1. Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer
- Author
-
Hossein Ansari, Vinicio Carloni, and Maryam Tahmasebi-Birgani
- Subjects
0301 basic medicine ,Cancer Research ,Carcinoma, Hepatocellular ,DNA damage ,Mitosis ,Aneuploidy ,Biology ,Genomic Instability ,03 medical and health sciences ,0302 clinical medicine ,Chromosomal Instability ,Chromosome Segregation ,Chromosome instability ,Genetics ,medicine ,Humans ,Genome, Human ,Liver Neoplasms ,G2-M DNA damage checkpoint ,HCCS ,medicine.disease ,digestive system diseases ,hepatocarcinoma, chromosomal instability ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Cancer research ,Liver cancer ,DNA Damage - Abstract
Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable HCCs show evidence for a paradoxically DNA damage response (DDR) which leads to ongoing chromosome segregation errors. The understanding of DDR induced by defective mitoses is crucial to our ability to develop or improve liver cancer therapeutic strategies.
- Published
- 2019