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13 results on '"Uzay E"'

2. A comprehensive guide to mega-press for GABA measurement

Author

Peek, A.L., primary, Rebbeck, T.J., additional, Leaver, A.M., additional, Foster, S.L., additional, Refshauge, K.M., additional, Puts, N.A., additional, Oeltzschner, G., additional, Andronesi, Ovidiu C., additional, Barker, Peter B., additional, Bogner, Wolfgang, additional, Cecil, Kim M., additional, Choi, In-Young, additional, Deelchand, Dinesh K., additional, de Graaf, Robin A., additional, Dydak, Ulrike, additional, Edden, Richard AE., additional, Emir, Uzay E., additional, Harris, Ashley D., additional, Lin, Alexander P., additional, Lythgoe, David J., additional, Mikkelsen, Mark, additional, Mullins, Paul G., additional, Near, Jamie, additional, Öz, Gülin, additional, Rae, Caroline D., additional, Terpstra, Melissa, additional, Williams, Stephen R., additional, and Wilson, Martin, additional

Published
2023
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3. A comprehensive guide to MEGA-PRESS for GABA measurement

Author

A.L. Peek, T.J. Rebbeck, A.M. Leaver, S.L. Foster, K.M. Refshauge, N.A. Puts, G. Oeltzschner, Ovidiu C. Andronesi, Peter B. Barker, Wolfgang Bogner, Kim M. Cecil, In-Young Choi, Dinesh K. Deelchand, Robin A. de Graaf, Ulrike Dydak, Richard AE. Edden, Uzay E. Emir, Ashley D. Harris, Alexander P. Lin, David J. Lythgoe, Mark Mikkelsen, Paul G. Mullins, Jamie Near, Gülin Öz, Caroline D. Rae, Melissa Terpstra, Stephen R. Williams, and Martin Wilson

Subjects
Biophysics, Cell Biology, Molecular Biology, Biochemistry
Published
2023

8. Short-Term Monocular Deprivation Alters GABA in the Adult Human Visual Cortex

Author

Maria Concetta Morrone, Holly Bridge, Claudia Lunghi, and Uzay E. Emir

Subjects
Genetics and Molecular Biology (all), Adult, Male, Binocular rivalry, Nervous system, genetic structures, Stimulation, Biology, Biochemistry, Article, General Biochemistry, Genetics and Molecular Biology, Ocular dominance, Young Adult, Homeostatic plasticity, Neuroplasticity, medicine, Humans, GABAergic Neurons, gamma-Aminobutyric Acid, Visual Cortex, Neuronal Plasticity, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Healthy Volunteers, eye diseases, Dominance, Ocular, Monocular deprivation, Visual cortex, medicine.anatomical_structure, Agricultural and Biological Sciences (all), Biochemistry, Genetics and Molecular Biology (all), Female, General Agricultural and Biological Sciences, Neuroscience
Abstract

SummaryNeuroplasticity is a fundamental property of the nervous system that is maximal early in life, within the critical period [1–3]. Resting GABAergic inhibition is necessary to trigger ocular dominance plasticity and to modulate the onset and offset of the critical period [4, 5]. GABAergic inhibition also plays a crucial role in neuroplasticity of adult animals: the balance between excitation and inhibition in the primary visual cortex (V1), measured at rest, modulates the susceptibility of ocular dominance to deprivation [6–10]. In adult humans, short-term monocular deprivation strongly modifies ocular balance, unexpectedly boosting the deprived eye, reflecting homeostatic plasticity [11, 12]. There is no direct evidence, however, to support resting GABAergic inhibition in homeostatic plasticity induced by visual deprivation. Here, we tested the hypothesis that GABAergic inhibition, measured at rest, is reduced by deprivation, as demonstrated by animal studies. GABA concentration in V1 of adult humans was measured using ultra-high-field 7T magnetic resonance spectroscopy before and after short-term monocular deprivation. After monocular deprivation, resting GABA concentration decreased in V1 but was unaltered in a control parietal area. Importantly, across participants, the decrease in GABA strongly correlated with the deprived eye perceptual boost measured by binocular rivalry. Furthermore, after deprivation, GABA concentration measured during monocular stimulation correlated with the deprived eye dominance. We suggest that reduction in resting GABAergic inhibition triggers homeostatic plasticity in adult human V1 after a brief period of abnormal visual experience. These results are potentially useful for developing new therapeutic strategies that could exploit the intrinsic residual plasticity of the adult human visual cortex.

Published
2015

12. P.2.c.001 Determining the CNS effects of ebselen: a potential lithium-mimetic

Author

Catherine J. Harmer, Sridhar R. Vasudevan, Charles Masaki, Trevor Sharp, Uzay E. Emir, Nisha Singh, P J Cowen, Ann L. Sharpley, and Grant C. Churchill

Subjects
Pharmacology, Lithium (medication), Chemistry, Ebselen, Cns effects, Psychiatry and Mental health, chemistry.chemical_compound, Neurology, medicine, Pharmacology (medical), Neurology (clinical), Biological Psychiatry, medicine.drug
Published
2015

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