1. A New Methodology for Model Free Optimization of L-Lysine Biosynthesis
- Author
-
Brian C. Center and Takoi K. Hamrita
- Subjects
Engineering ,Optimization problem ,Economic viability ,Process (engineering) ,business.industry ,Management science ,Biochemical engineering ,Model free ,Raw material ,business ,Lysine biosynthesis ,Flux (metabolism) - Abstract
Economic viability of lysine, a process intensive in its use of raw materials, is dependent upon how efficiently these materials are used. This paper discusses the lysine optimization problem in fed-batch culture through optimization of initial media composition and control of nutrient feed rate. Previous strategies for solving these problems are discussed and their limitations are identified. An analytical approach based on metabolic flux balancing is suggested for optimizing intial media composition. Additionally, a new methodology for controlling the feed rate is proposed.
- Published
- 1997