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7 results on '"Tyrer, Jonathan P"'

1. Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer

Author

Kar, Siddhartha P., primary, Considine, Daniel P.C., additional, Tyrer, Jonathan P., additional, Plummer, Jasmine T., additional, Chen, Stephanie, additional, Dezem, Felipe S., additional, Barbeira, Alvaro N., additional, Rajagopal, Padma S., additional, Rosenow, Will T., additional, Moreno, Fernando, additional, Bodelon, Clara, additional, Chang-Claude, Jenny, additional, Chenevix-Trench, Georgia, additional, deFazio, Anna, additional, Dörk, Thilo, additional, Ekici, Arif B., additional, Ewing, Ailith, additional, Fountzilas, George, additional, Goode, Ellen L., additional, Hartman, Mikael, additional, Heitz, Florian, additional, Hillemanns, Peter, additional, Høgdall, Estrid, additional, Høgdall, Claus K., additional, Huzarski, Tomasz, additional, Jensen, Allan, additional, Karlan, Beth Y., additional, Khusnutdinova, Elza, additional, Kiemeney, Lambertus A., additional, Kjaer, Susanne K., additional, Klapdor, Rüdiger, additional, Köbel, Martin, additional, Li, Jingmei, additional, Liebrich, Clemens, additional, May, Taymaa, additional, Olsson, Håkan, additional, Permuth, Jennifer B., additional, Peterlongo, Paolo, additional, Radice, Paolo, additional, Ramus, Susan J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Saloustros, Emmanouil, additional, Simard, Jacques, additional, Szafron, Lukasz M., additional, Titus, Linda, additional, Thompson, Cheryl L., additional, Vierkant, Robert A., additional, Winham, Stacey J., additional, Zheng, Wei, additional, Doherty, Jennifer A., additional, Berchuck, Andrew, additional, Lawrenson, Kate, additional, Im, Hae Kyung, additional, Manichaikul, Ani W., additional, Pharoah, Paul D.P., additional, Gayther, Simon A., additional, and Schildkraut, Joellen M., additional

Published
2021
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2. Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer

Author

Kerns, Sarah L, Dorling, Leila, Fachal, Laura, Bentzen, Søren, Pharoah, Paul D P, Barnes, Daniel R, Gómez-Caamaño, Antonio, Carballo, Ana M, Dearnaley, David P, Peleteiro, Paula, Gulliford, Sarah L, Hall, Emma, Michailidou, Kyriaki, Carracedo, Ángel, Sia, Michael, Stock, Richard, Stone, Nelson N, Sydes, Matthew R, Tyrer, Jonathan P, Ahmed, Shahana, Parliament, Matthew, Ostrer, Harry, Rosenstein, Barry S, Vega, Ana, Burnet, Neil G, Dunning, Alison M, Barnett, Gillian C, and West, Catharine M L

Subjects
Genetic Markers, Male, Quality of life, Genome-wide association study, Genotype, LD, linkage disequilibrium, Cancer survivorship, Radiogenomics, lcsh:Medicine, EBRT, external bean radiotherapy, STAT, standardized total average toxicity, MAF, minor allele frequency, Polymorphism, Single Nucleotide, Radiation Tolerance, eQTL, expression quantitative trait locus, Cohort Studies, Radiation toxicity, GTEx, Genotype-Tissue Expression project, Odds Ratio, Humans, BED, biologic effective dose, GWAS, genome-wide association study, ENCODE, encyclopedia of DNA elements, Alleles, Aged, Neoplasm Staging, lcsh:R5-920, Prostate cancer, Manchester Cancer Research Centre, Radiotherapy, ResearchInstitutes_Networks_Beacons/mcrc, lcsh:R, Prostatic Neoplasms, TURP, transurethral resection of the prostate, Middle Aged, SNP, single nucleotide polymorphism, Combined Modality Therapy, Treatment Outcome, PCA, principle components analysis, lcsh:Medicine (General), Research Paper
Abstract

Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test predicting risk of toxicity could benefit many cancer patients. We aimed to meta-analyze individual level data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic markers of toxicity. Prospectively assessed two-year toxicity endpoints (urinary frequency, decreased urine stream, rectal bleeding, overall toxicity) and single nucleotide polymorphism (SNP) associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors. A fixed-effects meta-analysis identified two SNPs: rs17599026 on 5q31.2 with urinary frequency (odds ratio [OR] 3.12, 95% confidence interval [CI] 2.08–4.69, p-value 4.16 × 10− 8) and rs7720298 on 5p15.2 with decreased urine stream (OR 2.71, 95% CI 1.90–3.86, p-value = 3.21 × 10− 8). These SNPs lie within genes that are expressed in tissues adversely affected by pelvic radiotherapy including bladder, kidney, rectum and small intestine. The results show that heterogeneous radiotherapy cohorts can be combined to identify new moderate-penetrance genetic variants associated with radiotherapy toxicity. The work provides a basis for larger collaborative efforts to identify enough variants for a future test involving polygenic risk profiling., Highlights • SNPs rs17599026 and rs7720298 increase risk of urinary toxicity following radiotherapy in prostate cancer patients. • Data from heterogeneous radiotherapy cohorts can be meta-analyzed to identify genetic variants associated with toxicity. • A SNP-based predictive assay could improve the therapeutic index of radiotherapy and aid in individualization of cancer treatment. Risk of radiotherapy side-effects in a minority limits doses given to the majority. A test is needed to predict risks so treatments are personalized. Recent whole-genome studies in a few hundred patients found none or one genetic variant increasing side-effect risk. Larger studies are needed, but difficult because treatments differ between centers. Our study of > 1500 prostate cancer patients from four centers found two variants. The research shows combining heterogeneous radiotherapy datasets works and larger collaborative efforts identifying enough variants for a future test are worthwhile. As nearly 50% of cancer patients have radiotherapy, our work could benefit many people.

Published
2016
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3. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Author

Mavaddat, Nasim, primary, Michailidou, Kyriaki, additional, Dennis, Joe, additional, Lush, Michael, additional, Fachal, Laura, additional, Lee, Andrew, additional, Tyrer, Jonathan P., additional, Chen, Ting-Huei, additional, Wang, Qin, additional, Bolla, Manjeet K., additional, Yang, Xin, additional, Adank, Muriel A., additional, Ahearn, Thomas, additional, Aittomäki, Kristiina, additional, Allen, Jamie, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Auer, Paul L., additional, Auvinen, Päivi, additional, Barrdahl, Myrto, additional, Beane Freeman, Laura E., additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Benitez, Javier, additional, Bermisheva, Marina, additional, Bernstein, Leslie, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bonanni, Bernardo, additional, Børresen-Dale, Anne-Lise, additional, Brauch, Hiltrud, additional, Bremer, Michael, additional, Brenner, Hermann, additional, Brentnall, Adam, additional, Brock, Ian W., additional, Brooks-Wilson, Angela, additional, Brucker, Sara Y., additional, Brüning, Thomas, additional, Burwinkel, Barbara, additional, Campa, Daniele, additional, Carter, Brian D., additional, Castelao, Jose E., additional, Chanock, Stephen J., additional, Chlebowski, Rowan, additional, Christiansen, Hans, additional, Clarke, Christine L., additional, Collée, J. Margriet, additional, Cordina-Duverger, Emilie, additional, Cornelissen, Sten, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dörk, Thilo, additional, dos-Santos-Silva, Isabel, additional, Dumont, Martine, additional, Durcan, Lorraine, additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Ekici, Arif B., additional, Eliassen, A. Heather, additional, Ellberg, Carolina, additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Fletcher, Olivia, additional, Flyger, Henrik, additional, Försti, Asta, additional, Fritschi, Lin, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, Gapstur, Susan M., additional, García-Sáenz, José A., additional, Gaudet, Mia M., additional, Georgoulias, Vassilios, additional, Giles, Graham G., additional, Gilyazova, Irina R., additional, Glendon, Gord, additional, Goldberg, Mark S., additional, Goldgar, David E., additional, González-Neira, Anna, additional, Grenaker Alnæs, Grethe I., additional, Grip, Mervi, additional, Gronwald, Jacek, additional, Grundy, Anne, additional, Guénel, Pascal, additional, Haeberle, Lothar, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Håkansson, Niclas, additional, Hamann, Ute, additional, Hankinson, Susan E., additional, Harkness, Elaine F., additional, Hart, Steven N., additional, He, Wei, additional, Hein, Alexander, additional, Heyworth, Jane, additional, Hillemanns, Peter, additional, Hollestelle, Antoinette, additional, Hooning, Maartje J., additional, Hoover, Robert N., additional, Hopper, John L., additional, Howell, Anthony, additional, Huang, Guanmengqian, additional, Humphreys, Keith, additional, Hunter, David J., additional, Jakimovska, Milena, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Johnson, Nichola, additional, Jones, Michael E., additional, Jukkola-Vuorinen, Arja, additional, Jung, Audrey, additional, Kaaks, Rudolf, additional, Kaczmarek, Katarzyna, additional, Kataja, Vesa, additional, Keeman, Renske, additional, Kerin, Michael J., additional, Khusnutdinova, Elza, additional, Kiiski, Johanna I., additional, Knight, Julia A., additional, Ko, Yon-Dschun, additional, Kosma, Veli-Matti, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Krüger, Ute, additional, Kühl, Tabea, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lilyquist, Jenna, additional, Lindblom, Annika, additional, Lindström, Sara, additional, Lissowska, Jolanta, additional, Lo, Wing-Yee, additional, Loibl, Sibylle, additional, Long, Jirong, additional, Lubiński, Jan, additional, Lux, Michael P., additional, MacInnis, Robert J., additional, Maishman, Tom, additional, Makalic, Enes, additional, Maleva Kostovska, Ivana, additional, Mannermaa, Arto, additional, Manoukian, Siranoush, additional, Margolin, Sara, additional, Martens, John W.M., additional, Martinez, Maria Elena, additional, Mavroudis, Dimitrios, additional, McLean, Catriona, additional, Meindl, Alfons, additional, Menon, Usha, additional, Middha, Pooja, additional, Miller, Nicola, additional, Moreno, Fernando, additional, Mulligan, Anna Marie, additional, Mulot, Claire, additional, Muñoz-Garzon, Victor M., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Neven, Patrick, additional, Newman, William G., additional, Nielsen, Sune F., additional, Nordestgaard, Børge G., additional, Norman, Aaron, additional, Offit, Kenneth, additional, Olson, Janet E., additional, Olsson, Håkan, additional, Orr, Nick, additional, Pankratz, V. Shane, additional, Park-Simon, Tjoung-Won, additional, Perez, Jose I.A., additional, Pérez-Barrios, Clara, additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Pinchev, Mila, additional, Plaseska-Karanfilska, Dijana, additional, Polley, Eric C., additional, Prentice, Ross, additional, Presneau, Nadege, additional, Prokofyeva, Darya, additional, Purrington, Kristen, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rau-Murthy, Rohini, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, Rhenius, Valerie, additional, Robson, Mark, additional, Romero, Atocha, additional, Ruddy, Kathryn J., additional, Ruebner, Matthias, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmidt, Daniel F., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Schumacher, Fredrick, additional, Schürmann, Peter, additional, Schwentner, Lukas, additional, Scott, Christopher, additional, Scott, Rodney J., additional, Seynaeve, Caroline, additional, Shah, Mitul, additional, Sherman, Mark E., additional, Shrubsole, Martha J., additional, Shu, Xiao-Ou, additional, Slager, Susan, additional, Smeets, Ann, additional, Sohn, Christof, additional, Soucy, Penny, additional, Southey, Melissa C., additional, Spinelli, John J., additional, Stegmaier, Christa, additional, Stone, Jennifer, additional, Swerdlow, Anthony J., additional, Tamimi, Rulla M., additional, Tapper, William J., additional, Taylor, Jack A., additional, Terry, Mary Beth, additional, Thöne, Kathrin, additional, Tollenaar, Rob A.E.M., additional, Tomlinson, Ian, additional, Truong, Thérèse, additional, Tzardi, Maria, additional, Ulmer, Hans-Ulrich, additional, Untch, Michael, additional, Vachon, Celine M., additional, van Veen, Elke M., additional, Vijai, Joseph, additional, Weinberg, Clarice R., additional, Wendt, Camilla, additional, Whittemore, Alice S., additional, Wildiers, Hans, additional, Willett, Walter, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Yang, Xiaohong R., additional, Yannoukakos, Drakoulis, additional, Zhang, Yan, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Dunning, Alison M., additional, Thompson, Deborah J., additional, Chenevix-Trench, Georgia, additional, Chang-Claude, Jenny, additional, Schmidt, Marjanka K., additional, Hall, Per, additional, Milne, Roger L., additional, Pharoah, Paul D.P., additional, Antoniou, Antonis C., additional, Chatterjee, Nilanjan, additional, Kraft, Peter, additional, García-Closas, Montserrat, additional, Simard, Jacques, additional, and Easton, Douglas F., additional

Published
2019
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4. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Author

Hollestelle, Antoinette, primary, van der Baan, Frederieke H., additional, Berchuck, Andrew, additional, Johnatty, Sharon E., additional, Aben, Katja K., additional, Agnarsson, Bjarni A., additional, Aittomäki, Kristiina, additional, Alducci, Elisa, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Antoniou, Antonis C., additional, Apicella, Carmel, additional, Arndt, Volker, additional, Arnold, Norbert, additional, Arun, Banu K., additional, Arver, Brita, additional, Ashworth, Alan, additional, Baglietto, Laura, additional, Balleine, Rosemary, additional, Bandera, Elisa V., additional, Barrowdale, Daniel, additional, Bean, Yukie T., additional, Beckmann, Lars, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Berger, Andreas, additional, Berger, Raanan, additional, Beuselinck, Benoit, additional, Bisogna, Maria, additional, Bjorge, Line, additional, Blomqvist, Carl, additional, Bogdanova, Natalia V., additional, Bojesen, Anders, additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Bonanni, Bernardo, additional, Brand, Judith S., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brinton, Louise, additional, Brooks-Wilson, Angela, additional, Bruinsma, Fiona, additional, Brunet, Joan, additional, Brüning, Thomas, additional, Budzilowska, Agnieszka, additional, Bunker, Clareann H., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Buys, Saundra S., additional, Caligo, Maria A., additional, Campbell, Ian, additional, Carter, Jonathan, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Claes, Kathleen B.M., additional, Collée, J. Margriet, additional, Cook, Linda S., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cramer, Daniel, additional, Cross, Simon S., additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Damiola, Francesca, additional, Dansonka-Mieszkowska, Agnieszka, additional, Darabi, Hatef, additional, de la Hoya, Miguel, additional, deFazio, Anna, additional, Dennis, Joseph, additional, Devilee, Peter, additional, Dicks, Ed M., additional, Diez, Orland, additional, Doherty, Jennifer A., additional, Domchek, Susan M., additional, Dorfling, Cecilia M., additional, Dörk, Thilo, additional, Silva, Isabel Dos Santos, additional, du Bois, Andreas, additional, Dumont, Martine, additional, Dunning, Alison M., additional, Duran, Mercedes, additional, Easton, Douglas F., additional, Eccles, Diana, additional, Edwards, Robert P., additional, Ehrencrona, Hans, additional, Ejlertsen, Bent, additional, Ekici, Arif B., additional, Ellis, Steve D., additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Fasching, Peter A., additional, Feliubadalo, Lidia, additional, Figueroa, Jonine, additional, Flesch-Janys, Dieter, additional, Fletcher, Olivia, additional, Fontaine, Annette, additional, Fortuzzi, Stefano, additional, Fostira, Florentia, additional, Fridley, Brooke L., additional, Friebel, Tara, additional, Friedman, Eitan, additional, Friel, Grace, additional, Frost, Debra, additional, Garber, Judy, additional, García-Closas, Montserrat, additional, Gayther, Simon A., additional, Gentry-Maharaj, Aleksandra, additional, Gerdes, Anne-Marie, additional, Giles, Graham G., additional, Glasspool, Rosalind, additional, Glendon, Gord, additional, Godwin, Andrew K., additional, Goodman, Marc T., additional, Gore, Martin, additional, Greene, Mark H., additional, Grip, Mervi, additional, Gronwald, Jacek, additional, Gschwantler Kaulich, Daphne, additional, Guénel, Pascal, additional, Guzman, Starr R., additional, Haeberle, Lothar, additional, Haiman, Christopher A., additional, Hall, Per, additional, Halverson, Sandra L., additional, Hamann, Ute, additional, Hansen, Thomas V.O., additional, Harter, Philipp, additional, Hartikainen, Jaana M., additional, Healey, Sue, additional, Hein, Alexander, additional, Heitz, Florian, additional, Henderson, Brian E., additional, Herzog, Josef, additional, T Hildebrandt, Michelle A., additional, Høgdall, Claus K., additional, Høgdall, Estrid, additional, Hogervorst, Frans B.L., additional, Hopper, John L., additional, Humphreys, Keith, additional, Huzarski, Tomasz, additional, Imyanitov, Evgeny N., additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, Janavicius, Ramunas, additional, Jaworska, Katarzyna, additional, Jensen, Allan, additional, Jensen, Uffe Birk, additional, Johnson, Nichola, additional, Jukkola-Vuorinen, Arja, additional, Kabisch, Maria, additional, Karlan, Beth Y., additional, Kataja, Vesa, additional, Kauff, Noah, additional, Kelemen, Linda E., additional, Kerin, Michael J., additional, Kiemeney, Lambertus A., additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Knol-Bout, Jacoba P., additional, Konstantopoulou, Irene, additional, Kosma, Veli-Matti, additional, Krakstad, Camilla, additional, Kristensen, Vessela, additional, Kuchenbaecker, Karoline B., additional, Kupryjanczyk, Jolanta, additional, Laitman, Yael, additional, Lambrechts, Diether, additional, Lambrechts, Sandrina, additional, Larson, Melissa C., additional, Lasa, Adriana, additional, Laurent-Puig, Pierre, additional, Lazaro, Conxi, additional, Le, Nhu D., additional, Le Marchand, Loic, additional, Leminen, Arto, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Jingmei, additional, Liang, Dong, additional, Lindblom, Annika, additional, Lindor, Noralane, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Karen H., additional, Lubinski, Jan, additional, Lundvall, Lene, additional, Lurie, Galina, additional, Mai, Phuong L., additional, Mannermaa, Arto, additional, Margolin, Sara, additional, Mariette, Frederique, additional, Marme, Frederik, additional, Martens, John W.M., additional, Massuger, Leon F.A.G., additional, Maugard, Christine, additional, Mazoyer, Sylvie, additional, McGuffog, Lesley, additional, McGuire, Valerie, additional, McLean, Catriona, additional, McNeish, Iain, additional, Meindl, Alfons, additional, Menegaux, Florence, additional, Menéndez, Primitiva, additional, Menkiszak, Janusz, additional, Menon, Usha, additional, Mensenkamp, Arjen R., additional, Miller, Nicola, additional, Milne, Roger L., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moysich, Kirsten B., additional, Müller, Heiko, additional, Mulligan, Anna Marie, additional, Muranen, Taru A., additional, Narod, Steven A., additional, Nathanson, Katherine L., additional, Ness, Roberta B., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Neven, Patrick, additional, Nielsen, Finn C., additional, Nielsen, Sune F., additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Odunsi, Kunle, additional, Offit, Kenneth, additional, Olah, Edith, additional, Olopade, Olufunmilayo I., additional, Olson, Janet E., additional, Olson, Sara H., additional, Oosterwijk, Jan C., additional, Orlow, Irene, additional, Orr, Nick, additional, Orsulic, Sandra, additional, Osorio, Ana, additional, Ottini, Laura, additional, Paul, James, additional, Pearce, Celeste L., additional, Pedersen, Inge Sokilde, additional, Peissel, Bernard, additional, Pejovic, Tanja, additional, Pelttari, Liisa M., additional, Perkins, Jo, additional, Permuth-Wey, Jenny, additional, Peterlongo, Paolo, additional, Peto, Julian, additional, Phelan, Catherine M., additional, Phillips, Kelly-Anne, additional, Piedmonte, Marion, additional, Pike, Malcolm C., additional, Platte, Radka, additional, Plisiecka-Halasa, Joanna, additional, Poole, Elizabeth M., additional, Poppe, Bruce, additional, Pylkäs, Katri, additional, Radice, Paolo, additional, Ramus, Susan J., additional, Rebbeck, Timothy R., additional, Reed, Malcolm W.R., additional, Rennert, Gad, additional, Risch, Harvey A., additional, Robson, Mark, additional, Rodriguez, Gustavo C., additional, Romero, Atocha, additional, Rossing, Mary Anne, additional, Rothstein, Joseph H., additional, Rudolph, Anja, additional, Runnebaum, Ingo, additional, Salani, Ritu, additional, Salvesen, Helga B., additional, Sawyer, Elinor J., additional, Schildkraut, Joellen M., additional, Schmidt, Marjanka K., additional, Schmutzler, Rita K., additional, Schneeweiss, Andreas, additional, Schoemaker, Minouk J., additional, Schrauder, Michael G., additional, Schumacher, Fredrick, additional, Schwaab, Ira, additional, Scuvera, Giulietta, additional, Sellers, Thomas A., additional, Severi, Gianluca, additional, Seynaeve, Caroline M., additional, Shah, Mitul, additional, Shrubsole, Martha, additional, Siddiqui, Nadeem, additional, Sieh, Weiva, additional, Simard, Jacques, additional, Singer, Christian F., additional, Sinilnikova, Olga M., additional, Smeets, Dominiek, additional, Sohn, Christof, additional, Soller, Maria, additional, Song, Honglin, additional, Soucy, Penny, additional, Southey, Melissa C., additional, Stegmaier, Christa, additional, Stoppa-Lyonnet, Dominique, additional, Sucheston, Lara, additional, Swerdlow, Anthony, additional, Tangen, Ingvild L., additional, Tea, Muy-Kheng, additional, Teixeira, Manuel R., additional, Terry, Kathryn L., additional, Terry, Mary Beth, additional, Thomassen, Mads, additional, Thompson, Pamela J., additional, Tihomirova, Laima, additional, Tischkowitz, Marc, additional, Toland, Amanda Ewart, additional, Tollenaar, Rob A.E.M., additional, Tomlinson, Ian, additional, Torres, Diana, additional, Truong, Thérèse, additional, Tsimiklis, Helen, additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Tyrer, Jonathan P., additional, Vachon, Celine M., additional, Van 't Veer, Laura J., additional, van Altena, Anne M., additional, Van Asperen, C.J., additional, van den Berg, David, additional, van den Ouweland, Ans M.W., additional, van Doorn, Helena C., additional, Van Nieuwenhuysen, Els, additional, van Rensburg, Elizabeth J., additional, Vergote, Ignace, additional, Verhoef, Senno, additional, Vierkant, Robert A., additional, Vijai, Joseph, additional, Vitonis, Allison F., additional, von Wachenfeldt, Anna, additional, Walsh, Christine, additional, Wang, Qin, additional, Wang-Gohrke, Shan, additional, Wappenschmidt, Barbara, additional, Weischer, Maren, additional, Weitzel, Jeffrey N., additional, Weltens, Caroline, additional, Wentzensen, Nicolas, additional, Whittemore, Alice S., additional, Wilkens, Lynne R., additional, Winqvist, Robert, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yang, Hannah P., additional, Zaffaroni, Daniela, additional, Pilar Zamora, M., additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Chenevix-Trench, Georgia, additional, Pharoah, Paul D.P., additional, Rookus, Matti A., additional, Hooning, Maartje J., additional, and Goode, Ellen L., additional

Published
2016
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5. Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study

Author

Lee, Alice W., primary, Tyrer, Jonathan P., additional, Doherty, Jennifer A., additional, Stram, Douglas A., additional, Kupryjanczyk, Jolanta, additional, Dansonka-Mieszkowska, Agnieszka, additional, Plisiecka-Halasa, Joanna, additional, Spiewankiewicz, Beata, additional, Myers, Emily J., additional, Chenevix-Trench, Georgia, additional, Fasching, Peter A., additional, Beckmann, Matthias W., additional, Ekici, Arif B., additional, Hein, Alexander, additional, Vergote, Ignace, additional, Van Nieuwenhuysen, Els, additional, Lambrechts, Diether, additional, Wicklund, Kristine G., additional, Eilber, Ursula, additional, Wang-Gohrke, Shan, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Sucheston-Campbell, Lara, additional, Odunsi, Kunle, additional, Moysich, Kirsten B., additional, Shvetsov, Yurii B., additional, Thompson, Pamela J., additional, Goodman, Marc T., additional, Wilkens, Lynne R., additional, Dörk, Thilo, additional, Hillemanns, Peter, additional, Dürst, Matthias, additional, Runnebaum, Ingo B., additional, Bogdanova, Natalia, additional, Pelttari, Liisa M., additional, Nevanlinna, Heli, additional, Leminen, Arto, additional, Edwards, Robert P., additional, Kelley, Joseph L., additional, Harter, Philipp, additional, Schwaab, Ira, additional, Heitz, Florian, additional, du Bois, Andreas, additional, Orsulic, Sandra, additional, Lester, Jenny, additional, Walsh, Christine, additional, Karlan, Beth Y., additional, Hogdall, Estrid, additional, Kjaer, Susanne K., additional, Jensen, Allan, additional, Vierkant, Robert A., additional, Cunningham, Julie M., additional, Goode, Ellen L., additional, Fridley, Brooke L., additional, Southey, Melissa C., additional, Giles, Graham G., additional, Bruinsma, Fiona, additional, Wu, Xifeng, additional, Hildebrandt, Michelle A.T., additional, Lu, Karen, additional, Liang, Dong, additional, Bisogna, Maria, additional, Levine, Douglas A., additional, Weber, Rachel Palmieri, additional, Schildkraut, Joellen M., additional, Iversen, Edwin S., additional, Berchuck, Andrew, additional, Terry, Kathryn L., additional, Cramer, Daniel W., additional, Tworoger, Shelley S., additional, Poole, Elizabeth M., additional, Olson, Sara H., additional, Orlow, Irene, additional, Bandera, Elisa V., additional, Bjorge, Line, additional, Tangen, Ingvild L., additional, Salvesen, Helga B., additional, Krakstad, Camilla, additional, Massuger, Leon F.A.G., additional, Kiemeney, Lambertus A., additional, Aben, Katja K.H., additional, van Altena, Anne M., additional, Bean, Yukie, additional, Pejovic, Tanja, additional, Kellar, Melissa, additional, Le, Nhu D., additional, Cook, Linda S., additional, Kelemen, Linda E., additional, Brooks-Wilson, Angela, additional, Lubinski, Jan, additional, Gronwald, Jacek, additional, Cybulski, Cezary, additional, Jakubowska, Anna, additional, Wentzensen, Nicolas, additional, Brinton, Louise A., additional, Lissowska, Jolanta, additional, Yang, Hannah, additional, Nedergaard, Lotte, additional, Lundvall, Lene, additional, Hogdall, Claus, additional, Song, Honglin, additional, Campbell, Ian G., additional, Eccles, Diana, additional, Glasspool, Rosalind, additional, Siddiqui, Nadeem, additional, Carty, Karen, additional, Paul, James, additional, McNeish, Iain A., additional, Sieh, Weiva, additional, McGuire, Valerie, additional, Rothstein, Joseph H., additional, Whittemore, Alice S., additional, McLaughlin, John R., additional, Risch, Harvey A., additional, Phelan, Catherine M., additional, Anton-Culver, Hoda, additional, Ziogas, Argyrios, additional, Menon, Usha, additional, Ramus, Susan J., additional, Gentry-Maharaj, Aleksandra, additional, Harrington, Patricia, additional, Pike, Malcolm C., additional, Modugno, Francesmary, additional, Rossing, Mary Anne, additional, Ness, Roberta B., additional, Pharoah, Paul D.P., additional, Stram, Daniel O., additional, Wu, Anna H., additional, and Pearce, Celeste Leigh, additional

Published
2015
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6. A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity

Author

Barnett, Gillian C., primary, Thompson, Deborah, additional, Fachal, Laura, additional, Kerns, Sarah, additional, Talbot, Chris, additional, Elliott, Rebecca M., additional, Dorling, Leila, additional, Coles, Charlotte E., additional, Dearnaley, David P., additional, Rosenstein, Barry S., additional, Vega, Ana, additional, Symonds, Paul, additional, Yarnold, John, additional, Baynes, Caroline, additional, Michailidou, Kyriaki, additional, Dennis, Joe, additional, Tyrer, Jonathan P., additional, Wilkinson, Jennifer S., additional, Gómez-Caamaño, Antonio, additional, Tanteles, George A., additional, Platte, Radka, additional, Mayes, Rebecca, additional, Conroy, Don, additional, Maranian, Mel, additional, Luccarini, Craig, additional, Gulliford, Sarah L., additional, Sydes, Matthew R., additional, Hall, Emma, additional, Haviland, Joanne, additional, Misra, Vivek, additional, Titley, Jennifer, additional, Bentzen, Søren M., additional, Pharoah, Paul D.P., additional, Burnet, Neil G., additional, Dunning, Alison M., additional, and West, Catharine M.L., additional

Published
2014
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7. Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer

Author

Kar, Siddhartha P, Considine, Daniel PC, Tyrer, Jonathan P, Plummer, Jasmine T, Chen, Stephanie, Dezem, Felipe S, Barbeira, Alvaro N, Rajagopal, Padma S, Rosenow, Will T, Moreno, Fernando, Bodelon, Clara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, DeFazio, Anna, Dörk, Thilo, Ekici, Arif B, Ewing, Ailith, Fountzilas, George, Goode, Ellen L, Hartman, Mikael, Heitz, Florian, Hillemanns, Peter, Høgdall, Estrid, Høgdall, Claus K, Huzarski, Tomasz, Jensen, Allan, Karlan, Beth Y, Khusnutdinova, Elza, Kiemeney, Lambertus A, Kjaer, Susanne K, Klapdor, Rüdiger, Köbel, Martin, Li, Jingmei, Liebrich, Clemens, May, Taymaa, Olsson, Håkan, Permuth, Jennifer B, Peterlongo, Paolo, Radice, Paolo, Ramus, Susan J, Riggan, Marjorie J, Risch, Harvey A, Saloustros, Emmanouil, Simard, Jacques, Szafron, Lukasz M, Titus, Linda, Thompson, Cheryl L, Vierkant, Robert A, Winham, Stacey J, Zheng, Wei, Doherty, Jennifer A, Berchuck, Andrew, Lawrenson, Kate, Im, Hae Kyung, Manichaikul, Ani W, Pharoah, Paul DP, Gayther, Simon A, and Schildkraut, Joellen M

Subjects
2 Aetiology, Prevention, Human Genome, 3105 Genetics, 3. Good health, Ovarian Cancer, Rare Diseases, FOS: Biological sciences, Breast Cancer, Genetics, 2.1 Biological and endogenous factors, 31 Biological Sciences, Cancer, Biotechnology
Abstract

Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWASs) to identify candidate breast cancer and ovarian cancer susceptibility genes. We built gene expression prediction models using the PrediXcan method in 681 breast and 295 ovarian tumors from The Cancer Genome Atlas and 211 breast and 99 ovarian normal tissue samples from the Genotype-Tissue Expression project and integrated these with GWAS meta-analysis data from the Breast Cancer Association Consortium (122,977 cases/105,974 controls) and the Ovarian Cancer Association Consortium (22,406 cases/40,941 controls). The integration was achieved through application of a pleiotropy-guided conditional/conjunction false discovery rate (FDR) approach in the setting of a TWASs. This identified 14 candidate breast cancer susceptibility genes spanning 11 genomic regions and 8 candidate ovarian cancer susceptibility genes spanning 5 genomic regions at conjunction FDR < 0.05 that were >1 Mb away from known breast and/or ovarian cancer susceptibility loci. We also identified 38 candidate breast cancer susceptibility genes and 17 candidate ovarian cancer susceptibility genes at conjunction FDR < 0.05 at known breast and/or ovarian susceptibility loci. The 22 genes identified by our cross-cancer analysis represent promising candidates that further elucidate the role of the transcriptome in mediating germline breast and ovarian cancer risk.

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