1. CD30-Positive anaplastic large cell lymphoma in a human T-cell lymphotropic virus-I endemic area
- Author
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Junji Suzumiya, Masahiro Kikuchi, Jyuichiro Nakayama, Koichi Ohshima, Minoru Akamatsu, Akiko Ohgami, Takashi Okamura, Uike N, and Morishige Takeshita
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,viruses ,Adult T-cell leukemia/lymphoma ,Virus ,Pathology and Forensic Medicine ,Antigens, CD ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Humans ,Anaplastic large-cell lymphoma ,Aged ,Southern blot ,Aged, 80 and over ,Human T-lymphotropic virus 1 ,Ploidies ,biology ,Deltaretrovirus Antibodies ,Large cell ,Middle Aged ,medicine.disease ,Lymphoma ,Survival Rate ,Leukemia ,DNA, Viral ,biology.protein ,Lymphoma, Large-Cell, Anaplastic ,Female ,Antibody - Abstract
Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the presence of adult T-cell leukemia/lymphoma (ATL). Seventeen of them showed a clonal integration of complete HTLV-I proviral DNA by the Southern blot hybridization method in materials obtained by biopsy. Their ages ranged from 37 to 81 years (median, 67.0), and they frequently presented with lymphadenopathy (82.4%) and extranodal tumors with (76.5%) as well as with rare leukemic changes (5.9%). Immunohistologically the lymphoma cells in 15 ATL patients showed a T-cell phenotype. In only one patient (5.9%) was there an expression of epithelial membrane antigen (EMA) in most of the lymphoma cells. Cytogenetically aberration of chromosome band 5q35 was not found in seven patients with HTLV-I proviral DNA. The overall median length of survival was 11.9 months for the patients with HTLV-I proviral DNA, indicating a worse prognosis compared with that of the age-matched patients with negative anti-HTLV-I antibody (P < .01). The specimens of the patients with HTLV-I proviral DNA had unique clinicopathological and cytogenetic features. These findings suggested that T-cell ALCL with HTLV-I proviral DNA should be considered to represent the lymphoma type of ATL.
- Published
- 1995
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