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Your search keyword '"Su, Yu‐Wen"' showing total 21 results
Start Over Author "Su, Yu‐Wen" Publisher elsevier bv
21 results on '"Su, Yu‐Wen"'

1. Immunogenicity and safety of a SARS-CoV-2 mRNA vaccine (SYS6006) in healthy Chinese participants: A randomized, observer-blinded, placebo-controlled phase 2 clinical trial

Author

Jin, Fei, primary, Qiu, Yuanzheng, additional, Wu, Zhiwei, additional, Wang, Yuan-Hui, additional, Cai, Chengye, additional, Fu, Liangcai, additional, Jiao, Wenbin, additional, Wang, Huixian, additional, Gao, Ming, additional, Su, Chang, additional, Ma, Jun-Heng, additional, Xu, Yan, additional, Huang, Chao-Chao, additional, Zhang, Qing, additional, Ni, Shaonan, additional, Zhao, Maosheng, additional, Guo, Lixian, additional, Ji, Li, additional, Yang, Hanyu, additional, Zhao, Yuliang, additional, Li, Chunlei, additional, Lu, Xiang, additional, Su, Yu-Wen, additional, and Li, Qi, additional

Published
2024
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5. Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice

Author

Chang, Cherng-Shyang, primary, Liao, Yi-Chu, additional, Huang, Chih-Ting, additional, Lin, Chiao-Mei, additional, Cheung, Chantal Hoi Yin, additional, Ruan, Jhen-Wei, additional, Yu, Wen-Hsuan, additional, Tsai, Yi-Ting, additional, Lin, I-Jung, additional, Huang, Chien-Hsun, additional, Liou, Jong-Shian, additional, Chou, Ya-Hsien, additional, Chien, Hung-Jen, additional, Chuang, Hsiao-Li, additional, Juan, Hsueh-Fen, additional, Huang, Hsuan-Cheng, additional, Chan, Hong-Lin, additional, Liao, Yu-Chieh, additional, Tang, Shiue-Cheng, additional, Su, Yu-Wen, additional, Tan, Tse-Hua, additional, Bäumler, Andreas J., additional, and Kao, Cheng-Yuan, additional

Published
2021
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8. Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats

Author

Su, Yu-Wen, primary, Chim, Shek Man, additional, Zhou, Lin, additional, Hassanshahi, Mohammadhossein, additional, Chung, Rosa, additional, Fan, Chiaming, additional, Song, Yunmei, additional, Foster, Bruce K., additional, Prestidge, Clive A., additional, Peymanfar, Yaser, additional, Tang, Qian, additional, Butler, Lisa M., additional, Gronthos, Stan, additional, Chen, Di, additional, Xie, Yangli, additional, Chen, Lin, additional, Zhou, Xin-Fu, additional, Xu, Jiake, additional, and Xian, Cory J., additional

Published
2018
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19. Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

Author

Hao, Zhenyue, primary, Duncan, Gordon S., additional, Seagal, Jane, additional, Su, Yu-Wen, additional, Hong, Claire, additional, Haight, Jillian, additional, Chen, Nien-Jung, additional, Elia, Andrew, additional, Wakeham, Andrew, additional, Li, Wanda Y., additional, Liepa, Jennifer, additional, Wood, Geoffrey A., additional, Casola, Stefano, additional, Rajewsky, Klaus, additional, and Mak, Tak W., additional

Published
2008
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21. Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats

Author

Di Chen, Yuwen Su, Xin-Fu Zhou, Lin Chen, Yangli Xie, Clive A. Prestidge, Rosa Chung, Jiake Xu, Lisa M. Butler, Shek Man Chim, Lin Zhou, Stan Gronthos, Cory J. Xian, Yaser Peymanfar, Mohammadhossein Hassanshahi, Chiaming Fan, Bruce K. Foster, Yunmei Song, Qian Tang, Su, Yu Wen, Chim, Shek Man, Zhou, Lin, Hassanshahi, Mohammadhossein, Chung, Rosa, Fan, Chiaming, Song, Yunmei, Foster, Bruce K., Prestidge, Clive A., Peymanfar, Yaser, Tang, Qian, Butler, Lisa M., Gronthos, Stan, Chen, Di, Xie, Yangli, Chen, Lin, Zhou, Xin Fu, Xu, Jiake, and Xian, Cory J.

Subjects
Cartilage, Articular, Male, musculoskeletal diseases, 0301 basic medicine, Proteases, Histology, Stromal cell, neurotrophic factors, growth plate injury, Physiology, Endocrinology, Diabetes and Metabolism, Osteoclasts, signal crosstalk, Article, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Neurotrophin 3, Osteogenesis, Osteoclast, medicine, Animals, Humans, Receptor, trkC, Growth Plate, RNA, Messenger, Bony Callus, Cathepsin, Bone growth, Osteoblasts, NFATC Transcription Factors, biology, Chemistry, Cartilage, RANK Ligand, NF-kappa B, Osteoblast, injury site remodelling, Cell biology, Enzyme Activation, RAW 264.7 Cells, 030104 developmental biology, medicine.anatomical_structure, RANKL, biology.protein, Cytokines, Peptide Hydrolases
Abstract

Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin‑3 (NT-3) and its important roles as an osteogenic and angiogenic factor promoting the bony repair. The current study investigated its roles in regulating injury site remodelling. In a rat tibial growth plate drill-hole injury repair model, NT-3 was expressed prominently in osteoblasts at the injury site. Recombinant NT-3 (rhNT-3) systemic treatment enhanced, but NT-3 immunoneutralization attenuated, expression of cartilage-removal proteases (MMP-9 and MMP-13), presence of bone-resorbing osteoclasts and expression of osteoclast protease cathepsin K, and remodelling at the injury site. NT-3 was also highly induced in cultured mineralizing rat bone marrow stromal cells, and the conditioned medium augmented osteoclast formation and resorptive activity, an ability that was blocked by presence of anti-NT-3 antibody. Moreover, NT-3 and receptor TrkC were induced during osteoclastogenesis, and rhNT-3 treatment activated TrkC downstream kinase Erk1/2 in differentiating osteoclasts although rhNT-3 alone did not affect activation of osteoclastogenic transcription factors NF-κB or NFAT in RAW264.7 osteoclast precursor cells. Furthermore, rhNT-3 treatment increased, but NT-3 neutralization reduced, expression of osteoclastogenic cytokines (RANKL, TNF-α and IL-1) in mineralizing osteoblasts and in growth plate injury site, and rhNT-3 augmented the induction of these cytokines caused by RANKL treatment in RAW264.7 cells. Thus, injury site osteoblast-derived NT-3 is important in promoting growth plate injury site remodelling, as it induces cartilage proteases for cartilage removal and augments osteoclastogenesis and resorption both directly (involving activing Erk1/2 and substantiating RANKL-induced increased expression of osteoclastogenic signals in differentiating osteoclasts) and indirectly (inducing osteoclastogenic signals in osteoblasts). Refereed/Peer-reviewed

Published
2018

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