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Your search keyword '"Tsuji, Shuhei"' showing total 16 results
Start Over Author "Tsuji, Shuhei" Publisher elsevier bv
16 results on '"Tsuji, Shuhei"'

1. Fragility and long-term clinical outcomes in patients with venous thromboembolism receiving direct oral anticoagulants: From the COMMAND VTE REGISTRY-2

Author

Ogihara, Yoshito, primary, Yamashita, Yugo, additional, Morimoto, Takeshi, additional, Chatani, Ryuki, additional, Kaneda, Kazuhisa, additional, Nishimoto, Yuji, additional, Ikeda, Nobutaka, additional, Kobayashi, Yohei, additional, Ikeda, Satoshi, additional, Kim, Kitae, additional, Inoko, Moriaki, additional, Takase, Toru, additional, Tsuji, Shuhei, additional, Oi, Maki, additional, Takada, Takuma, additional, Otsui, Kazunori, additional, Sakamoto, Jiro, additional, Inoue, Takeshi, additional, Usami, Shunsuke, additional, Chen, Po-Min, additional, Togi, Kiyonori, additional, Koitabashi, Norimichi, additional, Hiramori, Seiichi, additional, Doi, Kosuke, additional, Mabuchi, Hiroshi, additional, Tsuyuki, Yoshiaki, additional, Murata, Koichiro, additional, Takabayashi, Kensuke, additional, Nakai, Hisato, additional, Sueta, Daisuke, additional, Shioyama, Wataru, additional, Dohke, Tomohiro, additional, Sato, Toru, additional, Nishikawa, Ryusuke, additional, Kimura, Takeshi, additional, and Dohi, Kaoru, additional

Published
2024
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3. KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

Author

20565577, 30758446, 30528302, 40506466, Tsuji, Shuhei, Otani, Chiharu, Horie, Takahiro, Watanabe, Shin, Baba, Osamu, Sowa, Naoya, Ide, Yuya, Kashiwa, Asami, Makiyama, Takeru, Imai, Hirohiko, Nakashima, Yasuhiro, Yamasaki, Tomohiro, Xu, Sijia, Matsushita, Kazuki, Suzuki, Keita, Zou, Fuquan, Kume, Eitaro, Hasegawa, Koji, Kimura, Takeshi, Kakizuka, Akira, Ono, Koh, 20565577, 30758446, 30528302, 40506466, Tsuji, Shuhei, Otani, Chiharu, Horie, Takahiro, Watanabe, Shin, Baba, Osamu, Sowa, Naoya, Ide, Yuya, Kashiwa, Asami, Makiyama, Takeru, Imai, Hirohiko, Nakashima, Yasuhiro, Yamasaki, Tomohiro, Xu, Sijia, Matsushita, Kazuki, Suzuki, Keita, Zou, Fuquan, Kume, Eitaro, Hasegawa, Koji, Kimura, Takeshi, Kakizuka, Akira, and Ono, Koh

Abstract

[Aims] As heart failure (HF) progresses, ATP levels in myocardial cells decrease, and myocardial contractility also decreases. Inotropic drugs improve myocardial contractility but increase ATP consumption, leading to poor prognosis. Kyoto University Substance 121 (KUS121) is known to selectively inhibit the ATPase activity of valosin-containing protein, maintain cellular ATP levels, and manifest cytoprotective effects in several pathological conditions. The aim of this study is to determine the therapeutic effect of KUS121 on HF models. [Methods and results] Cultured cell, mouse, and canine models of HF were used to examine the therapeutic effects of KUS121. The mechanism of action of KUS121 was also examined. Administration of KUS121 to a transverse aortic constriction (TAC)-induced mouse model of HF rapidly improved the left ventricular ejection fraction and improved the creatine phosphate/ATP ratio. In a canine model of high frequency-paced HF, administration of KUS121 also improved left ventricular contractility and decreased left ventricular end-diastolic pressure without increasing the heart rate. Long-term administration of KUS121 to a TAC-induced mouse model of HF suppressed cardiac hypertrophy and fibrosis. In H9C2 cells, KUS121 reduced ER stress. Finally, in experiments using primary cultured cardiomyocytes, KUS121 improved contractility and diastolic capacity without changing peak Ca²⁺ levels or contraction time. These effects were not accompanied by an increase in cyclic adenosine monophosphate or phosphorylation of phospholamban and ryanodine receptors. [Conclusions] KUS121 ameliorated HF by a mechanism totally different from that of conventional catecholamines. We propose that KUS121 is a promising new option for the treatment of HF.

Published
2024

4. Cancer-associated venous thromboembolism in the direct oral anticoagulants era: Insight from the COMMAND VTE Registry-2

Author

Chatani, Ryuki, primary, Yamashita, Yugo, additional, Morimoto, Takeshi, additional, Mushiake, Kazunori, additional, Kadota, Kazushige, additional, Kaneda, Kazuhisa, additional, Nishimoto, Yuji, additional, Ikeda, Nobutaka, additional, Kobayashi, Yohei, additional, Ikeda, Satoshi, additional, Kim, Kitae, additional, Inoko, Moriaki, additional, Takase, Toru, additional, Tsuji, Shuhei, additional, Oi, Maki, additional, Takada, Takuma, additional, Otsui, Kazunori, additional, Sakamoto, Jiro, additional, Ogihara, Yoshito, additional, Inoue, Takeshi, additional, Usami, Shunsuke, additional, Chen, Po-Min, additional, Togi, Kiyonori, additional, Koitabashi, Norimichi, additional, Hiramori, Seiichi, additional, Doi, Kosuke, additional, Mabuchi, Hiroshi, additional, Tsuyuki, Yoshiaki, additional, Murata, Koichiro, additional, Takabayashi, Kensuke, additional, Nakai, Hisato, additional, Sueta, Daisuke, additional, Shioyama, Wataru, additional, Dohke, Tomohiro, additional, Nishikawa, Ryusuke, additional, and Kimura, Takeshi, additional

Published
2024
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5. KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

Author

Tsuji, Shuhei, primary, Otani, Chiharu, additional, Horie, Takahiro, additional, Watanabe, Shin, additional, Baba, Osamu, additional, Sowa, Naoya, additional, Ide, Yuya, additional, Kashiwa, Asami, additional, Makiyama, Takeru, additional, Imai, Hirohiko, additional, Nakashima, Yasuhiro, additional, Yamasaki, Tomohiro, additional, Xu, Sijia, additional, Matsushita, Kazuki, additional, Suzuki, Keita, additional, Zou, Fuquan, additional, Kume, Eitaro, additional, Hasegawa, Koji, additional, Kimura, Takeshi, additional, Kakizuka, Akira, additional, and Ono, Koh, additional

Published
2024
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6. Anticoagulation strategies and long-term recurrence in patients with venous thromboembolism in the era of direct oral anticoagulants

Author

Kaneda, Kazuhisa, primary, Yamashita, Yugo, additional, Morimoto, Takeshi, additional, Chatani, Ryuki, additional, Nishimoto, Yuji, additional, Ikeda, Nobutaka, additional, Kobayashi, Yohei, additional, Ikeda, Satoshi, additional, Kim, Kitae, additional, Inoko, Moriaki, additional, Takase, Toru, additional, Tsuji, Shuhei, additional, Oi, Maki, additional, Takada, Takuma, additional, Otsui, Kazunori, additional, and Kimura, Takeshi, additional

Published
2023
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7. Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

Author

20565577, 20565585, 70423150, 70378769, 80204329, Ide, Yuya, Horie, Takahiro, Saito, Naritatsu, Watanabe, Shin, Otani, Chiharu, Miyasaka, Yui, Kuwabara, Yasuhide, Nishino, Tomohiro, Nakao, Tetsushi, Nishiga, Masataka, Nishi, Hitoo, Nakashima, Yasuhiro, Nakazeki, Fumiko, Koyama, Satoshi, Kimura, Masahiro, Tsuji, Shuhei, Rodriguez, Randolph Ruiz, Xu, Sijia, Yamasaki, Tomohiro, Watanabe, Toshimitsu, Yamamoto, Masamichi, Yanagita, Motoko, Kimura, Takeshi, Kakizuka, Akira, Ono, Koh, 20565577, 20565585, 70423150, 70378769, 80204329, Ide, Yuya, Horie, Takahiro, Saito, Naritatsu, Watanabe, Shin, Otani, Chiharu, Miyasaka, Yui, Kuwabara, Yasuhide, Nishino, Tomohiro, Nakao, Tetsushi, Nishiga, Masataka, Nishi, Hitoo, Nakashima, Yasuhiro, Nakazeki, Fumiko, Koyama, Satoshi, Kimura, Masahiro, Tsuji, Shuhei, Rodriguez, Randolph Ruiz, Xu, Sijia, Yamasaki, Tomohiro, Watanabe, Toshimitsu, Yamamoto, Masamichi, Yanagita, Motoko, Kimura, Takeshi, Kakizuka, Akira, and Ono, Koh

Abstract

No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.

Published
2019

8. Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

Author

Ide, Yuya, primary, Horie, Takahiro, additional, Saito, Naritatsu, additional, Watanabe, Shin, additional, Otani, Chiharu, additional, Miyasaka, Yui, additional, Kuwabara, Yasuhide, additional, Nishino, Tomohiro, additional, Nakao, Tetsushi, additional, Nishiga, Masataka, additional, Nishi, Hitoo, additional, Nakashima, Yasuhiro, additional, Nakazeki, Fumiko, additional, Koyama, Satoshi, additional, Kimura, Masahiro, additional, Tsuji, Shuhei, additional, Rodriguez, Randolph Ruiz, additional, Xu, Sijia, additional, Yamasaki, Tomohiro, additional, Watanabe, Toshimitsu, additional, Yamamoto, Masamichi, additional, Yanagita, Motoko, additional, Kimura, Takeshi, additional, Kakizuka, Akira, additional, and Ono, Koh, additional

Published
2019
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10. Prognostic Impact of Left Ventricular Ejection Fraction in Patients With Severe Aortic Stenosis

Author

Taniguchi, Tomohiko, primary, Morimoto, Takeshi, additional, Shiomi, Hiroki, additional, Ando, Kenji, additional, Kanamori, Norio, additional, Murata, Koichiro, additional, Kitai, Takeshi, additional, Kadota, Kazushige, additional, Izumi, Chisato, additional, Nakatsuma, Kenji, additional, Sasa, Tomoki, additional, Watanabe, Hirotoshi, additional, Kuwabara, Yasuhide, additional, Makiyama, Takeru, additional, Ono, Koh, additional, Shizuta, Satoshi, additional, Kato, Takao, additional, Saito, Naritatsu, additional, Minatoya, Kenji, additional, Kimura, Takeshi, additional, Taniguchi, Tomohiko, additional, Imai, Masao, additional, Tazaki, Junichi, additional, Toyota, Toshiaki, additional, Higami, Hirooki, additional, Kawaji, Tetsuma, additional, Shirai, Shinichi, additional, Kourai, Kengo, additional, Arita, Takeshi, additional, Miura, Shiro, additional, Yamaji, Kyohei, additional, Aoyama, Takeshi, additional, Onodera, Tomoya, additional, Furukawa, Yutaka, additional, Kim, Kitae, additional, Kawase, Yuichi, additional, Iwasaki, Keiichiro, additional, Miyawaki, Hiroshi, additional, Misao, Ayumi, additional, Kuwayama, Akimune, additional, Ohya, Masanobu, additional, Shimada, Takenobu, additional, Amano, Hidewo, additional, Nakagawa, Yoshihisa, additional, Miyake, Makoto, additional, Amano, Masashi, additional, Takahashi, Yusuke, additional, Yoshikawa, Yusuke, additional, Nishimura, Shunsuke, additional, Kuroda, Maiko, additional, Shirotani, Manabu, additional, Mitsuoka, Hirokazu, additional, Miki, Shinji, additional, Mizoguchi, Tetsu, additional, Kato, Masashi, additional, Yokomatsu, Takafumi, additional, Kushiyama, Akihiro, additional, Yaku, Hidenori, additional, Watanabe, Toshimitsu, additional, Miyazaki, Shunichi, additional, Hirano, Yutaka, additional, Matsuda, Mitsuo, additional, Matsuda, Shintaro, additional, Sugioka, Sachiko, additional, Inada, Tsukasa, additional, Nagao, Kazuya, additional, Takahashi, Naoki, additional, Fukuchi, Kohei, additional, Murakami, Tomoyuki, additional, Mabuchi, Hiroshi, additional, Takeda, Teruki, additional, Sakaguchi, Tomoko, additional, Maeda, Keiko, additional, Yamaji, Masayuki, additional, Maenaka, Motoyoshi, additional, Tadano, Yutaka, additional, Sakamoto, Hiroki, additional, Takeuchi, Yasuyo, additional, Motooka, Makoto, additional, Nishikawa, Ryusuke, additional, Eizawa, Hiroshi, additional, Yamane, Keiichiro, additional, Kawato, Mitsunori, additional, Kinoshita, Minako, additional, Aida, Kenji, additional, Tamura, Takashi, additional, Toyofuku, Mamoru, additional, Takahashi, Kousuke, additional, Ko, Euihong, additional, Akao, Masaharu, additional, Ishii, Mitsuru, additional, Masunaga, Nobutoyo, additional, Ogawa, Hisashi, additional, Iguchi, Moritake, additional, Unoki, Takashi, additional, Takabayashi, Kensuke, additional, Hamatani, Yasuhiro, additional, Yamashita, Yugo, additional, Inoko, Moriaki, additional, Minamino-Muta, Eri, additional, Himura, Yoshihiro, additional, Ikeda, Tomoyuki, additional, Ishii, Katsuhisa, additional, Komasa, Akihiro, additional, Sato, Yukihito, additional, Hotta, Kozo, additional, Tsuji, Shuhei, additional, Hiraoka, Yuji, additional, Higashitani, Nobuya, additional, Kouchi, Ichiro, additional, Kato, Yoshihiro, additional, Ikeguchi, Shigeru, additional, Inuzuka, Yasutaka, additional, Nishio, Soji, additional, Seki, Jyunya, additional, Shinoda, Eiji, additional, Yamada, Miho, additional, Kawamoto, Akira, additional, Maeda, Chiyo, additional, Konishi, Takashi, additional, Jinnai, Toshikazu, additional, Sogabe, Kouji, additional, Tachiiri, Michiya, additional, Matsumura, Yukiko, additional, Ota, Chihiro, additional, Kitaguchi, Shoji, additional, Morikami, Yuko, additional, Sakata, Ryuzo, additional, Minakata, Kenji, additional, Hanyu, Michiya, additional, Yamazaki, Fumio, additional, Koyama, Tadaaki, additional, Komiya, Tatsuhiko, additional, Yamanaka, Kazuo, additional, Nishiwaki, Noboru, additional, Nakajima, Hiroyuki, additional, Ohnaka, Motoaki, additional, Osada, Hiroaki, additional, Meshii, Katsuaki, additional, Saga, Toshihiko, additional, Onoe, Masahiko, additional, Nakayama, Shogo, additional, Sakaguchi, Genichi, additional, Iwakura, Atsushi, additional, Shiraga, Kotaro, additional, Ueyama, Koji, additional, Fujiwara, Keiichi, additional, Fukumoto, Atsushi, additional, Park, Masaki, additional, Nishizawa, Junichiro, additional, and Kitano, Mitsuru, additional

Published
2018
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