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Your search keyword '"Theodore R. Hobbs"' showing total 5 results
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5 results on '"Theodore R. Hobbs"'

1. Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

Author

Helen L. Wu, Kathleen Busman-Sahay, Whitney C. Weber, Courtney M. Waytashek, Carla D. Boyle, Katherine B. Bateman, Jason S. Reed, Joseph M. Hwang, Christine Shriver-Munsch, Tonya Swanson, Mina Northrup, Kimberly Armantrout, Heidi Price, Mitch Robertson-LeVay, Samantha Uttke, Mithra R. Kumar, Emily J. Fray, Sol Taylor-Brill, Stephen Bondoc, Rebecca Agnor, Stephanie L. Junell, Alfred W. Legasse, Cassandra Moats, Rachele M. Bochart, Joseph Sciurba, Benjamin N. Bimber, Michelle N. Sullivan, Brandy Dozier, Rhonda P. MacAllister, Theodore R. Hobbs, Lauren D. Martin, Angela Panoskaltsis-Mortari, Lois M.A. Colgin, Robert F. Siliciano, Janet D. Siliciano, Jacob D. Estes, Jeremy V. Smedley, Michael K. Axthelm, Gabrielle Meyers, Richard T. Maziarz, Benjamin J. Burwitz, Jeffrey J. Stanton, and Jonah B. Sacha

Subjects
Infectious Diseases, Immunology, Immunology and Allergy
Published
2023
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2. Donor T cell chimerism correlates with viral reservoir clearance following allogeneic stem cell transplantation in fully cART-suppressed Mauritian cynomolgus macaques

Author

Jeremy Smedley, Lauren D. Martin, Alfred W. Legasse, Cassandra Moats, Heidi Price, Gabrielle Meyers, Christine Shriver-Munsch, Kimberly Armantrout, Jeffrey J. Stanton, Richard T. Maziarz, Jason S. Reed, Katherine B. Bateman, Rhonda MacAllister, Helen L. Wu, Benjamin J. Burwitz, Mitchell Robertson-LeVay, Theodore R. Hobbs, Benjamin N. Bimber, Tonya Swanson, Shaheed A. Abdulhaqq, Michael K. Axthelm, Mina Northrup, Whitney C. Weber, Jonah B. Sacha, and Stephanie L. Junell

Subjects
Cart, Epidemiology, T cell, Immunology, Public Health, Environmental and Occupational Health, Biology, Microbiology, QR1-502, Transplantation, Infectious Diseases, medicine.anatomical_structure, Virology, medicine, Public aspects of medicine, RA1-1270, Stem cell
Published
2019
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3. Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

Author

Ryan L. Boudreau, Brett D. Dufour, Mark R. Pitzer, Jodi L. McBride, Theodore R. Hobbs, Beverly L. Davidson, and Sergio R. Ojeda

Subjects
Male, Drug Evaluation, Preclinical, Striatum, Immunoenzyme Techniques, 0302 clinical medicine, RNA interference, Drug Discovery, Basal ganglia, Gliosis, RNA, Small Interfering, Neurons, Huntingtin Protein, 0303 health sciences, Behavior, Animal, biology, Putamen, Nuclear Proteins, Dependovirus, Magnetic Resonance Imaging, 3. Good health, Astrogliosis, Rhesus macaque, Huntington Disease, Immunity, Active, Molecular Medicine, RNA Interference, Original Article, medicine.symptom, Blotting, Western, Green Fluorescent Proteins, Nerve Tissue Proteins, Motor Activity, Real-Time Polymerase Chain Reaction, 03 medical and health sciences, Huntington's disease, mental disorders, Genetics, medicine, Animals, Humans, RNA, Messenger, Molecular Biology, 030304 developmental biology, Inflammation, Pharmacology, medicine.disease, biology.organism_classification, Macaca mulatta, MicroRNAs, nervous system, Neuroscience, 030217 neurology & neurosurgery
Abstract

To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder, remains elusive. HD is characterized by cell loss in the basal ganglia, with particular damage to the putamen, an area of the brain responsible for initiating and refining motor movements. Consequently, patients exhibit a hyperkinetic movement disorder. RNA interference (RNAi) offers therapeutic potential for this disorder by reducing the expression of HTT, the disease-causing gene. We have previously demonstrated that partial suppression of both wild-type and mutant HTT in the striatum prevents behavioral and neuropathological abnormalities in rodent models of HD. However, given the role of HTT in various cellular processes, it remains unknown whether a partial suppression of both alleles will be safe in mammals whose neurophysiology, basal ganglia anatomy, and behavioral repertoire more closely resembles that of a human. Here, we investigate whether a partial reduction of HTT in the normal non-human primate putamen is safe. We demonstrate that a 45% reduction of rhesus HTT expression in the mid- and caudal putamen does not induce motor deficits, neuronal degeneration, astrogliosis, or an immune response. Together, these data suggest that partial suppression of wild-type HTT expression is well tolerated in the primate putamen and further supports RNAi as a therapy for HD.

Published
2011
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5. 86: Maternal nicotine use increases fetal pulmonary arterial vasoconstriction during hypoxemia at near term gestation in a nonhuman primate model

Author

Amaryllis Arraut, Theodore R. Hobbs, Eliot R. Spindel, Antonio E. Frias, and Juha Rasanen

Subjects
Nicotine, Fetus, business.industry, Anesthesia, medicine, Obstetrics and Gynecology, medicine.symptom, business, Term gestation, Pulmonary Arterial Vasoconstriction, Nonhuman primate, Hypoxemia, medicine.drug
Published
2012
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