1. Recent trends in biodegradable polyester nanomaterials for cancer therapy
- Author
-
Sunny Dholpuria, Abhilasha Singh Mathuriya, Sreenath Pappuru, Kavitha Govarthanan, Piyush Kumar Gupta, Dillip Kumar Bishi, Rekha Gahtori, Soumya Pandit, and Vineeta Sharma
- Subjects
Materials science ,Polyesters ,Nanoparticle ,Antineoplastic Agents ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Polyhydroxyalkanoates ,Nanomaterials ,Excipients ,Biomaterials ,chemistry.chemical_compound ,Drug Delivery Systems ,Neoplasms ,021001 nanoscience & nanotechnology ,Combinatorial chemistry ,0104 chemical sciences ,Lactic acid ,Polyester ,PLGA ,chemistry ,Mechanics of Materials ,Propylene carbonate ,Drug delivery ,Nanoparticles ,0210 nano-technology - Abstract
Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.
- Published
- 2021