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Your search keyword '"Sujan Dilly Penchala"' showing total 4 results
Start Over Author "Sujan Dilly Penchala" Publisher elsevier bv
4 results on '"Sujan Dilly Penchala"'

1. On-Demand HIV Pre-Exposure Prophylaxis Dose Finding Study for Insertive Sex in Young Men in Sub-Saharan Africa: Comparison of Emtricitabine-Tenofovir Disoproxil Fumarate and Emtricitabine-Tenofovir Alafenamide in an Open-Label Randomised Controlled Trial

Author

Carolina Herrera, Jennifer Serwanga, Laura Else, Limakatso Lebina, Daniel Opoka, Andrew S. Ssemata, Azure-Dee Pillay, Patricia Namubiru, Thabiso B. Seiphetlo, Geoffrey Odoch, Susan Mugaba, Portia Seatlholo, Amara Alieu, Sujan Dilly Penchala, Richard Muhumuza, Berenice Alinde, Stefan Petkov, Kyle O’Hagan, Christian Callebaut, Janet Seeley, Helen A. Weiss, Saye Khoo, Francesca Chiodi, Clive M. Gray, Pontiano Kaleebu, Emily Webb, Neil A. Martinson, and Julie Fox

Published
2023
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4. Validation of an electrospray ionisation LC–MS/MS method for quantitative analysis of telaprevir and its R-diastereomer

Author

Sujan Dilly Penchala, Saye Khoo, Omar El Sherif, John Tjia, Laura Else, and David Back

Subjects
Spectrometry, Mass, Electrospray Ionization, Analyte, Electrospray, Clinical Biochemistry, Analytical chemistry, Hepacivirus, Tandem mass spectrometry, Antiviral Agents, Biochemistry, Analytical Chemistry, Telaprevir, Limit of Detection, Tandem Mass Spectrometry, medicine, Humans, Protease Inhibitors, Chromatography, Chemistry, Extraction (chemistry), Diastereomer, Stereoisomerism, Cell Biology, General Medicine, Hepatitis C, Standard curve, Oligopeptides, Quantitative analysis (chemistry), Chromatography, Liquid, medicine.drug
Abstract

A sensitive high-performance reverse phase liquid chromatography-positive ion electrospray tandem mass spectrometry method was developed and validated for the quantification of telaprevir and its inactive R-diastereomer (VRT-127394) in human plasma. The analytes and the internal standard (telaprevir-d11) were extracted from plasma by liquid-liquid extraction using tert-Butyl methyl ether (TBME). Chromatographic separation was achieved on a reversed-phase Accucore C18 column with a gradient programme consisting of water:ammonia (25%), 100:0.01 (v/v) (mobile phase A) and ACN:MeOH:ammonia (25%), 15:85:0.01 (v/v/v) (mobile phase B). The MS acquisition was performed with selective reaction monitoring mode using the respective [M+H](+) ions, m/z 680.59→322.42 for telaprevir and VRT-127394, and 691.15→110.13 for telaprevir-d11. The assay exhibited a linear dynamic range of 5-5000ng/mL for telaprevir and VRT-127394. Acceptable precision (%RSD

Published
2013
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