1. Infection with GB virus C in the patients with primary hepatocellular carcinoma in Japan
- Author
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Takeshi Tanaka, Shunichi Saeki, Takao Shibayama, Hiroaki Okamoto, Seishuu Hayashi, Satoshi Tanaka, Hiroo Ohtake, and Naoto Sawada
- Subjects
Hepatitis B virus ,Hepatology ,biology ,viruses ,Hepatitis C virus ,RNA ,Hepatitis B ,medicine.disease ,medicine.disease_cause ,biology.organism_classification ,GB virus C ,Virology ,Virus ,law.invention ,Infectious Diseases ,law ,Hepatocellular carcinoma ,medicine ,Polymerase chain reaction - Abstract
RNA of recently reported, putative non-A to E hepatitis virus designated GB virus C (GBV-C) was determined by reverse-transcription polymerase chain reaction in sera from 231 Japanese patients with primary hepatocellular carcinoma. GBV-C RNA was detected in 21 patients (9% of the total), including two of the 23 patients (8%) with markers of hepatitis B virus infection, 11 of the 114 patients (10%) with markers of hepatitis C virus infection, seven of the 86 patients (8%) with markers of both hepatitis B and C virus infections, and one of the eight patients (13%) without such markers. These results indicate that the contribution of GBV-C infection to the development of hepatocellular carcinoma would be small either by itself or in cooperation with hepatitis B and C viruses.
- Published
- 1997
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