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Your search keyword '"Svyatoslav Polovkovych"' showing total 3 results
Start Over Author "Svyatoslav Polovkovych" Publisher elsevier bv
3 results on '"Svyatoslav Polovkovych"'

1. Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone)

Author

Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczenko, Yuliia Kozak, Nataliya Finiuk, Olga Klyuchivska, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Danylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika, and Roman Lesyk

Subjects
Pharmacology, Organic Chemistry, Drug Discovery, General Medicine
Published
2023
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3. Application of the 2(5 H )furanone motif in the synthesis of new thiopyrano[2,3- d ]thiazoles via the hetero-Diels–Alder reaction and related tandem processes

Author

Andriy Karkhut, Roman Lesyk, Borys Zimenkovsky, Andrzej Gzella, Svyatoslav Polovkovych, and Andrii Lozynskyi

Subjects
Acylation, NMR spectra database, chemistry.chemical_compound, Tandem, Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Thiazole, Biochemistry, Cycloaddition, Diels–Alder reaction
Abstract

Novel thiopyrano[2,3-d]thiazole derivatives were synthesized from 5-arylidene-4-thioxo-2-thiazolidinones and 2(5H)furanone in 62–79% yields via hetero-Diels–Alder reactions and related acylation-based tandem processes. The reaction of 5-(4-fluorophenyl)-4-thioxo-2-thiazolidinone with 2(5H)furanone was studied by DFT at the M06-2X/6-31+G(d,p) level. The stereo- and regioselectivities of cycloaddition were confirmed by NMR spectra and single-crystal X-ray diffraction analyses.

Published
2016
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