76 results on '"Vijg, Jan"'
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2. Mitigating age-related somatic mutation burden
3. Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation
4. From DNA damage to mutations: All roads lead to aging
5. A workflow for simultaneous DNA copy number and methylome analysis of inner cell mass and trophectoderm cells from human blastocysts
6. Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging
7. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species
8. Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities
9. Single-Cell Whole-Genome Sequencing Reveals B Lymphocyte Mutational Landscapes Across the Human Lifespan
10. Genome instability and aging: Cause or effect?
11. Mutation and catastrophe in the aging genome
12. Genome instability: A conserved mechanism of aging?
13. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation
14. Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain
15. Do DNA Double-Strand Breaks Drive Aging?
16. Reply to Kashnitsky
17. High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?
18. Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles
19. Editorial
20. An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
21. Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo
22. Somatic mutations, genome mosaicism, cancer and aging
23. Editorial overview: Molecular and genetic bases of disease: The double life of DNA
24. Dietary restriction extends lifespan more than two fold in Ercc1Δ/− mice
25. Direct mutation analysis by high-throughput sequencing: From germline to low-abundant, somatic variants
26. Chromosomal aneuploidy in the aging brain
27. The Long and Short of Fertility and Longevity
28. Genome instability, cancer and aging
29. Mitochondrial DNA mutations and aging: devils in the details?
30. Aging: A Sirtuin Shake-Up?
31. Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues
32. Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations
33. The role of DNA damage and repair in aging: New approaches to an old problem
34. Genome instability: Cancer or aging?
35. Preface
36. Third International Conference on Functional Genomics of Ageing, March 29–April 1 2006, Palermo, Sicily, Italy
37. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
38. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice
39. Accelerated aging pathology in ad libitum fed XpdTTD mice is accompanied by features suggestive of caloric restriction
40. Corrigendum to “What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?” [Mechanisms of Ageing and Development 126 (2005) 421–429]
41. SNP discovery in associating genetic variation with human disease phenotypes
42. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
43. Impact of genome instability on transcription regulation of aging and senescence
44. Transcripts of aging
45. Catalase transgenic mice: characterization and sensitivity to oxidative stress
46. Attenuation of leukocyte-endothelium interaction by antioxidant enzymes
47. Functional Genomics of Ageing
48. Large genome rearrangements as a primary cause of aging
49. On key lesions and all that: a tribute to Paul Lohman
50. Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice
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