEMI reperfused by percutaneous coronary intervention (PCI). METHODS AND RESULTS: Patients with a first anterior STEMI, Killip class I-II, an acceptable echocardiographic window, and admitted within 4hours of the onset of symptoms, with an ejection fraction
- Published
- 2009
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