1. Efficient parallel synthesis of macrocyclic peptidomimetics
- Author
-
Nadia Fortin, Carl Saint-Louis, Annick Landry, René Gagnon, Gilles Olsen, Sylvain Bernard, Patrick Bherer, Eric Marsault, Véronique Plourde, Gilles Berthiaume, Martin Brassard, Robert Deziel, Axel Mathieu, Gérald Villeneuve, Xiaowen Peng, Hamid R. Hoveyda, Mark Peterson, Graeme L. Fraser, François Bilodeau, Ruoxi Lan, Shridhar Bhat, Annie Doucet, Maude Gauthier, Yves L. Dory, David Lonergan, Shigui Li, Sylvie Beaubien, Luc Ouellet, Pierre Deslongchamps, Alexandre Drouin, Fabrice Galaud, Sophie Beauchemin, Manon Champagne, Kamel Benakli, Mahesh Ramaseshan, Laurence Foucher, Jean François Pinault, Martin Vezina, Daniel Fortin, and Zhigang Wang
- Subjects
Models, Molecular ,Silver ,Stereochemistry ,Peptidomimetic ,Chemistry, Pharmaceutical ,Clinical Biochemistry ,Molecular Conformation ,Pharmaceutical Science ,Peptides, Cyclic ,Biochemistry ,Chemical synthesis ,Structure-Activity Relationship ,Solid-phase synthesis ,Drug Discovery ,Combinatorial Chemistry Techniques ,Molecular Biology ,chemistry.chemical_classification ,Molecular Structure ,Bicyclic molecule ,Molecular Mimicry ,Organic Chemistry ,Stereoisomerism ,Dipeptides ,respiratory system ,Combinatorial chemistry ,Cyclic peptide ,Models, Chemical ,chemistry ,Molecular Medicine ,Peptides ,Dimerization ,human activities - Abstract
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
- Published
- 2008