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Start Over Descriptor "TTC5" Publisher elsevier bv
1 results on '"TTC5"'

1. TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression

Author

Sunqiang Chen, Jun Wang, Yong Xiao, Tangyao Peng, Xiang Zhou, Leitao Yu, and Xingen Zhu

Subjects
p53, 0301 basic medicine, Epithelial-Mesenchymal Transition, TRIP13, Cell Survival, Apoptosis, Cell Cycle Proteins, RM1-950, Thyroid cancer, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Western blot, Cell Movement, Cell Line, Tumor, medicine, Humans, Thyroid Neoplasms, Epithelial–mesenchymal transition, Neoplasm Metastasis, Cell Proliferation, Pharmacology, TTC5, Thyroid hormone receptor, medicine.diagnostic_test, Chemistry, General Medicine, Cadherins, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, ATPases Associated with Diverse Cellular Activities, Immunohistochemistry, Therapeutics. Pharmacology, Tumor Suppressor Protein p53, Tumor metastasis, Transcription Factors
Abstract

This study aimed to investigate the effect of interfering thyroid hormone receptor interacting protein 13 (TRIP13) expression on the proliferation, apoptosis and metastasis of thyroid cancer (TC) cells and the involved mechanisms. RT-PCR, immunohistochemical analysis and western blot found that compared with normal tissues, the expressions of TRIP13 and N-cadherin in TC tissues were significantly increased, while the expressions of tetratricopeptide repeat protein 5 (TTC5), p-p53 and E-cadherin were significantly decreased (P

Published
2019

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