1. Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature
- Author
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M.M. Samim, Debjyoti Dhar, Faheem Arshad, D.D.S. Anudeep, Vishal G. Patel, Sriram Ramalakshmi Neeharika, Kamakshi Dhamija, Chowdary Mundlamuri Ravindranath, Ravi Yadav, Pritam Raja, M. Netravathi, Deepak Menon, Vikram V. Holla, Nitish L. Kamble, Pramod K. Pal, Atchayaram Nalini, and Seena Vengalil
- Subjects
Neurology ,Physiology (medical) ,Surgery ,Neurology (clinical) ,General Medicine - Abstract
Recent studies have shown various neurological adverse events associated with COVID-19 vaccine.We aimed to retrospectively review and report the neurological diseases temporally associated with COVID-19 vaccine.We performed a retrospective chart review of admitted patients from 1st February 2021 to 30th June 2022. A total of 4672 medical records were reviewed of which 51 cases were identified to have neurological illness temporally associated with COVID-19 vaccination.Out of 51 cases, 48 had probable association with COVID-19 vaccination while three had possible association. Neurological spectrum included CNS demyelination (n = 39, 76.5 %), Guillain-Barré-syndrome (n = 3, 5.9 %), stroke (n = 6, 11.8 %), encephalitis (n = 2, 3.9 %) and myositis (n = 1, 2.0 %). Female gender had a greater predisposition (F:M, 1.13:1). Neurological events were more commonly encountered after the first-dose (n = 37, 72.5%). The mean latency to onset of symptoms was 13.2 ± 10.7 days after the last dose of vaccination. COVIShield (ChAdOx1) was the most commonly administered vaccine (n = 43, 84.3 %). Majority of the cases with demyelination were seronegative (n = 23, 59.0 %) which was followed by anti-Myelin oligodendrocyte-glycoprotein associated demyelination (MOGAD) (n = 11, 28.2 %) and Neuromyelitis optica (NMOSD) (n = 5, 12.8 %). Out of 6 Stroke cases, 2 cases (33.3 %) had thrombocytopenia and coagulopathy. At discharge, 25/51 (49.0 %) of the cases had favourable outcome (mRS 0 to 1). Among six patients of stroke, only one of them had favourable outcome.In this series, we describe the wide variety of neurological syndromes temporally associated with COVID-19 vaccination. Further studies with larger sample size and longer duration of follow-up are needed to prove or disprove causality association of these syndromes with COVID-19 vaccination.
- Published
- 2023