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113 results on '"Tanzarella A"'

1. Bloodstream infections in COVID-19 patients undergoing extracorporeal membrane oxygenation in ICU: An observational cohort study

Author

Carelli, Simone, primary, Dell'Anna, Antonio Maria, additional, Montini, Luca, additional, Bernardi, Giulia, additional, Gozza, Mariangela, additional, Cutuli, Salvatore Lucio, additional, Natalini, Daniele, additional, Bongiovanni, Filippo, additional, Tanzarella, Eloisa Sofia, additional, Pintaudi, Gabriele, additional, Bocci, Maria Grazia, additional, Bisanti, Alessandra, additional, Bello, Giuseppe, additional, Grieco, Domenico Luca, additional, De Pascale, Gennaro, additional, and Antonelli, Massimo, additional

Published
2023
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2. Treatment of severe infections caused by ESBL or carbapenemases-producing Enterobacteriaceae

Author

G. Lombardi, E.S. Tanzarella, S.L. Cutuli, and G. De Pascale

Subjects
General Medicine, Critical Care and Intensive Care Medicine
Abstract

Enterobacteriaceae are the most frequent pathogens in the Intensive Care Unit. Due to their safety and activity, β-Lactams (BL) and carbapenems represented the most common strategy adopted against these germs. The increasing exposure to these molecules led to the development of several types of antimicrobial resistance as the expression of extended-spectrum β-lactamases (ESBLs) and carbapenemases. Great molecular variability exists among these enzymes, with significant clinical impact. To limit morbidity and mortality, old antibiotics were tested and represent viable alternatives for specific types of infections, or once the spectrum of susceptibility of each germ has been determined. Alongside, new molecules have been specifically designed but enzyme molecular variability prevents the existence of one single antibiotic which fits for all. Therefore, a quicker identification of the molecular identity of each germ, together with the knowledge of the activity spectrum of each antibiotic is crucial to tailor the therapy and make it effective.

Published
2023
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3. Usefulness of differential time to positivity between catheter and peripheral blood cultures for diagnosing catheter-related bloodstream infection: Data analysis from routine clinical practice in the intensive care unit

Author

Bisanti, Alessandra, primary, Giammatteo, Valentina, additional, Bello, Giuseppe, additional, Giannarelli, Diana, additional, Montini, Luca, additional, Tanzarella, Eloisa S., additional, Carelli, Simone, additional, Bongiovanni, Filippo, additional, D'Inzeo, Tiziana, additional, Fiori, Barbara, additional, Grieco, Domenico L., additional, Pennisi, Mariano A., additional, De Pascale, Gennaro, additional, and Antonelli, Massimo, additional

Published
2023
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4. Lung Microbiota Composition, Respiratory Mechanics, and Clinical Outcomes in COVID-19 Patients with ARDS

Author

De Pascale, Gennaro, primary, Posteraro, Brunella, additional, De Maio, Flavio, additional, Pafundi, Pia Clara, additional, Tanzarella, Eloisa Sofia, additional, Cutuli, Salvatore Lucio, additional, Lombardi, Gianmarco, additional, Grieco, Domenico Luca, additional, Santarelli, Giulia, additional, Infante, Amato, additional, Sanguinetti, Maurizio, additional, and Antonelli, Massimo, additional

Published
2023
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6. Lung Microbiota Composition, Respiratory Mechanics, and Clinical Outcomes in COVID-19 Patients with ARDS

Author

Gennaro De Pascale, Brunella Posteraro, Flavio De Maio, Pia Clara Pafundi, Eloisa Sofia Tanzarella, Salvatore Lucio Cutuli, Gianmarco Lombardi, Domenico Luca Grieco, Giulia Santarelli, Amato Infante, Maurizio Sanguinetti, and Massimo Antonelli

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2023
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7. Hemodynamic response to positive end-expiratory pressure and prone position in COVID-19 ARDS

Author

Dell’Anna, Antonio Maria, primary, Carelli, Simone, additional, Cicetti, Marta, additional, Stella, Claudia, additional, Bongiovanni, Filippo, additional, Natalini, Daniele, additional, Tanzarella, Eloisa Sofia, additional, De Santis, Paolo, additional, Bocci, Maria Grazia, additional, De Pascale, Gennaro, additional, Grieco, Domenico Luca, additional, and Antonelli, Massimo, additional

Published
2022
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8. Anomalous Coronary Artery Origin and Sudden Cardiac Death

Author

Gaia Tanzarella, Gherardo Finocchiaro, Igor Diemberger, Chris Miles, Mary N. Sheppard, Michael Papadakis, Harshil Dhutia, Sanjay Sharma, Elijah R. Behr, and Aneil Malhotra

Subjects
Pathology, medicine.medical_specialty, business.industry, Infarction, 030204 cardiovascular system & hematology, medicine.disease, Sudden death, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Left coronary artery, medicine.artery, Right coronary artery, Pulmonary artery, Coronary artery anomaly, medicine, 030212 general & internal medicine, business, Artery
Abstract

Objectives This study sought to describe the clinical and pathological features of anomalous origin of a coronary artery (AOCA) in sudden cardiac death (SCD) victims. Background AOCA from the inappropriate sinus of Valsalva or from the pulmonary artery is increasingly diagnosed with current imaging techniques. AOCA is a possible cause of SCD. Methods We reviewed a database of 5,100 consecutive cases of SCD referred to our specialist cardiac pathology center between January 1994 and March 2017 and identified a subgroup of 30 cases (0.6%) with AOCA. All cases underwent detailed post-mortem evaluation including histological analysis by an expert cardiac pathologist. Clinical information was obtained from referring coroners. Results The mean age was 28 ± 16 years and 23 individuals were male (77%). In 8 cases (27%), SCD occurred before 18 years of age. Cardiac symptoms were present in 11 individuals (37%), and syncope was the most common (n = 6, 20%). Anomalous left coronary artery arising from the right sinus of Valsalva (ALCA) with interarterial course (n = 11) and anomalous right coronary artery arising from the left sinus of Valsalva (ARCA) with interarterial course (n = 11) were the most common found. ALCA arising from pulmonary artery was present in 7 cases, whereas in 1 case, the left coronary artery arose from the noncoronary cusp. Left ventricular fibrosis was reported in 11 cases (37%) and was mainly subendocardial. There was evidence of acute infarction in 2 cases. Death occurred during exercise or emotional stress in 15 (50%) cases. The AOCA variant where death occurred more frequently during physical activity was ALCA (8 of 11, 73%), followed by ALCA arising from pulmonary artery (4 of 7, 57%) and ARCA (2 of 11, 18%). Conclusions AOCA is a rare cause of SCD. ALCA and ARCA with interarterial course are the most common anatomical variants recognized at the postmortem of SCD victims. ALCA is more commonly associated with death during exercise. Cardiac arrhythmias causing sudden death seem most likely in the cases without overt myocardial damage.

Published
2019
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9. COVID-19 influences lung microbiota dynamics and favors the emergence of rare infectious diseases: A case report of Hafnia Alvei pneumonia.

Author

Cutuli, Salvatore Lucio, primary, De Maio, Flavio, additional, De Pascale, Gennaro, additional, Grieco, Domenico Luca, additional, Monzo, Francesca Romana, additional, Carelli, Simone, additional, Tanzarella, Eloisa Sofia, additional, Pintaudi, Gabriele, additional, Piervincenzi, Edoardo, additional, Cascarano, Laura, additional, Xhemalaj, Rikardo, additional, Sanguinetti, Maurizio, additional, Posteraro, Brunella, additional, Spanu, Teresa, additional, and Antonelli, Massimo, additional

Published
2021
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10. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Author

Pun, Brenda T, primary, Badenes, Rafael, additional, Heras La Calle, Gabriel, additional, Orun, Onur M, additional, Chen, Wencong, additional, Raman, Rameela, additional, Simpson, Beata-Gabriela K, additional, Wilson-Linville, Stephanie, additional, Hinojal Olmedillo, Borja, additional, Vallejo de la Cueva, Ana, additional, van der Jagt, Mathieu, additional, Navarro Casado, Rosalía, additional, Leal Sanz, Pilar, additional, Orhun, Günseli, additional, Ferrer Gómez, Carolina, additional, Núñez Vázquez, Karla, additional, Piñeiro Otero, Patricia, additional, Taccone, Fabio Silvio, additional, Gallego Curto, Elena, additional, Caricato, Anselmo, additional, Woien, Hilde, additional, Lacave, Guillaume, additional, O'Neal, Hollis R, additional, Peterson, Sarah J, additional, Brummel, Nathan E, additional, Girard, Timothy D, additional, Ely, E Wesley, additional, Pandharipande, Pratik P, additional, Creteur, Jacques, additional, Bogossian, Elisa Govea, additional, Peluso, Lorenzo, additional, González-Seguel, Felipe, additional, Hidalgo-Calibin, Viviane, additional, Carreño-Montenegro, Pablo, additional, Rojas, Verónica, additional, Tobar, Eduardo, additional, Ramírez-Palma, Antonio, additional, Herrera-Davis, Karen, additional, Ferré, Alexis, additional, Legriel, Stéphane, additional, Godet, Thomas, additional, Fraisse, Ugo, additional, Gonçalves, Bruno, additional, Mazeraud, Aurélien, additional, Tzimou, Myrto, additional, Rasulo, Frank, additional, Beretta, Silvia, additional, Marchesi, Mattia, additional, Robba, Chiara, additional, Battaglini, Denise, additional, Pelosi, Paolo, additional, Mazzeo, Anna Teresa, additional, Noto, Alberto, additional, Servillo, Giuseppe, additional, Marra, Annachiara, additional, Cutuli, Salvatore Lucio, additional, Pintaudi, Gabriele, additional, Stival, Eleonora, additional, Tanzarella, Eloisa Sofia, additional, Roman-Pognuz, Erik, additional, Concetta Massaro, Chiara Maria, additional, Elhadi, Muhammed, additional, Smit, Lisa, additional, Olasveengen, Theresa, additional, Pereira, Isabel Jesus, additional, Teixeira, Carla Margarida, additional, Santos, Alice, additional, Valente, Miguel, additional, Granja, Cristina, additional, Pereia, Rita, additional, Silva, João, additional, Furquet, Blanca, additional, García Simón, Mónica, additional, Godoy Torres, Daniel A, additional, Monleón, Berta, additional, Morcillo, Esteban, additional, Romero, Nekane, additional, Serrano, Ainhoa, additional, Torrico Sánchez, Sara, additional, Pérez Caballero, Francisco Luis, additional, Peña Luna, Isabel, additional, Baeza Gómez, Ignacio, additional, Calizaya Vargas, Milagros, additional, Morillas Pérez, Jordi, additional, Carrasco Gómez, Genís, additional, Molina Latorre, Ricard, additional, Moya Gutiérrez, Sheila, additional, Barón Barrera, Irene Patricia, additional, Delgado Palacios, Cristina, additional, García Góngora, Beatriz, additional, Labrador Romero, Laura, additional, Galarza, Laura, additional, Catalán-Monzón, Ignacio, additional, Rodriguez-Martínez, Enver, additional, Murcia Gubianas, Cristina, additional, Bellès, Ariadna, additional, Rodriguez Delgado, María Esther, additional, Caballero, Jesús, additional, Morales, Dulce, additional, Pujol, Andrés, additional, Rubio, Jorge, additional, Álvarez Torres, Eva, additional, Carvajal Revuelta, Estefanía, additional, de la Calle Gil, Isabel, additional, Fernández Tomás, Blanca, additional, Gallego Rodríguez, Berta, additional, González Serrano, Matilde, additional, LaTorre Andreu, Paloma, additional, Pérez Lucendo, Aris, additional, Abril Palomares, Elena, additional, González González, Elena, additional, Martín Delgado, María Cruz, additional, Muñoz De Cabo, Carlos, additional, Aznar, Pablo T., additional, Calvo, Carlos A., additional, Garutti, Ignacio, additional, Higuero, Fernando, additional, Martínez-Gascueña, David, additional, Maseda, Emilio, additional, Insausti, Itziar, additional, Montero Feijoo, Ana, additional, Suarez-de-la-Rica, Alejandro, additional, Del Moral Barbudo, Beatriz, additional, García Blanco-Traba, Yago, additional, Giménez Santamarina, Maria Claudia, additional, Gonzalo Millán, Alba, additional, Llorente Damas, Sergio, additional, Pestaña Lagunas, David, additional, Reyes García, Isabel, additional, Ruiz Perea, Alejandro, additional, Ortega Guerrero, Álvaro, additional, Mármol Cubillo, María Jesús, additional, Díaz Muñoz, David, additional, García de Castrillón i Ramal, Silvia, additional, Andorrà Sunyer, Xavier, additional, Noci Moreno, María de las Nieves, additional, Pérez Manrique, Rosa María, additional, del Campo Molina, Emilio, additional, Martínez Quintana, María Elena, additional, Fernandez-Gonzalo, Sol, additional, Gomà Fernández, Gemma, additional, Navarra-Ventura, Guillem, additional, Baró Serra, Anna, additional, Fuster, Cristina, additional, Plans Galván, Oriol, additional, Gil-Castillejos, Diana, additional, Dalorzo González, Mario, additional, Morán Gallego, Francisco Javier, additional, Paredes Borrachero, Irene, additional, Rodríguez Villamizar, Patricia, additional, Romeu Prieto, Juan, additional, Sánchez Carretero, María José, additional, Gallardo Sánchez, Susana, additional, Bustos Molina, Filadelfo, additional, García Pérez, María Luisa, additional, Castello-Mora, Paula, additional, Puig, Jaume, additional, Sanchis-Martin, María Rosa, additional, Sanchis-Veryser, Carmen Andrea, additional, Vicente-Fernández, María Pilar, additional, Zaragoza, Rafael, additional, Lizama, Laura, additional, Torres, Irene, additional, Álvarez, Cristina, additional, Ramírez, Paula, additional, Martin Cerezuela, Meri, additional, Montero, María Jesús, additional, García Cantos, Jose, additional, Valls, Paola, additional, Aretxabala Cortajarena, Nerea, additional, García Domelo, Pablo, additional, González Cubillo, Laura, additional, Martín Martínez, Marta, additional, Pérez Francisco, Inés, additional, Poveda Hernández, Yolanda, additional, Quintano Rodero, Amaia, additional, Rodriguez Nuñez, César, additional, Siegemund, Martin, additional, Estermann, Anna, additional, Zellweger, Núria, additional, Ben Saida, Imen, additional, Boussarsar, Mohamed, additional, Esen, Figen, additional, Ergin Özcan, Perihan, additional, Berkey, Christopher, additional, Harb, Christine, additional, Tandy, Morgan H., additional, Morgan, Ellis, additional, Shephard, Karen, additional, Hyzy, Robert C, additional, Kenes, Michael, additional, Nelson, Kristine, additional, Hosse, Robert E., additional, Vance, Katie M., additional, Austin, C. Adrian, additional, Lerner, Aaron, additional, Sanders, Emily, additional, Balk, Robert A, additional, Bennett, David A, additional, Vogel, Andrew R., additional, Chowdhury, Lucia, additional, Devulapally, Kiran, additional, Woodham, Michelle, additional, Cohen, Sarah, additional, Patel, Nihal, additional, Kuza, Catherine M., additional, Sing, Mandeep, additional, Roberson, Spencer, additional, Drumright, Kelly, additional, Sehgal, Sameep, additional, LaHue, Sara C., additional, Douglas, Vanja C., additional, and Sarwal, Aarti, additional

Published
2021
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11. COVID-19 and intestinal inflammation: Role of fecal calprotectin

Author

Ojetti, Veronica, primary, Saviano, Angela, additional, Covino, Marcello, additional, Acampora, Nicola, additional, Troiani, Eliana, additional, Franceschi, Francesco, additional, Abbate, Valeria, additional, Addolorato, Giovanni, additional, Agostini, Fabiana, additional, Ainora, Maria Elena, additional, Akacha, Karim, additional, Amato, Elena, additional, Andreani, Francesca, additional, Andriollo, Gloria, additional, Annetta, Maria Giuseppina, additional, Annicchiarico, Brigida Eleonora, additional, Antonelli, Mariangela, additional, Antonucci, Gabriele, additional, Anzellotti, Gian Marco, additional, Armuzzi, Alessandro, additional, Baldi, Fabiana, additional, Barattucci, Ilaria, additional, Barillaro, Christian, additional, Barone, Fabiana, additional, Bellantone, Rocco Domenico Alfonso, additional, Bellieni, Andrea, additional, Bello, Giuseppe, additional, Benicchi, Andrea, additional, Benvenuto, Francesca, additional, Berardini, Ludovica, additional, Berloco, Filippo, additional, Bernabei, Roberto, additional, Bianchi, Antonio, additional, Biasucci, Daniele Guerino, additional, Biasucci, Luigi Marzio, additional, Bibbò, Stefano, additional, Bini, Alessandra, additional, Bisanti, Alessandra, additional, Biscetti, Federico, additional, Bocci, Maria Grazia, additional, Bonadia, Nicola, additional, Bongiovanni, Filippo, additional, Borghetti, Alberto, additional, Bosco, Giulia, additional, Bosello, Silvia, additional, Bove, Vincenzo, additional, Bramato, Giulia, additional, Brandi, Vincenzo, additional, Bruni, Teresa, additional, Bruno, Carmine, additional, Bruno, Dario, additional, Bungaro, Maria Chiara, additional, Buonomo, Alessandro, additional, Burzo, Livia, additional, Calabrese, Angelo, additional, Calvello, Maria Rosaria, additional, Cambieri, Andrea, additional, Cambise, Chiara, additional, Cammà, Giulia, additional, Candelli, Marcello, additional, Canistro, Gennaro, additional, Cantanale, Antonello, additional, Capalbo, Gennaro, additional, Capaldi, Lorenzo, additional, Capone, Emanuele, additional, Capristo, Esmeralda, additional, Carbone, Luigi, additional, Cardone, Silvia, additional, Carelli, Simone, additional, Carfì, Angelo, additional, Carnicelli, Annamaria, additional, Caruso, Cristiano, additional, Casciaro, Francesco Antonio, additional, Catalano, Lucio, additional, Cauda, Roberto, additional, Cecchini, Andrea Leonardo, additional, Cerrito, Lucia, additional, Cesarano, Melania, additional, Chiarito, Annalisa, additional, Cianci, Rossella, additional, Cicchinelli, Sara, additional, Ciccullo, Arturo, additional, Cicetti, Marta, additional, Ciciarello, Francesca, additional, Cingolani, Antonella, additional, Cipriani, Maria Camilla, additional, Consalvo, Maria Ludovica, additional, Coppola, Gaetano, additional, Corbo, Giuseppe Maria, additional, Corsello, Andrea, additional, Costante, Federico, additional, Costanzi, Matteo, additional, Crupi, Davide, additional, Cutuli, Salvatore Lucio, additional, D'Addio, Stefano, additional, D'Alessandro, Alessia, additional, D'AlfonsoD'Angelo, Maria ElenaEmanuela, additional, D'Aversa, Francesca, additional, Damiano, Fernando, additional, De Berardinis, Gian Maria, additional, De Cunzo, Tommaso, additional, De Gaetano, Donati Katleen, additional, De Luca, Giulio, additional, De Matteis, Giuseppe, additional, De Pascale, Gennaro, additional, De Santis, Paolo, additional, De Siena, Martina, additional, De Vito, Francesco, additional, Del Gatto, Valeria, additional, Del Giacomo, Paola, additional, Del Zompo, Fabio, additional, Dell'Anna, Antonio Maria, additional, Polla, Davide Della, additional, Di Gialleonardo, Luca, additional, Di Giambenedetto, Simona, additional, Di Luca, Roberta, additional, Di Maurizio, Luca, additional, Di Muro, Mariangela, additional, Dusina, Alex, additional, Eleuteri, Davide, additional, Esperide, Alessandra, additional, Fachechi, Daniele, additional, Faliero, Domenico, additional, Falsiroli, Cinzia, additional, Fantoni, Massimo, additional, Fedele, Annalaura, additional, Feliciani, Daniela, additional, Ferrante, Cristina, additional, Ferrone, Giuliano, additional, Festa, Rossano, additional, Fiore, Maria Chiara, additional, Flex, Andrea, additional, Forte, Evelina, additional, Francesconi, Alessandra, additional, Franza, Laura, additional, Funaro, Barbara, additional, Fuorlo, Mariella, additional, Fusco, Domenico, additional, Gabrielli, Maurizio, additional, Gaetani, Eleonora, additional, Galletta, Claudia, additional, Gallo, Antonella, additional, Gambassi, Giovanni, additional, Garcovich, Matteo, additional, Gasbarrini, Antonio, additional, Gasparrini, Irene, additional, Gelli, Silvia, additional, Giampietro, Antonella, additional, Gigante, Laura, additional, Giuliano, Gabriele, additional, Giuliano, Giorgia, additional, Giupponi, Bianca, additional, Gremese, Elisa, additional, Grieco, Domenico Luca, additional, Guerrera, Manuel, additional, Guglielmi, Valeria, additional, Guidone, Caterina, additional, Gullì, Antonio, additional, Iaconelli, Amerigo, additional, Iafrati, Aurora, additional, Ianiro, Gianluca, additional, Iaquinta, Angela, additional, Impagnatiello, Michele, additional, Inchingolo, Riccardo, additional, Intini, Enrica, additional, Iorio, Raffaele, additional, Izzi, Immacolata Maria, additional, Jovanovic, Tamara, additional, Kadhim, Cristina, additional, La Macchia, Rosa, additional, La Milia, Daniele Ignazio, additional, Landi, Francesco, additional, Landi, Giovanni, additional, Landi, Rosario, additional, Landolfi, Raffaele, additional, Leo, Massimo, additional, Leone, Paolo Maria, additional, Levantesi, Laura, additional, Liguori, Antonio, additional, Liperoti, Rosa, additional, Lizzio, Marco Maria, additional, Monaco, Maria Rita Lo, additional, Locantore, Pietro, additional, Lombardi, Francesco, additional, Lombardi, Gianmarco, additional, Lopetuso, Loris, additional, Loria, Valentina, additional, Losito, Angela Raffaella, additional, Lucia, Mothanje Barbara Patricia, additional, Macagno, Francesco, additional, Macerola, Noemi, additional, Maggi, Giampaolo, additional, Maiuro, Giuseppe, additional, Mancarella, Francesco, additional, Mangiola, Francesca, additional, Manno, Alberto, additional, Marchesini, Debora, additional, Maresca, Gian Marco, additional, Marrone, Giuseppe, additional, Martis, Ilaria, additional, Martone, Anna Maria, additional, Marzetti, Emanuele, additional, Mattana, Chiara, additional, Matteo, Maria Valeria, additional, Maviglia, Riccardo, additional, Mazzarella, Ada, additional, Memoli, Carmen, additional, Miele, Luca, additional, Migneco, Alessio, additional, Mignini, Irene, additional, Milani, Alessandro, additional, Milardi, Domenico, additional, Montalto, Massimo, additional, Montemurro, Giuliano, additional, Monti, Flavia, additional, Montini, Luca, additional, Morena, Tony Christian, additional, Morra, Vincenzina, additional, Morretta, Chiara, additional, Moschese, Davide, additional, Murace, Celeste Ambra, additional, Murdolo, Martina, additional, Murri, Rita, additional, Napoli, Marco, additional, Nardella, Elisabetta, additional, Natalello, Gerlando, additional, Natalini, Daniele, additional, Navarra, Simone Maria, additional, Nesci, Antonio, additional, Nicoletti, Alberto, additional, Nicoletti, Rocco, additional, Nicoletti, Tommaso Filippo, additional, Nicolò, Rebecca, additional, Nicolotti, Nicola, additional, Nista, Enrico Celestino, additional, Nuzzo, Eugenia, additional, Oggiano, Marco, additional, Ojetti, Veronica, additional, Pagano, Francesco Cosimo, additional, Paiano, Gianfranco, additional, Pais, Cristina, additional, Pallavicini, Federico, additional, Palombo, Andrea, additional, Paolillo, Federico, additional, Papa, Alfredo, additional, Papanice, Domenico, additional, Papparella, Luigi Giovanni, additional, Paratore, Mattia, additional, Parrinello, Giuseppe, additional, Pasciuto, Giuliana, additional, Pasculli, Pierpaolo, additional, Pecorini, Giovanni, additional, Perniola, Simone, additional, Pero, Erika, additional, Petricca, Luca, additional, Petrucci, Martina, additional, Picarelli, Chiara, additional, Piccioni, Andrea, additional, Piccolo, Annalisa, additional, Piervincenzi, Edoardo, additional, Pignataro, Giulia, additional, Pignataro, Raffaele, additional, Pintaudi, Gabriele, additional, Pisapia, Luca, additional, Pizzoferrato, Marco, additional, Pizzolante, Fabrizio, additional, Pola, Roberto, additional, Policola, Caterina, additional, Pompili, Maurizio, additional, Pontecorvi, Flavia, additional, Pontecorvi, Valerio, additional, Ponziani, Francesca, additional, Popolla, Valentina, additional, Porceddu, Enrica, additional, Porfidia, Angelo, additional, Porro, Lucia Maria, additional, Potenza, Annalisa, additional, Pozzana, Francesca, additional, Privitera, Giuseppe, additional, Pugliese, Daniela, additional, Pulcini, Gabriele, additional, Racco, Simona, additional, Raffaelli, Francesca, additional, Ramunno, Vittoria, additional, Rapaccini, Gian Ludovico, additional, Richeldi, Luca, additional, Rinninella, Emanuele, additional, Rocchi, Sara, additional, Romanò, Bruno, additional, Romano, Stefano, additional, Rosa, Federico, additional, Rossi, Laura, additional, Rossi, Raimondo, additional, Rossini, Enrica, additional, Rota, Elisabetta, additional, Rovedi, Fabiana, additional, Rubino, Carlotta, additional, Rumi, Gabriele, additional, Russo, Andrea, additional, Sabia, Luca, additional, Salerno, Andrea, additional, Salini, Sara, additional, Salvatore, Lucia, additional, Samori, Dehara, additional, Sandroni, Claudio, additional, Sanguinetti, Maurizio, additional, Santarelli, Luca, additional, Santini, Paolo, additional, Santolamazza, Danilo, additional, Santoliquido, Angelo, additional, Santopaolo, Francesco, additional, Santoro, Michele Cosimo, additional, Sardeo, Francesco, additional, Sarnari, Caterina, additional, Saviano, Luisa, additional, Scaldaferri, Franco, additional, Scarascia, Roberta, additional, Schepis, Tommaso, additional, Schiavello, Francesca, additional, Scoppettuolo, Giancarlo, additional, Sedda, Davide, additional, Sessa, Flaminio, additional, Sestito, Luisa, additional, Settanni, Carlo, additional, Siciliano, Matteo, additional, Siciliano, Valentina, additional, Sicuranza, Rossella, additional, Simeoni, Benedetta, additional, Simonetti, Jacopo, additional, Smargiassi, Andrea, additional, Soave, Paolo Maurizio, additional, Sonnino, Chiara, additional, Staiti, Domenico, additional, Stella, Claudia, additional, Stella, Leonardo, additional, Stival, Eleonora, additional, Taddei, Eleonora, additional, Talerico, Rossella, additional, Tamburello, Elio, additional, Tamburrini, Enrica, additional, Tanzarella, Eloisa Sofia, additional, Tarascio, Elena, additional, Tarli, Claudia, additional, Tersali, Alessandra, additional, Tilli, Pietro, additional, Timpano, Jacopo, additional, Torelli, Enrico, additional, Torrini, Flavia, additional, Tosato, Matteo, additional, Tosoni, Alberto, additional, Tricoli, Luca, additional, Tritto, Marcello, additional, Tumbarello, Mario, additional, Tummolo, Anita Maria, additional, Vallecoccia, Maria Sole, additional, Valletta, Federico, additional, Varone, Francesco, additional, Vassalli, Francesco, additional, Ventura, Giulio, additional, Verardi, Lucrezia, additional, Vetrone, Lorenzo, additional, Vetrugno, Giuseppe, additional, Visconti, Elena, additional, Visconti, Felicia, additional, Viviani, Andrea, additional, Zaccaria, Raffaella, additional, Zaccone, Carmelina, additional, Zelano, Lorenzo, additional, Dal Verme, Lorenzo Zileri, additional, and Zuccalà, Giuseppe, additional

Published
2020
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12. A Lagrangian modelling approach to assess the representativeness area of an industrial air quality monitoring station

Author

Gabriele Zanini, Tiziano Pastore, Mario Adani, Giorgio Assennato, Giuseppe Cremona, Angela Morabito, Stefano Spagnolo, Luisella Ciancarella, Annalisa Tanzarella, Gaia Righini, Felicita Russo, Roberto Giua, Antonio Piersanti, Lina Vitali, and Gianni Tinarelli

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, Meteorology, Air pollution, Context (language use), 010501 environmental sciences, engineering.material, medicine.disease_cause, 01 natural sciences, Pollution, Representativeness heuristic, symbols.namesake, Industrial mineral, symbols, engineering, medicine, Aeolian processes, Environmental science, Waste Management and Disposal, Air quality index, Reliability (statistics), Lagrangian, 0105 earth and related environmental sciences
Abstract

The evaluation of the spatial representativeness of air quality monitoring stations is of fundamental relevance when observed concentration levels are used in air quality assessment. Since no reference method is provided, there is a need to develop tools for its quantitative assessment. In this paper we test a recently developed methodology for spatial representativeness area assessment, based on the analysis of time series of model concentrations by means of a Concentration Similarity Frequency (CSF) function, on the Taranto-via Machiavelli industrial monitoring station, located in a mid-size city in Southern Italy. The complex territorial context, the peculiar anthropogenic emissions features, dominated by the contribution of the largest steelworks in Europe, and the critical situation of human health in the city make this application an interesting case study to assess the portability of the CSF approach, so far applied only to background stations, to industrial sites that experience high concentration variability. A comprehensive characterization of the main anthropogenic emissions of the area was carried out, with detailed treatment of dust emission by wind erosion from industrial mineral piles; a Lagrangian modelling approach was chosen to simulate PM10 dispersion patterns, to achieve a reliable and high resolution description of concentration variability around the site. The resulting representativeness area of the station is 0.067 km2, fulfilling EU prescriptions for industrial stations. The comprehensive evaluation results, through the comparison with the observed data, showed good performances pointing out the reliability of the estimated concentration fields around the site and consequently of the assessment of its representativeness area.

Published
2016
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13. Effects of postharvest light spectra on quality and health-related parameters in green Asparagus officinalis L

Author

Linda Mastropasqua, Costantino Paciolla, and Paola Tanzarella

Subjects
0106 biological sciences, Chlorophyll a, Sucrose, Starch, Horticulture, Biology, 01 natural sciences, 040501 horticulture, chemistry.chemical_compound, Pigment, Botany, Asparagus, Sugar, Carotenoid, chemistry.chemical_classification, food and beverages, 04 agricultural and veterinary sciences, biology.organism_classification, chemistry, visual_art, visual_art.visual_art_medium, Postharvest, 0405 other agricultural sciences, Agronomy and Crop Science, 010606 plant biology & botany, Food Science
Abstract

The monitoring of quality parameters in horticultural crops under artificial light during postharvest storage is important for controlling the shelf-life of the crops. In this work, white light, red light, blue light and dark conditions were used at various durations to evaluate the effects of different spectral properties of light on parameters related to physiological and biochemical processes in green asparagus, and on compounds related to human health. For this aim, the level of glucose, fructose and sucrose, as well as that of vitamin C and the levels of lignin, chlorophyll a and b, carotenoids and anthocyanins, were determined in apical and basal segments of the edible portion of green asparagus spears before and after light treatments. A dark control was stored at 4 °C. The irradiance levels of the light treatments were 100, 117 and 116 μmol m−2 s−1, respectively for white, blue and red light. Before treatments, in the apical segments, the content of analysed components were higher than in the basal segments, except for soluble sugars and starch, of which the basal segment exhibited higher levels; these results exhibited different nutritional value of the two segments. After the light treatments, the analysed quality-related parameters were differently influenced in the apical and basal segments during postharvest storage. The increase in dry matter content in the apical segment after both white light and red light treatments was most likely attributable to the presence of physiological postharvest activity, rather than to increased transpiration. The results indicated that light with different spectral properties vs. dark-stored controls had small or no effects on the measured parameters. Both light and dark caused the starch levels to increase in both segments. A decrease in the sugar content in the basal part might be explained by translocation of hexoses from basal towards apical regions of the spear. White light primarily determined the lignin deposition in the apical part most likely due to the synergistic effect of red and blue light on lignin biosynthesis. The vitamin C, chlorophyll a and b and carotenoids decreased in light and dark treatments in both segments. Anthocyanins were induced by light in the basal part only, most so by blue light.

Published
2016
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14. A YAP camera for the biodistribution of 188Re conjugated with Hyaluronic-Acid in 'in vivo' systems

Author

ANTOCCIA, Antonio, G. BALDAZZI, A. BANZATO, M. BELLO, P. BOCCACCIO, D. BOLLINI, F. DE NOTARISTEFANI, U. MAZZI, L. M. ALAFORT, G. MOSCHINI, F. L. NAVARRIA, R. PANI, A. PERROTTA, A. ROSATO, C. TANZARELLA, N. M. UZUNOV, A. Antoccia, G. Baldazzi, A. Banzato, M. Bello, P. Boccaccio, D. Bollini, F. De Notaristefani, U. Mazzi, L.M. Alafort, G. Moschini, F.L. Navarria, R. Pani, A. Perrotta, A. Rosato, C. Tanzarella, N.M. Uzunov, Antoccia, Antonio, G., Baldazzi, A., Banzato, M., Bello, P., Boccaccio, D., Bollini, F., DE NOTARISTEFANI, U., Mazzi, L. M., Alafort, G., Moschini, F. L., Navarria, R., Pani, A., Perrotta, A., Rosato, C., Tanzarella, and N. M., Uzunov

Subjects
Physics, Nuclear and High Energy Physics, Biodistribution, Photon, Light spot, business.industry, Collimator, Iterative reconstruction, Conjugated system, NUCLEAR MEDICINE, Noise (electronics), RHENIUM-188, law.invention, YAP CAMERA, Optics, law, In vivo, &#915,-RAY IMAGERS, SMALL ANIMALS IMAGING, business, Instrumentation
Abstract

The aim of the SCINTIRAD experiment is to determine the radio-response of 188Rhenium (Re) in in vitro cells and the biodistribution in different organs of in vivo mice, and subsequently to assess the therapeutic effect on liver tumours induced in mice. Both the γ- and β- emissions of 188Re have been exploited in the experiment. The in vivo biodistribution in mice was studied also with a γ-camera using different parallel hole collimators. In the 188Re spectrum, while the 155 keV γ-peak is useful for imaging, the photons emitted at larger energies and the β-particles act as noise in the image reconstruction. The γ-cameras previously used to image biodistributions obtained with 99Tc are, therefore, not optimized for use with 188Re. A new setup of the γ-camera has been studied for 188Re: 66×66 YAP:Ce crystals (0.6×0.6×10 mm3, 5 μm optical insulation) guarantee a FOV of 40×40 mm2, a Hamamatsu R2486 PSPMT, 3 in. diameter, converts their light into an electrical signal and allows reconstructing the spatial coordinates of the light spot; incoming photon directions are selected through a lead collimator with 1.5 mm diameter hexagonal holes, 0.18 mm septa, 40 mm thickness. Using this setup, results have been obtained both with 99Tc filled and 188Re filled capillaries and wells. The energy spectrum of the collected photons and the spatial resolutions obtainable with the 188Re source will be presented.

Published
2007
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15. Industrial air pollution and mortality in the Taranto area, Southern Italy: A difference-in-differences approach

Author

Leogrande, Simona, primary, Alessandrini, Ester Rita, additional, Stafoggia, Massimo, additional, Morabito, Angela, additional, Nocioni, Alessandra, additional, Ancona, Carla, additional, Bisceglia, Lucia, additional, Mataloni, Francesca, additional, Giua, Roberto, additional, Mincuzzi, Antonia, additional, Minerba, Sante, additional, Spagnolo, Stefano, additional, Pastore, Tiziano, additional, Tanzarella, Annalisa, additional, Assennato, Giorgio, additional, and Forastiere, Francesco, additional

Published
2019
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17. Anomalous Coronary Artery Origin and Sudden Cardiac Death

Author

Finocchiaro, Gherardo, primary, Behr, Elijah R., additional, Tanzarella, Gaia, additional, Papadakis, Michael, additional, Malhotra, Aneil, additional, Dhutia, Harshil, additional, Miles, Chris, additional, Diemberger, Igor, additional, Sharma, Sanjay, additional, and Sheppard, Mary N., additional

Published
2019
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19. Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells

Author

Caterina Tanzarella, Antonella Sgura, D. Nieri, Francesco Berardinelli, Antonio Antoccia, Berardinelli, Francesco, Nieri, D, Sgura, Antonella, Tanzarella, C, and Antoccia, Antonio

Subjects
telomere, education.field_of_study, Telomerase, Health, Toxicology and Mutagenesis, Lymphoblast, Population, Telomere Homeostasis, Biology, telomerase, Radiation Tolerance, Molecular biology, Cell Line, Telomere, Ionizing radiation, radiosensitivity, Radioresistance, Genetics, Humans, Lymphocytes, Radiosensitivity, education, Clonogenic assay, Molecular Biology, Telomere Shortening
Abstract

Many and varied are the proposed mechanisms that lead to resistance to ionizing radiation treatment. Among them, an inverse relationship between telomere length and radioresistance has been recently advanced. Investigating such a relationship in TK6 lymphoblasts, we found that clones originating from cells survived to 4 Gy of X-rays showed a significantly higher telomere length when compared with clones grown from untreated cells. The lengthening observed was not attributable to a radiation-induced increase in telomerase activity, as demonstrated by TRAP assay performed in the dose range of 1–10 Gy. Given the evidence that TK6 whole population was characterized by heterogeneity in cellular mean telomere length and telomere loss, we tested the hypothesis that a process of selection may favour cells with longer telomeres (more radioresistant cells) following exposure to irradiation. In order to do this 15 independent TK6 clones were selected and characterized for telomere length and loss on the basis of q-FISH and flow-FISH analysis. Among the screened clones four characterized by long telomeres and four characterized by short telomeres were tested for their radiosensitivity by means of clonogenic assay. The results obtained showed that, in our experimental conditions (cellular model, radiation doses) no significant correlation was observed between radiosensitivity and mean telomere lengths, whereas a positive correlation was observed with respect to telomere loss. Overall, these results indicate that telomere loss and not mean telomere length plays a critical role in the phenomenon of radiosensitivity/radioresistance.

Published
2012
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20. A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling 'Nijmegen breakage syndrome' phenotype

Author

S. Banerjee, Caterina Tanzarella, A. Di Masi, Francesco Berardinelli, Patrick Revy, Marco Salvatore, Kyungjae Myung, J.P. de Villartay, A. Soresina, Domenica Taruscio, A. Antoccia, Alessandro Plebani, Berardinelli, F, DI MASI, Alessandra, Salvatore, M, Banerjee, S, Myung, K, DE VILLARTAY J., P, Revy, P, Plebani, A, Soresina, A, Taruscio, D, Tanzarella, C, Antoccia, A., DE VILLARTAY, Jp, and Antoccia, Antonio

Subjects
Male, Microcephaly, DNA Repair, Nijmegen breakage syndrome, Cell Cycle Proteins, Biology, Radiation Tolerance, Craniofacial Abnormalities, Chromosome instability syndrome, Chromosome instability, Genetics, medicine, Chromosomes, Human, Humans, Nijmegen Breakage Syndrome, Genetics (clinical), Genetic heterogeneity, Nuclear Proteins, food and beverages, General Medicine, Telomere, medicine.disease, Phenotype, Nibrin, radiosensitivity, Rad50, embryonic structures, Female
Abstract

Genetic heterogeneity in Nijmegen breakage syndrome (NBS) is highlighted by patients showing clinical and cellular features of NBS but with no mutations in NBS1 and normal levels of nibrin. NBS is an autosomal recessive disorder, whose clinical cellular signs include growth and developmental defects, dysmorphic facies, immunodeficiency, cancer predisposition, chromosomal instability and radiosensitivity. NBS is caused by mutations in the NBS1 gene, whose product is part of the MRE11/RAD50/NBS1 complex involved in the DNA double-strand break (DSB) response pathway. Since the identification of the NBS1 gene, patients with NBS clinical signs, particularly severe congenital microcephaly, are screened for mutations in the NBS1 gene. Further analyses include X-ray-induced chromosome aberrations, telomere analysis, kinetics of DSBs repair, levels of a panel of proteins involved in the maintenance of genetic stability, radiation-induced phosphorylation of various substrates and cell cycle analysis. We describe a patient with a NBS clinical phenotype, chromosomal sensitivity to X-rays but without mutations in the whole NBS1 or in the Cernunnos gene. Enhanced response to irradiation was mediated neither by DSBs rejoining defects nor by the NBS/AT-dependent DNA-damage response pathway. Notably, we found that primary fibroblasts from this patient displayed telomere length alterations. Cross-talk between pathways controlling response to DSBs and those involved in maintaining telomeres has been shown in the present patient. Dissecting the cellular phenotype of radiosensitive NBS-like patients represents a useful tool for the research of new genes involved in the cellular response to DSBs.

Published
2007
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21. Gene expression and apoptosis induction in p53-heterozygous irradiated mice

Author

Ruggiero Mango, Alberta Argentino-Storino, Alessandra Di Masi, Antonio Antoccia, Alberto Mosiello, Ivan Dimauro, Caterina Tanzarella, Giuseppe Novelli, DI MASI, Alessandra, Antoccia, Antonio, Dimauro, I, ARGENTINO STORINO, A, Mosiello, A, Mango, R, Novelli, G, and Tanzarella, C.

Subjects
Cyclin-Dependent Kinase Inhibitor p21, Male, Cell cycle checkpoint, DNA damage, Health, Toxicology and Mutagenesis, Messenger, Apoptosis, Spleen, DNA Fragmentation, Biology, Heterozygote Detection, Inbred C57BL, Mice, Transactivation, In vivo, Gene expression, Genetics, medicine, Animals, RNA, Messenger, Molecular Biology, bcl-2-Associated X Protein, Regulation of gene expression, Genetic Carrier Screening, X-Rays, Cell Cycle, Homozygote, Molecular biology, Mice, Inbred C57BL, medicine.anatomical_structure, Settore MED/03 - Genetica Medica, Gene Expression Regulation, RNA, Tumor Suppressor Protein p53
Abstract

The role of the p53-genetic background in the expression of genes involved in either cell cycle checkpoint activation or apoptosis was evaluated in p53+/+ and p53+/- mouse strains at both basal levels and after DNA-induced damage. The spleen, colon, kidneys, lungs and liver of both strains were harvested from untreated animals and from mice exposed to 7.5 Gy of X-rays and sacrificed after 5 h. No significant differences were observed in the basal levels of p53 protein, CDKN1A and bax mRNA and spontaneous apoptosis, neither among the different organs within the same strain, nor between the same organ in the p53+/+ and p53+/- strains. After X-ray exposure, p53-dependent regulation was strikingly tissue-specific. In wild-type irradiated mice, p53 protein level increased after radiation treatment in all the organs analysed, whereas both CDKN1A and bax genes transcription increased in the spleen, colon and lungs, as assessed by means of quantitative RT-PCR. In p53+/- irradiated mice, on the contrary, a significant p53 induction was detected only in the spleen, while CDKN1A and bax genes levels increased in the spleen, colon and lungs, revealing the existence of different mechanisms of gene regulation in different organs. Apoptosis induction was observed in the spleen and colon of both strains, even if to lower extent in p53+/- mice compared to p53+/+ animals. In conclusion, in the spleen and colon, target gene transcription and apoptosis may be related to p53 genotype after DNA damage-induction. Moreover, our findings highlight the selectivity of p53 in transactivation following DNA damage in vivo, resulting in tissue-specific responses.

Published
2006
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22. The “Subtle” connection between development of cardiac implantable electrical device infection and survival after complete system removal: An observational prospective multicenter study

Author

Diemberger, Igor, primary, Migliore, Federico, additional, Biffi, Mauro, additional, Cipriani, Alberto, additional, Bertaglia, Emanuele, additional, Lorenzetti, Stefano, additional, Massaro, Giulia, additional, Tanzarella, Gaia, additional, and Boriani, Giuseppe, additional

Published
2018
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23. Prevalence and predictors of suicidal behaviour in a sample of adults with estimated borderline intellectual functioning: Results from a population survey

Author

Paul Bebbington, Angela Hassiotis, Colin Cooper, and M. Tanzarella

Subjects
Adult, Male, Intelligence, Poison control, Suicide, Attempted, Suicide prevention, Sex Factors, Borderline intellectual functioning, Intellectual Disability, Injury prevention, Prevalence, Humans, Socioeconomic status, Intelligence Tests, Psychiatric Status Rating Scales, Intelligence quotient, Suicide attempt, Age Factors, Odds ratio, Middle Aged, Suicide, Psychiatry and Mental health, Clinical Psychology, Logistic Models, England, Case-Control Studies, Multivariate Analysis, Income, Female, Psychology, Clinical psychology
Abstract

Background We aimed to investigate, for the first time, rates of suicidal behaviour (ideation and acts) in people with borderline intellectual functioning in a general population sample, and to compare these to rates in people with normal functioning. Methods We used data from the third Adult Psychiatric Morbidity Survey, carried out in England in 2007. It was designed to be representative of people living in private households. The analyses are based on 6872 individuals. Results 1053 (16.1%) participants met criteria for borderline intellectual functioning. People with borderline intellectual functioning were more likely to report ever having made a suicidal attempt or to have harmed themselves without the intention of taking their own life (Odds Ratio for both 1.7, 95% Confidence Interval 1.3–2.2). These associations were no longer significant after controlling for income and age. Limitations Our sample did not include people living in segregate environments, who were likely to display challenging behaviours, and have higher rates of self harm. Conclusion The increased rates of suicidal behaviour found in people with borderline intellectual functioning were explained by younger age and socioeconomic disadvantages, although the association is likely to be complex. Our findings would strongly support targeting those at the lower range of intelligence with interventions for suicide prevention.

Published
2011
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24. Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment

Author

María José Ramírez, Francesca Degrassi, Caterina Tanzarella, Antonella Sgura, Ricardo Marcos, Antonio Antoccia, Sgura, Antonella, Antoccia, A, Ramirez, Mj, Marcos, R, Tanzarella, C, Degrassi, F., Sgura, A, and Antoccia, Antonio

Subjects
Male, Cytochalasin B, Mitomycin, Health, Toxicology and Mutagenesis, Binucleated cells, Centromere, Biology, complex mixtures, Clastogen, chemistry.chemical_compound, Nondisjunction, Genetic, Genetics, Humans, Lymphocytes, In Situ Hybridization, Fluorescence, Chromosome 7 (human), Micronucleus Tests, Chromosomes, Human, Pair 11, Mitomycin C, Aneuploidy, Molecular biology, Nondisjunction, chemistry, Vincristine, Micronucleus test, Micronucleus, Cell Division, Chromosomes, Human, Pair 7, Mutagens
Abstract

The influence of sampling time on the frequencies of micronuclei, centromere-positive micronuclei and chromosome nondisjunction was investigated in binucleated lymphocytes following treatment with a known clastogen (mitomycin C) or an aneuploidy-inducing agent (vincristine sulfate). Cytochalasin B (6 micrograms/ml) was added 44 h after mitogen stimulation and cultures were harvested 12, 28, 36 and 48 h thereafter. Micronucleated cells and micronuclei were significantly induced by the two treatments at all sampling times. Furthermore, in situ hybridization with an 'all centromeres' probe showed that vincristine-induced micronuclei were prevalently centromere-positive whereas in mitomycin C-treated cultures only a minor fraction of induced micronuclei contained the hybridization signals. Chromosome nondisjunction rates, as measured by in situ hybridization with chromosome 7- and 11-specific alphoid probes, significantly increased following vincristine treatment. Chromosome nondisjunction and total micronucleus frequencies were found to increase with time both in controls and in mutagen-treated cultures, whereas the percentage of centromere-positive micronuclei in the different treatments was not influenced by the sampling time. Our data suggest that even in the presence of 6 micrograms/ml cytochalasin B, the abnormal segregation of binucleated cells may contribute to the baseline level of micronuclei and influence the results obtained. The introduction of a short cytochalasin B treatment (between 12 and 28 h) in the cytokinesis-blocked micronucleus assay may avoid the cytochalasin B effect on micronucleus frequencies.

Published
1997
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25. The detection and evaluation of aneugenic chemicals

Author

James M Parry, E.M Parry, R Boumer, A Doherty, S Ellard, J O'Donovan, B Hoebee, J.M de Stoppelaar, G.R Mohn, A Önfelt, A Renglin, N Schultz, C Soderpalm-Bemdes, K.G Jensen, M Kirsch-Volders, A Elhajouji, P Van Hummelen, F Degrassi, A Antoccia, D Cimini, M Izzo, C Tanzarella, I.-D Adler, U Kliesch, G Schriever-Schwemmer, P Gasser, R Crebelli, A Carere, C Andreoli, R Benigni, P Leopardi, F Marcon, Z Zinjo, A.T Natarajan, J.J.W.A Boei, A Kappas, G Voutsinas, F.E Zarani, A Patrinelli, F Pachierotti, C Tiveron, P Hess, Parry, Jm, Parry, Em, Bourner, R, Doherty, A, Ellard, S, O'Donovan, J, Hoebee, B, de Stoppelaar, Jm, Mohn, Gr, Onfelt, A, Renglin, A, Schultz, N, Söderpalm Berndes, C, Jensen, Kg, Kirsch Volders, M, Elhajouji, A, Van Hummelen, P, Degrassi, F, Antoccia, Antonio, Cimini, D, Izzo, M, Tanzarella, C, Adler, Id, Kliesch, U, and Hess, P.

Subjects
Male, Health, Toxicology and Mutagenesis, Mitosis, Aneuploidy, Biology, Mice, Tubulin, Cricetinae, Centromere, Genetics, medicine, Animals, Humans, media_common.cataloged_instance, European union, Molecular Biology, media_common, Chromosome, medicine.disease, Rats, Cell Transformation, Neoplastic, DNA Topoisomerases, Type II, Biochemistry, Micronucleus test, Chromatid, Chromosome Deletion, Chromosome breakage, Mutagens
Abstract

Although aneuploidy makes a significant contribution to both somatic and inherited disease the mechanisms by which environmental chemicals may induce numerical chromosome aberrations are only poorly defined. The European Union Project was aimed to further our understanding of those chemical interactions with the components of the mitotic and meiotic cell division cycle which may lead to aneuploidy and to characterise the parameters such as cellular metabolism which may influence the activity of aneugenic chemicals. C-mitosis can be induced by the highly lipophilic polychlorinated biphenyl and the completion of mitosis and cleavage can be modified by agents which deplete cellular levels of reduced glutathione. Modifications of the fidelity of chromosome segregation were produced by inhibiting the functioning of topoisomerase II during chromatid separation. In contrast, the modification of centromere integrity resulted in chromosome breakage as opposed to disturbance of segregation. Modifiers of tubulin assembly and centriolar functioning in somatic cells such as acrylamide, vinblastine and diazepam reproduced their activity in rodent bone marrow and male germ cells. The analysis of chromosome malsegregation in Aspergillus nidulans by a structurally related series of halogenated hydrocarbons was used to develop a QSAR model which had high predictive value for the results of fungal tests for previously untested related chemicals. Metabolic studies of potential aneugens in genetically engineered human lymphoblastoid cells demonstrated the detoxification of the aneugenic activity of chloral hydrate and the activation of 2,3-dichlorobutane, 1,1,2-trichloroethane and trichloroethylene by Phase I biotransforming enzymes. Cell transformation studies in Syrian hamster dermal cultures using a panel of 22 reference and or potential aneugens indicated that 15 of the 22 produced positive results following single exposures. Five of the aneugens which were negative following single exposures produced positive results where cultures were continuously exposed for up to 6 weeks to low concentrations following a single non-transforming exposure to the mutagen dimethyl sulphate. The transformation studies indicate that a significant proportion of chemical aneugens are potential complete carcinogens and/or co-carcinogens. To optimise the enumeration of chromosomes following exposure to potential chemical aneugens whole chromosome paints and centromere specific probes suitable for use in fluorescence in situ hybridisation (FISH) were developed for the rat, mouse and Chinese hamster and selected human probes evaluated for their suitability for routine use. Molecular chromosome probes were used to develop protocols for enumerating chromosomes in metaphase cells and centromeres and micronuclei in interphase cells. The analysis of segregation of specific centromeres in binucleate cells following cytochalasin B treatment was shown to be a potentially valuable system for characterising non-disjunction following chemical exposure. Whole chromosome paints and centromere specific probes were used to demonstrate the presence of dose-response thresholds following treatment with a reference panel of spindle inhibiting chemicals. These data indicate that the FISH technology is suitable for evaluating the relative hazards of low-dose exposures to aneugenic chemicals.

Published
1996
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26. Identification and characterization of gene sequences expressed in wheat spikelets at the heading stage

Author

O. A. Tanzarella, Enrico Porceddu, Elisa d'Aloisio, Anna Rita Paolacci, and Mario Ciaffi

Subjects
Genetics, DNA, Complementary, Reverse Transcriptase Polymerase Chain Reaction, Floral organ morphogenesis, Molecular Sequence Data, Morphogenesis, food and beverages, General Medicine, Biology, Genes, Plant, Homology (biology), Real-time polymerase chain reaction, Complementary DNA, Gene expression, RNA, Messenger, Cloning, Molecular, Gene, Transcription factor, Triticum
Abstract

Through differential analysis of transcripts (SDDM), 85 cDNA sequences specifically or preferentially expressed in wheat spikelets at heading time were identified and cloned; 54 of them had significant homology with genomic, cDNA and protein and 16 with EST sequences. Among these 54 clones, 44 matched genes with known functions, whereas 10 detected homology with putative genes encoding proteins whose functions have been deduced on the basis of bioinformatic comparisons. Seventeen clones corresponded to genes that had never been cloned in cereals, 5 were related to wheat genes with known functions, and the remaining 32 to genes cloned in other cereals. On the basis of their presumed functions, the 54 clones were assigned to seven groups. The first four of them contained 40 sequences likely involved in floral organ morphogenesis and gametogenesis, and precisely (i) sequences involved in the morphogenesis of floral organs; (ii) sequences expressed in pollen and/or anther tissues; (iii) sequences encoding transcription factors; (iv) sequences involved in signal perception and transduction (kinases and LRR proteins). The expression patterns of these 40 sequences have been studied by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of transcripts from different tissues and spike organs of wheat.

Published
2005
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27. A Lagrangian modelling approach to assess the representativeness area of an industrial air quality monitoring station

Author

Vitali, Lina, primary, Morabito, Angela, additional, Adani, Mario, additional, Assennato, Giorgio, additional, Ciancarella, Luisella, additional, Cremona, Giuseppe, additional, Giua, Roberto, additional, Pastore, Tiziano, additional, Piersanti, Antonio, additional, Righini, Gaia, additional, Russo, Felicita, additional, Spagnolo, Stefano, additional, Tanzarella, Annalisa, additional, Tinarelli, Gianni, additional, and Zanini, Gabriele, additional

Published
2016
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32. Genotoxic activity of nitrilotriacetic acid in Chinese hamster cells

Author

Francesca Degrassi, Daniela Modesti, and Caterina Tanzarella

Subjects
Nitrilotriacetic Acid, Hamster, Biology, Toxicology, Microtubules, Chinese hamster, chemistry.chemical_compound, Cricetulus, Cricetinae, Genetics, Animals, Cytotoxic T cell, Cells, Cultured, Carcinogen, Chelating Agents, Chromosome Aberrations, Micronucleus Tests, Dose-Response Relationship, Drug, Nitrilotriacetic acid, biology.organism_classification, Molecular biology, chemistry, Cell culture, Micronucleus test, Immunostaining, Mutagens
Abstract

Nitrilotriacetic acid (NTA), a chelating agent, was tested for its ability to induce chromosomal damage in Chinese hamster cells. The chemical was shown to exert a weak genotoxic activity increasing the frequency of micronuclei after prolonged treatments. The analysis of kinetochore containing-micronuclei showed that NTA prevailingly induces chromosomal aberrations as compared to chromosome loss in hamster cells. Furthermore, immunostaining with an α-tubulin antibody showed clear alterations in the interphase microtubule network of cells treated for 24 h with 3 mM NTA. The microtubule effects of the chemical may be partly responsible for its cytotoxic effects.

Published
1995
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35. Molecular analysis of gliadin and glutenin genes in T. durum cv. Lira. A model system to analyse the molecular bases of quality differences in durum wheat cultivars

Author

O. A. Tanzarella, Enrico Porceddu, and Renato D'Ovidio

Subjects
Genetics, biology, food and beverages, Model system, Biochemistry, Molecular analysis, Glutenin, biology.protein, Genetic variability, Cultivar, Gliadin, Gene, Food Science, Southern blot
Abstract

As a model system to study the molecular bases of differences between high- and lowquality durum wheat cultivars, designated as biotypes γ-45 and γ-42, respectively, the cultivar Lira, which contains both biotypes, was examined. Polymerase chain reaction analysis of biotypes 42 and 45 was carried out by using oligonucleotide primers from flanking nucleotide sequences coding for α-, β- and γ-gliadin and for high molecular weight (HMW) and low molecular weight (LMW) glutenins. A different amplified band for γ-gliadin sequences was observed between the two biotypes. Southern blot analysis of the same biotypes showed different hybridization patterns for both γ-gliadin and LMW glutenin genes. The hybridization patterns of LMW glutenin sequences revealed the presence of additional bands in biotype 45, suggesting that the quantitative differences in LMW glutenins between biotypes 42 and 45, considered responsible for their quality differences, are most probably due to a higher number of LMW genes in biotype 45. This conclusion seems also to be supported by the results obtained in other durum wheat cultivars belonging to types 42 and 45.

Published
1992
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36. Cloning and sequencing of a PCR amplified gamma-gliadin gene from durum wheat (Triticum turgidum (L.) Thell. conv. durum (Desf.) MK.)

Author

O. A. Tanzarella, Enrico Porceddu, and Renato D'Ovidio

Subjects
Genetics, chemistry.chemical_classification, Cloning, Nucleic acid sequence, food and beverages, Plant Science, General Medicine, Biology, Molecular cloning, Homology (biology), chemistry, Genotype, biology.protein, Storage protein, Gliadin, Agronomy and Crop Science, Gene
Abstract

Specific amplification by PCR of gamma-gliadin genes from Triticum turgidum conv. durum cv. Langdon was obtained using high temperature for DNA-primers annealing. Three amplified bands were obtained and one of these was cloned and sequenced. Comparison of this nucleotide sequence with those of published gamma-gliadin and gamma-hordein genes revealed a high sequence homology. In particular, the comparison with pW1020 clone isolated from T. aestivum showed that the sequences derived from two genotypes differed by obly two nucleotides. The advantages offered by this approach for rapid gene isolation from different genotypes and its importance in molecular genetic analysis of wheat storage proteins are discussed.

Published
1991
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37. Interaction between X-ray- and restriction endonuclease-induced lesions in the formation of chromosomal aberrations

Author

Francesca Degrassi, Caterina Tanzarella, Mario Fiore, F. Palliti, and R. De Salvia

Subjects
Chromosome Aberrations, Genetics, Deoxyribonuclease BamHI, DNA Restriction Enzymes, General Medicine, Biology, Molecular biology, Chromosomes, Restriction enzyme, Cricetinae, Animals, BamHI, Deoxyribonucleases, Type II Site-Specific, Cells, Cultured, Mutagens
Abstract

Experiments were performed to analyze the possible interaction between lesions induced by X-rays and restriction endonucleases in the production of chromosome-type exchanges. A stronger interaction was found between X-rays and the AluI-induced ‘blunt termini’ lesions than between X-rays and the BamHI- induced ‘cohesive termini’ lesions

Published
1990
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38. Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

Author

Ferretta, Anna, primary, Gaballo, Antonio, additional, Tanzarella, Paola, additional, Piccoli, Claudia, additional, Capitanio, Nazzareno, additional, Nico, Beatrice, additional, Annese, Tiziana, additional, Di Paola, Marco, additional, Dell'Aquila, Claudia, additional, De Mari, Michele, additional, Ferranini, Ermanno, additional, Bonifati, Vincenzo, additional, Pacelli, Consiglia, additional, and Cocco, Tiziana, additional

Published
2014
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39. 318 MEASUREMENTS OF BIOLOGICAL EFFECTIVENESS OF CARBON-IONS IN HUMAN AND RODENT CELLS FOR VALIDATION AND DEVELOPMENT OF RADIOBIOLOGICAL MODELS FOR TPS

Author

Caterina Tanzarella, Francesco Romano, S. La Rosa, Antonio Antoccia, P. Cirrone, Francesco Berardinelli, Roberto Cherubini, Antonella Sgura, V. De Nadal, S. Gerardi, and D. Nieri

Subjects
medicine.medical_specialty, Oncology, chemistry, Radiochemistry, medicine, chemistry.chemical_element, Radiology, Nuclear Medicine and imaging, Medical physics, Hematology, Carbon
Published
2012
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40. NAC Reduces Apoptosis and Telomeres Shortening Subsequent to HIV-1 Exposure in an Astrocytoma Cell Line

Author

Caterina Tanzarella, Paola Rodinò, Antonella Sgura, Alberto Biasin, Carolina Muscoli, Stefano Aquaro, Claudio Del Duca, Michela Pollicita, Carlo Federico Perno, Vincenzo Mollace, Pollicita, M, Muscoli, C, Sgura, Antonella, Biasin, A, Mollace, V, Tanzarella, C, DEL DUCA, C, Rodino, P, Perno, Cf, and Aquaro, S.

Subjects
Pharmacology, Genetics, business.industry, Human immunodeficiency virus (HIV), Astrocytoma, medicine.disease, medicine.disease_cause, Telomere, Cell culture, Apoptosis, Virology, medicine, Cancer research, business
Published
2008
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41. In utero exposure to DEHP affects liver morphology, metabolism and glycogen storage in post-natal CD-1 mice

Author

Rita Devito, Giuseppe Macino, Marco Salvatore, Antonio Antoccia, Antonio Di Virgilio, Mara Viganotti, Sara Nicolai, Antonella Romeo, Alessandra di Masi, Francesca Maranghi, Fabrizio Tosto, Caterina Tanzarella, Daniele Marcoccia, Roberta Tassinari, Gianluca Azzalin, Agostino Eusepi, Antonella D’Ambrosio, Domenica Taruscio, Gabriele Moracci, Stefano Lorenzetti, Alberto Mantovani, and Armando Magrelli

Subjects
Liver morphology, medicine.medical_specialty, chemistry.chemical_compound, Endocrinology, Glycogen, chemistry, In utero, Internal medicine, medicine, Metabolism, Biology, Toxicology
Published
2009
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46. In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice

Author

Maranghi, Francesca, primary, Lorenzetti, Stefano, additional, Tassinari, Roberta, additional, Moracci, Gabriele, additional, Tassinari, Valentina, additional, Marcoccia, Daniele, additional, Di Virgilio, Antonio, additional, Eusepi, Agostino, additional, Romeo, Antonella, additional, Magrelli, Armando, additional, Salvatore, Marco, additional, Tosto, Fabrizio, additional, Viganotti, Mara, additional, Antoccia, Antonio, additional, Di Masi, Alessandra, additional, Azzalin, Gianluca, additional, Tanzarella, Caterina, additional, Macino, Giuseppe, additional, Taruscio, Domenica, additional, and Mantovani, Alberto, additional

Published
2010
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47. In utero exposure to DEHP affects liver morphology, metabolism and glycogen storage in post-natal CD-1 mice

Author

Maranghi, Francesca, primary, Lorenzetti, Stefano, additional, D’Ambrosio, Antonella, additional, Marcoccia, Daniele, additional, Moracci, Gabriele, additional, Tassinari, Roberta, additional, Salvatore, Marco, additional, Viganotti, Mara, additional, Tosto, Fabrizio, additional, Di Masi, Alessandra, additional, Antoccia, Antonio, additional, Nicolai, Sara, additional, Magrelli, Armando, additional, Azzalin, Gianluca, additional, Devito, Rita, additional, Eusepi, Agostino, additional, Di Virgilio, Antonio, additional, Romeo, Antonella, additional, Taruscio, Domenica, additional, Macino, Giuseppe, additional, Tanzarella, Caterina, additional, and Mantovani, Alberto, additional

Published
2009
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48. Altered microRNA Expression Patterns in Hepatoblastoma Patients

Author

Magrelli, Armando, primary, Azzalin, Gianluca, additional, Salvatore, Marco, additional, Viganotti, Mara, additional, Tosto, Fabrizio, additional, Colombo, Teresa, additional, Devito, Rita, additional, Di Masi, Alessandra, additional, Antoccia, Antonio, additional, Lorenzetti, Stefano, additional, Maranghi, Francesca, additional, Mantovani, Alberto, additional, Tanzarella, Caterina, additional, Macino, Giuseppe, additional, and Taruscio, Domenica, additional

Published
2009
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