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3. Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study

Author

Chau, Steven Wai Ho, primary, Liu, Yaping, additional, Zhang, Jihui, additional, Leung, Eric, additional, Chen, Sirong, additional, Ho, Chi Lai, additional, Chan, Joey Wing Yan, additional, Tsang, Chi Ching, additional, Li, Shirley X., additional, Huang, Bei, additional, Lam, Siu Ping, additional, Mok, Vincent CT., additional, and Wing, Yun Kwok, additional

Published
2023
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5. Gut Microbiota Across Early Stages of Alpha-Synucleinopathy: From High-Risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease

Author

Bei Huang, Steven WH Chau, Yaping Liu, Joey W.Y. Chan, Jing Wang, Suk Ling, Jihui Zhang, Paul K.S. Chan, Yun Kit Yeoh, Zigui Chen, Li Zhou, Sunny H. Wong, Vincent CT Mok, Ka Fai To, Hei Ming Lai, Simon Ng, Claudia Trenkwalder, Francis KL Chan, and YK Wing

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

7. Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study

Author

Steven Wai Ho Chau, Yaping Liu, Jihui Zhang, Eric Leung, Sirong Chen, Chi Lai Ho, Joey Wing Yan Chan, Chi Ching Tsang, Shirley X. Li, Bei Huang, Siu Ping Lam, Vincent CT. Mok, and Yun Kwok Wing

Subjects
Neurology, Neurology (clinical), Geriatrics and Gerontology
Published
2023

8. Gut Microbiota Across Early Stages of Alpha-Synucleinopathy: From High-Risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease

Author

Huang, Bei, primary, Chau, Steven WH, additional, Liu, Yaping, additional, Chan, Joey W.Y., additional, Wang, Jing, additional, Ling, Suk, additional, Zhang, Jihui, additional, Chan, Paul K.S., additional, Yeoh, Yun Kit, additional, Chen, Zigui, additional, Zhou, Li, additional, Wong, Sunny H., additional, Mok, Vincent CT, additional, To, Ka Fai, additional, Lai, Hei Ming, additional, Ng, Simon, additional, Trenkwalder, Claudia, additional, Chan, Francis KL, additional, and Wing, YK, additional

Published
2022
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9. Improved Sensitivity and Precision in Multicentre Diffusion MRI Network Analysis Using Thresholding and Harmonization

Author

de Brito Robalo, Bruno Miguel, primary, de Luca, Alberto, additional, Chen, Christopher, additional, Dewenter, Anna, additional, Duering, Marco, additional, Hilal, Saima, additional, Koek, Huiberdina L., additional, Kopczak, Anna, additional, Lam, Bonnie Yin Ka, additional, Leemans, Alexander, additional, Mok, Vincent CT, additional, Onkenhout, Laurien P., additional, van den Brink, Hilde, additional, and Biessels, Geert Jan, additional

Published
2022
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11. Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity

Author

Shi Tang, Yanlin Wang, Yaping Liu, Steven WH Chau, Joey WY Chan, Winnie CW Chu, Jill M Abrigo, Vincent CT Mok, and Yun Kwok Wing

Subjects
Brain Mapping, Executive Function, Synucleinopathies, Neural Pathways, Brain, Humans, Parkinson Disease, General Medicine, Magnetic Resonance Imaging, General Biochemistry, Genetics and Molecular Biology
Abstract

Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with α-Synucleinopathy (α-Syn, i.e., Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy), a consistent pattern of dysfunction remains unclear. We aim to investigate network dysfunction in patients with α-Syn through a meta-analysis.Whole-brain seed-based resting-state functional connectivity studies (published before September 1st, 2020 in English) comparing α-Syn patients with healthy controls (HC) were retrieved from electronic databases (PubMed, Web of Science, and EMBASE). Seeds from each study were categorized into networks by their location within a priori functional networks. Seed-based effect size mapping with Permutation of Subject Images analysis of between-group effects identified the network systems in which α-Syn was associated with hyperconnectivity (increased connectivity in α-Syn vs. HC) or hypoconnectivity (decreased connectivity in α-Syn vs. HC) within and between each seed-network. This study was registered on PROSPERO (CRD42020210133).In total, 136 seed-based voxel-wise resting-state functional connectivity datasets from 72 publications (3093 α-Syn patients and 3331 HC) were included in the meta-analysis. We found that α-Syn patients demonstrated imbalanced connectivity among subcortical network, cerebellum, and frontal parietal networks that involved in motor functioning and executive control. The patient group was associated with hypoconnectivity in default mode network and ventral attention network that involved in cognition and attention. Additionally, the patient group exhibited hyperconnectivity between neural systems involved in top-down emotion regulation and hypoconnectivity between networks involved in bottom-up emotion processing.These findings supported neurocognitive models in which network dysfunction is tightly linked to motor, cognitive and psychiatric symptoms observed in α-Syn patients.This study was partially supported by the Research Grants Council of Hong Kong (Grant No. RGC14116121).

Published
2022

14. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study

Author

Mrkobrada, Marko, primary, Chan, Matthew T.V., additional, Cowan, David, additional, Campbell, Douglas, additional, Wang, Chew Yin, additional, Torres, David, additional, Malaga, German, additional, Sanders, Robert D., additional, Sharma, Manas, additional, Brown, Carl, additional, Sigamani, Alben, additional, Szczeklik, Wojciech, additional, Sharma, Mukul, additional, Guyatt, Gordon, additional, Smith, Eric E., additional, Agid, Ronit, additional, Dmytriw, Adam A., additional, Spence, Jessica, additional, Adunuri, Nikesh R., additional, Borges, Flavia K., additional, Short, Timothy G., additional, Hill, Michael D., additional, Saad, Feryal, additional, Copland, Ingrid, additional, Pettit, Shirley, additional, Ibrahim, Quazi, additional, Bangdiwala, Shrikant I., additional, Yusuf, Salim, additional, Tsai, Scott, additional, Sahlas, Demetrios J, additional, Mensinkai, Arun, additional, Sposato, Luciano A, additional, Hussain, Sara, additional, Yang, Steven, additional, Siegal, Deborah, additional, Khaw, Alexander, additional, Mandzia, Jennifer, additional, Simpson, Sara, additional, Raval, Manoj, additional, Karimuddin, Ahmer, additional, Phang, PT, additional, Mok, Vincent CT, additional, Wu, William KK, additional, Yu, Simon CH, additional, Gin, Tony, additional, Loh, Pui San, additional, Liew, Mun Thing, additional, Ramli, Norlisah, additional, Siow, Yee Lein, additional, Fuentes, Maite, additional, Ortiz-Soriano, Victor, additional, Waymouth, Ellen, additional, Kumar, Jonathan, additional, Sadana, Divya, additional, Thomas, Lenimol, additional, Kaczmarek, Bogusz, additional, Lindroth, Heidi, additional, Sessler, Daniel, additional, Apolcer, Sarah, additional, Trombetta, Amelia, additional, Handsor, Stephanie, additional, Dasgupta, Monidipa, additional, Murkin, John M, additional, Lee, Shun Fu, additional, and Devereaux, P.J., additional

Published
2019
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